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LRRC8D (leucine rich repeat containing 8 VRAC subunit D)

Gene

55144

Leucine rich repeat containing 8 VRAC subunit D

LRRC8D

HsLRRC8D, LRRC5

1p22.2

Show/Hide all(174)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005467	kshv-miR-K12-3-5p	Immunoprecipitaion, Luciferase reporter assay, Microarray, qRT-PCR	20413099
MIRT023944	hsa-miR-1-3p	Proteomics	18668040
MIRT029937	hsa-miR-26b-5p	Microarray	19088304
MIRT040025	hsa-miR-615-3p	CLASH	23622248
MIRT039220	hsa-miR-454-3p	CLASH	23622248
MIRT149117	hsa-miR-181a-5p	HITS-CLIP	22473208
MIRT149118	hsa-miR-181b-5p	HITS-CLIP	22473208
MIRT149119	hsa-miR-181c-5p	HITS-CLIP	22473208
MIRT149123	hsa-miR-181d-5p	HITS-CLIP	22473208
MIRT149112	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT149121	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT149115	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT149116	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT149122	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT1120745	hsa-miR-25	CLIP-seq
MIRT1120746	hsa-miR-32	CLIP-seq
MIRT1120747	hsa-miR-363	CLIP-seq
MIRT1120748	hsa-miR-367	CLIP-seq
MIRT1120749	hsa-miR-3942-5p	CLIP-seq
MIRT1120750	hsa-miR-4422	CLIP-seq
MIRT1120751	hsa-miR-4424	CLIP-seq
MIRT1120752	hsa-miR-4703-5p	CLIP-seq
MIRT1120753	hsa-miR-767-5p	CLIP-seq
MIRT1120754	hsa-miR-92a	CLIP-seq
MIRT1120755	hsa-miR-92b	CLIP-seq
MIRT1120756	hsa-miR-1208	CLIP-seq
MIRT1120757	hsa-miR-181a	CLIP-seq
MIRT1120758	hsa-miR-181b	CLIP-seq
MIRT1120759	hsa-miR-181c	CLIP-seq
MIRT1120760	hsa-miR-181d	CLIP-seq
MIRT1120761	hsa-miR-199a-3p	CLIP-seq
MIRT1120762	hsa-miR-199b-3p	CLIP-seq
MIRT1120745	hsa-miR-25	CLIP-seq
MIRT1120763	hsa-miR-3074-5p	CLIP-seq
MIRT1120764	hsa-miR-30a	CLIP-seq
MIRT1120765	hsa-miR-30b	CLIP-seq
MIRT1120766	hsa-miR-30c	CLIP-seq
MIRT1120767	hsa-miR-30d	CLIP-seq
MIRT1120768	hsa-miR-30e	CLIP-seq
MIRT1120769	hsa-miR-3129-5p	CLIP-seq
MIRT1120746	hsa-miR-32	CLIP-seq
MIRT1120747	hsa-miR-363	CLIP-seq
MIRT1120748	hsa-miR-367	CLIP-seq
MIRT1120770	hsa-miR-3689a-5p	CLIP-seq
MIRT1120771	hsa-miR-3689b	CLIP-seq
MIRT1120772	hsa-miR-3689e	CLIP-seq
MIRT1120773	hsa-miR-3689f	CLIP-seq
MIRT1120749	hsa-miR-3942-5p	CLIP-seq
MIRT1120774	hsa-miR-4262	CLIP-seq
MIRT1120750	hsa-miR-4422	CLIP-seq
MIRT1120751	hsa-miR-4424	CLIP-seq
MIRT1120775	hsa-miR-448	CLIP-seq
MIRT1120776	hsa-miR-4524	CLIP-seq
MIRT1120777	hsa-miR-4690-5p	CLIP-seq
MIRT1120778	hsa-miR-4699-3p	CLIP-seq
MIRT1120752	hsa-miR-4703-5p	CLIP-seq
MIRT1120779	hsa-miR-4729	CLIP-seq
MIRT1120780	hsa-miR-4742-5p	CLIP-seq
MIRT1120781	hsa-miR-499-3p	CLIP-seq
MIRT1120782	hsa-miR-499a-3p	CLIP-seq
MIRT1120783	hsa-miR-543	CLIP-seq
MIRT1120784	hsa-miR-656	CLIP-seq
MIRT1120753	hsa-miR-767-5p	CLIP-seq
MIRT1120754	hsa-miR-92a	CLIP-seq
MIRT1120755	hsa-miR-92b	CLIP-seq
MIRT1120785	hsa-miR-936	CLIP-seq
MIRT1120745	hsa-miR-25	CLIP-seq
MIRT1120746	hsa-miR-32	CLIP-seq
MIRT1120747	hsa-miR-363	CLIP-seq
MIRT1120748	hsa-miR-367	CLIP-seq
MIRT1120749	hsa-miR-3942-5p	CLIP-seq
MIRT1120750	hsa-miR-4422	CLIP-seq
MIRT1120752	hsa-miR-4703-5p	CLIP-seq
MIRT1120753	hsa-miR-767-5p	CLIP-seq
MIRT1120754	hsa-miR-92a	CLIP-seq
MIRT1120755	hsa-miR-92b	CLIP-seq
MIRT2034204	hsa-miR-103a	CLIP-seq
MIRT2034205	hsa-miR-107	CLIP-seq
MIRT1120757	hsa-miR-181a	CLIP-seq
