PREP (prolyl endopeptidase)

Gene

• Entrez ID: 5550
• Gene name: Prolyl endopeptidase
• Gene symbol: PREP
• Synonyms: PE, PEP
• Chromosome: 6
• Chromosome location: 6q21
• Summary: The protein encoded by this gene is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Prolyl endopeptidases have been reported to be invo

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT035971	hsa-miR-1301-3p	CLASH	23622248
MIRT1260883	hsa-miR-1229	CLIP-seq
MIRT1260884	hsa-miR-1264	CLIP-seq
MIRT1260885	hsa-miR-1286	CLIP-seq
MIRT1260886	hsa-miR-136	CLIP-seq
MIRT1260887	hsa-miR-146a	CLIP-seq
MIRT1260888	hsa-miR-146b-5p	CLIP-seq
MIRT1260889	hsa-miR-23a	CLIP-seq
MIRT1260890	hsa-miR-23b	CLIP-seq
MIRT1260891	hsa-miR-23c	CLIP-seq
MIRT1260892	hsa-miR-3143	CLIP-seq
MIRT1260893	hsa-miR-342-3p	CLIP-seq
MIRT1260894	hsa-miR-409-3p	CLIP-seq
MIRT1260895	hsa-miR-4277	CLIP-seq
MIRT1260896	hsa-miR-4291	CLIP-seq
MIRT1260897	hsa-miR-4684-3p	CLIP-seq
MIRT1260898	hsa-miR-4722-5p	CLIP-seq
MIRT1260899	hsa-miR-4729	CLIP-seq
MIRT1260900	hsa-miR-4760-3p	CLIP-seq
MIRT1260901	hsa-miR-4773	CLIP-seq
MIRT1260902	hsa-miR-4795-3p	CLIP-seq
MIRT1260903	hsa-miR-513b	CLIP-seq
MIRT1260904	hsa-miR-515-5p	CLIP-seq
MIRT1260905	hsa-miR-518a-5p	CLIP-seq
MIRT1260906	hsa-miR-527	CLIP-seq
MIRT1260907	hsa-miR-543	CLIP-seq
MIRT1260908	hsa-miR-545	CLIP-seq
MIRT1260909	hsa-miR-589	CLIP-seq
MIRT1260910	hsa-miR-942	CLIP-seq
MIRT2076765	hsa-miR-1246	CLIP-seq
MIRT2076766	hsa-miR-154	CLIP-seq
MIRT2076767	hsa-miR-3976	CLIP-seq
MIRT2303483	hsa-miR-129-3p	CLIP-seq
MIRT1260887	hsa-miR-146a	CLIP-seq
MIRT1260888	hsa-miR-146b-5p	CLIP-seq
MIRT1260895	hsa-miR-4277	CLIP-seq
MIRT1260896	hsa-miR-4291	CLIP-seq
MIRT2303484	hsa-miR-4423-5p	CLIP-seq
MIRT2303485	hsa-miR-4433	CLIP-seq
MIRT2303486	hsa-miR-4459	CLIP-seq
MIRT2303487	hsa-miR-4652-3p	CLIP-seq
MIRT2303488	hsa-miR-4659a-5p	CLIP-seq
MIRT2303489	hsa-miR-4659b-5p	CLIP-seq
MIRT1260900	hsa-miR-4760-3p	CLIP-seq
MIRT2303490	hsa-miR-4768-3p	CLIP-seq
MIRT1260901	hsa-miR-4773	CLIP-seq
MIRT2303491	hsa-miR-4776-3p	CLIP-seq
MIRT2303492	hsa-miR-4780	CLIP-seq
MIRT1260903	hsa-miR-513b	CLIP-seq
MIRT1260908	hsa-miR-545	CLIP-seq
MIRT2303493	hsa-miR-548a-3p	CLIP-seq
MIRT2303494	hsa-miR-548e	CLIP-seq
MIRT2303495	hsa-miR-548f	CLIP-seq
MIRT1260909	hsa-miR-589	CLIP-seq
MIRT2457135	hsa-miR-1299	CLIP-seq
MIRT2457136	hsa-miR-4436b-5p	CLIP-seq
MIRT2457137	hsa-miR-4653-3p	CLIP-seq
MIRT2457138	hsa-miR-4749-3p	CLIP-seq
MIRT2457139	hsa-miR-4782-5p	CLIP-seq
MIRT2457140	hsa-miR-516b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004175	Function	Endopeptidase activity	IBA	21873635
GO:0004252	Function	Serine-type endopeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	23348613
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	TAS	9695945
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0006508	Process	Proteolysis	IEA
GO:0008236	Function	Serine-type peptidase activity	TAS	7959018
GO:0016020	Component	Membrane	HDA	19946888
GO:0070012	Function	Oligopeptidase activity	IBA	21873635

Other IDs

• MIM: 600400
• HGNC: 9358
• e!Ensembl: ENSG00000085377

Protein

• UniProt ID: P48147
• Protein name: Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme)
• Protein function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
• PDB: 3DDU
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02897	Peptidase_S9_N	7 → 423	Prolyl oligopeptidase, N-terminal beta-propeller domain	Domain
  PF00326	Peptidase_S9	482 → 707	Prolyl oligopeptidase family	Domain

• Sequence:

  MLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIR
  GLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILS
  DDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTH
  DGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAEL
  SDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVF
  TFKTNRQSPNYRVINIDFRDPEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNI
  LQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPR
  VFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISI
  TPNYSVSRLIFVRHMGGILAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKE
  GYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYG
  CSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIV
  GRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNVDWIP

• Sequence length: 710

Pathways

KEGG:

Renin-angiotensin system

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	21364753

Unknown
Disease name	Disease term	dbSNP ID	References
Amnesia	Amnesia		8691432
Manic disorder	Manic		15911340
Retrograde amnesia	Retrograde amnesia		18318186
Stomach neoplasms	Malignant neoplasm of stomach, Stomach Neoplasms		21364753