ARHGEF38 (Rho guanine nucleotide exchange factor 38)

Gene

• Entrez ID: 54848
• Gene name: Rho guanine nucleotide exchange factor 38
• Gene symbol: ARHGEF38
• Synonyms: -
• Chromosome: 4
• Chromosome location: 4q24

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT795865	hsa-miR-101	CLIP-seq
MIRT795866	hsa-miR-1200	CLIP-seq
MIRT795867	hsa-miR-1273f	CLIP-seq
MIRT795868	hsa-miR-1297	CLIP-seq
MIRT795869	hsa-miR-139-5p	CLIP-seq
MIRT795870	hsa-miR-143	CLIP-seq
MIRT795871	hsa-miR-144	CLIP-seq
MIRT795872	hsa-miR-192	CLIP-seq
MIRT795873	hsa-miR-205	CLIP-seq
MIRT795874	hsa-miR-215	CLIP-seq
MIRT795875	hsa-miR-2355-5p	CLIP-seq
MIRT795876	hsa-miR-26a	CLIP-seq
MIRT795877	hsa-miR-26b	CLIP-seq
MIRT795878	hsa-miR-2964a-5p	CLIP-seq
MIRT795879	hsa-miR-3121-3p	CLIP-seq
MIRT795880	hsa-miR-3130-5p	CLIP-seq
MIRT795881	hsa-miR-3137	CLIP-seq
MIRT795882	hsa-miR-3140-5p	CLIP-seq
MIRT795883	hsa-miR-3156-5p	CLIP-seq
MIRT795884	hsa-miR-3160-5p	CLIP-seq
MIRT795885	hsa-miR-3618	CLIP-seq
MIRT795886	hsa-miR-3663-5p	CLIP-seq
MIRT795887	hsa-miR-3679-3p	CLIP-seq
MIRT795888	hsa-miR-3681	CLIP-seq
MIRT795889	hsa-miR-3686	CLIP-seq
MIRT795890	hsa-miR-412	CLIP-seq
MIRT795891	hsa-miR-4257	CLIP-seq
MIRT795892	hsa-miR-4286	CLIP-seq
MIRT795893	hsa-miR-4301	CLIP-seq
MIRT795894	hsa-miR-4307	CLIP-seq
MIRT795895	hsa-miR-4328	CLIP-seq
MIRT795896	hsa-miR-4446-5p	CLIP-seq
MIRT795897	hsa-miR-4465	CLIP-seq
MIRT795898	hsa-miR-4476	CLIP-seq
MIRT795899	hsa-miR-4482	CLIP-seq
MIRT795900	hsa-miR-4520a-3p	CLIP-seq
MIRT795901	hsa-miR-4520b-3p	CLIP-seq
MIRT795902	hsa-miR-4529-3p	CLIP-seq
MIRT795903	hsa-miR-4652-3p	CLIP-seq
MIRT795904	hsa-miR-4703-3p	CLIP-seq
MIRT795905	hsa-miR-4708-5p	CLIP-seq
MIRT795906	hsa-miR-4712-5p	CLIP-seq
MIRT795907	hsa-miR-4770	CLIP-seq
MIRT795908	hsa-miR-486-5p	CLIP-seq
MIRT795909	hsa-miR-561	CLIP-seq
MIRT795910	hsa-miR-570	CLIP-seq
MIRT795911	hsa-miR-578	CLIP-seq
MIRT795912	hsa-miR-770-5p	CLIP-seq
MIRT795913	hsa-miR-3119	CLIP-seq
MIRT795914	hsa-miR-3188	CLIP-seq
MIRT795915	hsa-miR-3653	CLIP-seq
MIRT795916	hsa-miR-3658	CLIP-seq
MIRT795917	hsa-miR-3692	CLIP-seq
MIRT795918	hsa-miR-4659a-3p	CLIP-seq
MIRT795919	hsa-miR-4659b-3p	CLIP-seq
MIRT2175007	hsa-miR-3127-5p	CLIP-seq
MIRT2175008	hsa-miR-3128	CLIP-seq
MIRT2175009	hsa-miR-3158-3p	CLIP-seq
MIRT2175010	hsa-miR-3622b-5p	CLIP-seq
MIRT2175011	hsa-miR-3918	CLIP-seq
MIRT2175012	hsa-miR-4716-5p	CLIP-seq
MIRT2175013	hsa-miR-4720-5p	CLIP-seq
MIRT2175014	hsa-miR-4799-3p	CLIP-seq
MIRT2384438	hsa-miR-202	CLIP-seq
MIRT2384439	hsa-miR-450b-5p	CLIP-seq
MIRT2384440	hsa-miR-518a-5p	CLIP-seq
MIRT2384441	hsa-miR-527	CLIP-seq
MIRT2443946	hsa-miR-1207-3p	CLIP-seq
MIRT2443947	hsa-miR-1265	CLIP-seq
MIRT2443948	hsa-miR-1299	CLIP-seq
MIRT2443949	hsa-miR-3125	CLIP-seq
MIRT2443950	hsa-miR-3148	CLIP-seq
MIRT2443951	hsa-miR-3916	CLIP-seq
MIRT2443952	hsa-miR-3978	CLIP-seq
MIRT2443953	hsa-miR-4493	CLIP-seq
MIRT2443954	hsa-miR-4522	CLIP-seq
MIRT2443955	hsa-miR-4700-3p	CLIP-seq
MIRT2443956	hsa-miR-548n	CLIP-seq
MIRT2443957	hsa-miR-548t	CLIP-seq
MIRT2443958	hsa-miR-875-3p	CLIP-seq
MIRT2443959	hsa-miR-877	CLIP-seq
MIRT2443947	hsa-miR-1265	CLIP-seq
MIRT2443948	hsa-miR-1299	CLIP-seq
MIRT2443949	hsa-miR-3125	CLIP-seq
MIRT2443951	hsa-miR-3916	CLIP-seq
MIRT2443952	hsa-miR-3978	CLIP-seq
MIRT2443954	hsa-miR-4522	CLIP-seq
MIRT2443955	hsa-miR-4700-3p	CLIP-seq
MIRT2443958	hsa-miR-875-3p	CLIP-seq
MIRT2443959	hsa-miR-877	CLIP-seq
MIRT2443948	hsa-miR-1299	CLIP-seq
MIRT2443949	hsa-miR-3125	CLIP-seq
MIRT2478212	hsa-miR-3149	CLIP-seq
MIRT2443951	hsa-miR-3916	CLIP-seq
MIRT2443952	hsa-miR-3978	CLIP-seq
MIRT795894	hsa-miR-4307	CLIP-seq
MIRT2443954	hsa-miR-4522	CLIP-seq
MIRT2478213	hsa-miR-568	CLIP-seq
MIRT2443958	hsa-miR-875-3p	CLIP-seq
MIRT2443959	hsa-miR-877	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IEA
GO:0050790	Process	Regulation of catalytic activity	IEA

