GeDiPNet: Comprehensive Gene Data - OMIM, HGNC, Ensembl, UniProt, GO, Transcription Factors & miRNA

Home
Browse
- Genes
- Diseases
- Pathways
  - Reactome
  - KEGG
Analysis
Help
Links
FAQ
Contact us

NUDT15 (nudix hydrolase 15)

Gene

55270

Nudix hydrolase 15

NUDT15

MTH2, NUDT15D

13q14.2

This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base

Show/Hide all(4)

SNP ID	Visualize variation	Clinical significance	Consequence
rs116855232	C>T	Drug-response	Genic downstream transcript variant, non coding transcript variant, missense variant, coding sequence variant
rs147390019	G>A	Drug-response	Non coding transcript variant, missense variant, genic downstream transcript variant, coding sequence variant
rs186364861	G>A	Drug-response	Missense variant, non coding transcript variant, coding sequence variant
rs746071566	GAGTCG>-,GAGTCGGAGTCG,GAGTCGGAGTCGGAGTCG	Drug-response	Non coding transcript variant, inframe deletion, inframe insertion, coding sequence variant

Show/Hide all(258)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024551	hsa-miR-215-5p	Microarray	19074876
MIRT026659	hsa-miR-192-5p	Microarray	19074876
MIRT051689	hsa-let-7e-5p	CLASH	23622248
MIRT1197546	hsa-let-7a	CLIP-seq
MIRT1197547	hsa-let-7b	CLIP-seq
MIRT1197548	hsa-let-7c	CLIP-seq
MIRT1197549	hsa-let-7d	CLIP-seq
MIRT1197550	hsa-let-7e	CLIP-seq
MIRT1197551	hsa-let-7f	CLIP-seq
MIRT1197552	hsa-let-7g	CLIP-seq
MIRT1197553	hsa-let-7i	CLIP-seq
MIRT1197554	hsa-miR-1236	CLIP-seq
MIRT1197555	hsa-miR-1237	CLIP-seq
MIRT1197556	hsa-miR-1248	CLIP-seq
MIRT1197557	hsa-miR-202	CLIP-seq
MIRT1197558	hsa-miR-216b	CLIP-seq
MIRT1197559	hsa-miR-3065-5p	CLIP-seq
MIRT1197560	hsa-miR-3140-3p	CLIP-seq
MIRT1197561	hsa-miR-3157-5p	CLIP-seq
MIRT1197562	hsa-miR-3160-3p	CLIP-seq
MIRT1197563	hsa-miR-3180-5p	CLIP-seq
MIRT1197564	hsa-miR-338-5p	CLIP-seq
MIRT1197565	hsa-miR-33a	CLIP-seq
MIRT1197566	hsa-miR-33b	CLIP-seq
MIRT1197567	hsa-miR-3671	CLIP-seq
MIRT1197568	hsa-miR-371-5p	CLIP-seq
MIRT1197569	hsa-miR-371b-5p	CLIP-seq
MIRT1197570	hsa-miR-3926	CLIP-seq
MIRT1197571	hsa-miR-4305	CLIP-seq
MIRT1197572	hsa-miR-4432	CLIP-seq
MIRT1197573	hsa-miR-4433	CLIP-seq
MIRT1197574	hsa-miR-4458	CLIP-seq
MIRT1197575	hsa-miR-4487	CLIP-seq
MIRT1197576	hsa-miR-4500	CLIP-seq
MIRT1197577	hsa-miR-450b-5p	CLIP-seq
MIRT1197578	hsa-miR-451b	CLIP-seq
MIRT1197579	hsa-miR-4686	CLIP-seq
MIRT1197580	hsa-miR-4696	CLIP-seq
MIRT1197581	hsa-miR-4730	CLIP-seq
MIRT1197582	hsa-miR-485-5p	CLIP-seq
MIRT1197583	hsa-miR-507	CLIP-seq
MIRT1197584	hsa-miR-513c	CLIP-seq
MIRT1197585	hsa-miR-514	CLIP-seq
MIRT1197586	hsa-miR-514b-3p	CLIP-seq
MIRT1197587	hsa-miR-514b-5p	CLIP-seq
MIRT1197588	hsa-miR-520a-5p	CLIP-seq
MIRT1197589	hsa-miR-525-5p	CLIP-seq
MIRT1197590	hsa-miR-548s	CLIP-seq
MIRT1197591	hsa-miR-549	CLIP-seq
MIRT1197592	hsa-miR-556-3p	CLIP-seq
MIRT1197593	hsa-miR-556-5p	CLIP-seq
MIRT1197594	hsa-miR-557	CLIP-seq
MIRT1197595	hsa-miR-558	CLIP-seq
MIRT1197596	hsa-miR-583	CLIP-seq
MIRT1197597	hsa-miR-643	CLIP-seq
MIRT1197598	hsa-miR-656	CLIP-seq
MIRT1197599	hsa-miR-658	CLIP-seq
MIRT1197600	hsa-miR-98	CLIP-seq
MIRT1197554	hsa-miR-1236	CLIP-seq
MIRT1197558	hsa-miR-216b	CLIP-seq
MIRT1197560	hsa-miR-3140-3p	CLIP-seq
MIRT1197561	hsa-miR-3157-5p	CLIP-seq
MIRT1197565	hsa-miR-33a	CLIP-seq
MIRT1197566	hsa-miR-33b	CLIP-seq
MIRT1197570	hsa-miR-3926	CLIP-seq
MIRT1197577	hsa-miR-450b-5p	CLIP-seq
