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RRN3 (RNA polymerase I transcription factor RRN3)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
54700
Gene nameGene Name - the full gene name approved by the HGNC.
RNA polymerase I transcription factor RRN3
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
RRN3
SynonymsGene synonyms aliases
A-270G1.2, TIFIA
ChromosomeChromosome number
16
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16p13.11
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT028106 hsa-miR-93-5p Sequencing 20371350
MIRT045801 hsa-miR-191-5p CLASH 23622248
MIRT554563 hsa-miR-3609 PAR-CLIP 21572407
MIRT554562 hsa-miR-548ah-5p PAR-CLIP 21572407
MIRT554561 hsa-miR-106a-5p PAR-CLIP 21572407
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001042 Function RNA polymerase I core binding IBA 21873635
GO:0001164 Function RNA polymerase I core promoter sequence-specific DNA binding IDA 22368283
GO:0001181 Function RNA polymerase I general transcription initiation factor activity IBA 21873635
GO:0001188 Process RNA polymerase I preinitiation complex assembly IEA
GO:0005634 Component Nucleus IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q9NYV6
Protein name RNA polymerase I-specific transcription initiation factor RRN3 (Transcription initiation factor IA) (TIF-IA)
Protein function Required for efficient transcription initiation by RNA polymerase I (Pol I). Required for the formation of the competent pre-initiation complex (PIC). {ECO:0000250, ECO:0000269|PubMed:10758157, ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:112
PDB 7OBA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05327 RRN3
50 586
RNA polymerase I specific transcription initiation factor RRN3
Family
Sequence
Sequence length 651
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 31374203

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