NEIL3 (nei like DNA glycosylase 3)

Gene

• Entrez ID: 55247
• Gene name: Nei like DNA glycosylase 3
• Gene symbol: NEIL3
• Synonyms: FGP2, FPG2, NEI3, ZGRF3, hFPG2, hNEI3
• Chromosome: 4
• Chromosome location: 4q34.3
• Summary: NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the ass

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024831	hsa-miR-215-5p	Microarray	19074876
MIRT026184	hsa-miR-192-5p	Microarray	19074876

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000405	Function	Bubble DNA binding	ISS
GO:0003684	Function	Damaged DNA binding	ISS
GO:0003690	Function	Double-stranded DNA binding	ISS
GO:0003697	Function	Single-stranded DNA binding	IDA	19170771
GO:0003906	Function	DNA-(apurinic or apyrimidinic site) endonuclease activity	IBA	21873635
GO:0003906	Function	DNA-(apurinic or apyrimidinic site) endonuclease activity	IDA	19170771
GO:0005634	Component	Nucleus	IDA	12433996
GO:0005654	Component	Nucleoplasm	IDA
GO:0005694	Component	Chromosome	IEA
GO:0006284	Process	Base-excision repair	IBA	21873635
GO:0006284	Process	Base-excision repair	IDA	23755964
GO:0006284	Process	Base-excision repair	ISS
GO:0008270	Function	Zinc ion binding	IEA
GO:0019104	Function	DNA N-glycosylase activity	IBA	21873635
GO:0019104	Function	DNA N-glycosylase activity	IDA	23755964
GO:0019104	Function	DNA N-glycosylase activity	ISS
GO:0036297	Process	Interstrand cross-link repair	ISS
GO:0140078	Function	Class I DNA-(apurinic or apyrimidinic site) endonuclease activity	IEA
GO:1904931	Function	MCM complex binding	ISS

Other IDs

• MIM: 608934
• HGNC: 24573
• e!Ensembl: ENSG00000109674

Protein

• UniProt ID: Q8TAT5
• Protein name: Endonuclease 8-like 3 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase FPG2) (DNA glycosylase/AP lyase Neil3) (Endonuclease VIII-like 3) (Nei-like protein 3)
• Protein function: DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA) (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964). Mediates interstran
• PDB: 7JL5, 7TMY
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06831	H2TH	153 → 231	Formamidopyrimidine-DNA glycosylase H2TH domain	Domain
  PF00641	zf-RanBP	317 → 346	Zn-finger in Ran binding protein and others	Domain
  PF06839	zf-GRF	505 → 550	GRF zinc finger	Domain
  PF06839	zf-GRF	552 → 596	GRF zinc finger	Domain

• Sequence:

  MVEGPGCTLNGEKIRARVLPGQAVTGVRGSALRSLQGRALRLAASTVVVSPQAAALNNDS
  SQNVLSLFNGYVYSGVETLGKELFMYFGPKALRIHFGMKGFIMINPLEYKYKNGASPVLE
  VQLTKDLICFFDSSVELRNSMESQQRIRMMKELDVCSPEFSFLRAESEVKKQKGRMLGDV
  LMDQNVLPGVGNIIKNEALFDSGLHPAVKVCQLTDEQIHHLMKMIRDFSILFYRCRKAGL
  ALSKHYKVYKRPNCGQCHCRITVCRFGDNNRMTYFCPHCQKENPQHVDICKLPTRNTIIS
  WTSSRVDHVMDSVARKSEEHWTCVVCTLINKPSSKACDACLTSRPIDSVLKSEENSTVFS
  HLMKYPCNTFGKPHTEVKINRKTAFGTTTLVLTDFSNKSSTLERKTKQNQILDEEFQNSP
  PASVCLNDIQHPSKKTTNDITQPSSKVNISPTISSESKLFSPAHKKPKTAQYSSPELKSC
  NPGYSNSELQINMTDGPRTLNPDSPRCSKHNRLCILRVVGKDGENKGRQFYACPLPREAQ
  CGFFEWADLSFPFCNHGKRSTMKTVLKIGPNNGKNFFVCPLGKEKQCNFFQWAENGPGIK
  IIPGC

• Sequence length: 605

Pathways

KEGG:

Base excision repair

Reactome:

Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Defective Base Excision Repair Associated with NEIL3
NEIL3-mediated resolution of ICLs

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		28284560