STEAP3 (STEAP3 metalloreductase)

Gene

• Entrez ID: 55240
• Gene name: STEAP3 metalloreductase
• Gene symbol: STEAP3
• Synonyms: AHMIO2, STMP3, TSAP6, dudlin-2, dudulin-2, pHyde
• Chromosome: 2
• Chromosome location: 2q14.2
• Summary: This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficienc

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT027494	hsa-miR-98-5p	Microarray	19088304
MIRT031486	hsa-miR-16-5p	Proteomics	18668040
MIRT052160	hsa-let-7b-5p	CLASH	23622248
MIRT049382	hsa-miR-92a-3p	CLASH	23622248
MIRT486983	hsa-miR-296-3p	PAR-CLIP	20371350
MIRT486982	hsa-miR-24-3p	PAR-CLIP	20371350
MIRT486981	hsa-miR-4437	PAR-CLIP	20371350
MIRT486980	hsa-miR-4283	PAR-CLIP	20371350
MIRT486979	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT486978	hsa-miR-4488	PAR-CLIP	20371350
MIRT486977	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT486976	hsa-miR-6846-5p	PAR-CLIP	20371350
MIRT486975	hsa-miR-6848-5p	PAR-CLIP	20371350
MIRT486974	hsa-miR-92a-1-5p	PAR-CLIP	20371350
MIRT486973	hsa-miR-1275	PAR-CLIP	20371350
MIRT486972	hsa-miR-4665-5p	PAR-CLIP	20371350
MIRT486971	hsa-miR-7109-5p	PAR-CLIP	20371350
MIRT486970	hsa-miR-6751-5p	PAR-CLIP	20371350
MIRT486969	hsa-miR-6803-5p	PAR-CLIP	20371350
MIRT512672	hsa-miR-3173-3p	PAR-CLIP	23446348
MIRT512671	hsa-miR-6891-5p	PAR-CLIP	23446348
MIRT512670	hsa-miR-5197-5p	PAR-CLIP	23446348
MIRT512669	hsa-miR-518c-5p	PAR-CLIP	23446348
MIRT512668	hsa-miR-875-3p	PAR-CLIP	23446348
MIRT512667	hsa-miR-6128	PAR-CLIP	23446348
MIRT512666	hsa-miR-7854-3p	PAR-CLIP	23446348
MIRT512665	hsa-miR-3689d	PAR-CLIP	23446348
MIRT512664	hsa-miR-6851-5p	PAR-CLIP	23446348
MIRT512663	hsa-miR-6822-3p	PAR-CLIP	23446348
MIRT512662	hsa-miR-760	PAR-CLIP	23446348
MIRT512661	hsa-miR-1299	PAR-CLIP	23446348
MIRT512660	hsa-miR-3978	PAR-CLIP	23446348
MIRT512659	hsa-miR-8057	PAR-CLIP	23446348
MIRT486983	hsa-miR-296-3p	PAR-CLIP	23592263
MIRT486982	hsa-miR-24-3p	PAR-CLIP	23592263
MIRT486981	hsa-miR-4437	PAR-CLIP	23592263
MIRT486980	hsa-miR-4283	PAR-CLIP	23592263
MIRT486979	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT486978	hsa-miR-4488	PAR-CLIP	23592263
MIRT486977	hsa-miR-4697-5p	PAR-CLIP	23592263
MIRT486976	hsa-miR-6846-5p	PAR-CLIP	23592263
MIRT486975	hsa-miR-6848-5p	PAR-CLIP	23592263
MIRT486974	hsa-miR-92a-1-5p	PAR-CLIP	23592263
MIRT486973	hsa-miR-1275	PAR-CLIP	23592263
MIRT486972	hsa-miR-4665-5p	PAR-CLIP	23592263
MIRT486971	hsa-miR-7109-5p	PAR-CLIP	23592263
MIRT486970	hsa-miR-6751-5p	PAR-CLIP	23592263
