MCM10 (minichromosome maintenance 10 replication initiation factor)

Gene

• Entrez ID: 55388
• Gene name: Minichromosome maintenance 10 replication initiation factor
• Gene symbol: MCM10
• Synonyms: CNA43, DNA43, IMD80, PRO2249
• Chromosome: 10
• Chromosome location: 10p13
• Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004854	hsa-miR-192-5p	Luciferase reporter assay, qRT-PCR	19074876
MIRT016315	hsa-miR-193b-3p	Microarray	20304954
MIRT019273	hsa-miR-148b-3p	Microarray	17612493
MIRT024276	hsa-miR-215-5p	Microarray	19074876
MIRT004854	hsa-miR-192-5p	Reporter assay;Microarray;Other	19074876
MIRT030381	hsa-miR-24-3p	qRT-PCR;Microarray	19748357
MIRT047354	hsa-miR-34a-5p	CLASH	23622248
MIRT016315	hsa-miR-193b-3p	CLASH	23622248
MIRT039760	hsa-miR-615-3p	CLASH	23622248
MIRT038395	hsa-miR-296-3p	CLASH	23622248
MIRT437480	hsa-miR-185-5p	Luciferase reporter assay, qRT-PCR, Western blot	24014023
MIRT684117	hsa-miR-4432	HITS-CLIP	23313552
MIRT684116	hsa-miR-3664-5p	HITS-CLIP	23313552
MIRT684115	hsa-miR-3613-3p	HITS-CLIP	23313552
MIRT684114	hsa-miR-371b-5p	HITS-CLIP	23313552
MIRT684113	hsa-miR-373-5p	HITS-CLIP	23313552
MIRT684112	hsa-miR-616-5p	HITS-CLIP	23313552
MIRT684111	hsa-miR-371a-5p	HITS-CLIP	23313552
MIRT684110	hsa-miR-372-5p	HITS-CLIP	23313552
MIRT684109	hsa-miR-3120-5p	HITS-CLIP	23313552
MIRT684108	hsa-miR-4522	HITS-CLIP	23313552
MIRT684107	hsa-miR-6888-3p	HITS-CLIP	23313552
MIRT684106	hsa-miR-6510-3p	HITS-CLIP	23313552
MIRT684117	hsa-miR-4432	HITS-CLIP	23313552
MIRT684116	hsa-miR-3664-5p	HITS-CLIP	23313552
MIRT684115	hsa-miR-3613-3p	HITS-CLIP	23313552
MIRT684114	hsa-miR-371b-5p	HITS-CLIP	23313552
MIRT684113	hsa-miR-373-5p	HITS-CLIP	23313552
MIRT684112	hsa-miR-616-5p	HITS-CLIP	23313552
MIRT684111	hsa-miR-371a-5p	HITS-CLIP	23313552
MIRT684110	hsa-miR-372-5p	HITS-CLIP	23313552
MIRT684109	hsa-miR-3120-5p	HITS-CLIP	23313552
MIRT684108	hsa-miR-4522	HITS-CLIP	23313552
MIRT684107	hsa-miR-6888-3p	HITS-CLIP	23313552
MIRT684106	hsa-miR-6510-3p	HITS-CLIP	23313552
MIRT1137527	hsa-miR-1267	CLIP-seq
MIRT1137528	hsa-miR-1297	CLIP-seq
MIRT1137529	hsa-miR-149	CLIP-seq
MIRT1137530	hsa-miR-200b	CLIP-seq
MIRT1137531	hsa-miR-200c	CLIP-seq
MIRT1137532	hsa-miR-21	CLIP-seq
MIRT1137533	hsa-miR-2116	CLIP-seq
MIRT1137534	hsa-miR-2278	CLIP-seq
MIRT1137535	hsa-miR-26a	CLIP-seq
MIRT1137536	hsa-miR-26b	CLIP-seq
MIRT1137537	hsa-miR-300	CLIP-seq
MIRT1137538	hsa-miR-302a	CLIP-seq
MIRT1137539	hsa-miR-302b	CLIP-seq
MIRT1137540	hsa-miR-302c	CLIP-seq
MIRT1137541	hsa-miR-302d	CLIP-seq
MIRT1137542	hsa-miR-302e	CLIP-seq
MIRT1137543	hsa-miR-3064-5p	CLIP-seq
MIRT1137544	hsa-miR-3065-3p	CLIP-seq
MIRT1137545	hsa-miR-3115	CLIP-seq
MIRT1137546	hsa-miR-3119	CLIP-seq
MIRT1137547	hsa-miR-3120-3p	CLIP-seq
