PPIA (peptidylprolyl isomerase A)
|
Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
5478 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Peptidylprolyl isomerase A |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
PPIA |
SynonymsGene synonyms aliases
|
CYPA, CYPH, HEL-S-69p |
ChromosomeChromosome number
|
7 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
7p13 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclospor |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000187 |
Process |
Activation of MAPK activity |
IDA |
15130913 |
GO:0000413 |
Process |
Protein peptidyl-prolyl isomerization |
IBA |
21873635 |
GO:0000413 |
Process |
Protein peptidyl-prolyl isomerization |
IDA |
14993672, 20676357 |
GO:0001933 |
Process |
Negative regulation of protein phosphorylation |
IDA |
26095851 |
GO:0001934 |
Process |
Positive regulation of protein phosphorylation |
IDA |
11943775 |
GO:0003723 |
Function |
RNA binding |
HDA |
22658674, 22681889 |
GO:0003755 |
Function |
Peptidyl-prolyl cis-trans isomerase activity |
IBA |
21873635 |
GO:0003755 |
Function |
Peptidyl-prolyl cis-trans isomerase activity |
IDA |
14993672, 20676357 |
GO:0003755 |
Function |
Peptidyl-prolyl cis-trans isomerase activity |
IMP |
2001362, 21245143, 21593166, 25678563 |
GO:0005178 |
Function |
Integrin binding |
ISS |
|
GO:0005515 |
Function |
Protein binding |
IPI |
11353871, 11943775, 12218175, 12357034, 12730686, 15358143, 15688292, 16049941, 16169070, 16273344, 20147391, 21245143, 21593166, 22046132, 22174692, 23152499, 23935497, 25416956, 25556234, 25678563, 26095851, 26656091, 31063815, 32814053 |
GO:0005576 |
Component |
Extracellular region |
IDA |
16527992 |
GO:0005576 |
Component |
Extracellular region |
TAS |
|
GO:0005615 |
Component |
Extracellular space |
HDA |
16502470 |
GO:0005634 |
Component |
Nucleus |
HDA |
16780588 |
GO:0005634 |
Component |
Nucleus |
IDA |
25678563 |
GO:0005737 |
Component |
Cytoplasm |
IBA |
21873635 |
GO:0005737 |
Component |
Cytoplasm |
IDA |
26095851 |
GO:0005829 |
Component |
Cytosol |
HDA |
16780588 |
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0005925 |
Component |
Focal adhesion |
HDA |
21423176 |
GO:0006278 |
Process |
RNA-dependent DNA biosynthetic process |
TAS |
|
GO:0006457 |
Process |
Protein folding |
IBA |
21873635 |
GO:0006457 |
Process |
Protein folding |
TAS |
2179953, 2644542 |
GO:0006469 |
Process |
Negative regulation of protein kinase activity |
IDA |
26095851 |
GO:0006915 |
Process |
Apoptotic process |
IDA |
15130913 |
GO:0006915 |
Process |
Apoptotic process |
IMP |
31063815 |
GO:0016018 |
Function |
Cyclosporin A binding |
IBA |
21873635 |
GO:0016018 |
Function |
Cyclosporin A binding |
IDA |
12218175, 12357034, 20676357 |
GO:0016018 |
Function |
Cyclosporin A binding |
IMP |
2001362 |
GO:0016020 |
Component |
Membrane |
HDA |
19946888 |
GO:0019058 |
Process |
Viral life cycle |
TAS |
|
GO:0019061 |
Process |
Uncoating of virus |
TAS |
|
GO:0019064 |
Process |
Fusion of virus membrane with host plasma membrane |
TAS |
|
GO:0019068 |
Process |
Virion assembly |
TAS |
|
GO:0019076 |
Process |
Viral release from host cell |
TAS |
21711559 |
GO:0030168 |
Process |
Platelet activation |
ISS |
|
GO:0030593 |
Process |
Neutrophil chemotaxis |
IDA |
11943775 |
GO:0030595 |
Process |
Leukocyte chemotaxis |
IMP |
21245143 |
GO:0031982 |
Component |
Vesicle |
HDA |
19190083 |
GO:0032148 |
Process |
Activation of protein kinase B activity |
IDA |
23180369 |
GO:0032873 |
Process |
Negative regulation of stress-activated MAPK cascade |
IMP |
26095851 |
GO:0032991 |
Component |
Protein-containing complex |
IDA |
12218175 |
GO:0034389 |
Process |
Lipid droplet organization |
IMP |
21711559 |
GO:0034599 |
Process |
Cellular response to oxidative stress |
IDA |
16527992 |
