KIF26B (kinesin family member 26B)

Gene

• Entrez ID: 55083
• Gene name: Kinesin family member 26B
• Gene symbol: KIF26B
• Synonyms: -
• Chromosome: 1
• Chromosome location: 1q44
• Summary: The protein encoded by this gene is an intracellular motor protein thought to transport organelles along microtubules. The encoded protein is required for kidney development. Elevated levels of this protein have been found in some breast and colorectal ca

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT667705	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT656874	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT656873	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT656872	hsa-miR-3944-3p	HITS-CLIP	23824327
MIRT667704	hsa-miR-4279	HITS-CLIP	23824327
MIRT656871	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT656874	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT656873	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT656872	hsa-miR-3944-3p	HITS-CLIP	23824327
MIRT656871	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT536468	hsa-miR-634	PAR-CLIP	22012620
MIRT536467	hsa-miR-4690-3p	PAR-CLIP	22012620
MIRT536466	hsa-miR-5685	PAR-CLIP	22012620
MIRT536464	hsa-miR-4530	PAR-CLIP	22012620
MIRT732249	hsa-miR-20a-5p	Luciferase reporter assay, qRT-PCR, Western blot	27499703
MIRT732249	hsa-miR-20a-5p	Luciferase reporter assay, qRT-PCR, Western blot	27499703
MIRT667705	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT656874	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT656873	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT656872	hsa-miR-3944-3p	HITS-CLIP	23824327
MIRT667704	hsa-miR-4279	HITS-CLIP	23824327
MIRT656871	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT656874	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT656873	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT656872	hsa-miR-3944-3p	HITS-CLIP	23824327
MIRT656871	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT536468	hsa-miR-634	PAR-CLIP	22012620
MIRT536467	hsa-miR-4690-3p	PAR-CLIP	22012620
MIRT536466	hsa-miR-5685	PAR-CLIP	22012620
MIRT536464	hsa-miR-4530	PAR-CLIP	22012620
MIRT1094412	hsa-miR-1253	CLIP-seq
MIRT1094413	hsa-miR-29a	CLIP-seq
MIRT1094414	hsa-miR-29b	CLIP-seq
MIRT1094415	hsa-miR-29c	CLIP-seq
MIRT1094416	hsa-miR-3158-3p	CLIP-seq
MIRT1094417	hsa-miR-451b	CLIP-seq
MIRT1094418	hsa-miR-4520a-3p	CLIP-seq
MIRT1094419	hsa-miR-4520b-3p	CLIP-seq
MIRT2025295	hsa-miR-3064-3p	CLIP-seq
MIRT2025296	hsa-miR-4715-3p	CLIP-seq
MIRT2025297	hsa-miR-499a-5p	CLIP-seq
MIRT2256568	hsa-miR-124	CLIP-seq
MIRT2256569	hsa-miR-2116	CLIP-seq
MIRT1094416	hsa-miR-3158-3p	CLIP-seq
MIRT2256570	hsa-miR-342-3p	CLIP-seq
MIRT2256571	hsa-miR-3924	CLIP-seq
MIRT2256572	hsa-miR-4274	CLIP-seq
MIRT2256573	hsa-miR-4277	CLIP-seq
MIRT2256574	hsa-miR-450b-5p	CLIP-seq
MIRT2256575	hsa-miR-4519	CLIP-seq
MIRT2256576	hsa-miR-4708-3p	CLIP-seq
MIRT2256577	hsa-miR-506	CLIP-seq
MIRT2256578	hsa-miR-513a-5p	CLIP-seq
MIRT2256579	hsa-miR-621	CLIP-seq
MIRT2256580	hsa-miR-622	CLIP-seq
MIRT1094413	hsa-miR-29a	CLIP-seq
MIRT1094414	hsa-miR-29b	CLIP-seq
MIRT1094415	hsa-miR-29c	CLIP-seq
MIRT2025295	hsa-miR-3064-3p	CLIP-seq
MIRT2025296	hsa-miR-4715-3p	CLIP-seq
MIRT2430433	hsa-miR-4731-3p	CLIP-seq
MIRT2430434	hsa-miR-4801	CLIP-seq
MIRT2025297	hsa-miR-499a-5p	CLIP-seq
MIRT2430435	hsa-miR-548l	CLIP-seq
MIRT2430436	hsa-miR-767-5p	CLIP-seq
MIRT1094413	hsa-miR-29a	CLIP-seq
MIRT1094414	hsa-miR-29b	CLIP-seq
MIRT1094415	hsa-miR-29c	CLIP-seq
MIRT2430433	hsa-miR-4731-3p	CLIP-seq
MIRT2430434	hsa-miR-4801	CLIP-seq
MIRT2430435	hsa-miR-548l	CLIP-seq
MIRT2430436	hsa-miR-767-5p	CLIP-seq
MIRT1094413	hsa-miR-29a	CLIP-seq
MIRT1094414	hsa-miR-29b	CLIP-seq
MIRT1094415	hsa-miR-29c	CLIP-seq
MIRT2430433	hsa-miR-4731-3p	CLIP-seq
MIRT2430434	hsa-miR-4801	CLIP-seq
MIRT2430435	hsa-miR-548l	CLIP-seq
MIRT2430436	hsa-miR-767-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003777	Function	Microtubule motor activity	IBA	21873635
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005871	Component	Kinesin complex	IBA	21873635
GO:0005874	Component	Microtubule	IBA	21873635
GO:0007018	Process	Microtubule-based movement	IBA	21873635
GO:0008017	Function	Microtubule binding	IBA	21873635
GO:0016887	Function	ATPase activity	IBA	21873635
GO:0022409	Process	Positive regulation of cell-cell adhesion	IEA
GO:0030010	Process	Establishment of cell polarity	IEA
GO:0072092	Process	Ureteric bud invasion	IEA