MIRT1197579	hsa-miR-4686	CLIP-seq
MIRT1197583	hsa-miR-507	CLIP-seq
MIRT1197590	hsa-miR-548s	CLIP-seq
MIRT1197594	hsa-miR-557	CLIP-seq
MIRT2057204	hsa-miR-577	CLIP-seq
MIRT1197546	hsa-let-7a	CLIP-seq
MIRT1197547	hsa-let-7b	CLIP-seq
MIRT1197548	hsa-let-7c	CLIP-seq
MIRT1197549	hsa-let-7d	CLIP-seq
MIRT1197550	hsa-let-7e	CLIP-seq
MIRT1197551	hsa-let-7f	CLIP-seq
MIRT1197552	hsa-let-7g	CLIP-seq
MIRT1197553	hsa-let-7i	CLIP-seq
MIRT2285559	hsa-miR-1273e	CLIP-seq
MIRT2285560	hsa-miR-1273f	CLIP-seq
MIRT2285561	hsa-miR-143	CLIP-seq
MIRT1197557	hsa-miR-202	CLIP-seq
MIRT2285562	hsa-miR-2964a-3p	CLIP-seq
MIRT2285563	hsa-miR-302f	CLIP-seq
MIRT2285564	hsa-miR-3122	CLIP-seq
MIRT1197563	hsa-miR-3180-5p	CLIP-seq
MIRT2285565	hsa-miR-323-5p	CLIP-seq
MIRT1197564	hsa-miR-338-5p	CLIP-seq
MIRT2285566	hsa-miR-339-5p	CLIP-seq
MIRT2285567	hsa-miR-3614-5p	CLIP-seq
MIRT2285568	hsa-miR-3661	CLIP-seq
MIRT2285569	hsa-miR-3664-3p	CLIP-seq
MIRT2285570	hsa-miR-3670	CLIP-seq
MIRT2285571	hsa-miR-3689a-3p	CLIP-seq
MIRT2285572	hsa-miR-3689c	CLIP-seq
MIRT2285573	hsa-miR-382	CLIP-seq
MIRT2285574	hsa-miR-3913-5p	CLIP-seq
MIRT1197570	hsa-miR-3926	CLIP-seq
MIRT2285575	hsa-miR-3929	CLIP-seq
MIRT2285576	hsa-miR-3934	CLIP-seq
MIRT2285577	hsa-miR-3938	CLIP-seq
MIRT2285578	hsa-miR-4419b	CLIP-seq
MIRT1197573	hsa-miR-4433	CLIP-seq
MIRT1197574	hsa-miR-4458	CLIP-seq
MIRT2285579	hsa-miR-4459	CLIP-seq
MIRT2285580	hsa-miR-4478	CLIP-seq
MIRT1197576	hsa-miR-4500	CLIP-seq
MIRT2285581	hsa-miR-4662a-5p	CLIP-seq
MIRT2285582	hsa-miR-4676-5p	CLIP-seq
MIRT2285583	hsa-miR-4684-3p	CLIP-seq
MIRT2285584	hsa-miR-4708-5p	CLIP-seq
MIRT2285585	hsa-miR-4728-5p	CLIP-seq
MIRT2285586	hsa-miR-4768-3p	CLIP-seq
MIRT2285587	hsa-miR-4770	CLIP-seq
MIRT1197582	hsa-miR-485-5p	CLIP-seq
MIRT2285588	hsa-miR-518a-5p	CLIP-seq
MIRT1197588	hsa-miR-520a-5p	CLIP-seq
MIRT1197589	hsa-miR-525-5p	CLIP-seq
MIRT2285589	hsa-miR-527	CLIP-seq
MIRT2285590	hsa-miR-541	CLIP-seq
MIRT2285591	hsa-miR-548c-3p	CLIP-seq
MIRT1197590	hsa-miR-548s	CLIP-seq
MIRT2285592	hsa-miR-575	CLIP-seq
MIRT2285593	hsa-miR-631	CLIP-seq
MIRT2285594	hsa-miR-654-5p	CLIP-seq
MIRT2285595	hsa-miR-676	CLIP-seq
MIRT2285596	hsa-miR-876-3p	CLIP-seq
MIRT1197600	hsa-miR-98	CLIP-seq
MIRT2285560	hsa-miR-1273f	CLIP-seq
MIRT2285561	hsa-miR-143	CLIP-seq
MIRT2285564	hsa-miR-3122	CLIP-seq
MIRT2285571	hsa-miR-3689a-3p	CLIP-seq
MIRT2285572	hsa-miR-3689c	CLIP-seq
MIRT2285574	hsa-miR-3913-5p	CLIP-seq
MIRT2285575	hsa-miR-3929	CLIP-seq
MIRT2285578	hsa-miR-4419b	CLIP-seq
MIRT2285580	hsa-miR-4478	CLIP-seq
MIRT2285584	hsa-miR-4708-5p	CLIP-seq
MIRT2285585	hsa-miR-4728-5p	CLIP-seq
MIRT2285587	hsa-miR-4770	CLIP-seq
MIRT1197582	hsa-miR-485-5p	CLIP-seq
MIRT2285560	hsa-miR-1273f	CLIP-seq
MIRT2285561	hsa-miR-143	CLIP-seq
MIRT2285564	hsa-miR-3122	CLIP-seq
MIRT2285571	hsa-miR-3689a-3p	CLIP-seq
MIRT2285572	hsa-miR-3689c	CLIP-seq
MIRT2285574	hsa-miR-3913-5p	CLIP-seq
MIRT1197570	hsa-miR-3926	CLIP-seq
MIRT2285575	hsa-miR-3929	CLIP-seq
MIRT2285576	hsa-miR-3934	CLIP-seq
MIRT2285578	hsa-miR-4419b	CLIP-seq
MIRT2285580	hsa-miR-4478	CLIP-seq
MIRT2285581	hsa-miR-4662a-5p	CLIP-seq
MIRT2285582	hsa-miR-4676-5p	CLIP-seq
MIRT2285584	hsa-miR-4708-5p	CLIP-seq
MIRT2285585	hsa-miR-4728-5p	CLIP-seq
MIRT2285587	hsa-miR-4770	CLIP-seq
MIRT1197582	hsa-miR-485-5p	CLIP-seq
MIRT2285591	hsa-miR-548c-3p	CLIP-seq
MIRT1197590	hsa-miR-548s	CLIP-seq
MIRT2285592	hsa-miR-575	CLIP-seq
MIRT2285581	hsa-miR-4662a-5p	CLIP-seq