GO:0034774 |
Component |
Secretory granule lumen |
TAS |
|
GO:0035307 |
Process |
Positive regulation of protein dephosphorylation |
IMP |
31063815 |
GO:0035722 |
Process |
Interleukin-12-mediated signaling pathway |
TAS |
|
GO:0042118 |
Process |
Endothelial cell activation |
IDA |
15130913 |
GO:0043231 |
Component |
Intracellular membrane-bounded organelle |
IBA |
21873635 |
GO:0043312 |
Process |
Neutrophil degranulation |
TAS |
|
GO:0045069 |
Process |
Regulation of viral genome replication |
IMP |
11250896 |
GO:0045069 |
Process |
Regulation of viral genome replication |
TAS |
7590732 |
GO:0045070 |
Process |
Positive regulation of viral genome replication |
IMP |
19932913 |
GO:0046790 |
Function |
Virion binding |
NAS |
11250896 |
GO:0050714 |
Process |
Positive regulation of protein secretion |
IMP |
21711559 |
GO:0050900 |
Process |
Leukocyte migration |
TAS |
|
GO:0051082 |
Function |
Unfolded protein binding |
TAS |
2644542 |
GO:0051092 |
Process |
Positive regulation of NF-kappaB transcription factor activity |
IDA |
15130913, 23180369 |
GO:0060352 |
Process |
Cell adhesion molecule production |
IDA |
15130913 |
GO:0061944 |
Process |
Negative regulation of protein K48-linked ubiquitination |
IMP |
30328013 |
GO:0070062 |
Component |
Extracellular exosome |
HDA |
19056867, 19199708, 20458337, 23533145 |
GO:0070062 |
Component |
Extracellular exosome |
TAS |
|
GO:0070527 |
Process |
Platelet aggregation |
ISS |
|
GO:0075713 |
Process |
Establishment of integrated proviral latency |
TAS |
|
GO:1902176 |
Process |
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
IMP |
26095851 |
GO:1903901 |
Process |
Negative regulation of viral life cycle |
IMP |
19207730, 22347431 |
GO:1904399 |
Function |
Heparan sulfate binding |
IDA |
11943775 |
GO:1904813 |
Component |
Ficolin-1-rich granule lumen |
TAS |
|
GO:2001233 |
Process |
Regulation of apoptotic signaling pathway |
IMP |
23180369 |
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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|
Protein
|
UniProt ID |
P62937 |
Protein name |
Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed] |
Protein function |
Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:2001362, PubMed:20676357, PubMed:21245143, PubMed:21593166, PubMed:25678563). Exerts a strong chemotactic effect on leukocytes partly through activati |
PDB |
1AK4
,
1AWQ
,
1AWR
,
1AWS
,
1AWT
,
1AWU
,
1AWV
,
1BCK
,
1CWA
,
1CWB
,
1CWC
,
1CWF
,
1CWH
,
1CWI
,
1CWJ
,
1CWK
,
1CWL
,
1CWM
,
1CWO
,
1FGL
,
1M63
,
1M9C
,
1M9D
,
1M9E
,
1M9F
,
1M9X
,
1M9Y
,
1MF8
,
1MIK
,
1NMK
,
1OCA
,
1RMH
,
1VBS
,
1VBT
,
1W8L
,
1W8M
,
1W8V
,
1YND
,
1ZKF
,
2ALF
,
2CPL
,
2CYH
,
2MS4
,
2MZU
,
2N0T
,
2RMA
,
2RMB
,
2X25
,
2X2A
,
2X2C
,
2X2D
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Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00160 |
Pro_isomerase |
7 → 163 |
Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD |
Domain |
|
Sequence |
|
Sequence length |
165 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Carcinoma |
Squamous cell carcinoma |
rs121912654, rs555607708, rs786202962, rs1564055259 |
15274141 |
Gastric cancer |
Hereditary Diffuse Gastric Cancer |
rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208 |
19424620 |
Lung carcinoma |
Non-Small Cell Lung Carcinoma |
rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193 |
17094902 |
Schizophrenia |
Schizophrenia |
rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 |
20073568 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Mouth neoplasms |
Mouth Neoplasms |
|
15274141 |
Malignant neoplasm of mouth |
Malignant neoplasm of mouth |
|
15274141 |
Stomach neoplasms |
Malignant neoplasm of stomach, Stomach Neoplasms |
|
19424620 |
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