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HJURP (Holliday junction recognition protein)

Gene

55355

Holliday junction recognition protein

HJURP

FAKTS, URLC9, hFLEG1

2q37.1

Show/Hide all(144)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024443	hsa-miR-215-5p	Microarray	19074876
MIRT026468	hsa-miR-192-5p	Microarray	19074876
MIRT039300	hsa-miR-671-5p	CLASH	23622248
MIRT691145	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT691144	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT691143	hsa-miR-3929	HITS-CLIP	23313552
MIRT691142	hsa-miR-4419b	HITS-CLIP	23313552
MIRT691141	hsa-miR-4478	HITS-CLIP	23313552
MIRT691140	hsa-miR-5690	HITS-CLIP	23313552
MIRT691139	hsa-miR-1247-3p	HITS-CLIP	23313552
MIRT691138	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT691137	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT691136	hsa-miR-1827	HITS-CLIP	23313552
MIRT691135	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT691134	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT691133	hsa-miR-298	HITS-CLIP	23313552
MIRT691132	hsa-miR-6720-3p	HITS-CLIP	23313552
MIRT691131	hsa-miR-4783-5p	HITS-CLIP	23313552
MIRT691130	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT691129	hsa-miR-4634	HITS-CLIP	23313552
MIRT691128	hsa-miR-7977	HITS-CLIP	23313552
MIRT691127	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT691126	hsa-miR-665	HITS-CLIP	23313552
MIRT440500	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440500	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT691145	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT691144	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT691143	hsa-miR-3929	HITS-CLIP	23313552
MIRT691142	hsa-miR-4419b	HITS-CLIP	23313552
MIRT691141	hsa-miR-4478	HITS-CLIP	23313552
MIRT691140	hsa-miR-5690	HITS-CLIP	23313552
MIRT691139	hsa-miR-1247-3p	HITS-CLIP	23313552
MIRT691138	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT691137	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT691136	hsa-miR-1827	HITS-CLIP	23313552
MIRT691135	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT691134	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT691133	hsa-miR-298	HITS-CLIP	23313552
MIRT691132	hsa-miR-6720-3p	HITS-CLIP	23313552
MIRT691131	hsa-miR-4783-5p	HITS-CLIP	23313552
MIRT691130	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT691129	hsa-miR-4634	HITS-CLIP	23313552
MIRT691128	hsa-miR-7977	HITS-CLIP	23313552
MIRT691127	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT691126	hsa-miR-665	HITS-CLIP	23313552
MIRT1048020	hsa-miR-1227	CLIP-seq
MIRT1048021	hsa-miR-3134	CLIP-seq
MIRT1048022	hsa-miR-3675-3p	CLIP-seq
MIRT1048023	hsa-miR-3921	CLIP-seq
MIRT1048024	hsa-miR-3976	CLIP-seq
MIRT1048025	hsa-miR-4486	CLIP-seq
MIRT1048026	hsa-miR-4502	CLIP-seq
MIRT1048027	hsa-miR-4534	CLIP-seq
MIRT1048028	hsa-miR-4649-5p	CLIP-seq
MIRT1048029	hsa-miR-4653-5p	CLIP-seq
MIRT1048030	hsa-miR-4684-5p	CLIP-seq
MIRT1048031	hsa-miR-508-5p	CLIP-seq
MIRT1048032	hsa-miR-661	CLIP-seq
MIRT1048033	hsa-miR-766	CLIP-seq
