HEATR3 (HEAT repeat containing 3)

Gene

• Entrez ID: 55027
• Gene name: HEAT repeat containing 3
• Gene symbol: HEATR3
• Synonyms: DBA21, SYO1, hsSyo1
• Chromosome: 16
• Chromosome location: 16q12.1
• Summary: The protein encoded by this gene plays a role in ribosomal protein transport and in the assembly of the 5S ribonucleoprotein particle (5S RNP). The encoded protein also may be involved in NOD2-mediated NF-kappaB signaling. [provided by RefSeq, Jul 2016]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT051302	hsa-miR-16-5p	CLASH	23622248
MIRT041524	hsa-miR-193b-3p	CLASH	23622248
MIRT459848	hsa-miR-3614-5p	PAR-CLIP	23592263
MIRT459847	hsa-miR-6500-3p	PAR-CLIP	23592263
MIRT459846	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT459845	hsa-miR-4786-5p	PAR-CLIP	23592263
MIRT459844	hsa-miR-769-5p	PAR-CLIP	23592263
MIRT459843	hsa-miR-3672	PAR-CLIP	23592263
MIRT459842	hsa-miR-6864-3p	PAR-CLIP	23592263
MIRT459848	hsa-miR-3614-5p	PAR-CLIP	23592263
MIRT459847	hsa-miR-6500-3p	PAR-CLIP	23592263
MIRT459846	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT459845	hsa-miR-4786-5p	PAR-CLIP	23592263
MIRT459844	hsa-miR-769-5p	PAR-CLIP	23592263
MIRT459843	hsa-miR-3672	PAR-CLIP	23592263
MIRT459842	hsa-miR-6864-3p	PAR-CLIP	23592263
MIRT1043179	hsa-miR-1227	CLIP-seq
MIRT1043180	hsa-miR-1245	CLIP-seq
MIRT1043181	hsa-miR-1275	CLIP-seq
MIRT1043182	hsa-miR-150	CLIP-seq
MIRT1043183	hsa-miR-181a	CLIP-seq
MIRT1043184	hsa-miR-181b	CLIP-seq
MIRT1043185	hsa-miR-181c	CLIP-seq
MIRT1043186	hsa-miR-181d	CLIP-seq
MIRT1043187	hsa-miR-18a	CLIP-seq
MIRT1043188	hsa-miR-18b	CLIP-seq
MIRT1043189	hsa-miR-4260	CLIP-seq
MIRT1043190	hsa-miR-4262	CLIP-seq
MIRT1043191	hsa-miR-4271	CLIP-seq
MIRT1043192	hsa-miR-4511	CLIP-seq
MIRT1043193	hsa-miR-4525	CLIP-seq
MIRT1043194	hsa-miR-455-5p	CLIP-seq
MIRT1043195	hsa-miR-4665-5p	CLIP-seq
MIRT1043196	hsa-miR-4713-5p	CLIP-seq
MIRT1043197	hsa-miR-4715-3p	CLIP-seq
MIRT1043198	hsa-miR-4723-5p	CLIP-seq
MIRT1043199	hsa-miR-4725-3p	CLIP-seq
MIRT1043200	hsa-miR-4735-3p	CLIP-seq
MIRT1043201	hsa-miR-4761-5p	CLIP-seq
MIRT1043202	hsa-miR-491-3p	CLIP-seq
MIRT1043203	hsa-miR-513a-5p	CLIP-seq
MIRT1043204	hsa-miR-532-3p	CLIP-seq
MIRT1043205	hsa-miR-582-3p	CLIP-seq
MIRT1043206	hsa-miR-586	CLIP-seq
MIRT1043207	hsa-miR-625	CLIP-seq
MIRT1043208	hsa-miR-640	CLIP-seq
MIRT1043182	hsa-miR-150	CLIP-seq
MIRT1043187	hsa-miR-18a	CLIP-seq
MIRT1043188	hsa-miR-18b	CLIP-seq
MIRT1549473	hsa-miR-197	CLIP-seq
MIRT1043196	hsa-miR-4713-5p	CLIP-seq
