SMOX (spermine oxidase)

Gene

• Entrez ID: 54498
• Gene name: Spermine oxidase
• Gene symbol: SMOX
• Synonyms: C20orf16, PAO, PAO-1, PAO1, PAOH, PAOH1, SMO
• Chromosome: 20
• Chromosome location: 20p13
• Summary: Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, an

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT040277	hsa-miR-615-3p	CLASH	23622248
MIRT457730	hsa-miR-370-5p	PAR-CLIP	23592263
MIRT457729	hsa-miR-3677-5p	PAR-CLIP	23592263
MIRT457728	hsa-miR-3135b	PAR-CLIP	23592263
MIRT457727	hsa-miR-3689d	PAR-CLIP	23592263
MIRT457726	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT457725	hsa-miR-6822-3p	PAR-CLIP	23592263
MIRT457724	hsa-miR-760	PAR-CLIP	23592263
MIRT457722	hsa-miR-3652	PAR-CLIP	23592263
MIRT457723	hsa-miR-4430	PAR-CLIP	23592263
MIRT457721	hsa-miR-4727-3p	PAR-CLIP	23592263
MIRT457720	hsa-miR-4460	PAR-CLIP	23592263
MIRT457719	hsa-miR-8057	PAR-CLIP	23592263
MIRT457730	hsa-miR-370-5p	PAR-CLIP	23592263
MIRT457729	hsa-miR-3677-5p	PAR-CLIP	23592263
MIRT457728	hsa-miR-3135b	PAR-CLIP	23592263
MIRT457727	hsa-miR-3689d	PAR-CLIP	23592263
MIRT457726	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT457725	hsa-miR-6822-3p	PAR-CLIP	23592263
MIRT457724	hsa-miR-760	PAR-CLIP	23592263
MIRT457722	hsa-miR-3652	PAR-CLIP	23592263
MIRT457723	hsa-miR-4430	PAR-CLIP	23592263
MIRT457721	hsa-miR-4727-3p	PAR-CLIP	23592263
MIRT457720	hsa-miR-4460	PAR-CLIP	23592263
MIRT457719	hsa-miR-8057	PAR-CLIP	23592263
MIRT1373807	hsa-miR-139-5p	CLIP-seq
MIRT1373808	hsa-miR-4668-3p	CLIP-seq
MIRT1373809	hsa-miR-4797-5p	CLIP-seq
MIRT1373810	hsa-miR-500a	CLIP-seq
MIRT1373811	hsa-miR-501-5p	CLIP-seq
MIRT1373812	hsa-miR-548c-3p	CLIP-seq
MIRT1373813	hsa-miR-577	CLIP-seq
MIRT1373814	hsa-miR-338-3p	CLIP-seq
MIRT1373815	hsa-miR-4257	CLIP-seq
MIRT1373816	hsa-miR-4530	CLIP-seq
MIRT1373817	hsa-miR-4713-3p	CLIP-seq
MIRT1373818	hsa-miR-95	CLIP-seq
MIRT2440578	hsa-miR-1178	CLIP-seq
MIRT2440579	hsa-miR-1224-3p	CLIP-seq
MIRT2440580	hsa-miR-1254	CLIP-seq
MIRT2440581	hsa-miR-3116	CLIP-seq
MIRT2440582	hsa-miR-4254	CLIP-seq
MIRT1373815	hsa-miR-4257	CLIP-seq
MIRT2440583	hsa-miR-4434	CLIP-seq
MIRT2440584	hsa-miR-4485	CLIP-seq
MIRT2440585	hsa-miR-4516	CLIP-seq
MIRT2440586	hsa-miR-4531	CLIP-seq
MIRT2440587	hsa-miR-767-3p	CLIP-seq
MIRT1373818	hsa-miR-95	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006596	Process	Polyamine biosynthetic process	TAS
GO:0006598	Process	Polyamine catabolic process	IDA	12477380
GO:0016491	Function	Oxidoreductase activity	IBA	21873635
GO:0031965	Component	Nuclear membrane	IDA
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0046208	Process	Spermine catabolic process	IEA
GO:0046592	Function	Polyamine oxidase activity	IBA	21873635
GO:0046592	Function	Polyamine oxidase activity	IDA	12477380
GO:0052894	Function	Norspermine:oxygen oxidoreductase activity	IEA
GO:0052895	Function	N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity	IEA
GO:0052901	Function	Spermine:oxygen oxidoreductase (spermidine-forming) activity	TAS

Other IDs

• MIM: 615854
• HGNC: 15862
• e!Ensembl: ENSG00000088826

Protein

• UniProt ID: Q9NWM0
• Protein name: Spermine oxidase (EC 1.5.3.16) (Polyamine oxidase 1) (PAO-1) (PAOh1)
• Protein function: Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important
• PDB: 7OXL, 7OY0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01593	Amino_oxidase	34 → 277	Flavin containing amine oxidoreductase	Domain
  PF01593	Amino_oxidase	304 → 544	Flavin containing amine oxidoreductase	Domain

• Sequence:

  MQSCESSGDSADDPLSRGLRRRGQPRVVVIGAGLAGLAAAKALLEQGFTDVTVLEASSHI
  GGRVQSVKLGHATFELGATWIHGSHGNPIYHLAEANGLLEETTDGERSVGRISLYSKNGV
  ACYLTNHGRRIPKDVVEEFSDLYNEVYNLTQEFFRHDKPVNAESQNSVGVFTREEVRNRI
  RNDPDDPEATKRLKLAMIQQYLKVESCESSSHSMDEVSLSAFGEWTEIPGAHHIIPSGFM
  RVVELLAEGIPAHVIQLGKPVRCIHWDQASARPRGPEIEPRGEGDHNHDTGEGGQGGEEP
  RGGRWDEDEQWSVVVECEDCELIPADHVIVTVSLGVLKRQYTSFFRPGLPTEKVAAIHRL
  GIGTTDKIFLEFEEPFWGPECNSLQFVWEDEAESHTLTYPPELWYRKICGFDVLYPPERY
  GHVLSGWICGEEALVMEKCDDEAVAEICTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRG
  SYSYTQVGSSGADVEKLAKPLPYTESSKTAPMQVLFSGEATHRKYYSTTHGALLSGQREA
  ARLIEMYRDLFQQGT

• Sequence length: 555

Pathways

KEGG:

Arginine and proline metabolism
beta-Alanine metabolism
Metabolic pathways

Reactome:

PAOs oxidise polyamines to amines
Interconversion of polyamines

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243

Unknown
Disease name	Disease term	dbSNP ID	References
Cerebral infraction	Infarction, Middle Cerebral Artery		30576531
Cerebral thrombosis	Middle Cerebral Artery Thrombosis		30576531
Dementia	Dementia		25188341
Mood disorder	Mood Disorders		21152090
Stroke	Cerebrovascular accident, Acute Cerebrovascular Accidents		16269634