ARHGEF10L (Rho guanine nucleotide exchange factor 10 like)

Gene

• Entrez ID: 55160
• Gene name: Rho guanine nucleotide exchange factor 10 like
• Gene symbol: ARHGEF10L
• Synonyms: GrinchGEF
• Chromosome: 1
• Chromosome location: 1p36.13
• Summary: This gene belongs to the RhoGEF subfamily of RhoGTPases. Members of this subfamily are activated by specific guanine nucleotide exchange factors (GEFs) and are involved in signal transduction. The encoded protein shows cytosolic distribution. Alternative

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs149908903	G>A,T	Likely-pathogenic	Missense variant, genic downstream transcript variant, coding sequence variant, non coding transcript variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT043172	hsa-miR-324-5p	CLASH	23622248
MIRT043172	hsa-miR-324-5p	CLASH	23622248
MIRT795306	hsa-miR-323b-3p	CLIP-seq
MIRT795307	hsa-miR-499a-5p	CLIP-seq
MIRT1934811	hsa-miR-329	CLIP-seq
MIRT1934812	hsa-miR-342-3p	CLIP-seq
MIRT1934813	hsa-miR-362-3p	CLIP-seq
MIRT1934814	hsa-miR-603	CLIP-seq
MIRT2174587	hsa-miR-1226	CLIP-seq
MIRT2174588	hsa-miR-1268	CLIP-seq
MIRT2174589	hsa-miR-1268b	CLIP-seq
MIRT2174590	hsa-miR-3184	CLIP-seq
MIRT1934811	hsa-miR-329	CLIP-seq
MIRT1934812	hsa-miR-342-3p	CLIP-seq
MIRT1934813	hsa-miR-362-3p	CLIP-seq
MIRT2174591	hsa-miR-377	CLIP-seq
MIRT2174592	hsa-miR-423-5p	CLIP-seq
MIRT2174593	hsa-miR-4459	CLIP-seq
MIRT2174594	hsa-miR-4474-3p	CLIP-seq
MIRT2174595	hsa-miR-4690-3p	CLIP-seq
MIRT2174596	hsa-miR-4779	CLIP-seq
MIRT1934814	hsa-miR-603	CLIP-seq
MIRT2174597	hsa-miR-644	CLIP-seq
MIRT2174598	hsa-miR-665	CLIP-seq
MIRT1934812	hsa-miR-342-3p	CLIP-seq
MIRT2174595	hsa-miR-4690-3p	CLIP-seq
MIRT1934814	hsa-miR-603	CLIP-seq
MIRT2426421	hsa-miR-150	CLIP-seq
MIRT795306	hsa-miR-323b-3p	CLIP-seq
MIRT2426422	hsa-miR-338-3p	CLIP-seq
MIRT2426423	hsa-miR-3655	CLIP-seq
MIRT2426424	hsa-miR-369-3p	CLIP-seq
MIRT2426425	hsa-miR-374a	CLIP-seq
MIRT2426426	hsa-miR-374b	CLIP-seq
MIRT2426427	hsa-miR-4530	CLIP-seq
MIRT2426428	hsa-miR-4643	CLIP-seq
MIRT2426429	hsa-miR-466	CLIP-seq
MIRT2426430	hsa-miR-4713-5p	CLIP-seq
MIRT2426431	hsa-miR-4789-3p	CLIP-seq
MIRT2426432	hsa-miR-4789-5p	CLIP-seq
MIRT795307	hsa-miR-499a-5p	CLIP-seq
MIRT2426433	hsa-miR-511	CLIP-seq
MIRT2426434	hsa-miR-532-3p	CLIP-seq
MIRT2426435	hsa-miR-618	CLIP-seq
MIRT2174588	hsa-miR-1268	CLIP-seq
MIRT2174589	hsa-miR-1268b	CLIP-seq
MIRT2443930	hsa-miR-1289	CLIP-seq
MIRT2443931	hsa-miR-3198	CLIP-seq
MIRT2443932	hsa-miR-4294	CLIP-seq
MIRT2443933	hsa-miR-4309	CLIP-seq
MIRT2443934	hsa-miR-4312	CLIP-seq
MIRT2443935	hsa-miR-432	CLIP-seq
MIRT2174594	hsa-miR-4474-3p	CLIP-seq
