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RIC8B (RIC8 guanine nucleotide exchange factor B)

Gene

55188

RIC8 guanine nucleotide exchange factor B

RIC8B

RIC8, hSyn

12q23.3

Show/Hide all(252)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024719	hsa-miR-215-5p	Microarray	19074876
MIRT026881	hsa-miR-192-5p	Microarray	19074876
MIRT515662	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT515661	hsa-miR-567	PAR-CLIP	21572407
MIRT515660	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT515659	hsa-miR-3924	PAR-CLIP	21572407
MIRT515658	hsa-miR-297	PAR-CLIP	21572407
MIRT515662	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT515661	hsa-miR-567	PAR-CLIP	23446348
MIRT515660	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT515659	hsa-miR-3924	PAR-CLIP	23446348
MIRT515658	hsa-miR-297	PAR-CLIP	23446348
MIRT515662	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT515661	hsa-miR-567	PAR-CLIP	21572407
MIRT515660	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT515659	hsa-miR-3924	PAR-CLIP	21572407
MIRT515658	hsa-miR-297	PAR-CLIP	21572407
MIRT515662	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT515661	hsa-miR-567	PAR-CLIP	23446348
MIRT515660	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT515659	hsa-miR-3924	PAR-CLIP	23446348
MIRT515658	hsa-miR-297	PAR-CLIP	23446348
MIRT1306482	hsa-miR-1228	CLIP-seq
MIRT1306483	hsa-miR-1233	CLIP-seq
MIRT1306484	hsa-miR-1260	CLIP-seq
MIRT1306485	hsa-miR-1260b	CLIP-seq
MIRT1306486	hsa-miR-188-3p	CLIP-seq
MIRT1306487	hsa-miR-192	CLIP-seq
MIRT1306488	hsa-miR-215	CLIP-seq
MIRT1306489	hsa-miR-3156-3p	CLIP-seq
MIRT1306490	hsa-miR-3171	CLIP-seq
MIRT1306491	hsa-miR-338-3p	CLIP-seq
MIRT1306492	hsa-miR-338-5p	CLIP-seq
MIRT1306493	hsa-miR-342-3p	CLIP-seq
MIRT1306494	hsa-miR-3680	CLIP-seq
MIRT1306495	hsa-miR-3682-5p	CLIP-seq
MIRT1306496	hsa-miR-376a	CLIP-seq
MIRT1306497	hsa-miR-376b	CLIP-seq
MIRT1306498	hsa-miR-3942-3p	CLIP-seq
MIRT1306499	hsa-miR-3945	CLIP-seq
MIRT1306500	hsa-miR-4253	CLIP-seq
MIRT1306501	hsa-miR-4301	CLIP-seq
MIRT1306502	hsa-miR-4310	CLIP-seq
MIRT1306503	hsa-miR-4506	CLIP-seq
MIRT1306504	hsa-miR-4667-3p	CLIP-seq
MIRT1306505	hsa-miR-4766-5p	CLIP-seq
MIRT1306506	hsa-miR-4778-3p	CLIP-seq
MIRT1306507	hsa-miR-488	CLIP-seq
MIRT1306482	hsa-miR-1228	CLIP-seq
MIRT2090800	hsa-miR-146b-3p	CLIP-seq
MIRT2090801	hsa-miR-15a	CLIP-seq
MIRT2090802	hsa-miR-15b	CLIP-seq
MIRT2090803	hsa-miR-16	CLIP-seq
MIRT2090804	hsa-miR-1915	CLIP-seq
MIRT2090805	hsa-miR-195	CLIP-seq
MIRT2090806	hsa-miR-22	CLIP-seq
MIRT2090807	hsa-miR-2467-3p	CLIP-seq
MIRT2090808	hsa-miR-2964a-3p	CLIP-seq
MIRT2090809	hsa-miR-3121-3p	CLIP-seq
MIRT2090810	hsa-miR-3133	CLIP-seq
MIRT2090811	hsa-miR-3173-5p	CLIP-seq
MIRT1306493	hsa-miR-342-3p	CLIP-seq
MIRT2090812	hsa-miR-361-3p	CLIP-seq
MIRT2090813	hsa-miR-3674	CLIP-seq
MIRT2090814	hsa-miR-424	CLIP-seq
MIRT2090815	hsa-miR-4511	CLIP-seq
MIRT2090816	hsa-miR-4524	CLIP-seq
MIRT1306504	hsa-miR-4667-3p	CLIP-seq
MIRT2090817	hsa-miR-4668-5p	CLIP-seq
MIRT2090818	hsa-miR-4726-3p	CLIP-seq
MIRT2090819	hsa-miR-4763-5p	CLIP-seq
MIRT2090820	hsa-miR-497	CLIP-seq
MIRT2090821	hsa-miR-503	CLIP-seq