Other IDs

• MIM: 619919
• HGNC: 25968
• e!Ensembl: ENSG00000236699

Protein

• UniProt ID: Q9NXL2
• Protein name: Rho guanine nucleotide exchange factor 38
• Protein function: May act as a guanine-nucleotide releasing factor.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00621	RhoGEF	98 → 283	RhoGEF domain	Domain
  PF07653	SH3_2	586 → 643	Variant SH3 domain	Domain
  PF14604	SH3_9	720 → 772	Variant SH3 domain	Domain

• Sequence:

  MEPKEATGKENMVTKKKNLAFLRSRLYMLERRKTDTVVESSVSGDHSGTLRRSQSDRTEY
  NQKLQEKMTPQGECSVAETLTPEEEHHMKRMMAKREKIIKELIQTEKDYLNDLELCVREV
  VQPLRNKKTDRLDVDSLFSNIESVHQISAKLLSLLEEATTDVEPAMQVIGEVFLQIKGPL
  EDIYKIYCYHHDEAHSILESYEKEEELKEHLSHCIQSLKKIYMQEGKPNLLDMGSLMIKP
  IQRVMKYPLLLCELRNSTPPSHPDYRALDDAFAAVKDINVNINELKRRKDLVLKYKKNDE
  DESLKDKLSKLNIHSISKKSKRVTNHLKILTRGESQVKDNTFNREEKLFRALEKTVRLCV
  KNISLCLQHIQDAMPLALQSVMDLQEISYNKDDEMDYSETLSNALNSCHDFASHLQRLIL
  TPLSALLSLFPGPHKLIQKRYDKLLDCNSYLQRSTGEESDLAKKEYEALNAQLVEELQAF
  NQAARKILLNCLCSFITLLRDLMLVAQQAYSTLVPMPLLVSSISEIQNQVLEEIQNLNCV
  KENSATFIERKLSFEKKKPVQILPEMPHQTDIHRSKLLSTYSAEELYQAKRKCNATQEYD
  INLLEGDLVAVIEQKDPLGSTSRWLVDTGNVKGYVYSSFLKPYNPAKMQKVDAENRFCDD
  DFENISLFVSSRPASDSVTGTSESSIGDSSSSLSGTCGKFETNGTDVDSFQEVDEQIFYA
  VHAFQARSDHELSLQEYQRVHILRFCDLSGNKEWWLAEAQGQKGYVPANYLGKMTYA

• Sequence length: 777

Pathways

Reactome:

NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease	rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928	28166215