MIRT2443936	hsa-miR-604	CLIP-seq
MIRT2174597	hsa-miR-644	CLIP-seq
MIRT2443937	hsa-miR-647	CLIP-seq
MIRT2478097	hsa-miR-1202	CLIP-seq
MIRT2174588	hsa-miR-1268	CLIP-seq
MIRT2174589	hsa-miR-1268b	CLIP-seq
MIRT2443930	hsa-miR-1289	CLIP-seq
MIRT2478098	hsa-miR-1294	CLIP-seq
MIRT2478099	hsa-miR-129-5p	CLIP-seq
MIRT2478100	hsa-miR-1296	CLIP-seq
MIRT2478101	hsa-miR-2113	CLIP-seq
MIRT2478102	hsa-miR-2682	CLIP-seq
MIRT2478103	hsa-miR-3136-3p	CLIP-seq
MIRT2174590	hsa-miR-3184	CLIP-seq
MIRT2443931	hsa-miR-3198	CLIP-seq
MIRT1934811	hsa-miR-329	CLIP-seq
MIRT1934813	hsa-miR-362-3p	CLIP-seq
MIRT2478104	hsa-miR-378g	CLIP-seq
MIRT2478105	hsa-miR-3972	CLIP-seq
MIRT2174592	hsa-miR-423-5p	CLIP-seq
MIRT2478106	hsa-miR-4282	CLIP-seq
MIRT2443932	hsa-miR-4294	CLIP-seq
MIRT2443933	hsa-miR-4309	CLIP-seq
MIRT2443934	hsa-miR-4312	CLIP-seq
MIRT2478107	hsa-miR-4316	CLIP-seq
MIRT2443935	hsa-miR-432	CLIP-seq
MIRT2174593	hsa-miR-4459	CLIP-seq
MIRT2174594	hsa-miR-4474-3p	CLIP-seq
MIRT2478108	hsa-miR-449c	CLIP-seq
MIRT2478109	hsa-miR-4512	CLIP-seq
MIRT2478110	hsa-miR-4514	CLIP-seq
MIRT2478111	hsa-miR-4645-5p	CLIP-seq
MIRT2478112	hsa-miR-4673	CLIP-seq
MIRT2478113	hsa-miR-4692	CLIP-seq
MIRT2478114	hsa-miR-4714-5p	CLIP-seq
MIRT2478115	hsa-miR-4755-3p	CLIP-seq
MIRT2478116	hsa-miR-4766-5p	CLIP-seq
MIRT2174596	hsa-miR-4779	CLIP-seq
MIRT2478117	hsa-miR-599	CLIP-seq
MIRT2443936	hsa-miR-604	CLIP-seq
MIRT2174597	hsa-miR-644	CLIP-seq
MIRT2443937	hsa-miR-647	CLIP-seq
MIRT2174598	hsa-miR-665	CLIP-seq
MIRT2174588	hsa-miR-1268	CLIP-seq
MIRT2174589	hsa-miR-1268b	CLIP-seq
MIRT2174590	hsa-miR-3184	CLIP-seq
MIRT1934811	hsa-miR-329	CLIP-seq
MIRT1934813	hsa-miR-362-3p	CLIP-seq
MIRT2174592	hsa-miR-423-5p	CLIP-seq
MIRT2478106	hsa-miR-4282	CLIP-seq
MIRT2174593	hsa-miR-4459	CLIP-seq
MIRT2174594	hsa-miR-4474-3p	CLIP-seq
MIRT2478114	hsa-miR-4714-5p	CLIP-seq
MIRT2478116	hsa-miR-4766-5p	CLIP-seq
MIRT2174596	hsa-miR-4779	CLIP-seq
MIRT2443936	hsa-miR-604	CLIP-seq
MIRT2174597	hsa-miR-644	CLIP-seq
MIRT2443937	hsa-miR-647	CLIP-seq
MIRT2174598	hsa-miR-665	CLIP-seq
MIRT2478114	hsa-miR-4714-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IDA	16112081
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA	16112081
GO:0030036	Process	Actin cytoskeleton organization	IBA	21873635
GO:0032933	Process	SREBP signaling pathway	IBA	21873635
GO:0032933	Process	SREBP signaling pathway	IDA	16112081
GO:0043547	Process	Positive regulation of GTPase activity	IEA
GO:0051496	Process	Positive regulation of stress fiber assembly	IBA	21873635
GO:0051496	Process	Positive regulation of stress fiber assembly	IDA	16112081