MIRT1043200	hsa-miR-4735-3p	CLIP-seq
MIRT1043201	hsa-miR-4761-5p	CLIP-seq
MIRT1043202	hsa-miR-491-3p	CLIP-seq
MIRT1549474	hsa-miR-5096	CLIP-seq
MIRT1043204	hsa-miR-532-3p	CLIP-seq
MIRT1043206	hsa-miR-586	CLIP-seq
MIRT2009224	hsa-miR-1182	CLIP-seq
MIRT2009225	hsa-miR-122	CLIP-seq
MIRT1043182	hsa-miR-150	CLIP-seq
MIRT1043187	hsa-miR-18a	CLIP-seq
MIRT1043188	hsa-miR-18b	CLIP-seq
MIRT2009226	hsa-miR-3135b	CLIP-seq
MIRT2009227	hsa-miR-3652	CLIP-seq
MIRT2009228	hsa-miR-4287	CLIP-seq
MIRT2009229	hsa-miR-4430	CLIP-seq
MIRT2009230	hsa-miR-4469	CLIP-seq
MIRT2009231	hsa-miR-450b-3p	CLIP-seq
MIRT2009232	hsa-miR-4685-3p	CLIP-seq
MIRT2009233	hsa-miR-4695-3p	CLIP-seq
MIRT2009234	hsa-miR-4713-3p	CLIP-seq
MIRT1043196	hsa-miR-4713-5p	CLIP-seq
MIRT2009235	hsa-miR-4731-5p	CLIP-seq
MIRT1043200	hsa-miR-4735-3p	CLIP-seq
MIRT2009236	hsa-miR-4740-3p	CLIP-seq
MIRT1043201	hsa-miR-4761-5p	CLIP-seq
MIRT1043203	hsa-miR-513a-5p	CLIP-seq
MIRT1043204	hsa-miR-532-3p	CLIP-seq
MIRT2009237	hsa-miR-638	CLIP-seq
MIRT2009238	hsa-miR-642a	CLIP-seq
MIRT2009239	hsa-miR-769-3p	CLIP-seq
MIRT2009225	hsa-miR-122	CLIP-seq
MIRT2241611	hsa-miR-1254	CLIP-seq
MIRT2241612	hsa-miR-3116	CLIP-seq
MIRT2009226	hsa-miR-3135b	CLIP-seq
MIRT2241613	hsa-miR-3186-5p	CLIP-seq
MIRT2009227	hsa-miR-3652	CLIP-seq
MIRT2009229	hsa-miR-4430	CLIP-seq
MIRT2241614	hsa-miR-4435	CLIP-seq
MIRT2009233	hsa-miR-4695-3p	CLIP-seq
MIRT2241615	hsa-miR-4772-3p	CLIP-seq
MIRT2241616	hsa-miR-661	CLIP-seq
MIRT2009224	hsa-miR-1182	CLIP-seq
MIRT2009227	hsa-miR-3652	CLIP-seq
MIRT2009228	hsa-miR-4287	CLIP-seq
MIRT2009229	hsa-miR-4430	CLIP-seq
MIRT2009230	hsa-miR-4469	CLIP-seq
MIRT2009232	hsa-miR-4685-3p	CLIP-seq
MIRT2009238	hsa-miR-642a	CLIP-seq
MIRT2009225	hsa-miR-122	CLIP-seq
MIRT1043179	hsa-miR-1227	CLIP-seq
MIRT2009226	hsa-miR-3135b	CLIP-seq
MIRT2009227	hsa-miR-3652	CLIP-seq
MIRT2009229	hsa-miR-4430	CLIP-seq
MIRT2009231	hsa-miR-450b-3p	CLIP-seq
MIRT1043194	hsa-miR-455-5p	CLIP-seq
MIRT2009233	hsa-miR-4695-3p	CLIP-seq
MIRT2009234	hsa-miR-4713-3p	CLIP-seq
MIRT1043197	hsa-miR-4715-3p	CLIP-seq
MIRT1043203	hsa-miR-513a-5p	CLIP-seq
MIRT2009237	hsa-miR-638	CLIP-seq
MIRT2009239	hsa-miR-769-3p	CLIP-seq
MIRT2682244	hsa-miR-4279	CLIP-seq
MIRT2009230	hsa-miR-4469	CLIP-seq
MIRT2009236	hsa-miR-4740-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0006606	Process	Protein import into nucleus	IBA	21873635
GO:0042273	Process	Ribosomal large subunit biogenesis	IBA	21873635
GO:0051082	Function	Unfolded protein binding	IBA	21873635

