RAB4B (RAB4B, member RAS oncogene family)

Gene

• Entrez ID: 53916
• Gene name: RAB4B, member RAS oncogene family
• Gene symbol: RAB4B
• Synonyms: -
• Chromosome: 19
• Chromosome location: 19q13.2
• Summary: RAB proteins, such as RAB4B, are members of the RAS superfamily of small GTPases that are involved in vesicular trafficking (He et al., 2002 [PubMed 12450215]).[supplied by OMIM, Aug 2009]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016915	hsa-miR-335-5p	Microarray	18185580
MIRT1284997	hsa-miR-1197	CLIP-seq
MIRT1284998	hsa-miR-1258	CLIP-seq
MIRT1284999	hsa-miR-1266	CLIP-seq
MIRT1285000	hsa-miR-15a	CLIP-seq
MIRT1285001	hsa-miR-15b	CLIP-seq
MIRT1285002	hsa-miR-16	CLIP-seq
MIRT1285003	hsa-miR-195	CLIP-seq
MIRT1285004	hsa-miR-1972	CLIP-seq
MIRT1285005	hsa-miR-214	CLIP-seq
MIRT1285006	hsa-miR-24	CLIP-seq
MIRT1285007	hsa-miR-30a	CLIP-seq
MIRT1285008	hsa-miR-30b	CLIP-seq
MIRT1285009	hsa-miR-30c	CLIP-seq
MIRT1285010	hsa-miR-30d	CLIP-seq
MIRT1285011	hsa-miR-30e	CLIP-seq
MIRT1285012	hsa-miR-3115	CLIP-seq
MIRT1285013	hsa-miR-3117-3p	CLIP-seq
MIRT1285014	hsa-miR-3122	CLIP-seq
MIRT1285015	hsa-miR-3125	CLIP-seq
MIRT1285016	hsa-miR-3127-3p	CLIP-seq
MIRT1285017	hsa-miR-3127-5p	CLIP-seq
MIRT1285018	hsa-miR-3155	CLIP-seq
MIRT1285019	hsa-miR-3155b	CLIP-seq
MIRT1285020	hsa-miR-3170	CLIP-seq
MIRT1285021	hsa-miR-3179	CLIP-seq
MIRT1285022	hsa-miR-3189-5p	CLIP-seq
MIRT1285023	hsa-miR-3202	CLIP-seq
MIRT1285024	hsa-miR-3619-5p	CLIP-seq
MIRT1285025	hsa-miR-3663-5p	CLIP-seq
MIRT1285026	hsa-miR-3664-3p	CLIP-seq
MIRT1285027	hsa-miR-3675-5p	CLIP-seq
MIRT1285028	hsa-miR-3679-3p	CLIP-seq
MIRT1285029	hsa-miR-3688-5p	CLIP-seq
MIRT1285030	hsa-miR-3689a-3p	CLIP-seq
MIRT1285031	hsa-miR-3689c	CLIP-seq
MIRT1285032	hsa-miR-3913-5p	CLIP-seq
MIRT1285033	hsa-miR-3916	CLIP-seq
MIRT1285034	hsa-miR-3934	CLIP-seq
MIRT1285035	hsa-miR-424	CLIP-seq
MIRT1285036	hsa-miR-4264	CLIP-seq
MIRT1285037	hsa-miR-4278	CLIP-seq
MIRT1285038	hsa-miR-4284	CLIP-seq
MIRT1285039	hsa-miR-4300	CLIP-seq
MIRT1285040	hsa-miR-431	CLIP-seq
MIRT1285041	hsa-miR-4436b-3p	CLIP-seq
MIRT1285042	hsa-miR-4462	CLIP-seq
MIRT1285043	hsa-miR-4518	CLIP-seq
MIRT1285044	hsa-miR-4640-5p	CLIP-seq
MIRT1285045	hsa-miR-4662a-5p	CLIP-seq
MIRT1285046	hsa-miR-4681	CLIP-seq
MIRT1285047	hsa-miR-4685-5p	CLIP-seq
MIRT1285048	hsa-miR-4716-3p	CLIP-seq
MIRT1285049	hsa-miR-4725-5p	CLIP-seq
MIRT1285050	hsa-miR-4726-5p	CLIP-seq
MIRT1285051	hsa-miR-4733-3p	CLIP-seq
MIRT1285052	hsa-miR-4736	CLIP-seq
MIRT1285053	hsa-miR-4747-5p	CLIP-seq
MIRT1285054	hsa-miR-4755-3p	CLIP-seq
MIRT1285055	hsa-miR-4758-3p	CLIP-seq
MIRT1285056	hsa-miR-484	CLIP-seq
MIRT1285057	hsa-miR-497	CLIP-seq
MIRT1285058	hsa-miR-504	CLIP-seq
MIRT1285059	hsa-miR-552	CLIP-seq
MIRT1285060	hsa-miR-584	CLIP-seq
MIRT1285061	hsa-miR-622	CLIP-seq
MIRT1285062	hsa-miR-635	CLIP-seq
MIRT1285063	hsa-miR-657	CLIP-seq
MIRT1285064	hsa-miR-761	CLIP-seq
MIRT1285065	hsa-miR-920	CLIP-seq
MIRT1285005	hsa-miR-214	CLIP-seq
MIRT2084591	hsa-miR-3150a-3p	CLIP-seq
MIRT2084592	hsa-miR-3175	CLIP-seq
MIRT1285024	hsa-miR-3619-5p	CLIP-seq
MIRT1285028	hsa-miR-3679-3p	CLIP-seq
MIRT2084593	hsa-miR-3918	CLIP-seq
MIRT2084594	hsa-miR-4259	CLIP-seq
MIRT1285044	hsa-miR-4640-5p	CLIP-seq
MIRT2084595	hsa-miR-4661-5p	CLIP-seq
MIRT1285050	hsa-miR-4726-5p	CLIP-seq
MIRT2084596	hsa-miR-571	CLIP-seq
MIRT1285064	hsa-miR-761	CLIP-seq
MIRT2084597	hsa-miR-939	CLIP-seq
MIRT1284999	hsa-miR-1266	CLIP-seq
MIRT1285000	hsa-miR-15a	CLIP-seq
MIRT1285001	hsa-miR-15b	CLIP-seq
MIRT1285002	hsa-miR-16	CLIP-seq
MIRT1285003	hsa-miR-195	CLIP-seq
MIRT1285004	hsa-miR-1972	CLIP-seq
MIRT1285005	hsa-miR-214	CLIP-seq
MIRT1285014	hsa-miR-3122	CLIP-seq
MIRT1285015	hsa-miR-3125	CLIP-seq
MIRT1285018	hsa-miR-3155	CLIP-seq
MIRT1285019	hsa-miR-3155b	CLIP-seq
MIRT1285020	hsa-miR-3170	CLIP-seq
MIRT1285024	hsa-miR-3619-5p	CLIP-seq
MIRT1285025	hsa-miR-3663-5p	CLIP-seq
MIRT1285026	hsa-miR-3664-3p	CLIP-seq
MIRT1285030	hsa-miR-3689a-3p	CLIP-seq
MIRT1285031	hsa-miR-3689c	CLIP-seq
MIRT1285032	hsa-miR-3913-5p	CLIP-seq
MIRT1285033	hsa-miR-3916	CLIP-seq
MIRT1285035	hsa-miR-424	CLIP-seq
MIRT1285039	hsa-miR-4300	CLIP-seq
MIRT1285043	hsa-miR-4518	CLIP-seq
MIRT1285044	hsa-miR-4640-5p	CLIP-seq
MIRT1285045	hsa-miR-4662a-5p	CLIP-seq
MIRT1285046	hsa-miR-4681	CLIP-seq
MIRT1285048	hsa-miR-4716-3p	CLIP-seq
MIRT1285049	hsa-miR-4725-5p	CLIP-seq
MIRT1285050	hsa-miR-4726-5p	CLIP-seq
MIRT1285051	hsa-miR-4733-3p	CLIP-seq
MIRT1285055	hsa-miR-4758-3p	CLIP-seq
MIRT1285056	hsa-miR-484	CLIP-seq
MIRT1285057	hsa-miR-497	CLIP-seq
MIRT1285058	hsa-miR-504	CLIP-seq
MIRT1285062	hsa-miR-635	CLIP-seq
MIRT1285064	hsa-miR-761	CLIP-seq
MIRT1285065	hsa-miR-920	CLIP-seq
MIRT1285005	hsa-miR-214	CLIP-seq
MIRT1285024	hsa-miR-3619-5p	CLIP-seq
MIRT1285028	hsa-miR-3679-3p	CLIP-seq
MIRT2084593	hsa-miR-3918	CLIP-seq
MIRT1285044	hsa-miR-4640-5p	CLIP-seq
MIRT2084595	hsa-miR-4661-5p	CLIP-seq
MIRT1285050	hsa-miR-4726-5p	CLIP-seq
MIRT1285064	hsa-miR-761	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CIITA	Unknown	17175541

