POU2AF1 (POU class 2 homeobox associating factor 1)

Gene

• Entrez ID: 5450
• Gene name: POU class 2 homeobox associating factor 1
• Gene symbol: POU2AF1
• Synonyms: BOB1, OBF-1, OBF1, OCAB
• Chromosome: 11
• Chromosome location: 11q23.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT439929	ebv-miR-BART4-5p	HITS-CLIP	22473208
MIRT439928	hsa-miR-210-3p	HITS-CLIP	22473208
MIRT439929	ebv-miR-BART4-5p	HITS-CLIP	22473208
MIRT726902	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT726901	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT726900	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT726899	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT439928	hsa-miR-210-3p	HITS-CLIP	22473208
MIRT1250513	hsa-miR-1252	CLIP-seq
MIRT1250514	hsa-miR-1254	CLIP-seq
MIRT1250515	hsa-miR-1269	CLIP-seq
MIRT1250516	hsa-miR-1269b	CLIP-seq
MIRT1250517	hsa-miR-1275	CLIP-seq
MIRT1250518	hsa-miR-1288	CLIP-seq
MIRT1250519	hsa-miR-1321	CLIP-seq
MIRT1250520	hsa-miR-15a	CLIP-seq
MIRT1250521	hsa-miR-15b	CLIP-seq
MIRT1250522	hsa-miR-16	CLIP-seq
MIRT1250523	hsa-miR-186	CLIP-seq
MIRT1250524	hsa-miR-195	CLIP-seq
MIRT1250525	hsa-miR-2278	CLIP-seq
MIRT1250526	hsa-miR-2392	CLIP-seq
MIRT1250527	hsa-miR-24	CLIP-seq
MIRT1250528	hsa-miR-2467-5p	CLIP-seq
MIRT1250529	hsa-miR-3116	CLIP-seq
MIRT1250530	hsa-miR-3125	CLIP-seq
MIRT1250531	hsa-miR-3133	CLIP-seq
MIRT1250532	hsa-miR-3145-5p	CLIP-seq
MIRT1250533	hsa-miR-3154	CLIP-seq
MIRT1250534	hsa-miR-3173-3p	CLIP-seq
MIRT1250535	hsa-miR-3175	CLIP-seq
MIRT1250536	hsa-miR-3185	CLIP-seq
MIRT1250537	hsa-miR-3202	CLIP-seq
MIRT1250538	hsa-miR-3607-3p	CLIP-seq
MIRT1250539	hsa-miR-3690	CLIP-seq
MIRT1250540	hsa-miR-378	CLIP-seq
MIRT1250541	hsa-miR-378b	CLIP-seq
MIRT1250542	hsa-miR-378c	CLIP-seq
MIRT1250543	hsa-miR-378d	CLIP-seq
MIRT1250544	hsa-miR-378e	CLIP-seq
MIRT1250545	hsa-miR-378f	CLIP-seq
MIRT1250546	hsa-miR-378h	CLIP-seq
MIRT1250547	hsa-miR-378i	CLIP-seq
MIRT1250548	hsa-miR-3916	CLIP-seq
MIRT1250549	hsa-miR-3978	CLIP-seq
MIRT1250550	hsa-miR-422a	CLIP-seq
MIRT1250551	hsa-miR-424	CLIP-seq
MIRT1250552	hsa-miR-4269	CLIP-seq
MIRT1250553	hsa-miR-4271	CLIP-seq
MIRT1250554	hsa-miR-4284	CLIP-seq
MIRT1250555	hsa-miR-4311	CLIP-seq
MIRT1250556	hsa-miR-4419a	CLIP-seq
MIRT1250557	hsa-miR-4428	CLIP-seq
MIRT1250558	hsa-miR-4434	CLIP-seq
MIRT1250559	hsa-miR-4466	CLIP-seq
MIRT1250560	hsa-miR-4476	CLIP-seq
