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PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha)

Gene

5534

Protein phosphatase 3 regulatory subunit B, alpha

PPP3R1

CALNB1, CNB, CNB1

2p14

Show/Hide all(63)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005180	hsa-miR-30a-5p	pSILAC, Proteomics;Other	18668040
MIRT025005	hsa-miR-183-5p	Sequencing	20371350
MIRT025426	hsa-miR-34a-5p	Sequencing	20371350
MIRT029303	hsa-miR-26b-5p	Sequencing	20371350
MIRT030457	hsa-miR-24-3p	Sequencing	20371350
MIRT037914	hsa-miR-532-3p	CLASH	23622248
MIRT159806	hsa-miR-5189-3p	PAR-CLIP	22100165
MIRT159806	hsa-miR-5189-3p	HITS-CLIP	23824327
MIRT303230	hsa-miR-33a-3p	PAR-CLIP	23446348
MIRT303230	hsa-miR-33a-3p	PAR-CLIP	20371350
MIRT303233	hsa-miR-409-3p	PAR-CLIP	23446348
MIRT303233	hsa-miR-409-3p	PAR-CLIP	20371350
MIRT439908	hsa-miR-376a-3p	HITS-CLIP	24374217
MIRT439909	hsa-miR-369-3p	HITS-CLIP	24374217
MIRT439910	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT439911	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT442615	hsa-miR-9-3p	PAR-CLIP	22100165
MIRT442616	hsa-miR-4714-3p	PAR-CLIP	22100165
MIRT442617	hsa-miR-656-3p	PAR-CLIP	22100165
MIRT510950	hsa-miR-6763-3p	PAR-CLIP	23446348
MIRT510950	hsa-miR-6763-3p	PAR-CLIP	20371350
MIRT510951	hsa-miR-6758-3p	PAR-CLIP	23446348
MIRT510951	hsa-miR-6758-3p	PAR-CLIP	20371350
MIRT510952	hsa-miR-5587-3p	PAR-CLIP	23446348
MIRT510952	hsa-miR-5587-3p	PAR-CLIP	20371350
MIRT510953	hsa-miR-4707-5p	PAR-CLIP	23446348
MIRT510953	hsa-miR-4707-5p	PAR-CLIP	20371350
MIRT510954	hsa-miR-4704-5p	PAR-CLIP	23446348
MIRT510954	hsa-miR-4704-5p	PAR-CLIP	20371350
MIRT521719	hsa-miR-651-3p	PAR-CLIP	23446348
MIRT521719	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT521720	hsa-miR-548as-3p	PAR-CLIP	23446348
MIRT521720	hsa-miR-548as-3p	PAR-CLIP	20371350
MIRT521721	hsa-miR-548z	PAR-CLIP	23446348
MIRT521721	hsa-miR-548z	PAR-CLIP	20371350
MIRT521722	hsa-miR-548h-3p	PAR-CLIP	23446348
MIRT521722	hsa-miR-548h-3p	PAR-CLIP	20371350
MIRT521723	hsa-miR-548d-3p	PAR-CLIP	23446348
MIRT521723	hsa-miR-548d-3p	PAR-CLIP	20371350
MIRT521724	hsa-miR-548bb-3p	PAR-CLIP	23446348
MIRT521724	hsa-miR-548bb-3p	PAR-CLIP	20371350
MIRT521725	hsa-miR-548ac	PAR-CLIP	23446348
MIRT521725	hsa-miR-548ac	PAR-CLIP	20371350
MIRT566293	hsa-miR-578	PAR-CLIP	20371350
MIRT566294	hsa-miR-340-5p	PAR-CLIP	20371350
MIRT566295	hsa-miR-3185	PAR-CLIP	20371350
MIRT566296	hsa-miR-3163	PAR-CLIP	20371350
MIRT571779	hsa-miR-5692a	PAR-CLIP	20371350
MIRT654811	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT654812	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT654813	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT654814	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT654815	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT654816	hsa-miR-623	HITS-CLIP	23824327
MIRT654817	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT654818	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT654819	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT654820	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT654821	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT726875	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT726876	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT726877	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT726878	hsa-miR-20b-5p	HITS-CLIP	22473208

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004723	Function	Calcium-dependent protein serine/threonine phosphatase activity	NAS	2558868
GO:0005509	Function	Calcium ion binding	NAS	2558868
GO:0005515	Function	Protein binding	IPI	8524402, 12218175, 12357034, 12809556, 16648474, 19896943, 22343722, 23468591, 24954618, 25416956, 26871637, 28514442, 32296183, 32814053
GO:0005516	Function	Calmodulin binding	NAS	2558868
GO:0005654	Component	Nucleoplasm	TAS
GO:0005739	Component	Mitochondrion	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005955	Component	Calcineurin complex	IDA	12218175, 12357034, 22343722, 22688515, 23468591, 26794871, 27974827
GO:0005955	Component	Calcineurin complex	NAS	2558868
GO:0006470	Process	Protein dephosphorylation	IEA
GO:0007223	Process	Wnt signaling pathway, calcium modulating pathway	TAS
GO:0008597	Function	Calcium-dependent protein serine/threonine phosphatase regulator activity	IEA
GO:0016018	Function	Cyclosporin A binding	IDA	12218175, 12357034
GO:0019902	Function	Phosphatase binding	IPI	26794871, 27974827
GO:0019904	Function	Protein domain specific binding	IPI	20639889
GO:0033173	Process	Calcineurin-NFAT signaling cascade	IDA	22688515
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0042383	Component	Sarcolemma	IEA
GO:0043666	Process	Regulation of phosphoprotein phosphatase activity	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	22688515
GO:1900740	Process	Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	TAS

MIM	HGNC	e!Ensembl
601302	9317	ENSG00000221823

Protein

UniProt ID

P63098

Protein name

Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1)

Protein function

Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

PDB

1AUI , 1M63 , 1MF8 , 2P6B , 3LL8 , 4F0Z , 4OR9 , 4ORA , 4ORC , 5SVE , 6NUC , 6NUF , 6NUU

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13499	EF-hand_7	20 → 80	EF-hand domain pair	Domain
PF13499	EF-hand_7	89 → 158	EF-hand domain pair	Domain
PF00036	EF-hand_1	132 → 160	EF hand	Domain

Sequence

MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVID
IFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMV
GNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV

Sequence length

170

Interactions

View interactions

	KEGG		Reactome
	MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway Oocyte meiosis Cellular senescence Wnt signaling pathway Axon guidance VEGF signaling pathway Osteoclast differentiation C-type lectin receptor signaling pathway Natural killer cell mediated cytotoxicity Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway B cell receptor signaling pathway Long-term potentiation Glutamatergic synapse Oxytocin signaling pathway Glucagon signaling pathway Renin secretion Alzheimer disease Amyotrophic lateral sclerosis (ALS) Amphetamine addiction Tuberculosis Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection PD-L1 expression and PD-1 checkpoint pathway in cancer		Activation of BAD and translocation to mitochondria Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation

Associated diseases

Show/Hide all(3)

Disease name	Disease term	References

	Left Ventricular Hypertrophy	18344631

	Myocardial Ischemia	16214533

	Schizophrenia	28991256, 12851458

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