MIRT2285582	hsa-miR-4676-5p	CLIP-seq
MIRT2285591	hsa-miR-548c-3p	CLIP-seq
MIRT2285592	hsa-miR-575	CLIP-seq
MIRT1197555	hsa-miR-1237	CLIP-seq
MIRT1197556	hsa-miR-1248	CLIP-seq
MIRT2285560	hsa-miR-1273f	CLIP-seq
MIRT2285561	hsa-miR-143	CLIP-seq
MIRT2583786	hsa-miR-203	CLIP-seq
MIRT2583787	hsa-miR-2964a-5p	CLIP-seq
MIRT2583788	hsa-miR-299-3p	CLIP-seq
MIRT2583789	hsa-miR-3121-3p	CLIP-seq
MIRT2285564	hsa-miR-3122	CLIP-seq
MIRT2583790	hsa-miR-3145-5p	CLIP-seq
MIRT2583791	hsa-miR-3163	CLIP-seq
MIRT2285565	hsa-miR-323-5p	CLIP-seq
MIRT2583792	hsa-miR-340	CLIP-seq
MIRT2583793	hsa-miR-3591-5p	CLIP-seq
MIRT2583794	hsa-miR-3606	CLIP-seq
MIRT2285567	hsa-miR-3614-5p	CLIP-seq
MIRT2285570	hsa-miR-3670	CLIP-seq
MIRT1197567	hsa-miR-3671	CLIP-seq
MIRT2285571	hsa-miR-3689a-3p	CLIP-seq
MIRT2285572	hsa-miR-3689c	CLIP-seq
MIRT1197568	hsa-miR-371-5p	CLIP-seq
MIRT1197569	hsa-miR-371b-5p	CLIP-seq
MIRT2285574	hsa-miR-3913-5p	CLIP-seq
MIRT2285575	hsa-miR-3929	CLIP-seq
MIRT2285576	hsa-miR-3934	CLIP-seq
MIRT2583795	hsa-miR-4252	CLIP-seq
MIRT2583796	hsa-miR-4255	CLIP-seq
MIRT2583797	hsa-miR-4265	CLIP-seq
MIRT2583798	hsa-miR-4296	CLIP-seq
MIRT2583799	hsa-miR-4322	CLIP-seq
MIRT2583800	hsa-miR-4417	CLIP-seq
MIRT2285578	hsa-miR-4419b	CLIP-seq
MIRT1197572	hsa-miR-4432	CLIP-seq
MIRT2285580	hsa-miR-4478	CLIP-seq
MIRT1197578	hsa-miR-451b	CLIP-seq
MIRT2285581	hsa-miR-4662a-5p	CLIP-seq
MIRT2285582	hsa-miR-4676-5p	CLIP-seq
MIRT1197580	hsa-miR-4696	CLIP-seq
MIRT2285584	hsa-miR-4708-5p	CLIP-seq
MIRT2285585	hsa-miR-4728-5p	CLIP-seq
MIRT2285587	hsa-miR-4770	CLIP-seq
MIRT2583801	hsa-miR-4793-3p	CLIP-seq
MIRT1197582	hsa-miR-485-5p	CLIP-seq
MIRT1197584	hsa-miR-513c	CLIP-seq
MIRT1197587	hsa-miR-514b-5p	CLIP-seq
MIRT2285590	hsa-miR-541	CLIP-seq
MIRT2285591	hsa-miR-548c-3p	CLIP-seq
MIRT2285592	hsa-miR-575	CLIP-seq
MIRT2285594	hsa-miR-654-5p	CLIP-seq
MIRT2285596	hsa-miR-876-3p	CLIP-seq
MIRT1197555	hsa-miR-1237	CLIP-seq
MIRT1197556	hsa-miR-1248	CLIP-seq
MIRT2285560	hsa-miR-1273f	CLIP-seq
MIRT2285561	hsa-miR-143	CLIP-seq
MIRT2583788	hsa-miR-299-3p	CLIP-seq
MIRT2285564	hsa-miR-3122	CLIP-seq
MIRT2583790	hsa-miR-3145-5p	CLIP-seq
MIRT2285565	hsa-miR-323-5p	CLIP-seq
MIRT2285567	hsa-miR-3614-5p	CLIP-seq
MIRT2285570	hsa-miR-3670	CLIP-seq
MIRT1197567	hsa-miR-3671	CLIP-seq
MIRT2285571	hsa-miR-3689a-3p	CLIP-seq
MIRT2285572	hsa-miR-3689c	CLIP-seq
MIRT1197568	hsa-miR-371-5p	CLIP-seq
MIRT1197569	hsa-miR-371b-5p	CLIP-seq
MIRT2285574	hsa-miR-3913-5p	CLIP-seq
MIRT2285575	hsa-miR-3929	CLIP-seq
MIRT2285576	hsa-miR-3934	CLIP-seq
MIRT2583795	hsa-miR-4252	CLIP-seq
MIRT2583797	hsa-miR-4265	CLIP-seq
MIRT2583798	hsa-miR-4296	CLIP-seq
MIRT2583799	hsa-miR-4322	CLIP-seq
MIRT2583800	hsa-miR-4417	CLIP-seq
MIRT2285578	hsa-miR-4419b	CLIP-seq
MIRT1197572	hsa-miR-4432	CLIP-seq
MIRT2285580	hsa-miR-4478	CLIP-seq
MIRT1197578	hsa-miR-451b	CLIP-seq
MIRT2285581	hsa-miR-4662a-5p	CLIP-seq
MIRT2285582	hsa-miR-4676-5p	CLIP-seq
MIRT1197580	hsa-miR-4696	CLIP-seq
MIRT2285584	hsa-miR-4708-5p	CLIP-seq
MIRT2285585	hsa-miR-4728-5p	CLIP-seq
MIRT2285587	hsa-miR-4770	CLIP-seq
MIRT2583801	hsa-miR-4793-3p	CLIP-seq
MIRT1197582	hsa-miR-485-5p	CLIP-seq
MIRT1197584	hsa-miR-513c	CLIP-seq
MIRT1197587	hsa-miR-514b-5p	CLIP-seq
MIRT2285590	hsa-miR-541	CLIP-seq
MIRT2285591	hsa-miR-548c-3p	CLIP-seq
MIRT2285592	hsa-miR-575	CLIP-seq
MIRT2285594	hsa-miR-654-5p	CLIP-seq
MIRT2285596	hsa-miR-876-3p	CLIP-seq

