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POU2F2 (POU class 2 homeobox 2)

Gene

5452

POU class 2 homeobox 2

POU2F2

OCT2, OTF2, Oct-2

19q13.2

The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5`-ATTTGCAT-3`, a common transcription factor binding site in immunoglobulin gene promoters. Several tr

Show/Hide all(239)

miRTarBase ID	miRNA	Experiments	Reference
MIRT000639	hsa-miR-9-5p	Luciferase reporter assay	19956200
MIRT720159	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT720158	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT720157	hsa-miR-29b-2-5p	HITS-CLIP	19536157
MIRT388051	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT388056	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT388055	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT720156	hsa-miR-659-3p	HITS-CLIP	19536157
MIRT720155	hsa-miR-6839-3p	HITS-CLIP	19536157
MIRT521796	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT509447	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509446	hsa-miR-4307	HITS-CLIP	21572407
MIRT509445	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509444	hsa-miR-6083	HITS-CLIP	21572407
MIRT509443	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT509447	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509446	hsa-miR-4307	HITS-CLIP	21572407
MIRT509445	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509444	hsa-miR-6083	HITS-CLIP	21572407
MIRT509443	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT614841	hsa-miR-6768-3p	HITS-CLIP	23824327
MIRT614840	hsa-miR-6512-5p	HITS-CLIP	23824327
MIRT614839	hsa-miR-6841-5p	HITS-CLIP	23824327
MIRT614838	hsa-miR-6755-5p	HITS-CLIP	23824327
MIRT666873	hsa-miR-504-5p	HITS-CLIP	23824327
MIRT666872	hsa-miR-10a-5p	HITS-CLIP	23824327
MIRT666871	hsa-miR-10b-5p	HITS-CLIP	23824327
MIRT666870	hsa-miR-510-5p	HITS-CLIP	23824327
MIRT666869	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT666868	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT666867	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT666866	hsa-miR-3120-5p	HITS-CLIP	23824327
MIRT666865	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT666864	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT614841	hsa-miR-6768-3p	HITS-CLIP	23824327
MIRT614840	hsa-miR-6512-5p	HITS-CLIP	23824327
MIRT614839	hsa-miR-6841-5p	HITS-CLIP	23824327
MIRT614838	hsa-miR-6755-5p	HITS-CLIP	23824327
MIRT509447	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT509446	hsa-miR-4307	PAR-CLIP	20371350
MIRT509445	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT509444	hsa-miR-6083	PAR-CLIP	20371350
MIRT509443	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT521799	hsa-miR-3606-3p	PAR-CLIP	21572407
MIRT521798	hsa-miR-513a-3p	PAR-CLIP	21572407
MIRT521797	hsa-miR-513c-3p	PAR-CLIP	21572407
MIRT521796	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT509447	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509446	hsa-miR-4307	PAR-CLIP	21572407
MIRT509445	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509444	hsa-miR-6083	PAR-CLIP	21572407
MIRT509443	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT521799	hsa-miR-3606-3p	PAR-CLIP	21572407
MIRT521798	hsa-miR-513a-3p	PAR-CLIP	21572407
MIRT521797	hsa-miR-513c-3p	PAR-CLIP	21572407
MIRT521796	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT509447	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509446	hsa-miR-4307	PAR-CLIP	21572407
MIRT509445	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509444	hsa-miR-6083	PAR-CLIP	21572407
MIRT509443	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT521799	hsa-miR-3606-3p	PAR-CLIP	23446348
MIRT521798	hsa-miR-513a-3p	PAR-CLIP	23446348
MIRT521797	hsa-miR-513c-3p	PAR-CLIP	23446348
MIRT521796	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT509447	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509446	hsa-miR-4307	PAR-CLIP	23446348
MIRT521795	hsa-miR-6832-3p	PAR-CLIP	23446348