MIRT1250561	hsa-miR-4510	CLIP-seq
MIRT1250562	hsa-miR-4514	CLIP-seq
MIRT1250563	hsa-miR-4515	CLIP-seq
MIRT1250564	hsa-miR-4516	CLIP-seq
MIRT1250565	hsa-miR-4525	CLIP-seq
MIRT1250566	hsa-miR-4533	CLIP-seq
MIRT1250567	hsa-miR-4665-5p	CLIP-seq
MIRT1250568	hsa-miR-4679	CLIP-seq
MIRT1250569	hsa-miR-4692	CLIP-seq
MIRT1250570	hsa-miR-4722-5p	CLIP-seq
MIRT1250571	hsa-miR-4723-5p	CLIP-seq
MIRT1250572	hsa-miR-4725-3p	CLIP-seq
MIRT1250573	hsa-miR-4728-5p	CLIP-seq
MIRT1250574	hsa-miR-4739	CLIP-seq
MIRT1250575	hsa-miR-4740-5p	CLIP-seq
MIRT1250576	hsa-miR-4742-5p	CLIP-seq
MIRT1250577	hsa-miR-4746-3p	CLIP-seq
MIRT1250578	hsa-miR-4747-5p	CLIP-seq
MIRT1250579	hsa-miR-4756-5p	CLIP-seq
MIRT1250580	hsa-miR-4768-3p	CLIP-seq
MIRT1250581	hsa-miR-497	CLIP-seq
MIRT1250582	hsa-miR-508-5p	CLIP-seq
MIRT1250583	hsa-miR-545	CLIP-seq
MIRT1250584	hsa-miR-548aa	CLIP-seq
MIRT1250585	hsa-miR-548p	CLIP-seq
MIRT1250586	hsa-miR-625	CLIP-seq
MIRT1250587	hsa-miR-661	CLIP-seq
MIRT1250588	hsa-miR-675	CLIP-seq
MIRT1250589	hsa-miR-767-5p	CLIP-seq
MIRT1250590	hsa-miR-940	CLIP-seq
MIRT1552504	hsa-miR-3689a-3p	CLIP-seq
MIRT1552505	hsa-miR-3689c	CLIP-seq
MIRT2073956	hsa-miR-1246	CLIP-seq
MIRT1250513	hsa-miR-1252	CLIP-seq
MIRT1250533	hsa-miR-3154	CLIP-seq
MIRT1250534	hsa-miR-3173-3p	CLIP-seq
MIRT2073957	hsa-miR-3921	CLIP-seq
MIRT2073958	hsa-miR-3926	CLIP-seq
MIRT2073959	hsa-miR-3929	CLIP-seq
MIRT2073960	hsa-miR-3974	CLIP-seq
MIRT2073961	hsa-miR-4251	CLIP-seq
MIRT2073962	hsa-miR-4320	CLIP-seq
MIRT2073963	hsa-miR-4329	CLIP-seq
MIRT2073964	hsa-miR-4419b	CLIP-seq
MIRT2073965	hsa-miR-4433	CLIP-seq
MIRT2073966	hsa-miR-4457	CLIP-seq
MIRT2073967	hsa-miR-4459	CLIP-seq
MIRT1250560	hsa-miR-4476	CLIP-seq
MIRT2073968	hsa-miR-4478	CLIP-seq
MIRT1250566	hsa-miR-4533	CLIP-seq
MIRT2073969	hsa-miR-4653-5p	CLIP-seq
MIRT1250568	hsa-miR-4679	CLIP-seq
MIRT2073970	hsa-miR-4714-5p	CLIP-seq
MIRT1250578	hsa-miR-4747-5p	CLIP-seq
MIRT2073971	hsa-miR-4767	CLIP-seq
MIRT1250580	hsa-miR-4768-3p	CLIP-seq
MIRT2073972	hsa-miR-4786-5p	CLIP-seq
MIRT2073973	hsa-miR-4802-3p	CLIP-seq
MIRT2073974	hsa-miR-485-5p	CLIP-seq
MIRT2073975	hsa-miR-490-5p	CLIP-seq
MIRT2073976	hsa-miR-513b	CLIP-seq
MIRT2073977	hsa-miR-548s	CLIP-seq
MIRT2073978	hsa-miR-617	CLIP-seq
MIRT2073979	hsa-miR-624	CLIP-seq
MIRT2300879	hsa-miR-122	CLIP-seq
MIRT2300880	hsa-miR-125a-3p	CLIP-seq