MIRT486969	hsa-miR-6803-5p	PAR-CLIP	23592263
MIRT486983	hsa-miR-296-3p	PAR-CLIP	20371350
MIRT486982	hsa-miR-24-3p	PAR-CLIP	20371350
MIRT486981	hsa-miR-4437	PAR-CLIP	20371350
MIRT486980	hsa-miR-4283	PAR-CLIP	20371350
MIRT486979	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT486978	hsa-miR-4488	PAR-CLIP	20371350
MIRT486977	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT486976	hsa-miR-6846-5p	PAR-CLIP	20371350
MIRT486975	hsa-miR-6848-5p	PAR-CLIP	20371350
MIRT486974	hsa-miR-92a-1-5p	PAR-CLIP	20371350
MIRT486973	hsa-miR-1275	PAR-CLIP	20371350
MIRT486972	hsa-miR-4665-5p	PAR-CLIP	20371350
MIRT486971	hsa-miR-7109-5p	PAR-CLIP	20371350
MIRT486970	hsa-miR-6751-5p	PAR-CLIP	20371350
MIRT486969	hsa-miR-6803-5p	PAR-CLIP	20371350
MIRT512672	hsa-miR-3173-3p	PAR-CLIP	23446348
MIRT512671	hsa-miR-6891-5p	PAR-CLIP	23446348
MIRT512670	hsa-miR-5197-5p	PAR-CLIP	23446348
MIRT512669	hsa-miR-518c-5p	PAR-CLIP	23446348
MIRT512668	hsa-miR-875-3p	PAR-CLIP	23446348
MIRT512667	hsa-miR-6128	PAR-CLIP	23446348
MIRT512666	hsa-miR-7854-3p	PAR-CLIP	23446348
MIRT512665	hsa-miR-3689d	PAR-CLIP	23446348
MIRT512664	hsa-miR-6851-5p	PAR-CLIP	23446348
MIRT512663	hsa-miR-6822-3p	PAR-CLIP	23446348
MIRT512662	hsa-miR-760	PAR-CLIP	23446348
MIRT512661	hsa-miR-1299	PAR-CLIP	23446348
MIRT512660	hsa-miR-3978	PAR-CLIP	23446348
MIRT512659	hsa-miR-8057	PAR-CLIP	23446348
MIRT486983	hsa-miR-296-3p	PAR-CLIP	23592263
MIRT486982	hsa-miR-24-3p	PAR-CLIP	23592263
MIRT486981	hsa-miR-4437	PAR-CLIP	23592263
MIRT486980	hsa-miR-4283	PAR-CLIP	23592263
MIRT486979	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT486978	hsa-miR-4488	PAR-CLIP	23592263
MIRT486977	hsa-miR-4697-5p	PAR-CLIP	23592263
MIRT486976	hsa-miR-6846-5p	PAR-CLIP	23592263
MIRT486975	hsa-miR-6848-5p	PAR-CLIP	23592263
MIRT486974	hsa-miR-92a-1-5p	PAR-CLIP	23592263
MIRT486973	hsa-miR-1275	PAR-CLIP	23592263
MIRT486972	hsa-miR-4665-5p	PAR-CLIP	23592263
MIRT486971	hsa-miR-7109-5p	PAR-CLIP	23592263
MIRT486970	hsa-miR-6751-5p	PAR-CLIP	23592263
MIRT486969	hsa-miR-6803-5p	PAR-CLIP	23592263
MIRT1396852	hsa-miR-124	CLIP-seq
MIRT1396853	hsa-miR-1253	CLIP-seq
MIRT1396854	hsa-miR-1273g	CLIP-seq
MIRT1396855	hsa-miR-128	CLIP-seq
MIRT1396856	hsa-miR-1280	CLIP-seq
MIRT1396857	hsa-miR-1289	CLIP-seq
MIRT1396858	hsa-miR-140-5p	CLIP-seq
MIRT1396859	hsa-miR-199a-5p	CLIP-seq
MIRT1396860	hsa-miR-199b-5p	CLIP-seq
MIRT1396861	hsa-miR-299-5p	CLIP-seq
MIRT1396862	hsa-miR-3127-5p	CLIP-seq
MIRT1396863	hsa-miR-3198	CLIP-seq
MIRT1396864	hsa-miR-345	CLIP-seq