MIRT509445	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT521794	hsa-miR-623	PAR-CLIP	23446348
MIRT521793	hsa-miR-204-5p	PAR-CLIP	23446348
MIRT521792	hsa-miR-211-5p	PAR-CLIP	23446348
MIRT509444	hsa-miR-6083	PAR-CLIP	23446348
MIRT521791	hsa-miR-4755-5p	PAR-CLIP	23446348
MIRT521790	hsa-miR-5006-3p	PAR-CLIP	23446348
MIRT509443	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT509447	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509446	hsa-miR-4307	PAR-CLIP	23446348
MIRT509445	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509444	hsa-miR-6083	PAR-CLIP	23446348
MIRT509443	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT731733	hsa-miR-218-5p	ChIP-seq, Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	26019213
MIRT731733	hsa-miR-218-5p	ChIP-seq, Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	26019213
MIRT720156	hsa-miR-659-3p	HITS-CLIP	27418678
MIRT736663	hsa-miR-489-3p	Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), qRT-PCR	31649850
MIRT736664	hsa-miR-630	Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), qRT-PCR	31649850
MIRT720159	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT720158	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT720157	hsa-miR-29b-2-5p	HITS-CLIP	19536157
MIRT388051	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT388056	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT388055	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT720156	hsa-miR-659-3p	HITS-CLIP	19536157
MIRT720155	hsa-miR-6839-3p	HITS-CLIP	19536157
MIRT521796	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT509447	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509446	hsa-miR-4307	HITS-CLIP	21572407
MIRT509445	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509444	hsa-miR-6083	HITS-CLIP	21572407
MIRT509443	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT509447	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509446	hsa-miR-4307	HITS-CLIP	21572407
MIRT509445	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509444	hsa-miR-6083	HITS-CLIP	21572407
MIRT509443	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT614841	hsa-miR-6768-3p	HITS-CLIP	23824327
MIRT614840	hsa-miR-6512-5p	HITS-CLIP	23824327
MIRT614839	hsa-miR-6841-5p	HITS-CLIP	23824327
MIRT614838	hsa-miR-6755-5p	HITS-CLIP	23824327
MIRT666873	hsa-miR-504-5p	HITS-CLIP	23824327
MIRT666872	hsa-miR-10a-5p	HITS-CLIP	23824327
MIRT666871	hsa-miR-10b-5p	HITS-CLIP	23824327
MIRT666870	hsa-miR-510-5p	HITS-CLIP	23824327
MIRT666869	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT666868	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT666867	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT666866	hsa-miR-3120-5p	HITS-CLIP	23824327
MIRT666865	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT666864	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT614841	hsa-miR-6768-3p	HITS-CLIP	23824327
MIRT614840	hsa-miR-6512-5p	HITS-CLIP	23824327
MIRT614839	hsa-miR-6841-5p	HITS-CLIP	23824327
MIRT614838	hsa-miR-6755-5p	HITS-CLIP	23824327
MIRT509447	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT509446	hsa-miR-4307	PAR-CLIP	20371350
MIRT509445	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT509444	hsa-miR-6083	PAR-CLIP	20371350
MIRT509443	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT521799	hsa-miR-3606-3p	PAR-CLIP	21572407
MIRT521798	hsa-miR-513a-3p	PAR-CLIP	21572407
MIRT521797	hsa-miR-513c-3p	PAR-CLIP	21572407
MIRT521796	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT509447	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509446	hsa-miR-4307	PAR-CLIP	21572407
MIRT509445	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509444	hsa-miR-6083	PAR-CLIP	21572407
MIRT509443	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT521799	hsa-miR-3606-3p	PAR-CLIP	21572407
MIRT521798	hsa-miR-513a-3p	PAR-CLIP	21572407
MIRT521797	hsa-miR-513c-3p	PAR-CLIP	21572407
