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RNF220 (ring finger protein 220)

Gene

55182

Ring finger protein 220

RNF220

C1orf164, HLD23

1p34.1

Show/Hide all(207)

miRTarBase ID	miRNA	Experiments	Reference
MIRT048901	hsa-miR-93-5p	CLASH	23622248
MIRT138278	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT138284	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT138279	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT138280	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT138286	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT1312327	hsa-miR-105	CLIP-seq
MIRT1312328	hsa-miR-1208	CLIP-seq
MIRT1312329	hsa-miR-1252	CLIP-seq
MIRT1312330	hsa-miR-140-3p	CLIP-seq
MIRT1312331	hsa-miR-196a	CLIP-seq
MIRT1312332	hsa-miR-196b	CLIP-seq
MIRT1312333	hsa-miR-214	CLIP-seq
MIRT1312334	hsa-miR-299-5p	CLIP-seq
MIRT1312335	hsa-miR-30a	CLIP-seq
MIRT1312336	hsa-miR-30b	CLIP-seq
MIRT1312337	hsa-miR-30c	CLIP-seq
MIRT1312338	hsa-miR-30d	CLIP-seq
MIRT1312339	hsa-miR-30e	CLIP-seq
MIRT1312340	hsa-miR-3149	CLIP-seq
MIRT1312341	hsa-miR-3153	CLIP-seq
MIRT1312342	hsa-miR-3202	CLIP-seq
MIRT1312343	hsa-miR-3619-5p	CLIP-seq
MIRT1312344	hsa-miR-3665	CLIP-seq
MIRT1312345	hsa-miR-371-3p	CLIP-seq
MIRT1312346	hsa-miR-371b-3p	CLIP-seq
MIRT1312347	hsa-miR-4300	CLIP-seq
MIRT1312348	hsa-miR-4475	CLIP-seq
MIRT1312349	hsa-miR-4488	CLIP-seq
MIRT1312350	hsa-miR-4505	CLIP-seq
MIRT1312351	hsa-miR-4530	CLIP-seq
MIRT1312352	hsa-miR-4646-3p	CLIP-seq
MIRT1312353	hsa-miR-4697-5p	CLIP-seq
MIRT1312354	hsa-miR-4703-3p	CLIP-seq
MIRT1312355	hsa-miR-4716-5p	CLIP-seq
MIRT1312356	hsa-miR-4717-3p	CLIP-seq
MIRT1312357	hsa-miR-4724-5p	CLIP-seq
MIRT1312358	hsa-miR-4729	CLIP-seq
MIRT1312359	hsa-miR-4731-3p	CLIP-seq
MIRT1312360	hsa-miR-4731-5p	CLIP-seq
MIRT1312361	hsa-miR-4736	CLIP-seq
MIRT1312362	hsa-miR-4747-5p	CLIP-seq
MIRT1312363	hsa-miR-4768-3p	CLIP-seq
MIRT1312364	hsa-miR-4789-5p	CLIP-seq
MIRT1312365	hsa-miR-4796-5p	CLIP-seq
MIRT1312366	hsa-miR-4801	CLIP-seq
MIRT1312367	hsa-miR-485-5p	CLIP-seq
MIRT1312368	hsa-miR-486-3p	CLIP-seq
MIRT1312369	hsa-miR-515-3p	CLIP-seq
MIRT1312370	hsa-miR-519e	CLIP-seq
MIRT1312371	hsa-miR-520d-5p	CLIP-seq
MIRT1312372	hsa-miR-524-5p	CLIP-seq
MIRT1312373	hsa-miR-550a	CLIP-seq
MIRT1312374	hsa-miR-568	CLIP-seq
MIRT1312375	hsa-miR-602	CLIP-seq
MIRT1312376	hsa-miR-637	CLIP-seq
MIRT1312377	hsa-miR-656	CLIP-seq
MIRT1312378	hsa-miR-761	CLIP-seq
MIRT1312379	hsa-miR-920	CLIP-seq
MIRT2092826	hsa-miR-1254	CLIP-seq
MIRT1312331	hsa-miR-196a	CLIP-seq
MIRT1312332	hsa-miR-196b	CLIP-seq