Other IDs

• MIM: 614026
• HGNC: 25484
• e!Ensembl: ENSG00000162849

Protein

• UniProt ID: Q2KJY2
• Protein name: Kinesin-like protein KIF26B
• Protein function: Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral inte
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00225	Kinesin	472 → 801	Kinesin motor domain	Domain

• Sequence:

  MNSVAGNKERLAVSTRGKKYGVNEVCSPTKPAAPFSPESWYRKAYEESRAGSRPTPEGAG
  SALGSSGTPSPGSGTSSPSSFTGSPGPASPGIGTSSPGSLGGSPGFGTGSPGSGSGGGSS
  PGSDRGVWCENCNARLVELKRQALRLLLPGPFPGKDPAFSAVIHDKLQVPNTIRKAWNDR
  DNRCDICATHLNQLKQEAIQMVLTLEQAAGSEHYDASPCSPPPLSNIPTLVGSRHVGGLQ
  QPRDWAFVPAPCATSNYTGFANKHGSKPSSLGVSNGAEKKSGSPTHQAKVSLQMATSPSN
  GNILNSVAIQAHQYLDGTWSLSRTNGVTLYPYQISQLMTESSREGLTEAVLNRYNADKPS
  ACSVPASQGSCVASETSTGTSVAASFFARAAQKLNLSSKKKKHRPSTSSAAEPPLFATSF
  SGILQTSPPPAPPCLLRAVNKVKDTPGLGKVKVMLRICSTLARDTSESSSFLKVDPRKKQ
  ITLYDPLTCGGQNAFQKRGNQVPPKMFAFDAVFPQDASQAEVCAGTVAEVIQSVVNGADG
  CVFCFGHAKLGKSYTMIGKDDSMQNLGIIPCAISWLFKLINERKEKTGARFSVRVSAVEV
  WGKEENLRDLLSEVATGSLQDGQSPGVYLCEDPICGTQLQNQSELRAPTAEKAAFFLDAA
  IASRRSHQQDCDEDDHRNSHVFFTLHIYQYRMEKSGKGGMSGGRSRLHLIDLGSCVKALS
  KNREGGSGLCLSLSALGNVILALVNGSKHIPYKESKLAMLLRESLGNMNCRTTMIAHISA
  AVGSYAETLSTIQIASRVLRMKKKKTKYTSSSSGGESSCEEGRMRRPTQLRPFHTRATVD
  PDFPIAHLSSDPDYSSSSEQSCDTVIYIGPNGTALSDKELTDNEGPPDFVPIVPALQKTR
  GDSRPAEAGEAAAGKSERDCLKCNTFAELQERLDCIDGSEEPSSFPFEELPAQFGPEQAS
  RGPRLSQAAGASPLSESDKEDNGSEGQLTNREGPELPASKMQRSHSPVPAAAPAHSPSPA
  SPRSVPGSSSQHSASPLVQSPSLQSSRESLNSCGFVEGKPRPMGSPRLGIASLSKTSEYK
  PPSSPSQRCKVYTQKGVLPSPAPLPPSSKDSGVASRESLLQPEVRTPPVGMSPQVLKKSM
  SAGSEGFPETPVDDEQQAATPSESKKEILSTTMVTVQQPLELNGEDELVFTLVEELTISG
  VLDSGRPTSIISFNSDCSARALASGSRPVSIISSISEDLECYSSTAPVSEVSITQFLPLP
  KMSLDEKAQDAGSRRSSISSWLSEMSAGSEGEQSCHSFIAQTCFGHGEAMAEPVASEFVS
  SLQNTAVVCREKPKASPDNLLILSEMGDDSFNKAAPIKGCKISTVSKAMVTISNTANLSS
  CEGYIPMKTNITVYPCIAMSPRNIQEPEAPTATPKAGPTLAQSRESKENSAKKEMKFEDP