MIRT2090822	hsa-miR-646	CLIP-seq
MIRT2090823	hsa-miR-874	CLIP-seq
MIRT2315460	hsa-miR-1255a	CLIP-seq
MIRT2315461	hsa-miR-1255b	CLIP-seq
MIRT2315462	hsa-miR-1343	CLIP-seq
MIRT2090801	hsa-miR-15a	CLIP-seq
MIRT2090802	hsa-miR-15b	CLIP-seq
MIRT2090803	hsa-miR-16	CLIP-seq
MIRT2090805	hsa-miR-195	CLIP-seq
MIRT2315463	hsa-miR-1972	CLIP-seq
MIRT2315464	hsa-miR-3137	CLIP-seq
MIRT2315465	hsa-miR-3192	CLIP-seq
MIRT2315466	hsa-miR-3689a-3p	CLIP-seq
MIRT2315467	hsa-miR-3689c	CLIP-seq
MIRT2315468	hsa-miR-3689d	CLIP-seq
MIRT2315469	hsa-miR-3907	CLIP-seq
MIRT2090814	hsa-miR-424	CLIP-seq
MIRT2315470	hsa-miR-4326	CLIP-seq
MIRT2315471	hsa-miR-4499	CLIP-seq
MIRT2090816	hsa-miR-4524	CLIP-seq
MIRT2315472	hsa-miR-4528	CLIP-seq
MIRT2315473	hsa-miR-4540	CLIP-seq
MIRT2315474	hsa-miR-4650-5p	CLIP-seq
MIRT2315475	hsa-miR-4660	CLIP-seq
MIRT2315476	hsa-miR-4670-3p	CLIP-seq
MIRT2315477	hsa-miR-4717-5p	CLIP-seq
MIRT2315478	hsa-miR-4728-5p	CLIP-seq
MIRT2315479	hsa-miR-4731-5p	CLIP-seq
MIRT2090820	hsa-miR-497	CLIP-seq
MIRT2090821	hsa-miR-503	CLIP-seq
MIRT2315480	hsa-miR-554	CLIP-seq
MIRT2090822	hsa-miR-646	CLIP-seq
MIRT2458227	hsa-miR-186	CLIP-seq
MIRT2090810	hsa-miR-3133	CLIP-seq
MIRT1306492	hsa-miR-338-5p	CLIP-seq
MIRT2611695	hsa-miR-1226	CLIP-seq
MIRT2611696	hsa-miR-1264	CLIP-seq
MIRT2611697	hsa-miR-1266	CLIP-seq
MIRT2611698	hsa-miR-1289	CLIP-seq
MIRT2611699	hsa-miR-146a	CLIP-seq
MIRT2611700	hsa-miR-146b-5p	CLIP-seq
MIRT2458227	hsa-miR-186	CLIP-seq
MIRT1306487	hsa-miR-192	CLIP-seq
MIRT1306488	hsa-miR-215	CLIP-seq
MIRT2090806	hsa-miR-22	CLIP-seq
MIRT2090807	hsa-miR-2467-3p	CLIP-seq
MIRT2611701	hsa-miR-2467-5p	CLIP-seq
MIRT2090809	hsa-miR-3121-3p	CLIP-seq
MIRT2090810	hsa-miR-3133	CLIP-seq
MIRT2611702	hsa-miR-3162-5p	CLIP-seq
MIRT2611703	hsa-miR-3168	CLIP-seq
MIRT1306490	hsa-miR-3171	CLIP-seq
MIRT2611704	hsa-miR-3188	CLIP-seq
MIRT2611705	hsa-miR-323-3p	CLIP-seq
MIRT2611706	hsa-miR-323-5p	CLIP-seq
MIRT2611707	hsa-miR-329	CLIP-seq
MIRT2611708	hsa-miR-345	CLIP-seq
MIRT2090812	hsa-miR-361-3p	CLIP-seq
MIRT2611709	hsa-miR-361-5p	CLIP-seq
MIRT2611710	hsa-miR-362-3p	CLIP-seq
MIRT2611711	hsa-miR-3662	CLIP-seq
MIRT2090813	hsa-miR-3674	CLIP-seq
MIRT1306494	hsa-miR-3680	CLIP-seq
MIRT1306495	hsa-miR-3682-5p	CLIP-seq
MIRT1306496	hsa-miR-376a	CLIP-seq
MIRT1306497	hsa-miR-376b	CLIP-seq
MIRT2611712	hsa-miR-377	CLIP-seq
MIRT2611713	hsa-miR-3923	CLIP-seq
MIRT2611714	hsa-miR-3975	CLIP-seq
MIRT2611715	hsa-miR-4251	CLIP-seq
MIRT2611716	hsa-miR-4255	CLIP-seq
MIRT2611717	hsa-miR-4270	CLIP-seq
MIRT2611718	hsa-miR-4277	CLIP-seq
MIRT2611719	hsa-miR-4324	CLIP-seq
MIRT2611720	hsa-miR-4328	CLIP-seq
MIRT2611721	hsa-miR-4441	CLIP-seq
MIRT1306503	hsa-miR-4506	CLIP-seq
MIRT2090815	hsa-miR-4511	CLIP-seq
MIRT2611722	hsa-miR-4518	CLIP-seq
MIRT2611723	hsa-miR-4649-3p	CLIP-seq
MIRT2611724	hsa-miR-4729	CLIP-seq
MIRT1306506	hsa-miR-4778-3p	CLIP-seq
MIRT2611725	hsa-miR-4799-5p	CLIP-seq
MIRT2611726	hsa-miR-485-5p	CLIP-seq
MIRT2611727	hsa-miR-510	CLIP-seq
MIRT2611728	hsa-miR-512-5p	CLIP-seq
MIRT2611729	hsa-miR-548a-5p	CLIP-seq
MIRT2611730	hsa-miR-548ab	CLIP-seq
MIRT2611731	hsa-miR-548ak	CLIP-seq
MIRT2611732	hsa-miR-548b-5p	CLIP-seq