MIRT1137548	hsa-miR-3121-5p	CLIP-seq
MIRT1137549	hsa-miR-3126-3p	CLIP-seq
MIRT1137550	hsa-miR-3160-5p	CLIP-seq
MIRT1137551	hsa-miR-3180-5p	CLIP-seq
MIRT1137552	hsa-miR-338-5p	CLIP-seq
MIRT1137553	hsa-miR-3678-5p	CLIP-seq
MIRT1137554	hsa-miR-372	CLIP-seq
MIRT1137555	hsa-miR-373	CLIP-seq
MIRT1137556	hsa-miR-381	CLIP-seq
MIRT1137557	hsa-miR-410	CLIP-seq
MIRT1137558	hsa-miR-429	CLIP-seq
MIRT1137559	hsa-miR-4328	CLIP-seq
MIRT1137560	hsa-miR-4446-5p	CLIP-seq
MIRT1137561	hsa-miR-4459	CLIP-seq
MIRT1137562	hsa-miR-4465	CLIP-seq
MIRT1137563	hsa-miR-4468	CLIP-seq
MIRT1137564	hsa-miR-4477a	CLIP-seq
MIRT1137565	hsa-miR-4501	CLIP-seq
MIRT1137566	hsa-miR-4652-3p	CLIP-seq
MIRT1137567	hsa-miR-4666-3p	CLIP-seq
MIRT1137568	hsa-miR-4672	CLIP-seq
MIRT1137569	hsa-miR-4690-5p	CLIP-seq
MIRT1137570	hsa-miR-4694-5p	CLIP-seq
MIRT1137571	hsa-miR-4695-5p	CLIP-seq
MIRT1137572	hsa-miR-4742-5p	CLIP-seq
MIRT1137573	hsa-miR-4789-5p	CLIP-seq
MIRT1137574	hsa-miR-4794	CLIP-seq
MIRT1137575	hsa-miR-4804-3p	CLIP-seq
MIRT1137576	hsa-miR-490-3p	CLIP-seq
MIRT1137577	hsa-miR-498	CLIP-seq
MIRT1137578	hsa-miR-499-3p	CLIP-seq
MIRT1137579	hsa-miR-499a-3p	CLIP-seq
MIRT1137580	hsa-miR-500a	CLIP-seq
MIRT1137581	hsa-miR-501-5p	CLIP-seq
MIRT1137582	hsa-miR-513a-5p	CLIP-seq
MIRT1137583	hsa-miR-520a-3p	CLIP-seq
MIRT1137584	hsa-miR-520a-5p	CLIP-seq
MIRT1137585	hsa-miR-520b	CLIP-seq
MIRT1137586	hsa-miR-520c-3p	CLIP-seq
MIRT1137587	hsa-miR-520d-3p	CLIP-seq
MIRT1137588	hsa-miR-520e	CLIP-seq
MIRT1137589	hsa-miR-520f	CLIP-seq
MIRT1137590	hsa-miR-525-5p	CLIP-seq
MIRT1137591	hsa-miR-548a-5p	CLIP-seq
MIRT1137592	hsa-miR-548ab	CLIP-seq
MIRT1137593	hsa-miR-548ak	CLIP-seq
MIRT1137594	hsa-miR-548b-5p	CLIP-seq
MIRT1137595	hsa-miR-548c-5p	CLIP-seq
MIRT1137596	hsa-miR-548d-5p	CLIP-seq
MIRT1137597	hsa-miR-548h	CLIP-seq
MIRT1137598	hsa-miR-548i	CLIP-seq
MIRT1137599	hsa-miR-548j	CLIP-seq
MIRT1137600	hsa-miR-548w	CLIP-seq
MIRT1137601	hsa-miR-548y	CLIP-seq
MIRT1137602	hsa-miR-559	CLIP-seq
MIRT1137603	hsa-miR-590-3p	CLIP-seq
MIRT1137604	hsa-miR-590-5p	CLIP-seq
MIRT1137605	hsa-miR-758	CLIP-seq
MIRT1137606	hsa-miR-1225-3p	CLIP-seq
MIRT1137607	hsa-miR-1233	CLIP-seq
MIRT1137527	hsa-miR-1267	CLIP-seq
MIRT1137608	hsa-miR-1273e	CLIP-seq
MIRT1137609	hsa-miR-1288	CLIP-seq
MIRT1137528	hsa-miR-1297	CLIP-seq
MIRT1137610	hsa-miR-1915	CLIP-seq
MIRT1137611	hsa-miR-217	CLIP-seq
MIRT1137535	hsa-miR-26a	CLIP-seq
MIRT1137536	hsa-miR-26b	CLIP-seq
MIRT1137612	hsa-miR-3169	CLIP-seq
MIRT1137613	hsa-miR-3646	CLIP-seq
MIRT1137614	hsa-miR-3648	CLIP-seq
MIRT1137615	hsa-miR-3689a-3p	CLIP-seq
MIRT1137616	hsa-miR-3689c	CLIP-seq
MIRT1137617	hsa-miR-3692	CLIP-seq
MIRT1137618	hsa-miR-4302	CLIP-seq
MIRT1137619	hsa-miR-4418	CLIP-seq
MIRT1137620	hsa-miR-4436b-5p	CLIP-seq