MIRT2010894	hsa-miR-3122	CLIP-seq
MIRT2010895	hsa-miR-3689a-3p	CLIP-seq
MIRT2010896	hsa-miR-3689c	CLIP-seq
MIRT2010897	hsa-miR-3913-5p	CLIP-seq
MIRT2010898	hsa-miR-4728-5p	CLIP-seq
MIRT1048020	hsa-miR-1227	CLIP-seq
MIRT2010894	hsa-miR-3122	CLIP-seq
MIRT1048021	hsa-miR-3134	CLIP-seq
MIRT2010895	hsa-miR-3689a-3p	CLIP-seq
MIRT2010896	hsa-miR-3689c	CLIP-seq
MIRT2010897	hsa-miR-3913-5p	CLIP-seq
MIRT1048025	hsa-miR-4486	CLIP-seq
MIRT1048028	hsa-miR-4649-5p	CLIP-seq
MIRT2243126	hsa-miR-4699-3p	CLIP-seq
MIRT2243127	hsa-miR-4715-3p	CLIP-seq
MIRT2010898	hsa-miR-4728-5p	CLIP-seq
MIRT1048031	hsa-miR-508-5p	CLIP-seq
MIRT1048032	hsa-miR-661	CLIP-seq
MIRT1048033	hsa-miR-766	CLIP-seq
MIRT2451211	hsa-miR-1283	CLIP-seq
MIRT2451212	hsa-miR-3613-3p	CLIP-seq
MIRT2451213	hsa-miR-371-5p	CLIP-seq
MIRT2451214	hsa-miR-371b-5p	CLIP-seq
MIRT1048030	hsa-miR-4684-5p	CLIP-seq
MIRT2451215	hsa-miR-495	CLIP-seq
MIRT2451216	hsa-miR-548a-3p	CLIP-seq
MIRT2451217	hsa-miR-548e	CLIP-seq
MIRT2451218	hsa-miR-548f	CLIP-seq
MIRT2451211	hsa-miR-1283	CLIP-seq
MIRT2451212	hsa-miR-3613-3p	CLIP-seq
MIRT2451213	hsa-miR-371-5p	CLIP-seq
MIRT2451214	hsa-miR-371b-5p	CLIP-seq
MIRT1048030	hsa-miR-4684-5p	CLIP-seq
MIRT2451215	hsa-miR-495	CLIP-seq
MIRT2451216	hsa-miR-548a-3p	CLIP-seq
MIRT2451217	hsa-miR-548e	CLIP-seq
MIRT2451218	hsa-miR-548f	CLIP-seq
MIRT1048020	hsa-miR-1227	CLIP-seq
MIRT2451211	hsa-miR-1283	CLIP-seq
MIRT2010894	hsa-miR-3122	CLIP-seq
MIRT2451212	hsa-miR-3613-3p	CLIP-seq
MIRT2010895	hsa-miR-3689a-3p	CLIP-seq
MIRT2010896	hsa-miR-3689c	CLIP-seq
MIRT2451213	hsa-miR-371-5p	CLIP-seq
MIRT2451214	hsa-miR-371b-5p	CLIP-seq
MIRT2010897	hsa-miR-3913-5p	CLIP-seq
MIRT1048025	hsa-miR-4486	CLIP-seq
MIRT2546342	hsa-miR-4662a-5p	CLIP-seq
MIRT2546343	hsa-miR-4676-5p	CLIP-seq
MIRT1048030	hsa-miR-4684-5p	CLIP-seq
MIRT2243127	hsa-miR-4715-3p	CLIP-seq
MIRT2010898	hsa-miR-4728-5p	CLIP-seq
MIRT2546344	hsa-miR-4755-3p	CLIP-seq
MIRT2451215	hsa-miR-495	CLIP-seq
MIRT1048031	hsa-miR-508-5p	CLIP-seq
MIRT2451216	hsa-miR-548a-3p	CLIP-seq
MIRT2451217	hsa-miR-548e	CLIP-seq
MIRT2451218	hsa-miR-548f	CLIP-seq
MIRT2546345	hsa-miR-575	CLIP-seq
MIRT1048032	hsa-miR-661	CLIP-seq
MIRT1048033	hsa-miR-766	CLIP-seq
MIRT1048020	hsa-miR-1227	CLIP-seq
MIRT2451211	hsa-miR-1283	CLIP-seq
MIRT2010894	hsa-miR-3122	CLIP-seq
MIRT2451212	hsa-miR-3613-3p	CLIP-seq
MIRT2010895	hsa-miR-3689a-3p	CLIP-seq
MIRT2010896	hsa-miR-3689c	CLIP-seq
MIRT2451213	hsa-miR-371-5p	CLIP-seq
MIRT2451214	hsa-miR-371b-5p	CLIP-seq
MIRT2010897	hsa-miR-3913-5p	CLIP-seq
MIRT1048025	hsa-miR-4486	CLIP-seq
MIRT2546342	hsa-miR-4662a-5p	CLIP-seq
MIRT2546343	hsa-miR-4676-5p	CLIP-seq
MIRT1048030	hsa-miR-4684-5p	CLIP-seq
MIRT2243127	hsa-miR-4715-3p	CLIP-seq
MIRT2010898	hsa-miR-4728-5p	CLIP-seq
MIRT2546344	hsa-miR-4755-3p	CLIP-seq
MIRT2451215	hsa-miR-495	CLIP-seq
MIRT1048031	hsa-miR-508-5p	CLIP-seq
MIRT2451216	hsa-miR-548a-3p	CLIP-seq
MIRT2451217	hsa-miR-548e	CLIP-seq
MIRT2451218	hsa-miR-548f	CLIP-seq
MIRT2546345	hsa-miR-575	CLIP-seq
MIRT1048032	hsa-miR-661	CLIP-seq
MIRT1048033	hsa-miR-766	CLIP-seq

