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PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5534
Gene nameGene Name - the full gene name approved by the HGNC.
Protein phosphatase 3 regulatory subunit B, alpha
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
PPP3R1
SynonymsGene synonyms aliases
CALNB1, CNB, CNB1
ChromosomeChromosome number
2
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p14
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005180 hsa-miR-30a-5p pSILAC 18668040
MIRT025005 hsa-miR-183-5p Sequencing 20371350
MIRT025426 hsa-miR-34a-5p Sequencing 20371350
MIRT005180 hsa-miR-30a-5p Proteomics;Other 18668040
MIRT029303 hsa-miR-26b-5p Sequencing 20371350
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004723 Function Calcium-dependent protein serine/threonine phosphatase activity NAS 2558868
GO:0005509 Function Calcium ion binding NAS 2558868
GO:0005515 Function Protein binding IPI 8524402, 12218175, 12357034, 12809556, 16648474, 19896943, 22343722, 23468591, 24954618, 25416956, 26871637, 28514442, 32296183, 32814053
GO:0005516 Function Calmodulin binding NAS 2558868
GO:0005654 Component Nucleoplasm TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P63098
Protein name Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1)
Protein function Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
PDB 1AUI , 1M63 , 1MF8 , 2P6B , 3LL8 , 4F0Z , 4OR9 , 4ORA , 4ORC , 5SVE , 6NUC , 6NUF , 6NUU , 7U0T , 9B9G , 9CHU , 9CHV , 9CHX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13499 EF-hand_7
20 80
EF-hand domain pair
Domain
PF13499 EF-hand_7
89 158
EF-hand domain pair
Domain
PF00036 EF-hand_1
132 160
EF hand
Domain
Sequence
Sequence length 170
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  MAPK signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Oocyte meiosis
Cellular senescence
Wnt signaling pathway
Axon guidance
VEGF signaling pathway
Osteoclast differentiation
C-type lectin receptor signaling pathway
Natural killer cell mediated cytotoxicity
Th1 and Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling pathway
B cell receptor signaling pathway
Long-term potentiation
Glutamatergic synapse
Oxytocin signaling pathway
Glucagon signaling pathway
Renin secretion
Alzheimer disease
Amyotrophic lateral sclerosis
Prion disease
Pathways of neurodegeneration - multiple diseases
Amphetamine addiction
Tuberculosis
Human cytomegalovirus infection
Human T-cell leukemia virus 1 infection
Kaposi sarcoma-associated herpesvirus infection
Human immunodeficiency virus 1 infection
PD-L1 expression and PD-1 checkpoint pathway in cancer
Lipid and atherosclerosis
  Activation of BAD and translocation to mitochondria
Calcineurin activates NFAT
FCERI mediated Ca+2 mobilization
Ca2+ pathway
CLEC7A (Dectin-1) induces NFAT activation
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Left ventricular hypertrophy Left Ventricular Hypertrophy rs397516037 18344631
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 28991256, 12851458
Unknown
Disease name Disease term dbSNP ID References
Myocardial ischemia Myocardial Ischemia 16214533

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