MIRT1396865	hsa-miR-3909	CLIP-seq
MIRT1396866	hsa-miR-4256	CLIP-seq
MIRT1396867	hsa-miR-4270	CLIP-seq
MIRT1396868	hsa-miR-4294	CLIP-seq
MIRT1396869	hsa-miR-4302	CLIP-seq
MIRT1396870	hsa-miR-4309	CLIP-seq
MIRT1396871	hsa-miR-4314	CLIP-seq
MIRT1396872	hsa-miR-4441	CLIP-seq
MIRT1396873	hsa-miR-4514	CLIP-seq
MIRT1396874	hsa-miR-4655-5p	CLIP-seq
MIRT1396875	hsa-miR-4668-5p	CLIP-seq
MIRT1396876	hsa-miR-4676-5p	CLIP-seq
MIRT1396877	hsa-miR-4692	CLIP-seq
MIRT1396878	hsa-miR-4712-5p	CLIP-seq
MIRT1396879	hsa-miR-4727-5p	CLIP-seq
MIRT1396880	hsa-miR-4769-3p	CLIP-seq
MIRT1396881	hsa-miR-506	CLIP-seq
MIRT1396882	hsa-miR-548al	CLIP-seq
MIRT1396883	hsa-miR-575	CLIP-seq
MIRT1396884	hsa-miR-770-5p	CLIP-seq
MIRT1396885	hsa-miR-1293	CLIP-seq
MIRT1396886	hsa-miR-1343	CLIP-seq
MIRT1396887	hsa-miR-153	CLIP-seq
MIRT1396888	hsa-miR-27a	CLIP-seq
MIRT1396889	hsa-miR-27b	CLIP-seq
MIRT1396890	hsa-miR-299-3p	CLIP-seq
MIRT1396891	hsa-miR-302f	CLIP-seq
MIRT1396892	hsa-miR-3148	CLIP-seq
MIRT1396893	hsa-miR-3157-5p	CLIP-seq
MIRT1396894	hsa-miR-3165	CLIP-seq
MIRT1396895	hsa-miR-3192	CLIP-seq
MIRT1396896	hsa-miR-3622b-5p	CLIP-seq
MIRT1396897	hsa-miR-3667-3p	CLIP-seq
MIRT1396898	hsa-miR-3670	CLIP-seq
MIRT1396899	hsa-miR-3674	CLIP-seq
MIRT1396900	hsa-miR-412	CLIP-seq
MIRT1396901	hsa-miR-4257	CLIP-seq
MIRT1396902	hsa-miR-4269	CLIP-seq
MIRT1396903	hsa-miR-4271	CLIP-seq
MIRT1396904	hsa-miR-4297	CLIP-seq
MIRT1396905	hsa-miR-4464	CLIP-seq
MIRT1396906	hsa-miR-4483	CLIP-seq
MIRT1396907	hsa-miR-4491	CLIP-seq
MIRT1396908	hsa-miR-4645-5p	CLIP-seq
MIRT1396909	hsa-miR-4657	CLIP-seq
MIRT1396910	hsa-miR-4659a-3p	CLIP-seq
MIRT1396911	hsa-miR-4659b-3p	CLIP-seq
MIRT1396912	hsa-miR-4673	CLIP-seq
MIRT1396913	hsa-miR-4691-3p	CLIP-seq
MIRT1396914	hsa-miR-4725-3p	CLIP-seq
MIRT1396915	hsa-miR-4747-5p	CLIP-seq
MIRT1396916	hsa-miR-4748	CLIP-seq
MIRT1396917	hsa-miR-508-5p	CLIP-seq
MIRT1396918	hsa-miR-513a-5p	CLIP-seq
MIRT1396919	hsa-miR-518a-5p	CLIP-seq
MIRT1396920	hsa-miR-527	CLIP-seq
MIRT1396921	hsa-miR-556-5p	CLIP-seq
MIRT1396922	hsa-miR-670	CLIP-seq
MIRT1396923	hsa-miR-9	CLIP-seq
MIRT1396856	hsa-miR-1280	CLIP-seq
MIRT2341180	hsa-miR-1285	CLIP-seq
MIRT1396885	hsa-miR-1293	CLIP-seq
MIRT2341181	hsa-miR-1915	CLIP-seq
MIRT2341182	hsa-miR-3155	CLIP-seq
MIRT2341183	hsa-miR-3155b	CLIP-seq
MIRT1396893	hsa-miR-3157-5p	CLIP-seq
MIRT2341184	hsa-miR-3187-5p	CLIP-seq
MIRT2341185	hsa-miR-326	CLIP-seq
MIRT2341186	hsa-miR-330-5p	CLIP-seq
MIRT2341187	hsa-miR-3614-3p	CLIP-seq
MIRT2341188	hsa-miR-3663-3p	CLIP-seq
