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CYCS (cytochrome c, somatic)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
54205
Gene nameGene Name - the full gene name approved by the HGNC.
Cytochrome c, somatic
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
CYCS
SynonymsGene synonyms aliases
CYC, HCS, THC4
ChromosomeChromosome number
7
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7p15.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and tran
SNPsSNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs121918552 C>T Pathogenic, likely-pathogenic Missense variant, coding sequence variant
rs886037737 A>G Pathogenic Missense variant, coding sequence variant
rs1562515878 TTT>- Pathogenic Coding sequence variant, inframe deletion
rs1583394629 G>C Likely-pathogenic Coding sequence variant, missense variant
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT025976 hsa-miR-148a-3p Sequencing 20371350
MIRT031466 hsa-miR-16-5p Proteomics 18668040
MIRT044075 hsa-miR-361-5p CLASH 23622248
MIRT038787 hsa-miR-93-3p CLASH 23622248
MIRT036158 hsa-miR-320c CLASH 23622248
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000159 Component Protein phosphatase type 2A complex TAS 8206937
GO:0004722 Function Protein serine/threonine phosphatase activity TAS 8206937
GO:0005515 Function Protein binding IPI 9267021, 10206961, 25241761, 25416956, 25595453, 25910212, 32296183, 32814053
GO:0005634 Component Nucleus HDA 21630459
GO:0005634 Component Nucleus IDA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P99999
Protein name Cytochrome c
Protein function Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase compl
PDB 1J3S , 2N3Y , 2N9I , 2N9J , 3NWV , 3ZCF , 3ZOO , 5EXQ , 5O10 , 5TY3 , 6DUJ , 6ECJ , 6XNK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00034 Cytochrom_C
4 103
Cytochrome c
Domain
Sequence
Sequence length 105
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Oxidative phosphorylation
Metabolic pathways
Platinum drug resistance
p53 signaling pathway
Apoptosis
Apoptosis - multiple species
Non-alcoholic fatty liver disease
Alzheimer disease
Parkinson disease
Amyotrophic lateral sclerosis
Huntington disease
Spinocerebellar ataxia
Prion disease
Pathways of neurodegeneration - multiple diseases
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Legionellosis
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Measles
Human cytomegalovirus infection
Influenza A
Kaposi sarcoma-associated herpesvirus infection
Herpes simplex virus 1 infection
Epstein-Barr virus infection
Human immunodeficiency virus 1 infection
Pathways in cancer
Colorectal cancer
Small cell lung cancer
Viral myocarditis
Lipid and atherosclerosis
  Release of apoptotic factors from the mitochondria
Formation of apoptosome
Activation of caspases through apoptosome-mediated cleavage
Transcriptional activation of mitochondrial biogenesis
Detoxification of Reactive Oxygen Species
TP53 Regulates Metabolic Genes
Respiratory electron transport
Regulation of the apoptosome activity
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Alzheimer disease Alzheimer`s Disease rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs145518263, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316 23535033
Obesity Obesity rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840 16317704
Thrombocytopenia Thrombocytopenia 4 rs121908064, rs104894816, rs132630269, rs132630270, rs132630273, rs5030764, rs80338831, rs28928907, rs121909752, rs121918552, rs863223318, rs267607337, rs587778516, rs146249964, rs587776456, rs724159947, rs724159946, rs724159945, rs886037737, rs786205155, rs879255268, rs782290433, rs1057517845, rs886039451, rs1060505056, rs745672593, rs1064797085, rs1555144911, rs139265251, rs1557007312, rs1569061762, rs1569061768, rs1060502579, rs1569494025, rs1562515878, rs1569008655, rs774867424, rs1589393759, rs1589393799, rs1589393809, rs1591749480, rs1594758038, rs1594758046, rs747559032, rs1597638598, rs1597638681, rs1597638745, rs1597638753, rs1597639057, rs1601239459, rs121912499, rs1569061786, rs1601248210, rs536874549, rs1601248859, rs1360071443, rs1577005203, rs1583394629, rs1591750551, rs1569084106, rs1601515718, rs1589257502, rs1602180058 18345000, 24326104, 30051457
Unknown
Disease name Disease term dbSNP ID References
Cerebral ischemia Brain Ischemia, Brain Stem Ischemia, Transient, Transient Cerebral Ischemia 11756504, 11333366
Fatty liver Fatty Liver, Steatohepatitis 10860543
Thrombocytopenia with normal platelets Autosomal thrombocytopenia with normal platelets
Transient ischemic attack Transient Ischemic Attack, Posterior Circulation Transient Ischemic Attack, Carotid Circulation Transient Ischemic Attack, Transient Ischemic Attack, Vertebrobasilar Circulation, Crescendo Transient Ischemic Attacks, Transient Ischemic Attack, Anterior Circulation 11333366

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