MIRT2300881	hsa-miR-1285	CLIP-seq
MIRT2300882	hsa-miR-2116	CLIP-seq
MIRT1250527	hsa-miR-24	CLIP-seq
MIRT1250532	hsa-miR-3145-5p	CLIP-seq
MIRT2300883	hsa-miR-3183	CLIP-seq
MIRT2300884	hsa-miR-3187-5p	CLIP-seq
MIRT2300885	hsa-miR-3620	CLIP-seq
MIRT2300886	hsa-miR-3622b-5p	CLIP-seq
MIRT2073958	hsa-miR-3926	CLIP-seq
MIRT2300887	hsa-miR-3934	CLIP-seq
MIRT2073960	hsa-miR-3974	CLIP-seq
MIRT2073961	hsa-miR-4251	CLIP-seq
MIRT1250554	hsa-miR-4284	CLIP-seq
MIRT2300888	hsa-miR-4287	CLIP-seq
MIRT2300889	hsa-miR-4300	CLIP-seq
MIRT2073965	hsa-miR-4433	CLIP-seq
MIRT2073966	hsa-miR-4457	CLIP-seq
MIRT2073967	hsa-miR-4459	CLIP-seq
MIRT1250559	hsa-miR-4466	CLIP-seq
MIRT2300890	hsa-miR-4469	CLIP-seq
MIRT1250566	hsa-miR-4533	CLIP-seq
MIRT2300891	hsa-miR-4645-5p	CLIP-seq
MIRT2300892	hsa-miR-4673	CLIP-seq
MIRT2300893	hsa-miR-4676-5p	CLIP-seq
MIRT2300894	hsa-miR-4677-5p	CLIP-seq
MIRT1250568	hsa-miR-4679	CLIP-seq
MIRT2300895	hsa-miR-4685-3p	CLIP-seq
MIRT2300896	hsa-miR-4700-3p	CLIP-seq
MIRT2300897	hsa-miR-4713-5p	CLIP-seq
MIRT2073970	hsa-miR-4714-5p	CLIP-seq
MIRT2300898	hsa-miR-4723-3p	CLIP-seq
MIRT1250577	hsa-miR-4746-3p	CLIP-seq
MIRT2300899	hsa-miR-4755-3p	CLIP-seq
MIRT2073971	hsa-miR-4767	CLIP-seq
MIRT1250580	hsa-miR-4768-3p	CLIP-seq
MIRT2073972	hsa-miR-4786-5p	CLIP-seq
MIRT1250582	hsa-miR-508-5p	CLIP-seq
MIRT2300900	hsa-miR-510	CLIP-seq
MIRT2073976	hsa-miR-513b	CLIP-seq
MIRT2073977	hsa-miR-548s	CLIP-seq
MIRT2300901	hsa-miR-575	CLIP-seq
MIRT2300902	hsa-miR-612	CLIP-seq
MIRT2073979	hsa-miR-624	CLIP-seq
MIRT1250587	hsa-miR-661	CLIP-seq
MIRT1250588	hsa-miR-675	CLIP-seq
MIRT2300903	hsa-miR-764	CLIP-seq
MIRT2300904	hsa-miR-766	CLIP-seq
MIRT1250589	hsa-miR-767-5p	CLIP-seq
MIRT2300905	hsa-miR-920	CLIP-seq
MIRT2456901	hsa-miR-10a	CLIP-seq
MIRT2456902	hsa-miR-10b	CLIP-seq
MIRT2300879	hsa-miR-122	CLIP-seq
MIRT2300881	hsa-miR-1285	CLIP-seq
MIRT2300884	hsa-miR-3187-5p	CLIP-seq
MIRT2456903	hsa-miR-34b	CLIP-seq
MIRT2456904	hsa-miR-3545-3p	CLIP-seq
MIRT2456905	hsa-miR-3614-5p	CLIP-seq
MIRT2300885	hsa-miR-3620	CLIP-seq
MIRT2300886	hsa-miR-3622b-5p	CLIP-seq
MIRT2456906	hsa-miR-3672	CLIP-seq
MIRT1552504	hsa-miR-3689a-3p	CLIP-seq
MIRT1552505	hsa-miR-3689c	CLIP-seq
MIRT2456907	hsa-miR-412	CLIP-seq
MIRT1250552	hsa-miR-4269	CLIP-seq
MIRT1250562	hsa-miR-4514	CLIP-seq
MIRT2300891	hsa-miR-4645-5p	CLIP-seq
MIRT2456908	hsa-miR-4662a-5p	CLIP-seq