Show/Hide all(24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000278	Process	Mitotic cell cycle	IMP	19419956
GO:0000302	Process	Response to reactive oxygen species	IEA
GO:0005515	Function	Protein binding	IPI	19419956, 32296183
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0006195	Process	Purine nucleotide catabolic process	IMP	26878724
GO:0006203	Process	DGTP catabolic process	IBA	21873635
GO:0006203	Process	DGTP catabolic process	IDA	22556419
GO:0008413	Function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	IDA	22556419
GO:0017110	Function	Nucleoside-diphosphatase activity	EXP	22556419
GO:0034656	Process	Nucleobase-containing small molecule catabolic process	TAS
GO:0035529	Function	NADH pyrophosphatase activity	IEA
GO:0035539	Function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	EXP	22556419
GO:0035539	Function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	IBA	21873635
GO:0035539	Function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	IDA	22556419
GO:0036218	Function	DTTP diphosphatase activity	IEA
GO:0042262	Process	DNA protection	IMP	26878724
GO:0042262	Process	DNA protection	IMP	26238318
GO:0042738	Process	Exogenous drug catabolic process	IMP	26878724
GO:0046872	Function	Metal ion binding	IEA
GO:0047429	Function	Nucleoside-triphosphate diphosphatase activity	IDA	26238318
GO:0061136	Process	Regulation of proteasomal protein catabolic process	IMP	19419956
GO:1901292	Process	Nucleoside phosphate catabolic process	IDA	26238318
GO:1901292	Process	Nucleoside phosphate catabolic process	IMP	26878724

