PPP2R2C (protein phosphatase 2 regulatory subunit Bgamma)

Gene

• Entrez ID: 5522
• Gene name: Protein phosphatase 2 regulatory subunit Bgamma
• Gene symbol: PPP2R2C
• Synonyms: B55-GAMMA, B55gamma, IMYPNO, IMYPNO1, PR52, PR55G
• Chromosome: 4
• Chromosome location: 4p16.1
• Summary: The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heter

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT021554	hsa-miR-142-3p	Microarray	17612493
MIRT1257566	hsa-miR-1284	CLIP-seq
MIRT1257567	hsa-miR-300	CLIP-seq
MIRT1257568	hsa-miR-3591-3p	CLIP-seq
MIRT1257569	hsa-miR-3613-3p	CLIP-seq
MIRT1257570	hsa-miR-3688-3p	CLIP-seq
MIRT1257571	hsa-miR-3691-3p	CLIP-seq
MIRT1257572	hsa-miR-381	CLIP-seq
MIRT1257573	hsa-miR-4261	CLIP-seq
MIRT1257574	hsa-miR-4506	CLIP-seq
MIRT1257575	hsa-miR-4666-3p	CLIP-seq
MIRT1257576	hsa-miR-548aa	CLIP-seq
MIRT1257577	hsa-miR-548p	CLIP-seq
MIRT1257578	hsa-miR-555	CLIP-seq
MIRT1257579	hsa-miR-561	CLIP-seq
MIRT1257580	hsa-miR-607	CLIP-seq
MIRT1257581	hsa-miR-942	CLIP-seq
MIRT1257582	hsa-miR-1207-5p	CLIP-seq
MIRT1257583	hsa-miR-1253	CLIP-seq
MIRT1257584	hsa-miR-24	CLIP-seq
MIRT1257585	hsa-miR-2467-3p	CLIP-seq
MIRT1257586	hsa-miR-2467-5p	CLIP-seq
MIRT1257587	hsa-miR-3665	CLIP-seq
MIRT1257588	hsa-miR-3919	CLIP-seq
MIRT1257589	hsa-miR-4736	CLIP-seq
MIRT1257590	hsa-miR-4756-3p	CLIP-seq
MIRT1257591	hsa-miR-4763-3p	CLIP-seq
MIRT1257592	hsa-miR-545	CLIP-seq
MIRT1257593	hsa-miR-610	CLIP-seq
MIRT1257594	hsa-miR-922	CLIP-seq
MIRT1257595	hsa-miR-1243	CLIP-seq
MIRT1257596	hsa-miR-1273f	CLIP-seq
MIRT1257597	hsa-miR-1290	CLIP-seq
MIRT1257598	hsa-miR-190	CLIP-seq
MIRT1257599	hsa-miR-190b	CLIP-seq
MIRT1257600	hsa-miR-198	CLIP-seq
MIRT1257601	hsa-miR-200b	CLIP-seq
MIRT1257602	hsa-miR-200c	CLIP-seq
MIRT1257603	hsa-miR-3134	CLIP-seq
MIRT1257604	hsa-miR-3167	CLIP-seq
MIRT1257571	hsa-miR-3691-3p	CLIP-seq
MIRT1257605	hsa-miR-369-3p	CLIP-seq
MIRT1257606	hsa-miR-374a	CLIP-seq
MIRT1257607	hsa-miR-374b	CLIP-seq
MIRT1257608	hsa-miR-429	CLIP-seq
MIRT1257609	hsa-miR-4487	CLIP-seq
MIRT1257574	hsa-miR-4506	CLIP-seq
MIRT1257610	hsa-miR-4753-5p	CLIP-seq
MIRT1257577	hsa-miR-548p	CLIP-seq
MIRT1257578	hsa-miR-555	CLIP-seq
MIRT1257611	hsa-miR-629	CLIP-seq
MIRT1257612	hsa-miR-876-5p	CLIP-seq
MIRT2075899	hsa-miR-2964a-3p	CLIP-seq
MIRT2302517	hsa-miR-1225-5p	CLIP-seq
MIRT2302518	hsa-miR-1226	CLIP-seq
MIRT2302519	hsa-miR-1262	CLIP-seq
MIRT2302520	hsa-miR-1914	CLIP-seq
MIRT2302521	hsa-miR-2113	CLIP-seq
MIRT2302522	hsa-miR-218	CLIP-seq
MIRT1257584	hsa-miR-24	CLIP-seq
MIRT1257585	hsa-miR-2467-3p	CLIP-seq
MIRT1257586	hsa-miR-2467-5p	CLIP-seq
MIRT2302523	hsa-miR-3140-3p	CLIP-seq
MIRT2302524	hsa-miR-3177-3p	CLIP-seq
MIRT2302525	hsa-miR-324-5p	CLIP-seq
MIRT2302526	hsa-miR-329	CLIP-seq
MIRT2302527	hsa-miR-362-3p	CLIP-seq
MIRT2302528	hsa-miR-3661	CLIP-seq
MIRT2302529	hsa-miR-3941	CLIP-seq
MIRT2302530	hsa-miR-4325	CLIP-seq
MIRT2302531	hsa-miR-4464	CLIP-seq
MIRT2302532	hsa-miR-4659a-5p	CLIP-seq
MIRT2302533	hsa-miR-4659b-5p	CLIP-seq
MIRT2302534	hsa-miR-466	CLIP-seq
MIRT2302535	hsa-miR-4672	CLIP-seq
MIRT2302536	hsa-miR-4701-3p	CLIP-seq
MIRT2302537	hsa-miR-4722-3p	CLIP-seq
MIRT2302538	hsa-miR-4733-3p	CLIP-seq
MIRT2302539	hsa-miR-4748	CLIP-seq
MIRT2302540	hsa-miR-4769-3p	CLIP-seq
MIRT2302541	hsa-miR-4773	CLIP-seq
MIRT1257592	hsa-miR-545	CLIP-seq
MIRT1257578	hsa-miR-555	CLIP-seq
MIRT2302542	hsa-miR-572	CLIP-seq
MIRT2302543	hsa-miR-603	CLIP-seq
MIRT2302544	hsa-miR-631	CLIP-seq
MIRT2302545	hsa-miR-636	CLIP-seq
MIRT1257594	hsa-miR-922	CLIP-seq
MIRT2302546	hsa-miR-1343	CLIP-seq
MIRT2302531	hsa-miR-4464	CLIP-seq
MIRT1257589	hsa-miR-4736	CLIP-seq
MIRT2302539	hsa-miR-4748	CLIP-seq
MIRT2302547	hsa-miR-657	CLIP-seq
MIRT2457064	hsa-miR-188-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000159	Component	Protein phosphatase type 2A complex	IBA	21873635
GO:0000159	Component	Protein phosphatase type 2A complex	NAS	10945473
GO:0005515	Function	Protein binding	IPI	19156129, 24126060, 25816751
GO:0005829	Component	Cytosol	IBA	21873635
GO:0019888	Function	Protein phosphatase regulator activity	IBA	21873635
GO:0019888	Function	Protein phosphatase regulator activity	NAS	10945473
GO:0043666	Process	Regulation of phosphoprotein phosphatase activity	IEA
GO:0070262	Process	Peptidyl-serine dephosphorylation	IBA	21873635