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0003924	Function	GTPase activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005525	Function	GTP binding	IEA
GO:0005768	Component	Endosome	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0015031	Process	Protein transport	IEA
GO:0030100	Process	Regulation of endocytosis	IBA	21873635
GO:0030667	Component	Secretory granule membrane	TAS
GO:0032482	Process	Rab protein signal transduction	IEA
GO:0032593	Component	Insulin-responsive compartment	IBA	21873635
GO:0032593	Component	Insulin-responsive compartment	IDA	19590752
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0046323	Process	Glucose import	IMP	19590752
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	19590752
GO:0055037	Component	Recycling endosome	IDA	19590752

Other IDs

• MIM: 612945
• HGNC: 9782
• e!Ensembl: ENSG00000167578

Protein

• UniProt ID: P61018
• Protein name: Ras-related protein Rab-4B (EC 3.6.5.2)
• Protein function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to r
• PDB: 2O52
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00071	Ras	10 → 171	Ras family	Domain

• Sequence:

  MAETYDFLFKFLVIGSAGTGKSCLLHQFIENKFKQDSNHTIGVEFGSRVVNVGGKTVKLQ
  IWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNSLAAWLTDARTLASPNIVVILCG
  NKKDLDPEREVTFLEASRFAQENELMFLETSALTGENVEEAFLKCARTILNKIDSGELDP
  ERMGSGIQYGDASLRQLRQPRSAQAVAPQPCGC

• Sequence length: 213

Pathways

Reactome:

Neutrophil degranulation
RAB geranylgeranylation
MET receptor recycling

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease	rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928	22080838, 28166215
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		17013881