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PI4K2B (phosphatidylinositol 4-kinase type 2 beta)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55300
Gene nameGene Name - the full gene name approved by the HGNC.
Phosphatidylinositol 4-kinase type 2 beta
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
PI4K2B
SynonymsGene synonyms aliases
PI4KIIB, PIK42B
ChromosomeChromosome number
4
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4p15.2
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the type II PI4 kinase protein family. The encoded protein is primarily cytosolic and contributes to overall PI4-kinase activity along with other protein family members. This protein is involved in early T cell activation. [p
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT022232 hsa-miR-124-3p Microarray 18668037
MIRT031512 hsa-miR-16-5p Sequencing 20371350
MIRT685544 hsa-miR-548l HITS-CLIP 23313552
MIRT685543 hsa-miR-3973 HITS-CLIP 23313552
MIRT685542 hsa-miR-186-3p HITS-CLIP 23313552
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004430 Function 1-phosphatidylinositol 4-kinase activity IBA 21873635
GO:0005524 Function ATP binding IEA
GO:0005768 Component Endosome IBA 21873635
GO:0005802 Component Trans-Golgi network IBA 21873635
GO:0005829 Component Cytosol TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q8TCG2
Protein name Phosphatidylinositol 4-kinase type 2-beta (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-beta) (PI4KII-BETA)
Protein function Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell (PubMed:11923287, PubMed:12324459). This contribution may be especially significant in plasma membrane, endosomal and G
PDB 4WTV , 8A5X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00454 PI3_PI4_kinase
129 429
Phosphatidylinositol 3- and 4-kinase
Family
Sequence
Sequence length 481
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Inositol phosphate metabolism
Metabolic pathways
Phosphatidylinositol signaling system
  Synthesis of PIPs at the ER membrane
Synthesis of PIPs at the plasma membrane
Synthesis of PIPs at the Golgi membrane
Synthesis of PIPs at the early endosome membrane
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Attention deficit hyperactivity disorder Attention deficit hyperactivity disorder rs120074176, rs786205019 30563984
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 19539307

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