ENOX1 (ecto-NOX disulfide-thiol exchanger 1)

Gene

• Entrez ID: 55068
• Gene name: Ecto-NOX disulfide-thiol exchanger 1
• Gene symbol: ENOX1
• Synonyms: CNOX, PIG38, bA64J21.1, cCNOX
• Chromosome: 13
• Chromosome location: 13q14.11
• Summary: The protein encoded by this gene is involved in plasma membrane electron transport pathways. The encoded protein has both a hydroquinone (NADH) oxidase activity and a protein disulfide-thiol interchange activity. The two activities cycle with a periodicit

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT030280	hsa-miR-26b-5p	Microarray	19088304
MIRT450466	hsa-miR-5692a	PAR-CLIP	22100165
MIRT450465	hsa-miR-5692b	PAR-CLIP	22100165
MIRT450464	hsa-miR-5692c	PAR-CLIP	22100165
MIRT450463	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT450462	hsa-miR-3161	PAR-CLIP	22100165
MIRT450461	hsa-miR-599	PAR-CLIP	22100165
MIRT450466	hsa-miR-5692a	PAR-CLIP	22100165
MIRT450465	hsa-miR-5692b	PAR-CLIP	22100165
MIRT450464	hsa-miR-5692c	PAR-CLIP	22100165
MIRT450463	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT450462	hsa-miR-3161	PAR-CLIP	22100165
MIRT450461	hsa-miR-599	PAR-CLIP	22100165
MIRT963827	hsa-miR-3658	CLIP-seq
MIRT963828	hsa-miR-4528	CLIP-seq
MIRT963829	hsa-miR-4659a-5p	CLIP-seq
MIRT963830	hsa-miR-4659b-5p	CLIP-seq
MIRT963831	hsa-miR-4776-3p	CLIP-seq
MIRT963832	hsa-miR-221	CLIP-seq
MIRT963833	hsa-miR-222	CLIP-seq
MIRT963834	hsa-miR-4317	CLIP-seq
MIRT963835	hsa-miR-548v	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 25416956, 32296183
GO:0005615	Component	Extracellular space	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0007624	Process	Ultradian rhythm	IEA
GO:0009897	Component	External side of plasma membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA

Other IDs

• MIM: 610914
• HGNC: 25474
• e!Ensembl: ENSG00000120658

Protein

• UniProt ID: Q8TC92
• Protein name: Ecto-NOX disulfide-thiol exchanger 1 (Candidate growth-related and time keeping constitutive hydroquinone [NADH] oxidase) (cCNOX) (Cell proliferation-inducing gene 38 protein) (Constitutive Ecto-NOX) (cNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-
• Protein function: Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activi
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00076	RRM_1	144 → 204	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

• Sequence:

  MVDAGGVENITQLPQELPQMMAAAADGLGSIAIDTTQLNMSVTDPTAWATAMNNLGMVPV
  GLPGQQLVSDSICVPGFDPSLNMMTGITPINPMIPGLGLVPPPPPTEVAVVKEIIHCKSC
  TLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIQEVFEQCGDITAIRKSKKNFCH
  IRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREER
  HRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSA
  NQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQK
  AWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDES
  ALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGM
  QQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN
  VLTVALVNQDRENNIEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSK
  ISANEIEMLLMRLPRMFKQEFTGVGATLEKRWKLCAFEGIKTT

• Sequence length: 643

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	22491018

Unknown
Disease name	Disease term	dbSNP ID	References
Achoo syndrome	Autosomal dominant compelling helio ophthalmic outburst syndrome		27182965
Diabetic nephropathy	Diabetic Nephropathy		21150874
Mental depression	Major Depressive Disorder	rs587778876, rs587778877	29700475, 23377640