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ADI1 (acireductone dioxygenase 1)

Gene

55256

Acireductone dioxygenase 1

ADI1

APL1, ARD, ARD', Fe-ARD, HMFT1638, MTCBP1, Ni-ARD, SIPL, mtnD

2p25.3

This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending o

Show/Hide all(132)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016389	hsa-miR-193b-3p	Proteomics	21512034
MIRT029129	hsa-miR-26b-5p	Microarray	19088304
MIRT723437	hsa-miR-6816-3p	HITS-CLIP	19536157
MIRT302584	hsa-miR-142-5p	HITS-CLIP	19536157
MIRT302608	hsa-miR-5590-3p	HITS-CLIP	19536157
MIRT723436	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT723435	hsa-miR-711	HITS-CLIP	19536157
MIRT723434	hsa-miR-340-5p	HITS-CLIP	19536157
MIRT723437	hsa-miR-6816-3p	HITS-CLIP	19536157
MIRT302584	hsa-miR-142-5p	HITS-CLIP	19536157
MIRT302608	hsa-miR-5590-3p	HITS-CLIP	19536157
MIRT723436	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT723435	hsa-miR-711	HITS-CLIP	19536157
MIRT723434	hsa-miR-340-5p	HITS-CLIP	19536157
MIRT768738	hsa-miR-1236	CLIP-seq
MIRT768739	hsa-miR-124	CLIP-seq
MIRT768740	hsa-miR-1302	CLIP-seq
MIRT768741	hsa-miR-2682	CLIP-seq
MIRT768742	hsa-miR-3065-3p	CLIP-seq
MIRT768743	hsa-miR-3122	CLIP-seq
MIRT768744	hsa-miR-3140-5p	CLIP-seq
MIRT768745	hsa-miR-3145-5p	CLIP-seq
MIRT768746	hsa-miR-3160-5p	CLIP-seq
MIRT768747	hsa-miR-3162-3p	CLIP-seq
MIRT768748	hsa-miR-3199	CLIP-seq
MIRT768749	hsa-miR-3671	CLIP-seq
MIRT768750	hsa-miR-3679-3p	CLIP-seq
MIRT768751	hsa-miR-3691-3p	CLIP-seq
MIRT768752	hsa-miR-3714	CLIP-seq
MIRT768753	hsa-miR-3910	CLIP-seq
MIRT768754	hsa-miR-3913-5p	CLIP-seq
MIRT768755	hsa-miR-3918	CLIP-seq
MIRT768756	hsa-miR-4286	CLIP-seq
MIRT768757	hsa-miR-4298	CLIP-seq
MIRT768758	hsa-miR-4300	CLIP-seq
MIRT768759	hsa-miR-4302	CLIP-seq
MIRT768760	hsa-miR-4427	CLIP-seq
MIRT768761	hsa-miR-449c	CLIP-seq
MIRT768762	hsa-miR-4522	CLIP-seq
MIRT768763	hsa-miR-4749-3p	CLIP-seq
MIRT768764	hsa-miR-4762-3p	CLIP-seq
MIRT768765	hsa-miR-4764-3p	CLIP-seq
MIRT768766	hsa-miR-4777-5p	CLIP-seq
MIRT768767	hsa-miR-4778-5p	CLIP-seq
MIRT768768	hsa-miR-4795-5p	CLIP-seq
MIRT768769	hsa-miR-496	CLIP-seq
MIRT768770	hsa-miR-501-5p	CLIP-seq
MIRT768771	hsa-miR-506	CLIP-seq
MIRT768772	hsa-miR-518d-5p	CLIP-seq
MIRT768773	hsa-miR-519b-5p	CLIP-seq
MIRT768774	hsa-miR-519c-5p	CLIP-seq
MIRT768775	hsa-miR-520c-5p	CLIP-seq
MIRT768776	hsa-miR-520d-5p	CLIP-seq
MIRT768777	hsa-miR-524-5p	CLIP-seq
MIRT768778	hsa-miR-526a	CLIP-seq
MIRT768779	hsa-miR-548ag	CLIP-seq
MIRT768780	hsa-miR-548ai	CLIP-seq
MIRT768781	hsa-miR-579	CLIP-seq
MIRT768782	hsa-miR-920	CLIP-seq
MIRT768783	hsa-miR-935	CLIP-seq
MIRT768739	hsa-miR-124	CLIP-seq
MIRT1926710	hsa-miR-1248	CLIP-seq
MIRT1926711	hsa-miR-183	CLIP-seq
MIRT1926712	hsa-miR-198	CLIP-seq
MIRT1926713	hsa-miR-2110	CLIP-seq
MIRT1926714	hsa-miR-217	CLIP-seq
MIRT768741	hsa-miR-2682	CLIP-seq
MIRT1926715	hsa-miR-3144-5p	CLIP-seq
MIRT1926716	hsa-miR-3150a-3p	CLIP-seq
MIRT1926717	hsa-miR-3159	CLIP-seq
MIRT1926718	hsa-miR-3173-5p	CLIP-seq
MIRT1926719	hsa-miR-3191	CLIP-seq
MIRT1926720	hsa-miR-3649	CLIP-seq
MIRT768752	hsa-miR-3714	CLIP-seq
MIRT768753	hsa-miR-3910	CLIP-seq
MIRT1926721	hsa-miR-3945	CLIP-seq
MIRT1926722	hsa-miR-4253	CLIP-seq
MIRT1926723	hsa-miR-4264	CLIP-seq
MIRT768759	hsa-miR-4302	CLIP-seq
MIRT1926724	hsa-miR-4479	CLIP-seq
MIRT768761	hsa-miR-449c	CLIP-seq
MIRT1926725	hsa-miR-4521	CLIP-seq
MIRT1926726	hsa-miR-4652-5p	CLIP-seq
MIRT1926727	hsa-miR-4704-3p	CLIP-seq
MIRT768763	hsa-miR-4749-3p	CLIP-seq
MIRT768768	hsa-miR-4795-5p	CLIP-seq
MIRT768771	hsa-miR-506	CLIP-seq
MIRT1926728	hsa-miR-544	CLIP-seq
MIRT1926729	hsa-miR-600	CLIP-seq
MIRT1926730	hsa-miR-602	CLIP-seq
MIRT1926731	hsa-miR-767-3p	CLIP-seq
MIRT768783	hsa-miR-935	CLIP-seq
MIRT1926712	hsa-miR-198	CLIP-seq
MIRT1926724	hsa-miR-4479	CLIP-seq
MIRT1926712	hsa-miR-198	CLIP-seq
MIRT1926714	hsa-miR-217	CLIP-seq
MIRT768746	hsa-miR-3160-5p	CLIP-seq
MIRT2470372	hsa-miR-3646	CLIP-seq
MIRT2470373	hsa-miR-3662	CLIP-seq
MIRT768751	hsa-miR-3691-3p	CLIP-seq
MIRT768755	hsa-miR-3918	CLIP-seq
MIRT1926721	hsa-miR-3945	CLIP-seq
MIRT1926722	hsa-miR-4253	CLIP-seq
MIRT2470374	hsa-miR-4424	CLIP-seq
MIRT1926724	hsa-miR-4479	CLIP-seq
MIRT1926725	hsa-miR-4521	CLIP-seq
MIRT768762	hsa-miR-4522	CLIP-seq
MIRT768766	hsa-miR-4777-5p	CLIP-seq
MIRT2470375	hsa-miR-493	CLIP-seq
MIRT768772	hsa-miR-518d-5p	CLIP-seq
MIRT768773	hsa-miR-519b-5p	CLIP-seq
MIRT768774	hsa-miR-519c-5p	CLIP-seq
MIRT768775	hsa-miR-520c-5p	CLIP-seq
MIRT768778	hsa-miR-526a	CLIP-seq
MIRT1926730	hsa-miR-602	CLIP-seq
MIRT2674600	hsa-miR-143	CLIP-seq
MIRT1926712	hsa-miR-198	CLIP-seq
MIRT1926714	hsa-miR-217	CLIP-seq
MIRT2470372	hsa-miR-3646	CLIP-seq
MIRT2470373	hsa-miR-3662	CLIP-seq
MIRT768755	hsa-miR-3918	CLIP-seq
MIRT1926721	hsa-miR-3945	CLIP-seq
MIRT1926722	hsa-miR-4253	CLIP-seq
MIRT2470374	hsa-miR-4424	CLIP-seq
MIRT1926724	hsa-miR-4479	CLIP-seq
MIRT1926725	hsa-miR-4521	CLIP-seq
MIRT768762	hsa-miR-4522	CLIP-seq
MIRT2674601	hsa-miR-4738-3p	CLIP-seq
MIRT2674602	hsa-miR-4770	CLIP-seq
MIRT2470375	hsa-miR-493	CLIP-seq
MIRT768781	hsa-miR-579	CLIP-seq
MIRT1926730	hsa-miR-602	CLIP-seq