MIRT2611733	hsa-miR-548c-3p	CLIP-seq
MIRT2611734	hsa-miR-548c-5p	CLIP-seq
MIRT2611735	hsa-miR-548d-5p	CLIP-seq
MIRT2611736	hsa-miR-548h	CLIP-seq
MIRT2611737	hsa-miR-548i	CLIP-seq
MIRT2611738	hsa-miR-548j	CLIP-seq
MIRT2611739	hsa-miR-548n	CLIP-seq
MIRT2611740	hsa-miR-548t	CLIP-seq
MIRT2611741	hsa-miR-548w	CLIP-seq
MIRT2611742	hsa-miR-548y	CLIP-seq
MIRT2611743	hsa-miR-559	CLIP-seq
MIRT2611744	hsa-miR-589	CLIP-seq
MIRT2611745	hsa-miR-618	CLIP-seq
MIRT2611746	hsa-miR-628-5p	CLIP-seq
MIRT2611747	hsa-miR-634	CLIP-seq
MIRT2611748	hsa-miR-876-3p	CLIP-seq
MIRT2611749	hsa-miR-885-5p	CLIP-seq
MIRT2611695	hsa-miR-1226	CLIP-seq
MIRT2611696	hsa-miR-1264	CLIP-seq
MIRT2611697	hsa-miR-1266	CLIP-seq
MIRT2611698	hsa-miR-1289	CLIP-seq
MIRT2689761	hsa-miR-1303	CLIP-seq
MIRT1306487	hsa-miR-192	CLIP-seq
MIRT1306488	hsa-miR-215	CLIP-seq
MIRT2090807	hsa-miR-2467-3p	CLIP-seq
MIRT2611701	hsa-miR-2467-5p	CLIP-seq
MIRT2090809	hsa-miR-3121-3p	CLIP-seq
MIRT2090810	hsa-miR-3133	CLIP-seq
MIRT2611702	hsa-miR-3162-5p	CLIP-seq
MIRT2611703	hsa-miR-3168	CLIP-seq
MIRT1306490	hsa-miR-3171	CLIP-seq
MIRT2689762	hsa-miR-3182	CLIP-seq
MIRT2689763	hsa-miR-3184	CLIP-seq
MIRT2611704	hsa-miR-3188	CLIP-seq
MIRT2611705	hsa-miR-323-3p	CLIP-seq
MIRT2611706	hsa-miR-323-5p	CLIP-seq
MIRT2611707	hsa-miR-329	CLIP-seq
MIRT2611708	hsa-miR-345	CLIP-seq
MIRT2090812	hsa-miR-361-3p	CLIP-seq
MIRT2611709	hsa-miR-361-5p	CLIP-seq
MIRT2611710	hsa-miR-362-3p	CLIP-seq
MIRT2611711	hsa-miR-3662	CLIP-seq
MIRT1306494	hsa-miR-3680	CLIP-seq
MIRT1306495	hsa-miR-3682-5p	CLIP-seq
MIRT1306496	hsa-miR-376a	CLIP-seq
MIRT1306497	hsa-miR-376b	CLIP-seq
MIRT2611712	hsa-miR-377	CLIP-seq
MIRT2611713	hsa-miR-3923	CLIP-seq
MIRT2611714	hsa-miR-3975	CLIP-seq
MIRT2689764	hsa-miR-423-5p	CLIP-seq
MIRT2611716	hsa-miR-4255	CLIP-seq
MIRT2611717	hsa-miR-4270	CLIP-seq
MIRT2689765	hsa-miR-4271	CLIP-seq
MIRT2611718	hsa-miR-4277	CLIP-seq
MIRT2611720	hsa-miR-4328	CLIP-seq
MIRT2611721	hsa-miR-4441	CLIP-seq
MIRT1306503	hsa-miR-4506	CLIP-seq
MIRT2090815	hsa-miR-4511	CLIP-seq
MIRT2611722	hsa-miR-4518	CLIP-seq
MIRT2689766	hsa-miR-4533	CLIP-seq
MIRT2611723	hsa-miR-4649-3p	CLIP-seq
MIRT2689767	hsa-miR-4725-3p	CLIP-seq
MIRT2689768	hsa-miR-4731-3p	CLIP-seq
MIRT2689769	hsa-miR-4747-5p	CLIP-seq
MIRT1306506	hsa-miR-4778-3p	CLIP-seq
MIRT2611725	hsa-miR-4799-5p	CLIP-seq
MIRT2689770	hsa-miR-4801	CLIP-seq
MIRT2611726	hsa-miR-485-5p	CLIP-seq
MIRT2611727	hsa-miR-510	CLIP-seq
MIRT2611728	hsa-miR-512-5p	CLIP-seq
MIRT2611729	hsa-miR-548a-5p	CLIP-seq
MIRT2611730	hsa-miR-548ab	CLIP-seq
MIRT2611731	hsa-miR-548ak	CLIP-seq
MIRT2611732	hsa-miR-548b-5p	CLIP-seq
MIRT2611733	hsa-miR-548c-3p	CLIP-seq
MIRT2611734	hsa-miR-548c-5p	CLIP-seq
MIRT2611735	hsa-miR-548d-5p	CLIP-seq
MIRT2611736	hsa-miR-548h	CLIP-seq
MIRT2611737	hsa-miR-548i	CLIP-seq
MIRT2611738	hsa-miR-548j	CLIP-seq
MIRT2611739	hsa-miR-548n	CLIP-seq
MIRT2611740	hsa-miR-548t	CLIP-seq
MIRT2611741	hsa-miR-548w	CLIP-seq
MIRT2611742	hsa-miR-548y	CLIP-seq
MIRT2611743	hsa-miR-559	CLIP-seq
MIRT2611746	hsa-miR-628-5p	CLIP-seq
MIRT2611747	hsa-miR-634	CLIP-seq
MIRT2611748	hsa-miR-876-3p	CLIP-seq
MIRT2611749	hsa-miR-885-5p	CLIP-seq

