CRTAC1 (cartilage acidic protein 1)

Gene

• Entrez ID: 55118
• Gene name: Cartilage acidic protein 1
• Gene symbol: CRTAC1
• Synonyms: ASPIC, ASPIC1, CEP-68, CEP68, LOTUS
• Chromosome: 10
• Chromosome location: 10q24.2
• Summary: This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in cultur

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT910550	hsa-miR-1182	CLIP-seq
MIRT910551	hsa-miR-1193	CLIP-seq
MIRT910552	hsa-miR-1197	CLIP-seq
MIRT910553	hsa-miR-2110	CLIP-seq
MIRT910554	hsa-miR-3117-5p	CLIP-seq
MIRT910555	hsa-miR-3150a-3p	CLIP-seq
MIRT910556	hsa-miR-3175	CLIP-seq
MIRT910557	hsa-miR-3545-3p	CLIP-seq
MIRT910558	hsa-miR-3664-3p	CLIP-seq
MIRT910559	hsa-miR-4436a	CLIP-seq
MIRT910560	hsa-miR-4680-5p	CLIP-seq
MIRT910561	hsa-miR-4728-5p	CLIP-seq
MIRT910562	hsa-miR-490-5p	CLIP-seq
MIRT910563	hsa-miR-510	CLIP-seq
MIRT910564	hsa-miR-939	CLIP-seq
MIRT1969926	hsa-miR-2682	CLIP-seq
MIRT1969927	hsa-miR-449c	CLIP-seq
MIRT1969928	hsa-miR-645	CLIP-seq
MIRT1969929	hsa-miR-940	CLIP-seq
MIRT2447688	hsa-miR-1260	CLIP-seq
MIRT2447689	hsa-miR-1260b	CLIP-seq
MIRT2447690	hsa-miR-188-3p	CLIP-seq
MIRT2447691	hsa-miR-3156-3p	CLIP-seq
MIRT2447692	hsa-miR-4301	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 31515488, 32296183
GO:0070062	Component	Extracellular exosome	HDA	23533145

Other IDs

• MIM: 606276
• HGNC: 14882
• e!Ensembl: ENSG00000095713

Protein

• UniProt ID: Q9NQ79
• Protein name: Cartilage acidic protein 1 (68 kDa chondrocyte-expressed protein) (CEP-68) (ASPIC)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13517	VCBS	62 → 132	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	Repeat
  PF13517	VCBS	253 → 310	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	Repeat
  PF13517	VCBS	299 → 363	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	Repeat
  PF07593	UnbV_ASPIC	458 → 521	ASPIC and UnbV	Family
  PF07645	EGF_CA	559 → 605	Calcium-binding EGF domain	Domain

• Sequence:

  MAPSADPGMSRMLPFLLLLWFLPITEGSQRAEPMFTAVTNSVLPPDYDSNPTQLNYGVAV
  TDVDHDGDFEIVVAGYNGPNLVLKYDRAQKRLVNIAVDERSSPYYALRDRQGNAIGVTAC
  DIDGDGREEIYFLNTNNAFSGVATYTDKLFKFRNNRWEDILSDEVNVARGVASLFAGRSV
  ACVDRKGSGRYSIYIANYAYGNVGPDALIEMDPEASDLSRGILALRDVAAEAGVSKYTGG
  RGVSVGPILSSSASDIFCDNENGPNFLFHNRGDGTFVDAAASAGVDDPHQHGRGVALADF
  NRDGKVDIVYGNWNGPHRLYLQMSTHGKVRFRDIASPKFSMPSPVRTVITADFDNDQELE
  IFFNNIAYRSSSANRLFRVIRREHGDPLIEELNPGDALEPEGRGTGGVVTDFDGDGMLDL
  ILSHGESMAQPLSVFRGNQGFNNNWLRVVPRTRFGAFARGAKVVLYTKKSGAHLRIIDGG
  SGYLCEMEPVAHFGLGKDEASSVEVTWPDGKMVSRNVASGEMNSVLEILYPRDEDTLQDP
  APLECGQGFSQQENGHCMDTNECIQFPFVCPRDKPVCVNTYGSYRCRTNKKCSRGYEPNE
  DGTACVGTLGQSPGPRPTTPTAAAATAAAAAAAGAATAAPVLVDGDLNLGSVVKESCEPS
  C

• Sequence length: 661

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Lung carcinoma	Carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193	28604730