PLXNB1 (plexin B1)

Gene

• Entrez ID: 5364
• Gene name: Plexin B1
• Gene symbol: PLXNB1
• Synonyms: PLEXIN-B1, PLXN5, SEP
• Chromosome: 3
• Chromosome location: 3p21.31

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005765	hsa-miR-214-3p	GFP reporter assay, Immunohistochemistry, qRT-PCR, Western blot	21216304
MIRT005765	hsa-miR-214-3p	GFP reporter assay, Immunohistochemistry, qRT-PCR, Western blot	21216304
MIRT005765	hsa-miR-214-3p	Microarray;Other	19859982
MIRT1243801	hsa-miR-1193	CLIP-seq
MIRT1243802	hsa-miR-1265	CLIP-seq
MIRT1243803	hsa-miR-142-3p	CLIP-seq
MIRT1243804	hsa-miR-2392	CLIP-seq
MIRT1243805	hsa-miR-3135	CLIP-seq
MIRT1243806	hsa-miR-3183	CLIP-seq
MIRT1243807	hsa-miR-3667-3p	CLIP-seq
MIRT1243808	hsa-miR-3675-5p	CLIP-seq
MIRT1243809	hsa-miR-3677-5p	CLIP-seq
MIRT1243810	hsa-miR-3684	CLIP-seq
MIRT1243811	hsa-miR-4270	CLIP-seq
MIRT1243812	hsa-miR-4279	CLIP-seq
MIRT1243813	hsa-miR-4283	CLIP-seq
MIRT1243814	hsa-miR-4441	CLIP-seq
MIRT1243815	hsa-miR-4489	CLIP-seq
MIRT1243816	hsa-miR-4723-3p	CLIP-seq
MIRT1243802	hsa-miR-1265	CLIP-seq
MIRT1243817	hsa-miR-15a	CLIP-seq
MIRT1243818	hsa-miR-15b	CLIP-seq
MIRT1243819	hsa-miR-16	CLIP-seq
MIRT1243820	hsa-miR-195	CLIP-seq
MIRT1243804	hsa-miR-2392	CLIP-seq
MIRT1243821	hsa-miR-3688-5p	CLIP-seq
MIRT1243822	hsa-miR-3922-5p	CLIP-seq
MIRT1243823	hsa-miR-424	CLIP-seq
MIRT1243811	hsa-miR-4270	CLIP-seq
MIRT1243814	hsa-miR-4441	CLIP-seq
MIRT1243824	hsa-miR-4660	CLIP-seq
MIRT1243825	hsa-miR-4753-5p	CLIP-seq
MIRT1243826	hsa-miR-4764-5p	CLIP-seq
MIRT1243827	hsa-miR-497	CLIP-seq
MIRT1243828	hsa-miR-885-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002116	Component	Semaphorin receptor complex	IBA	21873635
GO:0002116	Component	Semaphorin receptor complex	IDA	19843518
GO:0002116	Component	Semaphorin receptor complex	TAS	19909241
GO:0004888	Function	Transmembrane signaling receptor activity	NAS	10520995
GO:0005096	Function	GTPase activator activity	TAS
GO:0005515	Function	Protein binding	IPI	12730235, 14732713, 15184888, 15218527, 19843518, 20877282, 22404908, 29040270
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	IDA	19843518
GO:0005887	Component	Integral component of plasma membrane	NAS	10520995
GO:0007162	Process	Negative regulation of cell adhesion	IBA	21873635
GO:0007162	Process	Negative regulation of cell adhesion	IDA	15218527
GO:0007165	Process	Signal transduction	TAS	8570614
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0008360	Process	Regulation of cell shape	IBA	21873635
GO:0008360	Process	Regulation of cell shape	IDA	19843518
GO:0014068	Process	Positive regulation of phosphatidylinositol 3-kinase signaling	ISS
GO:0016477	Process	Cell migration	NAS	10520995
GO:0017154	Function	Semaphorin receptor activity	IBA	21873635
GO:0017154	Function	Semaphorin receptor activity	IDA	19843518
GO:0017154	Function	Semaphorin receptor activity	TAS	10520995
GO:0030215	Function	Semaphorin receptor binding	TAS	10520995
GO:0030334	Process	Regulation of cell migration	IBA	21873635
GO:0032794	Function	GTPase activating protein binding	ISS
GO:0033689	Process	Negative regulation of osteoblast proliferation	ISS
GO:0035556	Process	Intracellular signal transduction	NAS	10520995
GO:0038023	Function	Signaling receptor activity	TAS	8570614
GO:0043087	Process	Regulation of GTPase activity	IBA	21873635
GO:0043547	Process	Positive regulation of GTPase activity	ISS
GO:0043931	Process	Ossification involved in bone maturation	ISS
GO:0048812	Process	Neuron projection morphogenesis	ISS
GO:0050772	Process	Positive regulation of axonogenesis	IBA	21873635
GO:0051493	Process	Regulation of cytoskeleton organization	IDA	19843518
GO:0071526	Process	Semaphorin-plexin signaling pathway	IDA	15218527, 19843518
GO:1900220	Process	Semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis	ISS
GO:1902287	Process	Semaphorin-plexin signaling pathway involved in axon guidance	IBA	21873635
GO:1904862	Process	Inhibitory synapse assembly	ISS