MIRT1120758	hsa-miR-181b	CLIP-seq
MIRT1120759	hsa-miR-181c	CLIP-seq
MIRT1120760	hsa-miR-181d	CLIP-seq
MIRT1120745	hsa-miR-25	CLIP-seq
MIRT1120746	hsa-miR-32	CLIP-seq
MIRT1120747	hsa-miR-363	CLIP-seq
MIRT1120748	hsa-miR-367	CLIP-seq
MIRT2034206	hsa-miR-3691-3p	CLIP-seq
MIRT1120749	hsa-miR-3942-5p	CLIP-seq
MIRT1120774	hsa-miR-4262	CLIP-seq
MIRT1120750	hsa-miR-4422	CLIP-seq
MIRT1120751	hsa-miR-4424	CLIP-seq
MIRT1120776	hsa-miR-4524	CLIP-seq
MIRT1120777	hsa-miR-4690-5p	CLIP-seq
MIRT1120778	hsa-miR-4699-3p	CLIP-seq
MIRT1120752	hsa-miR-4703-5p	CLIP-seq
MIRT1120779	hsa-miR-4729	CLIP-seq
MIRT1120780	hsa-miR-4742-5p	CLIP-seq
MIRT2034207	hsa-miR-520d-5p	CLIP-seq
MIRT2034208	hsa-miR-524-5p	CLIP-seq
MIRT1120753	hsa-miR-767-5p	CLIP-seq
MIRT1120754	hsa-miR-92a	CLIP-seq
MIRT1120755	hsa-miR-92b	CLIP-seq
MIRT2034204	hsa-miR-103a	CLIP-seq
MIRT2034205	hsa-miR-107	CLIP-seq
MIRT1120757	hsa-miR-181a	CLIP-seq
MIRT1120758	hsa-miR-181b	CLIP-seq
MIRT1120759	hsa-miR-181c	CLIP-seq
MIRT1120760	hsa-miR-181d	CLIP-seq
MIRT1120761	hsa-miR-199a-3p	CLIP-seq
MIRT1120762	hsa-miR-199b-3p	CLIP-seq
MIRT1120745	hsa-miR-25	CLIP-seq
MIRT1120769	hsa-miR-3129-5p	CLIP-seq
MIRT2264565	hsa-miR-3183	CLIP-seq
MIRT1120746	hsa-miR-32	CLIP-seq
MIRT2264566	hsa-miR-324-5p	CLIP-seq
MIRT2264567	hsa-miR-3614-3p	CLIP-seq
MIRT1120747	hsa-miR-363	CLIP-seq
MIRT1120748	hsa-miR-367	CLIP-seq
MIRT2034206	hsa-miR-3691-3p	CLIP-seq
MIRT1120749	hsa-miR-3942-5p	CLIP-seq
MIRT1120774	hsa-miR-4262	CLIP-seq
MIRT1120750	hsa-miR-4422	CLIP-seq
MIRT1120752	hsa-miR-4703-5p	CLIP-seq
MIRT2264568	hsa-miR-4723-3p	CLIP-seq
MIRT2034207	hsa-miR-520d-5p	CLIP-seq
MIRT2034208	hsa-miR-524-5p	CLIP-seq
MIRT1120783	hsa-miR-543	CLIP-seq
MIRT2264569	hsa-miR-586	CLIP-seq
MIRT2264570	hsa-miR-654-3p	CLIP-seq
MIRT1120753	hsa-miR-767-5p	CLIP-seq
MIRT1120754	hsa-miR-92a	CLIP-seq
MIRT1120755	hsa-miR-92b	CLIP-seq
MIRT1120785	hsa-miR-936	CLIP-seq
MIRT1120757	hsa-miR-181a	CLIP-seq
MIRT1120758	hsa-miR-181b	CLIP-seq
MIRT1120759	hsa-miR-181c	CLIP-seq
MIRT1120760	hsa-miR-181d	CLIP-seq
MIRT1120774	hsa-miR-4262	CLIP-seq
MIRT2034204	hsa-miR-103a	CLIP-seq
MIRT2034205	hsa-miR-107	CLIP-seq
MIRT1120757	hsa-miR-181a	CLIP-seq
MIRT1120758	hsa-miR-181b	CLIP-seq
MIRT1120759	hsa-miR-181c	CLIP-seq
MIRT1120760	hsa-miR-181d	CLIP-seq
MIRT1120761	hsa-miR-199a-3p	CLIP-seq
MIRT1120762	hsa-miR-199b-3p	CLIP-seq
MIRT1120764	hsa-miR-30a	CLIP-seq
MIRT1120765	hsa-miR-30b	CLIP-seq
MIRT1120766	hsa-miR-30c	CLIP-seq
MIRT1120767	hsa-miR-30d	CLIP-seq
MIRT1120768	hsa-miR-30e	CLIP-seq
MIRT1120769	hsa-miR-3129-5p	CLIP-seq
MIRT2034206	hsa-miR-3691-3p	CLIP-seq
MIRT1120774	hsa-miR-4262	CLIP-seq
MIRT1120780	hsa-miR-4742-5p	CLIP-seq
MIRT2034207	hsa-miR-520d-5p	CLIP-seq
MIRT2034208	hsa-miR-524-5p	CLIP-seq
MIRT1120783	hsa-miR-543	CLIP-seq
MIRT1120785	hsa-miR-936	CLIP-seq
MIRT2563518	hsa-miR-1283	CLIP-seq
MIRT1120757	hsa-miR-181a	CLIP-seq
MIRT1120758	hsa-miR-181b	CLIP-seq
MIRT1120759	hsa-miR-181c	CLIP-seq
MIRT1120760	hsa-miR-181d	CLIP-seq
MIRT2264565	hsa-miR-3183	CLIP-seq
MIRT2264566	hsa-miR-324-5p	CLIP-seq
MIRT2264567	hsa-miR-3614-3p	CLIP-seq
MIRT1120774	hsa-miR-4262	CLIP-seq
MIRT2264568	hsa-miR-4723-3p	CLIP-seq
MIRT1120783	hsa-miR-543	CLIP-seq
MIRT2563519	hsa-miR-548aa	CLIP-seq
MIRT2264569	hsa-miR-586	CLIP-seq
MIRT2264570	hsa-miR-654-3p	CLIP-seq
MIRT2563520	hsa-miR-935	CLIP-seq