MIRT2300892	hsa-miR-4673	CLIP-seq
MIRT2300893	hsa-miR-4676-5p	CLIP-seq
MIRT2456909	hsa-miR-4684-5p	CLIP-seq
MIRT2456910	hsa-miR-4690-3p	CLIP-seq
MIRT1250569	hsa-miR-4692	CLIP-seq
MIRT1250570	hsa-miR-4722-5p	CLIP-seq
MIRT1250576	hsa-miR-4742-5p	CLIP-seq
MIRT2300899	hsa-miR-4755-3p	CLIP-seq
MIRT1250580	hsa-miR-4768-3p	CLIP-seq
MIRT1250582	hsa-miR-508-5p	CLIP-seq
MIRT2456911	hsa-miR-548c-3p	CLIP-seq
MIRT2300901	hsa-miR-575	CLIP-seq
MIRT2300902	hsa-miR-612	CLIP-seq
MIRT1250587	hsa-miR-661	CLIP-seq
MIRT2300904	hsa-miR-766	CLIP-seq
MIRT1250590	hsa-miR-940	CLIP-seq
MIRT2300886	hsa-miR-3622b-5p	CLIP-seq
MIRT2300891	hsa-miR-4645-5p	CLIP-seq
MIRT2456908	hsa-miR-4662a-5p	CLIP-seq
MIRT2300892	hsa-miR-4673	CLIP-seq
MIRT2300893	hsa-miR-4676-5p	CLIP-seq
MIRT2456909	hsa-miR-4684-5p	CLIP-seq
MIRT2300899	hsa-miR-4755-3p	CLIP-seq
MIRT2456911	hsa-miR-548c-3p	CLIP-seq
MIRT2300901	hsa-miR-575	CLIP-seq
MIRT2597647	hsa-miR-140-3p	CLIP-seq
MIRT2597648	hsa-miR-182	CLIP-seq
MIRT2597649	hsa-miR-3619-3p	CLIP-seq
MIRT2300886	hsa-miR-3622b-5p	CLIP-seq
MIRT2597650	hsa-miR-3663-5p	CLIP-seq
MIRT2597651	hsa-miR-3689d	CLIP-seq
MIRT2073965	hsa-miR-4433	CLIP-seq
MIRT2073967	hsa-miR-4459	CLIP-seq
MIRT2597652	hsa-miR-4492	CLIP-seq
MIRT2597653	hsa-miR-4498	CLIP-seq
MIRT2597654	hsa-miR-4508	CLIP-seq
MIRT2597655	hsa-miR-4641	CLIP-seq
MIRT2300891	hsa-miR-4645-5p	CLIP-seq
MIRT2456908	hsa-miR-4662a-5p	CLIP-seq
MIRT2300892	hsa-miR-4673	CLIP-seq
MIRT2300893	hsa-miR-4676-5p	CLIP-seq
MIRT2456909	hsa-miR-4684-5p	CLIP-seq
MIRT2300899	hsa-miR-4755-3p	CLIP-seq
MIRT1250580	hsa-miR-4768-3p	CLIP-seq
MIRT2597656	hsa-miR-4776-5p	CLIP-seq
MIRT2597657	hsa-miR-499a-5p	CLIP-seq
MIRT2597658	hsa-miR-501-3p	CLIP-seq
MIRT2597659	hsa-miR-502-3p	CLIP-seq
MIRT2456911	hsa-miR-548c-3p	CLIP-seq
MIRT2300901	hsa-miR-575	CLIP-seq
MIRT2597660	hsa-miR-626	CLIP-seq
MIRT2597661	hsa-miR-762	CLIP-seq
MIRT2300886	hsa-miR-3622b-5p	CLIP-seq
MIRT2456906	hsa-miR-3672	CLIP-seq
MIRT1250560	hsa-miR-4476	CLIP-seq
MIRT1250566	hsa-miR-4533	CLIP-seq
MIRT2300891	hsa-miR-4645-5p	CLIP-seq
MIRT2456908	hsa-miR-4662a-5p	CLIP-seq
MIRT2300892	hsa-miR-4673	CLIP-seq
MIRT2300893	hsa-miR-4676-5p	CLIP-seq
MIRT2456909	hsa-miR-4684-5p	CLIP-seq
MIRT2300899	hsa-miR-4755-3p	CLIP-seq
MIRT2456911	hsa-miR-548c-3p	CLIP-seq
MIRT2300901	hsa-miR-575	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
POU2F1	Unknown	11847120