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000775	Component	Chromosome, centromeric region	IDA	19410544
GO:0000777	Component	Condensed chromosome kinetochore	IDA	19410545
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	19410544, 19410545, 20080577, 21478274, 26496610
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	19410545
GO:0005739	Component	Mitochondrion	IDA
GO:0007049	Process	Cell cycle	IEA
GO:0007059	Process	Chromosome segregation	IMP	19410544, 19410545
GO:0034080	Process	CENP-A containing nucleosome assembly	IMP	19410544, 19410545
GO:0034080	Process	CENP-A containing nucleosome assembly	TAS
GO:0042393	Function	Histone binding	IDA	21478274
GO:0042393	Function	Histone binding	IPI	19410544, 19410545
GO:0042802	Function	Identical protein binding	IPI	23771058
GO:0043254	Process	Regulation of protein-containing complex assembly	IDA	21478274
GO:0051101	Process	Regulation of DNA binding	IDA	21478274

MIM	HGNC	e!Ensembl
612667	25444	ENSG00000123485

Protein

UniProt ID

Q8NCD3

Protein name

Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9)

Protein function

Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules

PDB

3R45

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10384	Scm3	18 → 75	Centromere protein Scm3	Family
PF12346	HJURP_mid	271 → 385	Holliday junction recognition protein-associated repeat	Domain
PF12347	HJURP_C	409 → 470	Holliday junction regulator protein family C-terminal repeat	Domain
PF12347	HJURP_C	554 → 613	Holliday junction regulator protein family C-terminal repeat	Domain

Sequence

MLGTLRAMEGEDVEDDQLLQKLRASRRRFQRRMQRLIEKYNQPFEDTPVVQMATLTYETP
QGLRIWGGRLIKERNEGEIQDSSMKPADRTDGSVQAAAWGPELPSHRTVLGADSKSGEVD
ATSDQEESVAWALAPAVPQSPLKNELRRKYLTQVDILLQGAEYFECAGNRAGRDVRVTPL
PSLASPAVPAPGYCSRISRKSPGDPAKPASSPREWDPLHPSSTDMALVPRNDSLSLQETS
SSSFLSSQPFEDDDICNVTISDLYAGMLHSMSRLLSTKPSSIISTKTFIMQNWNSRRRHR
YKSRMNKTYCKGARRSQRSSKENFIPCSEPVKGTGALRDCKNVLDVSCRKTGLKLEKAFL
EVNRPQIHKLDPSWKERKVTPSKYSSLIYFDSSATYNLDEENRFRTLKWLISPVKIVSRP
TIRQGHGENRQREIEIRFDQLHREYCLSPRNQPRRMCLPDSWAMNMYRGGPASPGGLQGL
ETRRLSLPSSKAKAKSLSEAFENLGKRSLEAGRCLPKSDSSSSLPKTNPTHSATRPQQTS
DLHVQGNSSGIFRKSVSPSKTLSVPDKEVPGHGRNRYDEIKEEFDKLHQKYCLKSPGQMT
VPLCIGVSTDKASMEVRYQTEGFLGKLNPDPHFQGFQKLPSSPLGCRKSLLGSTAIEAPS
STCVARAITRDGTRDHQFPAKRPRLSEPQGSGRQGNSLGASDGVDNTVRPGDQGSSSQPN
SEERGENTSYRMEEKSDFMLEKLETKSV

Sequence length

748

Interactions

View interactions

	Reactome
			Deposition of new CENPA-containing nucleosomes at the centromere

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Migraine	Migraine Disorders	rs794727411	27322543

Show/Hide Unknown Diseases (1)

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		28284560

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