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ATG16L1 (autophagy related 16 like 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55054
Gene nameGene Name - the full gene name approved by the HGNC.
Autophagy related 16 like 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
ATG16L1
SynonymsGene synonyms aliases
APG16L, ATG16A, ATG16L, IBD10, WDR30
ChromosomeChromosome number
2
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q37.1
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to infla
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT049399 hsa-miR-92a-3p CLASH 23622248
MIRT048211 hsa-miR-196a-5p CLASH 23622248
MIRT038607 hsa-miR-188-3p CLASH 23622248
MIRT053623 hsa-miR-106b-5p HeLa 24036151
MIRT053623 hsa-miR-106b-5p HeLa 24036151
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000045 Process Autophagosome assembly IBA 21873635
GO:0000045 Process Autophagosome assembly NAS 15620219
GO:0000421 Component Autophagosome membrane IBA 21873635
GO:0005515 Function Protein binding IPI 20562859, 23202584, 23262492, 23376921, 23392225, 26347139, 28561066, 32296183
GO:0005776 Component Autophagosome ISS 15620219
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q676U5
Protein name Autophagy-related protein 16-1 (APG16-like 1)
Protein function Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP) (PubMed:23376921, PubMed:23392225
PDB 4GDK , 4GDL , 4NAW , 4TQ0 , 5D7G , 5NPV , 5NPW , 5NUV , 5ZYX , 7F69 , 7W36 , 7XFR , 8ZQG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08614 ATG16
16 206
Autophagy protein 16 (ATG16)
Coiled-coil
PF00400 WD40
313 350
WD domain, G-beta repeat
Repeat
PF00400 WD40
356 394
WD domain, G-beta repeat
Repeat
PF00400 WD40
398 436
WD domain, G-beta repeat
Repeat
PF00400 WD40
523 562
WD domain, G-beta repeat
Repeat
PF00400 WD40
566 604
WD domain, G-beta repeat
Repeat
Sequence
Sequence length 607
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Autophagy - other
Autophagy - animal
NOD-like receptor signaling pathway
Shigellosis
  Macroautophagy
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Arthritis Juvenile arthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 26301688
Asthma Asthma rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283 21150878
Autoimmune diseases Autoimmune Diseases, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2 rs41285370, rs869025224 26301688
Common variable immunodeficiency Common Variable Immunodeficiency rs72553883, rs121908379, rs104894650, rs587776775, rs398122863, rs398122864, rs397514332, rs397514331, rs727502786, rs727502787, rs72553882, rs869320688, rs869320689, rs869320754, rs773694113, rs1553319504, rs201017642, rs1555550717, rs1558192723, rs1030733127, rs749636258, rs185689791, rs1559035937, rs1565214594, rs1560679469, rs1560711146, rs1569376229, rs1578790573, rs939459600, rs1572952530, rs1572950925, rs772481080, rs369363360, rs72553885, rs72553879, rs1265262160, rs1303637368, rs757598952, rs1016142312, rs1578771120, rs1578771197, rs1578793298, rs1578793312, rs1578809101, rs1578811073, rs1590715754, rs144718007, rs759649059, rs1723945421, rs2061279365 26301688
Unknown
Disease name Disease term dbSNP ID References
Ankylosing spondylitis Ankylosing spondylitis 26974007, 26301688
Autoimmune thyroiditis Autoimmune thyroiditis 26301688
Celiac disease Celiac Disease rs2305764, rs35218876 26301688
Cholangitis Cholangitis, Sclerosing 26974007

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