Other IDs

• MIM: 614951
• HGNC: 26087
• e!Ensembl: ENSG00000155393

Protein

• UniProt ID: Q7Z4Q2
• Protein name: HEAT repeat-containing protein 3 (Symportin Syo1) (hsSyo1)
• Protein function: Plays a role in ribosome biogenesis and in nuclear import of the 60S ribosomal protein L5/large ribosomal subunit protein uL18 (RPL5) (PubMed:35213692). Required for proper erythrocyte maturation (PubMed:35213692).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13513	HEAT_EZ	41 → 106		Repeat

• Sequence:

  MGKSRTKRFKRPQFSPTGDCQAEAAAAANGTGGEEDDGPAAELLEKLQHPSAEVRECACA
  GLARLVQQRPALPGLARRDAVRRLGPLLLDPSLAVRETAAGALRNLSACGGFEVCDDMVT
  KDIMTPLVALLKECSAGLDSNEMSLQEKKDQNRNSIENIANETVNVLWNICECSSRAVSI
  FNKEGCLEIVLKYLSRFPTNVDLAISVAYCLQTVTEDNPELLKSFSATALNMLESALLSP
  VSSMESLLLKTLVAGTIWNLKDIIPCKSQAEIINALLKILSEVLGMDAGEMVIQMKEAET
  QRLKTAAEAEEILENTNGDDLIEDDEMEGISHKRRVRRKTFVSDLLPPTDKELRETIALL
  TAQQTALEIIVNMCCNEDPSDDEWEELSSSDESDAFMENSFSECGGQLFSPLCLSHEVHT
  ALTNYLIPKKIFEKTAFPNSIAVDLCSRNPTWKPLIRKMNTIQCRALFCLQSLVSLLDVE
  HLGGAAALQTLAQHLSQLLFSQPDFAKHVDFLEAISSALRALLQTMASKNISQCMTPDQL
  MTLCKAGIHSSNVGVRVNVVSILGITGSVLAKEDGTLETLKNIGCFLLEVTTKDPSLVVA
  GEALDALFDVFADGKEAERASIQIKLLSALKEFQPVFKMKIRKEGRGNYSTDQLCVLDNV
  KMNLRRFIAYQETVEKRLTS

• Sequence length: 680

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Carcinoma	Squamous cell carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	22960999
Esophagus neoplasm	Esophageal Neoplasms	rs28934578, rs121918714, rs1567556006, rs1575166666	22960999
Glioblastoma	Glioblastoma, Glioblastoma Multiforme	rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888	28346443
Glioma	Glioma	rs121909219, rs121909224, rs587776667, rs587776671, rs121909239, rs121909241, rs28933368, rs121913500, rs55863639, rs786201995, rs786202517, rs786201044, rs398123317, rs1057518425, rs121913499, rs1060500122, rs781647403, rs1060500126, rs1554897889, rs1114167629, rs1114167656, rs587782603, rs1554893824, rs1554900615, rs1564568660, rs786204900, rs762518389, rs1339631701	28346443

Unknown
Disease name	Disease term	dbSNP ID	References
Central nervous system neoplasms	Central Nervous System Neoplasms		28346443