Show/Hide all(16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005225	Function	Volume-sensitive anion channel activity	IMP	26824658
GO:0005225	Function	Volume-sensitive anion channel activity	IMP	28193731
GO:0005515	Function	Protein binding	IPI	24790029
GO:0005737	Component	Cytoplasm	IDA	24790029
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005886	Component	Plasma membrane	IDA	24790029
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IMP	26824658, 28193731
GO:0015698	Process	Inorganic anion transport	IEA
GO:0015734	Process	Taurine transport	IMP	28193731
GO:0015810	Process	Aspartate transmembrane transport	IMP	28193731
GO:0016020	Component	Membrane	HDA	19946888
GO:0034702	Component	Ion channel complex	IMP	28193731
GO:0055085	Process	Transmembrane transport	TAS
GO:0071470	Process	Cellular response to osmotic stress	IMP	28193731
GO:0098656	Process	Anion transmembrane transport	IMP	24790029

MIM	HGNC	e!Ensembl
612890	16992	ENSG00000171492

Protein

UniProt ID

Q7L1W4

Protein name

Volume-regulated anion channel subunit LRRC8D (Leucine-rich repeat-containing protein 5) (Leucine-rich repeat-containing protein 8D) (HsLRRC8D)

Protein function

Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:2

PDB

6M04

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12534	Pannexin_like	1 → 384	Pannexin-like TM region of LRRC8	Family
PF13855	LRR_8	635 → 695	Leucine rich repeat	Repeat
PF13855	LRR_8	683 → 741	Leucine rich repeat	Repeat

Sequence

MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS
PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF
ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS
NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST
SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED
SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY
MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL
HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS
GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR
CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT
KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL
QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES
LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL
NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL
EVKEALNQDINIPFANGI

Sequence length

858

Interactions

View interactions

	Reactome
			Miscellaneous transport and binding events

Associated diseases

Show/Hide Causal Diseases (2)

Causal
Disease name	Disease term	dbSNP ID	References
Inflammatory bowel disease	Inflammatory Bowel Diseases	rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs139868987, rs750447828, rs368138379, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468	29923122
Lung carcinoma	Squamous cell carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193	28604730

Show/Hide Unknown Diseases (3)

Unknown
Disease name	Disease term	dbSNP ID	References
Digestive system disorders	Digestive System Disorders		29923122
Gastrointestinal diseases	Gastrointestinal Diseases		29923122
Intestinal diseases	Intestinal Diseases		29923122

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