  WLKREEEVKKETAHPNEEGMMRCETATGPSNAETRAEQEQDGKPSPGDRLSSSSGEVSAS
  PVTDNFRRVVDGCEMALPGLATQSPVHPNKSVKSSSLPRAFQKASRQEEPDSLSYYCAAE
  TNGVGAASGTPPSKATLEGKVASPKHCVLARPKGTPPLPPVRKSSLDQKNRASPQHSASG
  SGTSSPLNQPAAFPAGLPDEPSGKTKDASSSSKLFSAKLEQLASRSNSLGRATVSHYECL
  SLERAESLSSVSSRLHAGKDGTMPRAGRSLGRSAGTSPPSSGASPKAGQSKISAVSRLLL
  ASPRARGPSASTTKTLSFSTKSLPQAVGQGSSSPPGGKHTPWSTQSLSRNRSSGLASKLP
  LRAVSGRISELLQGGAGARGLQLRAGPEAEARGGALAEDEPAAAHLLPSPYSKITPPRRP
  HRCSSGHGSDNSSVLSGELPPAMGKTALFYHSGGSSGYESVMRDSEATGSASSAQDSTSE
  NSSSVGGRCRSLKTPKKRSNPGSQRRRLIPALSLDTSSPVRKPPNSTGVRWVDGPLRSSP
  RGLGEPFEIKVYEIDDVERLQRRRGGASKEAMCFNAKLKILEHRQQRIAEVRAKYEWLMK
  ELEATKQYLMLDPNKWLSEFDLEQVWELDSLEYLEALECVTERLESRVNFCKAHLMMITC
  FDITSRRR

• Sequence length: 2108

Pathways

KEGG:

Motor proteins

Reactome:

COPI-dependent Golgi-to-ER retrograde traffic
Kinesins

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Arthritis	Degenerative polyarthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	30664745
Glioma	Glioma	rs121909219, rs121909224, rs587776667, rs587776671, rs121909239, rs121909241, rs28933368, rs121913500, rs55863639, rs786201995, rs786202517, rs786201044, rs398123317, rs1057518425, rs121913499, rs1060500122, rs781647403, rs1060500126, rs1554897889, rs1114167629, rs1114167656, rs587782603, rs1554893824, rs1554900615, rs1564568660, rs786204900, rs762518389, rs1339631701	19578366
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	30251476

Unknown
Disease name	Disease term	dbSNP ID	References
Central nervous system neoplasms	Central Nervous System Neoplasms		19578366
Coloboma of optic disc	Coloboma of optic disc		26571382
Diverticular diseases	Diverticular Diseases		30177863
Ischemic myocardial dysfunction	Ischemic cardiomyopathy		30251476
Ischemic stroke	Ischemic stroke	rs6025, rs1799963, rs1799983	26718567