Show/Hide all(12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001965	Function	G-protein alpha-subunit binding	IBA	21873635
GO:0001965	Function	G-protein alpha-subunit binding	IDA	12652642
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA	21873635
GO:0005096	Function	GTPase activator activity	IBA	21873635
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	IDA	12652642
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	12652642
GO:0005938	Component	Cell cortex	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA	21873635
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	IDA	12652642
GO:0043547	Process	Positive regulation of GTPase activity	IEA

MIM	HGNC	e!Ensembl
609147	25555	ENSG00000111785

Protein

UniProt ID

Q9NVN3

Protein name

Chaperone Ric-8B (Brain synembryn) (hSyn) (Synembryn-B)

Protein function

Chaperone that specifically binds and folds nascent G(s) G-alpha proteins (GNAS and GNAL) prior to G protein heterotrimer formation, promoting their association with the plasma membrane (By similarity). Also acts as a guanine nucleotide exchange

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10165	Ric8	66 → 485	Guanine nucleotide exchange factor synembryn	Family

Sequence

MDEERALYIVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIPT
TCQVSCLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKC
LCNIVFNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRS
QLRYELQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVD
SWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPL
THEETAQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYR
EGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGV
KQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKN
AKPKEELLKPMGLKPDGTITPLEEALNQYSVIEETSSDTD

Sequence length

520

Interactions

View interactions

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	26974007

Show/Hide Unknown Diseases (5)

Unknown
Disease name	Disease term	dbSNP ID	References
Ankylosing spondylitis	Ankylosing spondylitis		26974007
Cholangitis	Cholangitis, Sclerosing		26974007
Crohn disease	Crohn Disease	rs2066847, rs2066844, rs886052047, rs5743265, rs111608429, rs104895438	26974007
Sclerosing cholangitis	Primary sclerosing cholangitis		23603763
Ulcerative colitis	Ulcerative Colitis		26974007

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