MIM	HGNC	e!Ensembl
615792	23063	ENSG00000136159

Protein

UniProt ID

Q9NV35

Protein name

Nucleotide triphosphate diphosphatase NUDT15 (EC 3.6.1.9) (MutT homolog 2) (MTH2) (Nucleoside diphosphate-linked moiety X motif 15) (Nudix motif 15) (Nucleoside diphosphate-linked to another moiety X hydrolase 15) (Nudix hydrolase 15)

Protein function

May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:26238318). Could also catalyze the hydrolysis of s

PDB

5BON , 5LPG , 6T5J , 7AOM , 7AOP , 7B63 , 7B64 , 7B65 , 7B66 , 7B67 , 7B7V , 7NR6 , 7R0D

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00293	NUDIX	11 → 144	NUDIX domain	Domain

Sequence

MTASAQPRGRRPGVGVGVVVTSCKHPRCVLLGKRKGSVGAGSFQLPGGHLEFGETWEECA
QRETWEEAALHLKNVHFASVVNSFIEKENYHYVTILMKGEVDVTHDSEPKNVEPEKNESW
EWVPWEELPPLDQLFWGLRCLKEQGYDPFKEDLNHLVGYKGNHL

Sequence length

164

Interactions

View interactions

	Reactome
			Phosphate bond hydrolysis by NUDT proteins

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Inflammatory bowel disease	Inflammatory Bowel Diseases	rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs139868987, rs750447828, rs368138379, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468	27558924, 29923122

Show/Hide Unknown Diseases (4)

Unknown
Disease name	Disease term	dbSNP ID	References
Alopecia	Alopecia		29923122
Crohn disease	Crohn Disease	rs2066847, rs2066844, rs886052047, rs5743265, rs111608429, rs104895438	25108385
Leukopenia	Leukopenia		27558924, 25108385, 29923122
Nudt15 deficiency	NUDT15 deficiency

| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412