Other IDs

• MIM: 605997
• HGNC: 9306
• e!Ensembl: ENSG00000074211

Protein

• UniProt ID: Q9Y2T4
• Protein name: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (IMYPNO1) (PP2A subunit B isoform B55-gamma) (PP2A subunit B isoform PR55-gamma) (PP2A subunit B isoform R2-gamma) (PP2A subunit B isoform gamma)
• Protein function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment.
• Sequence:

  MGEDTDTRKINHSFLRDHSYVTEADIISTVEFNHTGELLATGDKGGRVVIFQREPESKNA
  PHSQGEYDVYSTFQSHEPEFDYLKSLEIEEKINKIKWLPQQNAAHSLLSTNDKTIKLWKI
  TERDKRPEGYNLKDEEGKLKDLSTVTSLQVPVLKPMDLMVEVSPRRIFANGHTYHINSIS
  VNSDCETYMSADDLRINLWHLAITDRSFNIVDIKPANMEDLTEVITASEFHPHHCNLFVY
  SSSKGSLRLCDMRAAALCDKHSKLFEEPEDPSNRSFFSEIISSVSDVKFSHSGRYMLTRD
  YLTVKVWDLNMEARPIETYQVHDYLRSKLCSLYENDCIFDKFECAWNGSDSVIMTGAYNN
  FFRMFDRNTKRDVTLEASRESSKPRAVLKPRRVCVGGKRRRDDISVDSLDFTKKILHTAW
  HPAENIIAIAATNNLYIFQDKVNSDMH

• Sequence length: 447

Pathways

KEGG:

mRNA surveillance pathway
Sphingolipid signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
Hippo signaling pathway
Tight junction
T cell receptor signaling pathway
Dopaminergic synapse
Chagas disease
Hepatitis C
Human papillomavirus infection

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	30718926
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	27903959

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		20308991, 24387768
Vascular diseases	Peripheral Arterial Diseases		27082954