MIRT1137562	hsa-miR-4465	CLIP-seq
MIRT1137566	hsa-miR-4652-3p	CLIP-seq
MIRT1137570	hsa-miR-4694-5p	CLIP-seq
MIRT1137621	hsa-miR-4728-5p	CLIP-seq
MIRT1137622	hsa-miR-4786-3p	CLIP-seq
MIRT1137623	hsa-miR-4793-3p	CLIP-seq
MIRT1137624	hsa-miR-508-5p	CLIP-seq
MIRT1137625	hsa-miR-509-3-5p	CLIP-seq
MIRT1137626	hsa-miR-509-5p	CLIP-seq
MIRT1137627	hsa-miR-548ac	CLIP-seq
MIRT1137628	hsa-miR-548ae	CLIP-seq
MIRT1137629	hsa-miR-548aj	CLIP-seq
MIRT1137630	hsa-miR-548am	CLIP-seq
MIRT1137631	hsa-miR-548d-3p	CLIP-seq
MIRT1137632	hsa-miR-548v	CLIP-seq
MIRT1137633	hsa-miR-548x	CLIP-seq
MIRT1137634	hsa-miR-548z	CLIP-seq
MIRT1137635	hsa-miR-607	CLIP-seq
MIRT1137636	hsa-miR-648	CLIP-seq
MIRT1137637	hsa-miR-671-5p	CLIP-seq
MIRT1137605	hsa-miR-758	CLIP-seq
MIRT1137638	hsa-miR-766	CLIP-seq
MIRT1137606	hsa-miR-1225-3p	CLIP-seq
MIRT1137607	hsa-miR-1233	CLIP-seq
MIRT1137608	hsa-miR-1273e	CLIP-seq
MIRT1137610	hsa-miR-1915	CLIP-seq
MIRT2039102	hsa-miR-192	CLIP-seq
MIRT1137532	hsa-miR-21	CLIP-seq
MIRT2039103	hsa-miR-215	CLIP-seq
MIRT1137615	hsa-miR-3689a-3p	CLIP-seq
MIRT1137616	hsa-miR-3689c	CLIP-seq
MIRT1137569	hsa-miR-4690-5p	CLIP-seq
MIRT1137621	hsa-miR-4728-5p	CLIP-seq
MIRT1137622	hsa-miR-4786-3p	CLIP-seq
MIRT1137591	hsa-miR-548a-5p	CLIP-seq
MIRT1137592	hsa-miR-548ab	CLIP-seq
MIRT1137593	hsa-miR-548ak	CLIP-seq
MIRT1137594	hsa-miR-548b-5p	CLIP-seq
MIRT1137595	hsa-miR-548c-5p	CLIP-seq
MIRT1137596	hsa-miR-548d-5p	CLIP-seq
MIRT1137597	hsa-miR-548h	CLIP-seq
MIRT1137598	hsa-miR-548i	CLIP-seq
MIRT1137599	hsa-miR-548j	CLIP-seq
MIRT1137600	hsa-miR-548w	CLIP-seq
MIRT1137601	hsa-miR-548y	CLIP-seq
MIRT1137602	hsa-miR-559	CLIP-seq
MIRT1137604	hsa-miR-590-5p	CLIP-seq
MIRT1137637	hsa-miR-671-5p	CLIP-seq
MIRT1137537	hsa-miR-300	CLIP-seq
MIRT1137550	hsa-miR-3160-5p	CLIP-seq
MIRT1137551	hsa-miR-3180-5p	CLIP-seq
MIRT2269083	hsa-miR-3620	CLIP-seq
MIRT1137615	hsa-miR-3689a-3p	CLIP-seq
MIRT1137616	hsa-miR-3689c	CLIP-seq
MIRT1137556	hsa-miR-381	CLIP-seq
MIRT1137557	hsa-miR-410	CLIP-seq
MIRT1137567	hsa-miR-4666-3p	CLIP-seq
MIRT1137621	hsa-miR-4728-5p	CLIP-seq
MIRT1137573	hsa-miR-4789-5p	CLIP-seq
MIRT1137582	hsa-miR-513a-5p	CLIP-seq
MIRT1137584	hsa-miR-520a-5p	CLIP-seq
MIRT1137590	hsa-miR-525-5p	CLIP-seq
MIRT2269084	hsa-miR-656	CLIP-seq
MIRT2453830	hsa-miR-1283	CLIP-seq
MIRT2453831	hsa-miR-3675-3p	CLIP-seq
MIRT2453832	hsa-miR-378g	CLIP-seq
MIRT2453833	hsa-miR-4684-5p	CLIP-seq
MIRT2453830	hsa-miR-1283	CLIP-seq
MIRT2453831	hsa-miR-3675-3p	CLIP-seq
MIRT2568370	hsa-miR-4293	CLIP-seq
MIRT2568371	hsa-miR-4470	CLIP-seq
MIRT2453833	hsa-miR-4684-5p	CLIP-seq
MIRT2568372	hsa-miR-4786-5p	CLIP-seq
MIRT2568373	hsa-miR-769-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
E2F4	Repression	15195143
MYCN	Activation	17826980

