PELO (pelota mRNA surveillance and ribosome rescue factor)

Gene

• Entrez ID: 53918
• Gene name: Pelota mRNA surveillance and ribosome rescue factor
• Gene symbol: PELO
• Synonyms: CGI-17, PRO1770
• Chromosome: 5
• Chromosome location: 5q11.2
• Summary: This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT031869	hsa-miR-16-5p	Proteomics	18668040
MIRT050281	hsa-miR-25-3p	CLASH	23622248
MIRT046857	hsa-miR-221-3p	CLASH	23622248
MIRT641445	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT641444	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT641443	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT641442	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT641441	hsa-miR-331-5p	HITS-CLIP	23824327
MIRT641440	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT641439	hsa-miR-6509-5p	HITS-CLIP	23824327
MIRT641437	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT641438	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT641436	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT641445	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT641444	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT641443	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT641442	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT641441	hsa-miR-331-5p	HITS-CLIP	23824327
MIRT641440	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT641439	hsa-miR-6509-5p	HITS-CLIP	23824327
MIRT641437	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT641438	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT641436	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT471347	hsa-miR-561-3p	PAR-CLIP	23592263
MIRT471346	hsa-miR-548ao-3p	PAR-CLIP	23592263
MIRT471345	hsa-miR-6768-5p	PAR-CLIP	23592263
MIRT471344	hsa-miR-34c-3p	PAR-CLIP	23592263
MIRT471343	hsa-miR-4999-3p	PAR-CLIP	23592263
MIRT641445	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT641444	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT641443	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT641442	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT641441	hsa-miR-331-5p	HITS-CLIP	23824327
MIRT641440	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT641439	hsa-miR-6509-5p	HITS-CLIP	23824327
MIRT641437	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT641438	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT641436	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT641445	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT641444	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT641443	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT641442	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT641441	hsa-miR-331-5p	HITS-CLIP	23824327
MIRT641440	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT641439	hsa-miR-6509-5p	HITS-CLIP	23824327
MIRT641437	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT641438	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT641436	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT471347	hsa-miR-561-3p	PAR-CLIP	23592263
MIRT471346	hsa-miR-548ao-3p	PAR-CLIP	23592263
MIRT471345	hsa-miR-6768-5p	PAR-CLIP	23592263
MIRT471344	hsa-miR-34c-3p	PAR-CLIP	23592263
MIRT471343	hsa-miR-4999-3p	PAR-CLIP	23592263
MIRT1224887	hsa-miR-106a	CLIP-seq
MIRT1224888	hsa-miR-106b	CLIP-seq
MIRT1224889	hsa-miR-1183	CLIP-seq
MIRT1224890	hsa-miR-1270	CLIP-seq
MIRT1224891	hsa-miR-132	CLIP-seq
