MSL2 (MSL complex subunit 2)

Gene

• Entrez ID: 55167
• Gene name: MSL complex subunit 2
• Gene symbol: MSL2
• Synonyms: MSL-2, MSL2L1, RNF184
• Chromosome: 3
• Chromosome location: 3q22.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT047821	hsa-miR-30d-5p	CLASH	23622248
MIRT049962	hsa-miR-30a-5p	CLASH	23622248
MIRT566718	hsa-miR-578	PAR-CLIP	20371350
MIRT566719	hsa-miR-192-3p	PAR-CLIP	20371350
MIRT566720	hsa-miR-664b-3p	PAR-CLIP	20371350
MIRT566721	hsa-miR-5696	PAR-CLIP	20371350
MIRT566722	hsa-miR-579-3p	PAR-CLIP	20371350
MIRT566723	hsa-miR-6853-3p	PAR-CLIP	20371350
MIRT566724	hsa-miR-569	PAR-CLIP	20371350
MIRT566725	hsa-miR-6086	PAR-CLIP	20371350
MIRT566726	hsa-miR-377-5p	PAR-CLIP	20371350
MIRT566727	hsa-miR-655-5p	PAR-CLIP	20371350
MIRT566728	hsa-miR-153-5p	PAR-CLIP	20371350
MIRT566729	hsa-miR-1250-3p	PAR-CLIP	20371350
MIRT566730	hsa-miR-33a-3p	PAR-CLIP	20371350
MIRT566731	hsa-miR-409-3p	PAR-CLIP	20371350
MIRT571879	hsa-miR-135b-3p	PAR-CLIP	20371350
MIRT571880	hsa-miR-4691-5p	PAR-CLIP	20371350
MIRT571881	hsa-miR-6792-3p	PAR-CLIP	20371350
MIRT571882	hsa-miR-2276-3p	PAR-CLIP	20371350
MIRT571883	hsa-miR-4772-3p	PAR-CLIP	20371350
MIRT571884	hsa-miR-885-5p	PAR-CLIP	20371350
MIRT571885	hsa-miR-4686	PAR-CLIP	20371350
MIRT571886	hsa-miR-296-3p	PAR-CLIP	20371350
MIRT571887	hsa-miR-483-3p	PAR-CLIP	20371350
MIRT571888	hsa-miR-136-5p	PAR-CLIP	20371350
MIRT701749	hsa-miR-3943	HITS-CLIP	23313552
MIRT701750	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT701751	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT701752	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT701753	hsa-miR-3689c	HITS-CLIP	23313552
MIRT701754	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT701755	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT701756	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT701757	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT701758	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT701759	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT701760	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT701761	hsa-miR-6807-5p	HITS-CLIP	23313552
MIRT701762	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT701763	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT701764	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT701765	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT701766	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT701767	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT701768	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT701769	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT701770	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT701771	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT701772	hsa-miR-1827	HITS-CLIP	23313552
MIRT701773	hsa-miR-1233-3p	HITS-CLIP	23313552
MIRT701774	hsa-miR-1225-3p	HITS-CLIP	23313552
MIRT701775	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT701776	hsa-miR-665	HITS-CLIP	23313552
MIRT701777	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT701778	hsa-miR-4478	HITS-CLIP	23313552
MIRT701779	hsa-miR-4419b	HITS-CLIP	23313552
MIRT701780	hsa-miR-3929	HITS-CLIP	23313552
MIRT701781	hsa-miR-940	HITS-CLIP	23313552
MIRT701782	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT701783	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT701784	hsa-miR-4323	HITS-CLIP	23313552

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005654	Component	Nucleoplasm	TAS
GO:0016567	Process	Protein ubiquitination	IBA	21873635
GO:0043984	Process	Histone H4-K16 acetylation	IBA	21873635
GO:0043984	Process	Histone H4-K16 acetylation	IDA	20018852
GO:0046872	Function	Metal ion binding	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA	21873635
GO:0072487	Component	MSL complex	IBA	21873635
GO:0072487	Component	MSL complex	IDA	20018852

Other IDs

• MIM: 614802
• HGNC: 25544
• e!Ensembl: ENSG00000174579

Protein

• UniProt ID: Q9HCI7
• Protein name: E3 ubiquitin-protein ligase MSL2 (EC 2.3.2.-) (E3 ubiquitin-protein transferase MSL2) (Male-specific lethal 2-like 1) (MSL2-like 1) (Male-specific lethal-2 homolog) (MSL-2) (Male-specific lethal-2 homolog 1) (RING finger protein 184)
• Protein function: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.
• PDB: 4B7Y, 4B86
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16685	zf-RING_10	42 → 111	zinc RING finger of MSL2	Domain
  PF16682	MSL2-CXC	455 → 509	CXC domain of E3 ubiquitin-protein ligase MSL2	Domain

• Sequence:

  MNPVNATALYISASRLVLNYDPGDPKAFTEINRLLPYFRQSLSCCVCGHLLQDPIAPTNS
  TCQHYVCKTCKGKKMMMKPSCSWCKDYEQFEENKQLSILVNCYKKLCEYITQTTLARDII
  EAVDCSSDILALLNDGSLFCEETEKPSDSSFTLCLTHSPLPSTSEPTTDPQASLSPMSES
  TLSIAIGSSVINGLPTYNGLSIDRFGINIPSPEHSNTIDVCNTVDIKTEDLSDSLPPVCD
  TVATDLCSTGIDICSFSEDIKPGDSLLLSVEEVLRSLETVSNTEVCCPNLQPNLEATVSN
  GPFLQLSSQSLSHNVFMSTSPALHGLSCTAATPKIAKLNRKRSRSESDSEKVQPLPISTI
  IRGPTLGASAPVTVKRESKISLQPIATVPNGGTTPKISKTVLLSTKSMKKSHEHGSKKSH
  SKTKPGILKKDKAVKEKIPSHHFMPGSPTKTVYKKPQEKKGCKCGRATQNPSVLTCRGQR
  CPCYSNRKACLDCICRGCQNSYMANGEKKLEAFAVPEKALEQTRLTLGINVTSIAVRNAS
  TSTSVINVTGSPVTTFLAASTHDDKSLDEAIDMRFDC

• Sequence length: 577

Pathways

Reactome:

HATs acetylate histones

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs-1, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537	29212778