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002314	Process	Germinal center B cell differentiation	ISS
GO:0003677	Function	DNA binding	IEA
GO:0003712	Function	Transcription coregulator activity	TAS	7859290
GO:0003713	Function	Transcription coactivator activity	IBA	21873635
GO:0003713	Function	Transcription coactivator activity	IMP	11380252
GO:0003713	Function	Transcription coactivator activity	ISS
GO:0005515	Function	Protein binding	IPI	11483518, 32296183
GO:0006959	Process	Humoral immune response	TAS	7859290
GO:0032755	Process	Positive regulation of interleukin-6 production	ISS
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA	21873635
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IGI	11380252
GO:0090575	Component	RNA polymerase II transcription regulator complex	IBA	21873635
GO:0090575	Component	RNA polymerase II transcription regulator complex	IDA	11380252
GO:0090575	Component	RNA polymerase II transcription regulator complex	IMP	10329190
GO:0098586	Process	Cellular response to virus	ISS

Other IDs

• MIM: 601206
• HGNC: 9211
• e!Ensembl: ENSG00000110777

Protein

• UniProt ID: Q16633
• Protein name: POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (BOB-1) (OCA-B) (OCT-binding factor 1)
• Protein function: Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2 (PubMed:7859290). It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2 (PubMed:7779176). It recognizes th
• PDB: 1CQT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09310	PD-C2-AF1	7 → 255	POU domain, class 2, associating factor 1	Domain

• Sequence:

  MLWQKPTAPEQAPAPARPYQGVRVKEPVKELLRRKRGHASSGAAPAPTAVVLPHQPLATY
  TTVGPSCLDMEGSVSAVTEEAALCAGWLSQPTPATLQPLAPWTPYTEYVPHEAVSCPYSA
  DMYVQPVCPSYTVVGPSSVLTYASPPLITNVTTRSSATPAVGPPLEGPEHQAPLTYFPWP
  QPLSTLPTSTLQYQPPAPALPGPQFVQLPISIPEPVLQDMEDPRRAASSLTIDKLLLEEE
  DSDAYALNHTLSVEGF

• Sequence length: 256

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Liver failure	Liver Failure	rs118203990, rs118203991, rs118203992, rs387907022, rs201861847, rs796065037, rs759315662, rs368196005, rs796052121, rs369437593, rs367683258, rs766314948, rs368085185, rs770446752, rs753039116, rs776797592, rs1490906786, rs1562849964, rs759960319, rs776597537, rs375350359, rs1573008071, rs1601977105, rs1174791046, rs1019313682
Osteoporosis	Osteoporosis	rs72658152, rs72667023, rs587776916, rs72656370, rs768615287

Unknown
Disease name	Disease term	dbSNP ID	References
Biliary cholangitis	Primary biliary cholangitis
Biliary cirrhosis	Biliary cirrhosis, Primary biliary cirrhosis		23000144, 28062665, 23000144
Celiac disease	Celiac Disease	rs2305764, rs35218876
Cirrhosis	Cirrhosis	rs119465999, rs144369314, rs8056684, rs112053857, rs75998507
Conjugated hyperbilirubinemia	Conjugated hyperbilirubinemia
Dermatographic urticaria	Dermatographic urticaria
Gastrointestinal inflammation	Gastrointestinal inflammation
Hodgkin disease	Hodgkin Disease		30194254
Hypoalbuminemia	Hypoalbuminemia
Liver carcinoma	Liver carcinoma
Liver fibrosis	Fibrosis, Liver
Portal hypertension	Portal Hypertension