MIRT1224892	hsa-miR-17	CLIP-seq
MIRT1224893	hsa-miR-194	CLIP-seq
MIRT1224894	hsa-miR-20a	CLIP-seq
MIRT1224895	hsa-miR-20b	CLIP-seq
MIRT1224896	hsa-miR-212	CLIP-seq
MIRT1224897	hsa-miR-216a	CLIP-seq
MIRT1224898	hsa-miR-216b	CLIP-seq
MIRT1224899	hsa-miR-3160-5p	CLIP-seq
MIRT1224900	hsa-miR-3613-3p	CLIP-seq
MIRT1224901	hsa-miR-3617	CLIP-seq
MIRT1224902	hsa-miR-4251	CLIP-seq
MIRT1224903	hsa-miR-4280	CLIP-seq
MIRT1224904	hsa-miR-4426	CLIP-seq
MIRT1224905	hsa-miR-4428	CLIP-seq
MIRT1224906	hsa-miR-4457	CLIP-seq
MIRT1224907	hsa-miR-4496	CLIP-seq
MIRT1224908	hsa-miR-4647	CLIP-seq
MIRT1224909	hsa-miR-4652-3p	CLIP-seq
MIRT1224910	hsa-miR-4662a-5p	CLIP-seq
MIRT1224911	hsa-miR-4662b	CLIP-seq
MIRT1224912	hsa-miR-4663	CLIP-seq
MIRT1224913	hsa-miR-4683	CLIP-seq
MIRT1224914	hsa-miR-4728-3p	CLIP-seq
MIRT1224915	hsa-miR-513b	CLIP-seq
MIRT1224916	hsa-miR-519d	CLIP-seq
MIRT1224917	hsa-miR-539	CLIP-seq
MIRT1224918	hsa-miR-548c-3p	CLIP-seq
MIRT1224919	hsa-miR-548t	CLIP-seq
MIRT1224920	hsa-miR-605	CLIP-seq
MIRT1224921	hsa-miR-620	CLIP-seq
MIRT1224922	hsa-miR-641	CLIP-seq
MIRT1224923	hsa-miR-651	CLIP-seq
MIRT1224924	hsa-miR-93	CLIP-seq
MIRT1224889	hsa-miR-1183	CLIP-seq
MIRT1224891	hsa-miR-132	CLIP-seq
MIRT1224893	hsa-miR-194	CLIP-seq
MIRT1224896	hsa-miR-212	CLIP-seq
MIRT2065603	hsa-miR-330-3p	CLIP-seq
MIRT1224902	hsa-miR-4251	CLIP-seq
MIRT2065604	hsa-miR-4302	CLIP-seq
MIRT2065605	hsa-miR-4422	CLIP-seq
MIRT1224906	hsa-miR-4457	CLIP-seq
MIRT2065606	hsa-miR-452	CLIP-seq
MIRT1224912	hsa-miR-4663	CLIP-seq
MIRT2065607	hsa-miR-4676-3p	CLIP-seq
MIRT1224914	hsa-miR-4728-3p	CLIP-seq
MIRT1224915	hsa-miR-513b	CLIP-seq
MIRT1224917	hsa-miR-539	CLIP-seq
MIRT2065608	hsa-miR-548a-3p	CLIP-seq
MIRT2065609	hsa-miR-548e	CLIP-seq
MIRT2065610	hsa-miR-548f	CLIP-seq
MIRT2065611	hsa-miR-548g	CLIP-seq
MIRT2065612	hsa-miR-607	CLIP-seq
MIRT1224923	hsa-miR-651	CLIP-seq
MIRT2293427	hsa-miR-186	CLIP-seq
MIRT2293428	hsa-miR-3133	CLIP-seq
MIRT2293429	hsa-miR-590-3p	CLIP-seq
MIRT1224903	hsa-miR-4280	CLIP-seq
MIRT2456251	hsa-miR-4705	CLIP-seq
MIRT2456252	hsa-miR-4719	CLIP-seq
MIRT1224889	hsa-miR-1183	CLIP-seq
MIRT1224891	hsa-miR-132	CLIP-seq
MIRT1224893	hsa-miR-194	CLIP-seq
MIRT1224896	hsa-miR-212	CLIP-seq
MIRT2591507	hsa-miR-219-5p	CLIP-seq
MIRT1224902	hsa-miR-4251	CLIP-seq
MIRT2591508	hsa-miR-4261	CLIP-seq
MIRT1224906	hsa-miR-4457	CLIP-seq
MIRT1224907	hsa-miR-4496	CLIP-seq
MIRT1224912	hsa-miR-4663	CLIP-seq
MIRT1224914	hsa-miR-4728-3p	CLIP-seq
MIRT2591509	hsa-miR-4731-3p	CLIP-seq
MIRT2591510	hsa-miR-4782-3p	CLIP-seq
MIRT2591511	hsa-miR-4801	CLIP-seq
MIRT1224915	hsa-miR-513b	CLIP-seq
MIRT1224917	hsa-miR-539	CLIP-seq
MIRT2293429	hsa-miR-590-3p	CLIP-seq
MIRT1224923	hsa-miR-651	CLIP-seq
MIRT1224889	hsa-miR-1183	CLIP-seq
MIRT1224891	hsa-miR-132	CLIP-seq
MIRT1224893	hsa-miR-194	CLIP-seq
MIRT1224896	hsa-miR-212	CLIP-seq
MIRT2591507	hsa-miR-219-5p	CLIP-seq
MIRT1224902	hsa-miR-4251	CLIP-seq
MIRT2591508	hsa-miR-4261	CLIP-seq
MIRT1224906	hsa-miR-4457	CLIP-seq
MIRT1224907	hsa-miR-4496	CLIP-seq
MIRT1224912	hsa-miR-4663	CLIP-seq
MIRT1224914	hsa-miR-4728-3p	CLIP-seq
MIRT2591509	hsa-miR-4731-3p	CLIP-seq
MIRT2591510	hsa-miR-4782-3p	CLIP-seq
MIRT2591511	hsa-miR-4801	CLIP-seq
MIRT1224915	hsa-miR-513b	CLIP-seq
MIRT1224917	hsa-miR-539	CLIP-seq
MIRT2293429	hsa-miR-590-3p	CLIP-seq
MIRT1224923	hsa-miR-651	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SP1	Unknown	17669516