MIRT1312334	hsa-miR-299-5p	CLIP-seq
MIRT2092827	hsa-miR-3116	CLIP-seq
MIRT2092828	hsa-miR-3151	CLIP-seq
MIRT1312341	hsa-miR-3153	CLIP-seq
MIRT2092829	hsa-miR-3189-5p	CLIP-seq
MIRT1312344	hsa-miR-3665	CLIP-seq
MIRT1312345	hsa-miR-371-3p	CLIP-seq
MIRT1312346	hsa-miR-371b-3p	CLIP-seq
MIRT2092830	hsa-miR-4283	CLIP-seq
MIRT2092831	hsa-miR-4292	CLIP-seq
MIRT1312349	hsa-miR-4488	CLIP-seq
MIRT2092832	hsa-miR-4489	CLIP-seq
MIRT1312350	hsa-miR-4505	CLIP-seq
MIRT2092833	hsa-miR-4640-5p	CLIP-seq
MIRT1312353	hsa-miR-4697-5p	CLIP-seq
MIRT2092834	hsa-miR-4716-3p	CLIP-seq
MIRT2092835	hsa-miR-4723-5p	CLIP-seq
MIRT2092836	hsa-miR-4726-5p	CLIP-seq
MIRT2092837	hsa-miR-4728-5p	CLIP-seq
MIRT1312360	hsa-miR-4731-5p	CLIP-seq
MIRT1312361	hsa-miR-4736	CLIP-seq
MIRT2092838	hsa-miR-4758-3p	CLIP-seq
MIRT2092839	hsa-miR-485-3p	CLIP-seq
MIRT1312367	hsa-miR-485-5p	CLIP-seq
MIRT1312368	hsa-miR-486-3p	CLIP-seq
MIRT2092840	hsa-miR-487a	CLIP-seq
MIRT1312369	hsa-miR-515-3p	CLIP-seq
MIRT1312370	hsa-miR-519e	CLIP-seq
MIRT1312371	hsa-miR-520d-5p	CLIP-seq
MIRT1312372	hsa-miR-524-5p	CLIP-seq
MIRT1312373	hsa-miR-550a	CLIP-seq
MIRT1312376	hsa-miR-637	CLIP-seq
MIRT2092841	hsa-miR-661	CLIP-seq
MIRT2317436	hsa-miR-1228	CLIP-seq
MIRT2092826	hsa-miR-1254	CLIP-seq
MIRT2317437	hsa-miR-1287	CLIP-seq
MIRT1312330	hsa-miR-140-3p	CLIP-seq
MIRT2317438	hsa-miR-185	CLIP-seq
MIRT1312335	hsa-miR-30a	CLIP-seq
MIRT1312336	hsa-miR-30b	CLIP-seq
MIRT1312337	hsa-miR-30c	CLIP-seq
MIRT1312338	hsa-miR-30d	CLIP-seq
MIRT1312339	hsa-miR-30e	CLIP-seq
MIRT2092827	hsa-miR-3116	CLIP-seq
MIRT2317439	hsa-miR-3135b	CLIP-seq
MIRT2092828	hsa-miR-3151	CLIP-seq
MIRT1312342	hsa-miR-3202	CLIP-seq
MIRT2317440	hsa-miR-3612	CLIP-seq
MIRT1312344	hsa-miR-3665	CLIP-seq
MIRT2317441	hsa-miR-3918	CLIP-seq
MIRT2317442	hsa-miR-3977	CLIP-seq
MIRT2092830	hsa-miR-4283	CLIP-seq
MIRT2317443	hsa-miR-4306	CLIP-seq
MIRT2317444	hsa-miR-4443	CLIP-seq
MIRT1312348	hsa-miR-4475	CLIP-seq
MIRT1312349	hsa-miR-4488	CLIP-seq
MIRT2092832	hsa-miR-4489	CLIP-seq
MIRT1312350	hsa-miR-4505	CLIP-seq
MIRT2317445	hsa-miR-4644	CLIP-seq
MIRT1312352	hsa-miR-4646-3p	CLIP-seq
MIRT2317446	hsa-miR-4666-5p	CLIP-seq
MIRT1312353	hsa-miR-4697-5p	CLIP-seq
MIRT2092834	hsa-miR-4716-3p	CLIP-seq
MIRT1312356	hsa-miR-4717-3p	CLIP-seq
MIRT2092835	hsa-miR-4723-5p	CLIP-seq
MIRT1312357	hsa-miR-4724-5p	CLIP-seq
MIRT2092837	hsa-miR-4728-5p	CLIP-seq
MIRT1312358	hsa-miR-4729	CLIP-seq
MIRT1312359	hsa-miR-4731-3p	CLIP-seq
MIRT1312360	hsa-miR-4731-5p	CLIP-seq
MIRT1312361	hsa-miR-4736	CLIP-seq
MIRT1312362	hsa-miR-4747-5p	CLIP-seq