Show/Hide all(12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005506	Function	Iron ion binding	IEA
GO:0005515	Function	Protein binding	IPI	14718544, 32296183
GO:0005634	Component	Nucleus	IDA	11602742, 14718544
GO:0005737	Component	Cytoplasm	IDA	11602742, 14718544
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	14718544
GO:0006555	Process	Methionine metabolic process	IBA	21873635
GO:0010309	Function	Acireductone dioxygenase [iron(II)-requiring] activity	IBA	21873635
GO:0016491	Function	Oxidoreductase activity	IDA	15938715
GO:0019509	Process	L-methionine salvage from methylthioadenosine	IDA	15938715
GO:0019509	Process	L-methionine salvage from methylthioadenosine	IEA
GO:0019509	Process	L-methionine salvage from methylthioadenosine	TAS

MIM	HGNC	e!Ensembl
613400	30576	ENSG00000182551

Protein

UniProt ID

Q9BV57

Protein name

Acireductone dioxygenase (Acireductone dioxygenase (Fe(2+)-requiring)) (ARD') (Fe-ARD) (EC 1.13.11.54) (Acireductone dioxygenase (Ni(2+)-requiring)) (ARD) (Ni-ARD) (EC 1.13.11.53) (Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein

Protein function

Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site (By similarity). Fe-containing acireductone dioxygenase (Fe-ARD) produces

PDB

4QGN , 7JXG

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03079	ARD	3 → 157		Domain

Sequence

MVQAWYMDDAPGDPRQPHRPDPGRPVGLEQLRRLGVLYWKLDADKYENDPELEKIRRERN
YSWMDIITICKDKLPNYEEKIKMFYEEHLHLDDEIRYILDGSGYFDVRDKEDQWIRIFME
KGDMVTLPAGIYHRFTVDEKNYTKAMRLFVGEPVWTAYNRPADHFEARGQYVKFLAQTA

Sequence length

179

Interactions

View interactions

	KEGG		Reactome
	Cysteine and methionine metabolism Metabolic pathways		Methionine salvage pathway

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17786183

Show/Hide Unknown Diseases (1)

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		17786183

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