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001833	Process	Inner cell mass cell proliferation	IEA
GO:0004519	Function	Endonuclease activity	IEA
GO:0005515	Function	Protein binding	IPI	20406461, 25277244, 25416956, 31515488, 32296183, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0007049	Process	Cell cycle	IEA
GO:0007492	Process	Endoderm development	IEA
GO:0019827	Process	Stem cell population maintenance	IEA
GO:0030513	Process	Positive regulation of BMP signaling pathway	IEA
GO:0032790	Process	Ribosome disassembly	IBA	21873635
GO:0046872	Function	Metal ion binding	IEA
GO:0051276	Process	Chromosome organization	IEA
GO:0051301	Process	Cell division	IEA
GO:0060231	Process	Mesenchymal to epithelial transition	IEA
GO:0070481	Process	Nuclear-transcribed mRNA catabolic process, non-stop decay	IEA
GO:0070651	Process	Nonfunctional rRNA decay	IBA	21873635
GO:0070966	Process	Nuclear-transcribed mRNA catabolic process, no-go decay	IBA	21873635
GO:0071025	Process	RNA surveillance	IEA
GO:0090305	Process	Nucleic acid phosphodiester bond hydrolysis	IEA

Other IDs

• MIM: 605757
• HGNC: 8829
• e!Ensembl: ENSG00000152684

Protein

• UniProt ID: Q9BRX2
• Protein name: Protein pelota homolog (hPelota) (Protein Dom34 homolog)
• Protein function: Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27543824, PubMed:27863242). In the Pelota-HBS1L complex, PELO recognizes ribo
• PDB: 1X52, 5EO3, 5LZW, 5LZX, 5LZY, 5LZZ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03463	eRF1_1	1 → 129	eRF1 domain 1	Domain
  PF03464	eRF1_2	136 → 268	eRF1 domain 2	Domain
  PF03465	eRF1_3	271 → 370	eRF1 domain 3	Domain

• Sequence:

  MKLVRKNIEKDNAGQVTLVPEEPEDMWHTYNLVQVGDSLRASTIRKVQTESSTGSVGSNR
  VRTTLTLCVEAIDFDSQACQLRVKGTNIQENEYVKMGAYHTIELEPNRQFTLAKKQWDSV
  VLERIEQACDPAWSADVAAVVMQEGLAHICLVTPSMTLTRAKVEVNIPRKRKGNCSQHDR
  ALERFYEQVVQAIQRHIHFDVVKCILVASPGFVREQFCDYLFQQAVKTDNKLLLENRSKF
  LQVHASSGHKYSLKEALCDPTVASRLSDTKAAGEVKALDDFYKMLQHEPDRAFYGLKQVE
  KANEAMAIDTLLISDELFRHQDVATRSRYVRLVDSVKENAGTVRIFSSLHVSGEQLSQLT
  GVAAILRFPVPELSDQEGDSSSEED

• Sequence length: 385

Pathways

KEGG:

mRNA surveillance pathway

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	30718926