MIRT521796	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT509447	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509446	hsa-miR-4307	PAR-CLIP	21572407
MIRT509445	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509444	hsa-miR-6083	PAR-CLIP	21572407
MIRT509443	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT521799	hsa-miR-3606-3p	PAR-CLIP	23446348
MIRT521798	hsa-miR-513a-3p	PAR-CLIP	23446348
MIRT521797	hsa-miR-513c-3p	PAR-CLIP	23446348
MIRT521796	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT509447	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509446	hsa-miR-4307	PAR-CLIP	23446348
MIRT521795	hsa-miR-6832-3p	PAR-CLIP	23446348
MIRT509445	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT521794	hsa-miR-623	PAR-CLIP	23446348
MIRT521793	hsa-miR-204-5p	PAR-CLIP	23446348
MIRT521792	hsa-miR-211-5p	PAR-CLIP	23446348
MIRT509444	hsa-miR-6083	PAR-CLIP	23446348
MIRT521791	hsa-miR-4755-5p	PAR-CLIP	23446348
MIRT521790	hsa-miR-5006-3p	PAR-CLIP	23446348
MIRT509443	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT509447	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509446	hsa-miR-4307	PAR-CLIP	23446348
MIRT509445	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509444	hsa-miR-6083	PAR-CLIP	23446348
MIRT509443	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT1250900	hsa-miR-3127-5p	CLIP-seq
MIRT1250901	hsa-miR-4261	CLIP-seq
MIRT1250902	hsa-miR-4270	CLIP-seq
MIRT1250903	hsa-miR-4441	CLIP-seq
MIRT1250904	hsa-miR-659	CLIP-seq
MIRT1250905	hsa-miR-1237	CLIP-seq
MIRT1250906	hsa-miR-1238	CLIP-seq
MIRT1250907	hsa-miR-1248	CLIP-seq
MIRT1250908	hsa-miR-1976	CLIP-seq
MIRT1250909	hsa-miR-223	CLIP-seq
MIRT1250910	hsa-miR-3150a-3p	CLIP-seq
MIRT1250911	hsa-miR-3175	CLIP-seq
MIRT1250912	hsa-miR-3180-5p	CLIP-seq
MIRT1250913	hsa-miR-320e	CLIP-seq
MIRT1250914	hsa-miR-370	CLIP-seq
MIRT1250915	hsa-miR-4277	CLIP-seq
MIRT1250916	hsa-miR-4287	CLIP-seq
MIRT1250917	hsa-miR-4419a	CLIP-seq
MIRT1250918	hsa-miR-4505	CLIP-seq
MIRT1250919	hsa-miR-4510	CLIP-seq
MIRT1250920	hsa-miR-4642	CLIP-seq
MIRT1250921	hsa-miR-4667-5p	CLIP-seq
MIRT1250922	hsa-miR-4685-3p	CLIP-seq
MIRT1250923	hsa-miR-4691-5p	CLIP-seq
MIRT1250924	hsa-miR-4700-5p	CLIP-seq
MIRT1250925	hsa-miR-4720-5p	CLIP-seq
MIRT1250926	hsa-miR-4728-5p	CLIP-seq
MIRT1250927	hsa-miR-4731-5p	CLIP-seq
MIRT1250928	hsa-miR-4780	CLIP-seq
MIRT1250929	hsa-miR-4799-3p	CLIP-seq
MIRT1250930	hsa-miR-483-3p	CLIP-seq
MIRT1250931	hsa-miR-520a-5p	CLIP-seq
MIRT1250932	hsa-miR-525-5p	CLIP-seq
MIRT1250933	hsa-miR-668	CLIP-seq
MIRT1250934	hsa-miR-939	CLIP-seq
MIRT1250935	hsa-miR-942	CLIP-seq
MIRT1552506	hsa-miR-3150b-3p	CLIP-seq
MIRT1552507	hsa-miR-4784	CLIP-seq
MIRT1250914	hsa-miR-370	CLIP-seq
MIRT2074066	hsa-miR-4492	CLIP-seq
MIRT2074067	hsa-miR-4498	CLIP-seq
MIRT1250927	hsa-miR-4731-5p	CLIP-seq
MIRT1250928	hsa-miR-4780	CLIP-seq
MIRT2074068	hsa-miR-762	CLIP-seq
MIRT2301015	hsa-miR-1287	CLIP-seq
MIRT2301016	hsa-miR-204	CLIP-seq
MIRT2301017	hsa-miR-211	CLIP-seq
MIRT2301018	hsa-miR-3135b	CLIP-seq
MIRT2301019	hsa-miR-3188	CLIP-seq
MIRT2301020	hsa-miR-331-3p	CLIP-seq
MIRT2301021	hsa-miR-3545-3p	CLIP-seq
MIRT2301022	hsa-miR-3612	CLIP-seq
MIRT2301023	hsa-miR-3661	CLIP-seq
MIRT1250914	hsa-miR-370	CLIP-seq
MIRT2301024	hsa-miR-4256	CLIP-seq
MIRT2301025	hsa-miR-4443	CLIP-seq
MIRT2301026	hsa-miR-4680-5p	CLIP-seq
MIRT2301027	hsa-miR-4725-5p	CLIP-seq
MIRT1250927	hsa-miR-4731-5p	CLIP-seq
MIRT1250928	hsa-miR-4780	CLIP-seq
MIRT2301028	hsa-miR-504	CLIP-seq
MIRT2301029	hsa-miR-631	CLIP-seq
MIRT2301030	hsa-miR-650	CLIP-seq
MIRT1250904	hsa-miR-659	CLIP-seq
MIRT2392858	hsa-miR-1267	CLIP-seq
MIRT2456923	hsa-miR-1185	CLIP-seq
MIRT2456924	hsa-miR-1255a	CLIP-seq
MIRT2456925	hsa-miR-1255b	CLIP-seq
MIRT2456926	hsa-miR-3605-5p	CLIP-seq
MIRT2456927	hsa-miR-3679-5p	CLIP-seq
MIRT2456928	hsa-miR-4709-3p	CLIP-seq
MIRT2456929	hsa-miR-765	CLIP-seq
MIRT2456926	hsa-miR-3605-5p	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
NFKB1	Unknown	9360945
RELA	Unknown	9360945

