PPP6C (protein phosphatase 6 catalytic subunit)
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Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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5537 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Protein phosphatase 6 catalytic subunit |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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PPP6C |
SynonymsGene synonyms aliases
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PP6, PP6C |
ChromosomeChromosome number
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9 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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9q33.3 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provi |
SNPsSNP information provided by dbSNP.
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SNP ID |
Visualize variation |
Clinical significance |
Consequence |
rs763733111 |
G>A |
Likely-pathogenic |
Coding sequence variant, missense variant |
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miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000082 |
Process |
G1/S transition of mitotic cell cycle |
TAS |
9013334 |
GO:0000139 |
Component |
Golgi membrane |
IEA |
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GO:0004722 |
Function |
Protein serine/threonine phosphatase activity |
IDA |
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GO:0004722 |
Function |
Protein serine/threonine phosphatase activity |
TAS |
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GO:0005515 |
Function |
Protein binding |
IPI |
9647778, 16085932, 16769727, 17079228, 17384681, 18186651, 21187329, 24255178, 26496610, 28330616, 32296183 |
GO:0005739 |
Component |
Mitochondrion |
IEA |
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GO:0005829 |
Component |
Cytosol |
IDA |
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GO:0005829 |
Component |
Cytosol |
TAS |
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GO:0006470 |
Process |
Protein dephosphorylation |
IDA |
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GO:0045087 |
Process |
Innate immune response |
IEA |
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GO:0046872 |
Function |
Metal ion binding |
IEA |
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GO:0048208 |
Process |
COPII vesicle coating |
TAS |
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GO:0106306 |
Function |
Protein serine phosphatase activity |
IEA |
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GO:0106307 |
Function |
Protein threonine phosphatase activity |
IEA |
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
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UniProt ID |
O00743 |
Protein name |
Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed] |
Protein function |
Catalytic subunit of protein phosphatase 6 (PP6) (PubMed:17079228, PubMed:29053956, PubMed:32474700). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation (PubMed:10227379). N-termin |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00149 |
Metallophos |
46 → 241 |
Calcineurin-like phosphoesterase |
Domain |
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Sequence |
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Sequence length |
305 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Carcinoma |
Carcinoma, Basal Cell |
rs121912654, rs555607708, rs786202962, rs1564055259 |
26950094 |
Lung carcinoma |
Squamous cell carcinoma of lung |
rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193 |
26619011 |
Melanoma |
melanoma, Cutaneous Melanoma |
rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs1563902635, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050 |
22842228, 26619011 |
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