Other IDs

• MIM: 601053
• HGNC: 9103
• e!Ensembl: ENSG00000164050

Protein

• UniProt ID: O43157
• Protein name: Plexin-B1 (Semaphorin receptor SEP)
• Protein function: Receptor for SEMA4D (PubMed:19843518, PubMed:20877282, PubMed:21912513). Plays a role in GABAergic synapse development (By similarity). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity). Plays a role in RHOA ac
• PDB: 2JPH, 2OS6, 2R2O, 2REX, 3HM6, 3OL2, 3SU8, 3SUA, 5B4W, 7VF3, 7VG7, 8B3K
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01403	Sema	37 → 460	Sema domain	Family
  PF01437	PSI	481 → 534	Plexin repeat	Family
  PF17960	TIG_plexin	540 → 627	TIG domain	Domain
  PF18020	TIG_2	921 → 1020	TIG domain found in plexin	Domain
  PF01833	TIG	1070 → 1159	IPT/TIG domain	Domain
  PF01833	TIG	1162 → 1248	IPT/TIG domain	Domain
  PF01833	TIG	1252 → 1374	IPT/TIG domain	Domain
  PF08337	Plexin_cytopl	1562 → 2102	Plexin cytoplasmic RasGAP domain	Family

• Sequence:

  MPALGPALLQALWAGWVLTLQPLPPTAFTPNGTYLQHLARDPTSGTLYLGATNFLFQLSP
  GLQLEATVSTGPVLDSRDCLPPVMPDECPQAQPTNNPNQLLLVSPGALVVCGSVHQGVCE
  QRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTSRGVGGG
  IPPITTRALWPPDPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFLFLRRDLQAQ
  SRAFRAYVSRVCLRDQHYYSYVELPLACEGGRYGLIQAAAVATSREVAHGEVLFAAFSSA
  APPTVGRPPSAAAGASGASALCAFPLDEVDRLANRTRDACYTREGRAEDGTEVAYIEYDV
  NSDCAQLPVDTLDAYPCGSDHTPSPMASRVPLEATPILEWPGIQLTAVAVTMEDGHTIAF
  LGDSQGQLHRVYLGPGSDGHPYSTQSIQQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVA
  SCAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSRGQGPEQWLWSFQPELGCLQVAAMS
  PANISREETREVFLSVPDLPPLWPGESYSCHFGEHQSPALLTGSGVMCPSPDPSEAPVLP
  RGADYVSVSVELRFGAVVIAKTSLSFYDCVAVTELRPSAQCQACVSSRWGCNWCVWQHLC
  THKASCDAGPMVASHQSPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTAT
  ASDISPGASPSLLSPWGPWAGSGSISSPGSTGSPLHEEPSPPSPQNGPGTAVPAPTDFRP
  SATPEDLLASPLSPSEVAAVPPADPGPEALHPTVPLDLPPATVPATTFPGAMGSVKPALD
  WLTREGGELPEADEWTGGDAPAFSTSTLLSGDGDSAELEGPPAPLILPSSLDYQYDTPGL
  WELEEATLGASSCPCVESVQGSTLMPVHVEREIRLLGRNLHLFQDGPGDNECVMELEGLE
  VVVEARVECEPPPDTQCHVTCQQHQLSYEALQPELRVGLFLRRAGRLRVDSAEGLHVVLY
  DCSVGHGDCSRCQTAMPQYGCVWCEGERPRCVTREACGEAEAVATQCPAPLIHSVEPLTG
  PVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITGASGEEVAGA
  TAVEVPGRGRGVSEHDFAYQDPKVHSIFPARGPRAGGTRLTLNGSKLLTGRLEDIRVVVG
  DQPCHLLPEQQSEQLRCETSPRPTPATLPVAVWFGATERRLQRGQFKYTLDPNITSAGPT
  KSFLSGGREICVRGQNLDVVQTPRIRVTVVSRMLQPSQGLGRRRRVVPETACSLGPSCSS
  QQFEEPCHVNSSQLITCRTPALPGLPEDPWVRVEFILDNLVFDFATLNPTPFSYEADPTL
  QPLNPEDPTMPFRHKPGSVFSVEGENLDLAMSKEEVVAMIGDGPCVVKTLTRHHLYCEPP
  VEQPLPRHHALREAPDSLPEFTVQMGNLRFSLGHVQYDGESPGAFPVAAQVGLGVGTSLL
  ALGVIIIVLMYRRKSKQALRDYKKVQIQLENLESSVRDRCKKEFTDLMTEMTDLTSDLLG
  SGIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFI
  HTLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTE
  TVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVDSVTGKAKYTLNDNRLL
  REDVEYRPLTLNALLAVGPGAGEAQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQRPDP
  RTLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVPDGATVALVPCLTKHVLRE
  NQDYVPGERTPMLEDVDEGGIRPWHLVKPSDEPEPPRPRRGSLRGGERERAKAIPEIYLT
  RLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTNS
  LPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLYAR
  DIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYD
  QIITALEEDGTAQKMQLGYRLQQIAAAVENKVTDL

• Sequence length: 2135

Pathways

KEGG:

Axon guidance

Reactome:

G alpha (12/13) signalling events
Sema4D mediated inhibition of cell attachment and migration
Sema4D induced cell migration and growth-cone collapse

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243
Neurodevelopmental disorders	Neurodevelopmental Disorders	rs869312846, rs869312840, rs869312848, rs869312849, rs869312845, rs886041956, rs1064795110, rs1555762734, rs1555764992, rs1568512728, rs1568532361, rs1595472741, rs1595472764, rs1595476797, rs1016320330, rs1595127294, rs1600392059	28191889