MIRT2317447	hsa-miR-4763-5p	CLIP-seq
MIRT1312363	hsa-miR-4768-3p	CLIP-seq
MIRT1312364	hsa-miR-4789-5p	CLIP-seq
MIRT1312365	hsa-miR-4796-5p	CLIP-seq
MIRT1312366	hsa-miR-4801	CLIP-seq
MIRT2092839	hsa-miR-485-3p	CLIP-seq
MIRT1312367	hsa-miR-485-5p	CLIP-seq
MIRT1312368	hsa-miR-486-3p	CLIP-seq
MIRT2092840	hsa-miR-487a	CLIP-seq
MIRT1312375	hsa-miR-602	CLIP-seq
MIRT1312376	hsa-miR-637	CLIP-seq
MIRT2317448	hsa-miR-650	CLIP-seq
MIRT1312377	hsa-miR-656	CLIP-seq
MIRT2092841	hsa-miR-661	CLIP-seq
MIRT1312335	hsa-miR-30a	CLIP-seq
MIRT1312336	hsa-miR-30b	CLIP-seq
MIRT1312337	hsa-miR-30c	CLIP-seq
MIRT1312338	hsa-miR-30d	CLIP-seq
MIRT1312339	hsa-miR-30e	CLIP-seq
MIRT1312341	hsa-miR-3153	CLIP-seq
MIRT1312365	hsa-miR-4796-5p	CLIP-seq
MIRT1312375	hsa-miR-602	CLIP-seq
MIRT2092837	hsa-miR-4728-5p	CLIP-seq
MIRT2317436	hsa-miR-1228	CLIP-seq
MIRT1312330	hsa-miR-140-3p	CLIP-seq
MIRT2613285	hsa-miR-1915	CLIP-seq
MIRT1312333	hsa-miR-214	CLIP-seq
MIRT2092828	hsa-miR-3151	CLIP-seq
MIRT1312341	hsa-miR-3153	CLIP-seq
MIRT2613286	hsa-miR-3175	CLIP-seq
MIRT1312343	hsa-miR-3619-5p	CLIP-seq
MIRT1312344	hsa-miR-3665	CLIP-seq
MIRT2613287	hsa-miR-3714	CLIP-seq
MIRT2317441	hsa-miR-3918	CLIP-seq
MIRT2092830	hsa-miR-4283	CLIP-seq
MIRT2613288	hsa-miR-4291	CLIP-seq
MIRT2092831	hsa-miR-4292	CLIP-seq
MIRT2613289	hsa-miR-4308	CLIP-seq
MIRT2613290	hsa-miR-4446-5p	CLIP-seq
MIRT1312349	hsa-miR-4488	CLIP-seq
MIRT2092832	hsa-miR-4489	CLIP-seq
MIRT1312350	hsa-miR-4505	CLIP-seq
MIRT2613291	hsa-miR-4646-5p	CLIP-seq
MIRT2613292	hsa-miR-4660	CLIP-seq
MIRT2613293	hsa-miR-4668-5p	CLIP-seq
MIRT1312353	hsa-miR-4697-5p	CLIP-seq
MIRT2613294	hsa-miR-4726-3p	CLIP-seq
MIRT2092837	hsa-miR-4728-5p	CLIP-seq
MIRT1312360	hsa-miR-4731-5p	CLIP-seq
MIRT1312361	hsa-miR-4736	CLIP-seq
MIRT2613295	hsa-miR-4755-5p	CLIP-seq
MIRT2613296	hsa-miR-4790-3p	CLIP-seq
MIRT1312367	hsa-miR-485-5p	CLIP-seq
MIRT1312368	hsa-miR-486-3p	CLIP-seq
MIRT2613297	hsa-miR-542-5p	CLIP-seq
MIRT2613298	hsa-miR-548an	CLIP-seq
MIRT1312376	hsa-miR-637	CLIP-seq
MIRT2613299	hsa-miR-670	CLIP-seq
MIRT1312378	hsa-miR-761	CLIP-seq
MIRT2613300	hsa-miR-922	CLIP-seq
MIRT2317436	hsa-miR-1228	CLIP-seq
MIRT1312330	hsa-miR-140-3p	CLIP-seq
MIRT1312341	hsa-miR-3153	CLIP-seq
MIRT2613287	hsa-miR-3714	CLIP-seq
MIRT2317441	hsa-miR-3918	CLIP-seq
MIRT2092831	hsa-miR-4292	CLIP-seq
MIRT2613289	hsa-miR-4308	CLIP-seq
MIRT2613290	hsa-miR-4446-5p	CLIP-seq
MIRT2613291	hsa-miR-4646-5p	CLIP-seq
MIRT2613293	hsa-miR-4668-5p	CLIP-seq
MIRT2613295	hsa-miR-4755-5p	CLIP-seq
MIRT2613298	hsa-miR-548an	CLIP-seq
MIRT2613299	hsa-miR-670	CLIP-seq

