RNF111 (ring finger protein 111)
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Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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54778 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Ring finger protein 111 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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RNF111 |
SynonymsGene synonyms aliases
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ARK, hRNF111 |
ChromosomeChromosome number
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15 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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15q22.1-q22.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negativ |
miRNAmiRNA information provided by mirtarbase database.
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Transcription factors
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Transcription factor |
Regulation |
Reference |
XPC |
Repression |
23751493 |
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000209 |
Process |
Protein polyubiquitination |
IEA |
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GO:0005515 |
Function |
Protein binding |
IPI |
16601693, 19549727, 19690564, 20936779, 21516116, 25260751, 25416956, 29892012, 31515488 |
GO:0005634 |
Component |
Nucleus |
IBA |
21873635 |
GO:0005654 |
Component |
Nucleoplasm |
IDA |
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GO:0005654 |
Component |
Nucleoplasm |
TAS |
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GO:0005737 |
Component |
Cytoplasm |
IBA |
21873635 |
GO:0005829 |
Component |
Cytosol |
IDA |
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GO:0006511 |
Process |
Ubiquitin-dependent protein catabolic process |
IBA |
21873635 |
GO:0007389 |
Process |
Pattern specification process |
IEA |
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GO:0016567 |
Process |
Protein ubiquitination |
IMP |
16601693 |
GO:0016605 |
Component |
PML body |
IEA |
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GO:0030511 |
Process |
Positive regulation of transforming growth factor beta receptor signaling pathway |
IBA |
21873635 |
GO:0030579 |
Process |
Ubiquitin-dependent SMAD protein catabolic process |
IBA |
21873635 |
GO:0031398 |
Process |
Positive regulation of protein ubiquitination |
IEA |
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GO:0032184 |
Function |
SUMO polymer binding |
IBA |
21873635 |
GO:0032184 |
Function |
SUMO polymer binding |
IDA |
23086935 |
GO:0032991 |
Component |
Protein-containing complex |
IEA |
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GO:0045893 |
Process |
Positive regulation of transcription, DNA-templated |
IBA |
21873635 |
GO:0045893 |
Process |
Positive regulation of transcription, DNA-templated |
IMP |
16601693 |
GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
TAS |
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GO:0046332 |
Function |
SMAD binding |
IBA |
21873635 |
GO:0046872 |
Function |
Metal ion binding |
IEA |
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GO:0061630 |
Function |
Ubiquitin protein ligase activity |
IBA |
21873635 |
GO:0061630 |
Function |
Ubiquitin protein ligase activity |
IMP |
16601693 |
GO:0061630 |
Function |
Ubiquitin protein ligase activity |
TAS |
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GO:0070911 |
Process |
Global genome nucleotide-excision repair |
TAS |
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
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UniProt ID |
Q6ZNA4 |
Protein name |
E3 ubiquitin-protein ligase Arkadia (EC 2.3.2.27) (RING finger protein 111) (hRNF111) (RING-type E3 ubiquitin transferase Arkadia) |
Protein function |
E3 ubiquitin-protein ligase (PubMed:26656854). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BM |
PDB |
2KIZ
,
5LG0
,
5LG7
,
7P2K
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF15303 |
RNF111_N |
18 → 292 |
E3 ubiquitin-protein ligase Arkadia N-terminus |
Family |
PF13639 |
zf-RING_2 |
940 → 983 |
Ring finger domain |
Domain |
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Sequence |
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Sequence length |
994 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Dermatitis |
Dermatitis, Atopic |
rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 |
25865352 |
Jeune thoracic dystrophy |
Jeune thoracic dystrophy |
rs137853025, rs137853028, rs137853030, rs137853031, rs137853032, rs431905500, rs201188361, rs587776909, rs397514637, rs431905507, rs199952377, rs431905521, rs587777352, rs750396637, rs755338872, rs794727595, rs776315442, rs780539887, rs864622358, rs864622111, rs200460601, rs755883373, rs878852996, rs754919042, rs770185023, rs201858128, rs771487311, rs773858865, rs1043384862, rs562139820, rs771003300, rs754049402, rs552436294, rs943680446, rs746068882, rs368631447, rs1202784860, rs1236962991, rs1453462442, rs1553316926, rs776631281, rs764906529, rs1553753582, rs372576954, rs1553905326, rs748656635, rs377160857, rs1215108056, rs772599282, rs1191056931, rs745603321, rs1553815019, rs1553836165, rs761707323, rs1554770453, rs1554771175, rs555811074, rs755305630, rs771511132, rs762873763, rs764769351, rs369614706, rs371011047, rs748906528, rs1555042801, rs1555043520, rs373335226, rs1555049536, rs1555051720, rs745870321, rs1555052511, rs1555052524, rs1555053115, rs901629870, rs762666243, rs1555056464, rs1380132788, rs1555057838, rs753662982, rs747348765, rs1555063811, rs537704873, rs1350329646, rs758155107, rs1196317554, rs747857715, rs969015057, rs1555068270, rs1555068636, rs1555070451, rs1555071484, rs1555071503, rs776407305, rs373924400, rs1218198013, rs780600124, rs1261505725, rs200710887, rs1555081345, rs181011657, rs759649136, rs1555098222, rs1453448143, rs766816050, rs368654019, rs1555052497, rs1223907858, rs759549373, rs1555096711, rs200335504, rs1555038664, rs747165335, rs1565311145, rs1565317399, rs1260978141, rs1565329461, rs767846762, rs376892534, rs1566883760, rs1309577378, rs1565423740, rs1565371538, rs1565359085, rs1159774355, rs1291197898, rs751891969, rs1565390180, rs1558104145, rs1401798992, rs561778796, rs1266078341, rs1565368793, rs373536938, rs765454943, rs1160036887, rs767206815, rs372878677 |
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