Other IDs

• MIM: 612494
• HGNC: 25540
• e!Ensembl: ENSG00000074964

Protein

• UniProt ID: Q9HCE6
• Protein name: Rho guanine nucleotide exchange factor 10-like protein (GrinchGEF)
• Protein function: Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00621	RhoGEF	320 → 501	RhoGEF domain	Domain
  PF19057	PH_19	525 → 681		Domain
  PF19056	WD40_2	789 → 1279		Repeat

• Sequence:

  MASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERD
  TDPPLIHLDSIPVTDPDPAAAPPGTGVPAWVSNGDAADAAFSGARHSSWKRKSSRRIDRF
  TFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSED
  SGEEAKPEVEVEPAKHRVSFQPKLSPDLTRLKERYARTKRDILALRVGGRDMQELKHKYD
  CKMTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVSVSDIKPPA
  PELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQ
  VVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSA
  MSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGH
  PDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLC
  ETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVK
  WNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQ
  KDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPG
  KPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWC
  PILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVE
  IFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQD
  GSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGVLWDL
  ESPPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVSVTHMV
  KAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWV
  GTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVATSILAPDILRSDQEEAEG
  PRAEEDKPDGQAHEPMPDSHVGRELTRKKGILLQYRLRSTAHLPGPLLSMREPAPADGAA
  LEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNFGSALGSSGRQ
  APCGETDSTLLIWQVPLML

• Sequence length: 1279

Pathways

Reactome:

NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs1801155, rs121908380, rs121908702, rs267606674, rs4939827, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800, rs63750198, rs63751109, rs863223312, rs63750710, rs63751615, rs63750206, rs63750781, rs63750899, rs63750691, rs63750217, rs121912965, rs63749939, rs63751194, rs63750693, rs63750540, rs63751221, rs193922370, rs80359596, rs397514632, rs483352909, rs200495564, rs397514684, rs397516436, rs398122386, rs79512956, rs74953290, rs587779001, rs63750677, rs63749837, rs267607816, rs63751715, rs267607819, rs267607815, rs267607822, rs63749906, rs587778883, rs63750472, rs63751012, rs63750715, rs63750580, rs267607706, rs267607709, rs267607710, rs587778894, rs63750749, rs63750483, rs63751015, rs63751153, rs63751094, rs63751118, rs63750316, rs63749981, rs587778906, rs267607821, rs587778908, rs63750020, rs587778909, rs63750713, rs267607825, rs63751592, rs281864936, rs587778913, rs587778914, rs63749795, rs63750855, rs63749916, rs63749923, rs63751472, rs63751689, rs267607832, rs267607837, rs267607836, rs587778923, rs63750028, rs587778928, rs587778929, rs587778930, rs63751277, rs587778933, rs267607842, rs267607843, rs63750192, rs587778934, rs63750193, rs587778937, rs587778938, rs267607845, rs63751244, rs63751393, rs63751460, rs267607849, rs267607853, rs267607856, rs267607850, rs63751657, rs267607854, rs267607852, rs587778942, rs63750309, rs63750587, rs63749863, rs63751486, rs63750016, rs63749868, rs63750375, rs63750035, rs63750604, rs63750386, rs63750150, rs63750486, rs63751428, rs267607866, rs63749986, rs63751594, rs63750152, rs63750850, rs267607867, rs267607868, rs63751632, rs267607871, rs63751892, rs587778956, rs63750469, rs587778958, rs63749792, rs267607875, rs63751255, rs281864938, rs63751202, rs63750726, rs63751310, rs63749900, rs587778964, rs267607879, rs267607878, rs587778966, rs267607883, rs267607887, rs63750061, rs63750663, rs587778968, rs587778971, rs63750809, rs63749867, rs63750864, rs587778972, rs63751275, rs267607718, rs267607722, rs63750769, rs267607717, rs587778973, rs267607716, rs267607720, rs63749995, rs63750859, rs587778975, rs63750114, rs587778976, rs63750603, rs267607889, rs267607723, rs63750561, rs63750499, rs63751642, rs63751022, rs587778981, rs63750971, rs267607898, rs267607906, rs267607903, rs587778989, rs587778992, rs267607894, rs267607901, rs267607892, rs63750437, rs587778997, rs587778998, rs63750005, rs63750641, rs63751421, rs11541859, rs63750266, rs111052004, rs267607726, rs267607727, rs63750453, rs267607734, rs267607735, rs63751665, rs267607736, rs267607732, rs63749816, rs63750539, rs267607739, rs587779006, rs587779008, rs267607745, rs267607742, rs63751595, rs267607743, rs587779010, rs587779012, rs63750057, rs63749818, rs63751124, rs587779014, rs587779015, rs63749820, rs63751302, rs267607750, rs267607751, rs267607749, rs63750891, rs63749959, rs63749804, rs267607765, rs267607760, rs587779021, rs267607759, rs63750515, rs587779023, rs63751021, rs63751480, rs267607772, rs267607773, rs587779024, rs63751653, rs587779027, rs267607767, rs587779029, rs63750706, rs63750385, rs267607774, rs267607778, rs267607780, rs587779034, rs63751711, rs267607784, rs587779035, rs63750823, rs63750822, rs267607787, rs63750303, rs63749839, rs63749827, rs267607789, rs267607790, rs267607791, rs267607786, rs267607771, rs267607795, rs267607794, rs267607788, rs267607799, rs267607801, rs587779045, rs63750034, rs587779047, rs63750216, rs63751707, rs63751598, rs267607803, rs267607777, rs63750144, rs267607805, rs63750547, rs63750489, rs63750993, rs587779054, rs63751259, rs63749926, rs63750796, rs587779058, rs63750745, rs63750582, rs180177084, rs587779866, rs200389141, rs587779950, rs587780104, rs587780183, rs587778536, rs587780683, rs587781554, rs267607712, rs587777627, rs587783057, rs730881734, rs41542214, rs730881273, rs786203456, rs786201990, rs786202767, rs748005072, rs786204317, rs786204318, rs797045117, rs63750549, rs863225383, rs863225384, rs863225373, rs863225376, rs863225377, rs863225378, rs863225379, rs863225380, rs863225381, rs63750059, rs267607823, rs864622457, rs869312767, rs869312753, rs876661059, rs876658915, rs876658923, rs876660860, rs876660822, rs876660458, rs876660214, rs876658657, rs876658247, rs876659226, rs876658821, rs876660589, rs876659068, rs876659681, rs876659608, rs878853794, rs878853778, rs878853780, rs878853785, rs886039423, rs886039424, rs1057517543, rs1057517541, rs756843954, rs1057517617, rs1057517558, rs1057519256, rs1060500689, rs764085979, rs1060500707, rs1060500699, rs1060500706, rs1060500703, rs1064795341, rs1064793607, rs1064794348, rs1064795441, rs1064794373, rs1064793172, rs1064794122, rs1064795515, rs1064794331, rs63750978, rs1114167435, rs1553641362, rs63751448, rs1553648029, rs1553648058, rs587778903, rs1553653237, rs1553664353, rs267607744, rs1553647995, rs1553648047, rs1553653084, rs1553663750, rs1553664436, rs1553488015, rs1553637293, rs63750310, rs63750443, rs63751596, rs1553646681, rs550890395, rs1064796057, rs1553642079, rs1553648023, rs587782087, rs746536721, rs1553653037, rs1248251121, rs1553646602, rs1434898623, rs1553665683, rs1553648068, rs1553645331, rs1553644123, rs1553658246, rs1553651299, rs1553648149, rs1553663159, rs1302248679, rs1553664119, rs1553658009, rs1553665977, rs1416171624, rs1553663834, rs1553664617, rs1553664702, rs1553647969, rs1553648040, rs1437454428, rs1553641273, rs63751101, rs1553646764, rs1553648225, rs1554082118, rs1553648201, rs1553149467, rs1553638868, rs1553665866, rs376736188, rs1553642707, rs1553645226, rs1553652883, rs63751435, rs1553653115, rs1553653195, rs63750300, rs1553662622, rs1553658104, rs1553648220, rs1559544064, rs63750584, rs267608083, rs1559551570, rs1559575107, rs1559553501, rs1565986506, rs1559524405, rs1559553492, rs1559554339, rs1559588540, rs1559558071, rs761329565, rs1559521039, rs1559574795, rs1567221417, rs1559578422, rs1481129490, rs1570714352, rs779783209, rs1575376830, rs1575469070, rs1575537843, rs1575620443, rs1575621506, rs587779022, rs1575414904, rs1575449093, rs1575469505, rs1575536254, rs1575537933, rs1575632112, rs1575639851, rs1575441094, rs1575449402, rs267607831, rs2081922847, rs2083403132, rs2085415927, rs2085469647, rs2043913790, rs147542208
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	27903959
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	29064472

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		29064472
Schizoaffective disorder	Schizoaffective Disorder		29064472