MIRT2341189	hsa-miR-371-5p	CLIP-seq
MIRT2341190	hsa-miR-378g	CLIP-seq
MIRT1396901	hsa-miR-4257	CLIP-seq
MIRT2341191	hsa-miR-4265	CLIP-seq
MIRT2341192	hsa-miR-4292	CLIP-seq
MIRT2341193	hsa-miR-4296	CLIP-seq
MIRT2341194	hsa-miR-4308	CLIP-seq
MIRT2341195	hsa-miR-4322	CLIP-seq
MIRT2341196	hsa-miR-4436b-3p	CLIP-seq
MIRT1396906	hsa-miR-4483	CLIP-seq
MIRT2341197	hsa-miR-4486	CLIP-seq
MIRT1396873	hsa-miR-4514	CLIP-seq
MIRT2341198	hsa-miR-4535	CLIP-seq
MIRT1396874	hsa-miR-4655-5p	CLIP-seq
MIRT1396876	hsa-miR-4676-5p	CLIP-seq
MIRT2341199	hsa-miR-4685-5p	CLIP-seq
MIRT1396913	hsa-miR-4691-3p	CLIP-seq
MIRT1396877	hsa-miR-4692	CLIP-seq
MIRT1396878	hsa-miR-4712-5p	CLIP-seq
MIRT2341200	hsa-miR-4768-5p	CLIP-seq
MIRT2341201	hsa-miR-4776-5p	CLIP-seq
MIRT2341202	hsa-miR-484	CLIP-seq
MIRT2341203	hsa-miR-492	CLIP-seq
MIRT2341204	hsa-miR-520a-5p	CLIP-seq
MIRT2341205	hsa-miR-525-5p	CLIP-seq
MIRT1396882	hsa-miR-548al	CLIP-seq
MIRT1396883	hsa-miR-575	CLIP-seq
MIRT2341206	hsa-miR-612	CLIP-seq
MIRT1396884	hsa-miR-770-5p	CLIP-seq
MIRT2395326	hsa-let-7a	CLIP-seq
MIRT2395327	hsa-let-7b	CLIP-seq
MIRT2395328	hsa-let-7c	CLIP-seq
MIRT2395329	hsa-let-7d	CLIP-seq
MIRT2395330	hsa-let-7e	CLIP-seq
MIRT2395331	hsa-let-7f	CLIP-seq
MIRT2395332	hsa-let-7g	CLIP-seq
MIRT2395333	hsa-let-7i	CLIP-seq
MIRT2395334	hsa-miR-1294	CLIP-seq
MIRT2395335	hsa-miR-202	CLIP-seq
MIRT2395336	hsa-miR-4299	CLIP-seq
MIRT2395337	hsa-miR-4458	CLIP-seq
MIRT2395338	hsa-miR-4500	CLIP-seq
MIRT2395339	hsa-miR-4519	CLIP-seq
MIRT2395340	hsa-miR-4710	CLIP-seq
MIRT2395341	hsa-miR-4792	CLIP-seq
MIRT2395342	hsa-miR-7	CLIP-seq
MIRT2395343	hsa-miR-98	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	22624035
GO:0005737	Component	Cytoplasm	IDA	25468996
GO:0005768	Component	Endosome	IBA	21873635
GO:0005771	Component	Multivesicular body	IDA	15319436
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0006915	Process	Apoptotic process	IEA
GO:0007049	Process	Cell cycle	IEA
GO:0008823	Function	Cupric reductase activity	IBA	21873635
GO:0009306	Process	Protein secretion	IDA	15319436
GO:0009306	Process	Protein secretion	IMP	22624035
GO:0010008	Component	Endosome membrane	TAS
GO:0015677	Process	Copper ion import	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA
GO:0033572	Process	Transferrin transport	TAS
GO:0042981	Process	Regulation of apoptotic process	TAS
GO:0046872	Function	Metal ion binding	IEA
GO:0052851	Function	Ferric-chelate reductase (NADPH) activity	IBA	21873635
GO:0055072	Process	Iron ion homeostasis	IEA