Show/Hide all(9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004842	Function	Ubiquitin-protein transferase activity	ISS
GO:0005515	Function	Protein binding	IPI	25266658
GO:0005737	Component	Cytoplasm	ISS
GO:0016567	Process	Protein ubiquitination	IBA	21873635
GO:0016567	Process	Protein ubiquitination	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0051865	Process	Protein autoubiquitination	ISS
GO:0061630	Function	Ubiquitin protein ligase activity	IBA	21873635
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IMP	25266658

MIM	HGNC	e!Ensembl
616136	25552	ENSG00000187147

Protein

UniProt ID

Q5VTB9

Protein name

E3 ubiquitin-protein ligase RNF220 (EC 2.3.2.27) (RING finger protein 220) (RING-type E3 ubiquitin transferase RNF220)

Protein function

E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wn

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15926	RNF220	217 → 339	E3 ubiquitin-protein ligase RNF220	Family
PF15926	RNF220	336 → 444	E3 ubiquitin-protein ligase RNF220	Family
PF13923	zf-C3HC4_2	513 → 552		Domain

Sequence

MDLHRAAFKMENSSYLPNPLASPALMVLASTAEASRDASIPCQQPRPFGVPVSVDKDVHI
PFTNGSYTFASMYHRQGGVPGTFANRDFPPSLLHLHPQFAPPNLDCTPISMLNHSGVGAF
RPFASTEDRESYQSAFTPAKRLKNCHDTESPHLRFSDADGKEYDFGTQLPSSSPGSLKVD
DTGKKIFAVSGLISDREASSSPEDRNDRCKKKAAALFDSQAPICPICQVLLRPSELQEHM
EQELEQLAQLPSSKNSLLKDAMAPGTPKSLLLSASIKREGESPTASPHSSATDDLHHSDR
YQTFLRVRANRQTRLNARIGKMKRRKQDEGQREGSCMAEDDAVDIEHENNNRFEEYEWCG
QKRIRATTLLEGGFRGSGFIMCSGKENPDSDADLDVDGDDTLEYGKPQYTEADVIPCTGE
EPGEAKEREALRGAVLNGGPPSTRITPEFSKWASDEMPSTSNGESSKQEAMQKTCKNSDI
EKITEDSAVTTFEALKARVRELERQLSRGDRYKCLICMDSYSMPLTSIQCWHVHCEECWL
RTLGAKKLCPQCNTITAPGDLRRIYL

Sequence length

566

Interactions

View interactions

	Reactome
			Antigen processing: Ubiquitination & Proteasome degradation

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease	rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928	30804561

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