Show/Hide all(19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000976	Function	Transcription regulatory region sequence-specific DNA binding	ISS
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003700	Function	DNA-binding transcription factor activity	ISS
GO:0005634	Component	Nucleus	IDA	9242494
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0006959	Process	Humoral immune response	TAS	9442393
GO:0032755	Process	Positive regulation of interleukin-6 production	ISS
GO:0042795	Process	SnRNA transcription by RNA polymerase II	TAS
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0043565	Function	Sequence-specific DNA binding	IDA	9242494
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS
GO:0098586	Process	Cellular response to virus	ISS
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
164176	9213	ENSG00000028277

Protein

UniProt ID

P09086

Protein name

POU domain, class 2, transcription factor 2 (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2) (Octamer-binding protein 2) (Oct-2) (Octamer-binding transcription factor 2) (OTF-2)

Protein function

Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:2904654, PubMed:7859290). Regulates IL6 expression in B cells with POU2AF1 (By similarity). Regulates transcription in a number of tissues in addition to

PDB

1HDP , 9DZM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00157	Pou	198 → 269	Pou domain - N-terminal to homeobox domain	Domain
PF00046	Homeodomain	298 → 354	Homeodomain	Domain

Sequence

MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS
TKIKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHL
QPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQAVTRPTLPDPHLS
HPQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTT
ISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKK
RTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSA
APMLPSPGKPASYSPHMVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGG
GGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPSTGPGLWWNPAPYQP

Sequence length

479

Interactions

View interactions

	KEGG		Reactome
	Herpes simplex virus 1 infection Lipid and atherosclerosis		RNA polymerase II transcribes snRNA genes

Associated diseases

Show/Hide Causal Diseases (2)

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Prostate cancer, familial	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29892016
Prostate cancer, hereditary	PROSTATE CANCER, HEREDITARY, 1	rs387906327, rs193929331, rs74315365, rs10993994, rs397516896, rs794729219, rs121913349, rs587782641, rs1114167673, rs1597371666, rs2073394466	29892016

Show/Hide Unknown Diseases (1)

Unknown
Disease name	Disease term	dbSNP ID	References
Digestive system neuroendocrine neoplasm	Gastro-enteropancreatic neuroendocrine tumor		29915428

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