Other IDs

• MIM: 609671
• HGNC: 24592
• e!Ensembl: ENSG00000115107

Protein

• UniProt ID: Q658P3
• Protein name: Metalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde)
• Protein function: Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (PubMed:26205815). Mediates sequential t
• PDB: 2VNS, 2VQ3
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03807	F420_oxidored	30 → 117	NADP oxidoreductase coenzyme F420-dependent	Family
  PF01794	Ferric_reduct	259 → 406	Ferric reductase like transmembrane component	Family

• Sequence:

  MPEEMDKPLISLHLVDSDSSLAKVPDEAPKVGILGSGDFARSLATRLVGSGFKVVVGSRN
  PKRTARLFPSAAQVTFQEEAVSSPEVIFVAVFREHYSSLCSLSDQLAGKILVDVSNPTEQ
  EHLQHRESNAEYLASLFPTCTVVKAFNVISAWTLQAGPRDGNRQVPICGDQPEAKRAVSE
  MALAMGFMPVDMGSLASAWEVEAMPLRLLPAWKVPTLLALGLFVCFYAYNFVRDVLQPYV
  QESQNKFFKLPVSVVNTTLPCVAYVLLSLVYLPGVLAAALQLRRGTKYQRFPDWLDHWLQ
  HRKQIGLLSFFCAALHALYSFCLPLRRAHRYDLVNLAVKQVLANKSHLWVEEEVWRMEIY
  LSLGVLALGTLSLLAVTSLPSIANSLNWREFSFVQSSLGFVALVLSTLHTLTYGWTRAFE
  ESRYKFYLPPTFTLTLLVPCVVILAKALFLLPCISRRLARIRRGWERESTIKFTLPTDHA
  LAEKTSHV

• Sequence length: 488

Pathways

KEGG:

p53 signaling pathway
Ferroptosis

Reactome:

TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Transferrin endocytosis and recycling

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Anemia	Anemia, Anemia, Hypochromic Microcytic, With Iron Overload, ANEMIA, HYPOCHROMIC MICROCYTIC, WITH IRON OVERLOAD 2	rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966, rs137853122, rs137853123, rs786205060, rs267607121, rs121908584, rs80338697, rs80338699, rs120074166, rs120074167, rs1050828, rs74575103, rs137852314, rs5030868, rs137852316, rs137852317, rs137852318, rs137852319, rs137852320, rs137852321, rs137852322, rs137852323, rs137852324, rs72554665, rs387906468, rs5030872, rs137852326, rs137852333, rs137852327, rs137852328, rs137852329, rs137852330, rs137852331, rs137852332, rs137852334, rs137852335, rs137852336, rs137852339, rs76645461, rs137852340, rs137852341, rs78478128, rs137852343, rs137852344, rs137852345, rs587776730, rs137852346, rs137852347, rs137852349, rs2070404412, rs2070350038, rs2070350009, rs137852303, rs137852304, rs33946267, rs34378160, rs33933298, rs11549407, rs35724775, rs34598529, rs41469945, rs267607201, rs80338694, rs80338696, rs387907018, rs398123546, rs78365220, rs587777100, rs587777101, rs483352840, rs869312752, rs765487627, rs1557229599, rs1557230040, rs1555524842, rs782090947, rs1358275550, rs1557229736, rs1557230573, rs1556323334, rs1233124208, rs1293528130, rs146864395, rs1595503440, rs1603411214, rs137852325, rs1575247302, rs1603411177, rs1336651679, rs782322505	22031863
Azoospermia	Azoospermia	rs200969445, rs144567652, rs765353898
Hypothyroidism	Hypothyroidism	rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912, rs121917847, rs104893655, rs104893657, rs104893658, rs104893659, rs104893660, rs104893656, rs121917719, rs786204790, rs189261858, rs879255608, rs868197660, rs879255609, rs1586744173, rs1586182837, rs771222349, rs1587618417, rs1601844140, rs760832986, rs780982673, rs1603336347, rs1691155605
Renal carcinoma	Renal Cell Carcinoma	rs121913668, rs121913670, rs121913243, rs786202724	31231134
Severe congenital hypochromic anemia with ringed sideroblasts	Severe congenital hypochromic anemia with ringed sideroblasts	rs587776963

Unknown
Disease name	Disease term	dbSNP ID	References
Dysplastic erythropoesis	Dysplastic erythropoesis
Hypochromic anemia	Hypochromic anemia
Hypogonadism	Hypogonadism