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000082	Process	G1/S transition of mitotic cell cycle	TAS
GO:0003688	Function	DNA replication origin binding	IBA	21873635
GO:0003697	Function	Single-stranded DNA binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	11095689, 15232106, 16189514
GO:0005634	Component	Nucleus	IDA	11095689
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA
GO:0006260	Process	DNA replication	TAS
GO:0006270	Process	DNA replication initiation	IBA	21873635
GO:0006974	Process	Cellular response to DNA damage stimulus	IMP	24726359
GO:0008283	Process	Cell population proliferation	IEA
GO:0019899	Function	Enzyme binding	IEA
GO:0031298	Component	Replication fork protection complex	IBA	21873635
GO:0042802	Function	Identical protein binding	IPI	17823614
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 609357
• HGNC: 18043
• e!Ensembl: ENSG00000065328

Protein

• UniProt ID: Q7L590
• Protein name: Protein MCM10 homolog (HsMCM10)
• Protein function: Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effec
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09329	zf-primase	382 → 427	Primase zinc finger	Domain
  PF09332	Mcm10	524 → 873	Mcm10 replication factor	Domain

• Sequence:

  MDEEEDNLSLLTALLEENESALDCNSEENNFLTRENGEPDAFDELFDADGDGESYTEEAD
  DGETGETRDEKENLATLFGDMEDLTDEEEVPASQSTENRVLPAPAPRREKTNEELQEELR
  NLQEQMKALQEQLKVTTIKQTASPARLQKSPVEKSPRPPLKERRVQRIQESTCFSAELDV
  PALPRTKRVARTPKASPPDPKSSSSRMTSAPSQPLQTISRNKPSGITRGQIVGTPGSSGE
  TTQPICVEAFSGLRLRRPRVSSTEMNKKMTGRKLIRLSQIKEKMAREKLEEIDWVTFGVI
  LKKVTPQSVNSGKTFSIWKLNDLRDLTQCVSLFLFGEVHKALWKTEQGTVVGILNANPMK
  PKDGSEEVCLSIDHPQKVLIMGEALDLGTCKAKKKNGEPCTQTVNLRDCEYCQYHVQAQY
  KKLSAKRADLQSTFSGGRIPKKFARRGTSLKERLCQDGFYYGGVSSASYAASIAAAVAPK
  KKIQTTLSNLVVKGTNLIIQETRQKLGIPQKSLSCSEEFKELMDLPTCGARNLKQHLAKA
  TASGIMGSPKPAIKSISASALLKQQKQRMLEMRRRKSEEIQKRFLQSSSEVESPAVPSSS
  RQPPAQPPRTGSEFPRLEGAPATMTPKLGRGVLEGDDVLFYDESPPPRPKLSALAEAKKL
  AAITKLRAKGQVLTKTNPNSIKKKQKDPQDILEVKERVEKNTMFSSQAEDELEPARKKRR
  EQLAYLESEEFQKILKAKSKHTGILKEAEAEMQERYFEPLVKKEQMEEKMRNIREVKCRV
  VTCKTCAYTHFKLLETCVSEQHEYHWHDGVKRFFKCPCGNRSISLDRLPNKHCSNCGLYK
  WERDGMLKEKTGPKIGGETLLPRGEEHAKFLNSLK

• Sequence length: 875

Pathways

Reactome:

Activation of ATR in response to replication stress
Activation of the pre-replicative complex

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		28284560