PTOV1 (PTOV1 extended AT-hook containing adaptor protein)

Gene

• Entrez ID: 53635
• Gene name: PTOV1 extended AT-hook containing adaptor protein
• Gene symbol: PTOV1
• Synonyms: ACID2, PTOV-1
• Chromosome: 19
• Chromosome location: 19q13.33
• Summary: This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT045949	hsa-miR-125b-5p	CLASH	23622248
MIRT044008	hsa-miR-378a-5p	CLASH	23622248
MIRT1273766	hsa-miR-1288	CLIP-seq
MIRT1273767	hsa-miR-3144-5p	CLIP-seq
MIRT1273768	hsa-miR-3189-3p	CLIP-seq
MIRT1273769	hsa-miR-3191	CLIP-seq
MIRT1273770	hsa-miR-3199	CLIP-seq
MIRT1273771	hsa-miR-4287	CLIP-seq
MIRT1273772	hsa-miR-432	CLIP-seq
MIRT1273773	hsa-miR-4443	CLIP-seq
MIRT1273774	hsa-miR-4469	CLIP-seq
MIRT1273775	hsa-miR-4651	CLIP-seq
MIRT1273776	hsa-miR-4652-5p	CLIP-seq
MIRT1273777	hsa-miR-4685-3p	CLIP-seq
MIRT1273778	hsa-miR-491-5p	CLIP-seq
MIRT1273779	hsa-miR-608	CLIP-seq
MIRT1273780	hsa-miR-642a	CLIP-seq
MIRT2080511	hsa-miR-4706	CLIP-seq
MIRT2080512	hsa-miR-4734	CLIP-seq
MIRT2080513	hsa-miR-4749-5p	CLIP-seq
MIRT2080514	hsa-miR-593	CLIP-seq
MIRT2080515	hsa-miR-744	CLIP-seq
MIRT2306639	hsa-miR-1197	CLIP-seq
MIRT2306640	hsa-miR-1226	CLIP-seq
MIRT2306641	hsa-miR-3612	CLIP-seq
MIRT2306642	hsa-miR-3664-3p	CLIP-seq
MIRT1273772	hsa-miR-432	CLIP-seq
MIRT2306643	hsa-miR-4436a	CLIP-seq
MIRT2306644	hsa-miR-4438	CLIP-seq
MIRT1273773	hsa-miR-4443	CLIP-seq
MIRT2306645	hsa-miR-4447	CLIP-seq
MIRT2306646	hsa-miR-4472	CLIP-seq
MIRT2306647	hsa-miR-4488	CLIP-seq
MIRT2306648	hsa-miR-4697-5p	CLIP-seq
MIRT2306649	hsa-miR-4701-5p	CLIP-seq
MIRT2080511	hsa-miR-4706	CLIP-seq
MIRT2306650	hsa-miR-4733-3p	CLIP-seq
MIRT2080512	hsa-miR-4734	CLIP-seq
MIRT2080513	hsa-miR-4749-5p	CLIP-seq
MIRT2306651	hsa-miR-588	CLIP-seq
MIRT2080514	hsa-miR-593	CLIP-seq
MIRT2306652	hsa-miR-650	CLIP-seq
MIRT2080515	hsa-miR-744	CLIP-seq
MIRT2439705	hsa-miR-3940-3p	CLIP-seq
MIRT2439706	hsa-miR-4532	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005654	Component	Nucleoplasm	IDA
GO:0005667	Component	Transcription regulator complex	IBA	21873635
GO:0005886	Component	Plasma membrane	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA	21873635
GO:0048471	Component	Perinuclear region of cytoplasm	IEA

Other IDs

• MIM: 610195
• HGNC: 9632
• e!Ensembl: ENSG00000104960

Protein

• UniProt ID: Q86YD1
• Protein name: Prostate tumor-overexpressed gene 1 protein (PTOV-1) (Activator interaction domain-containing protein 2)
• Protein function: May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF11232	Med25	89 → 238	Mediator complex subunit 25 PTOV activation and synapsin 2	Domain
  PF11232	Med25	254 → 399	Mediator complex subunit 25 PTOV activation and synapsin 2	Domain

• Sequence:

  MVRPRRAPYRSGAGGPLGGRGRPPRPLVVRAVRSRSWPASPRGPQPPRIRARSAPPMEGA
  RVFGALGPIGPSSPGLTLGGLAVSEHRLSNKLLAWSGVLEWQEKRRPYSDSTAKLKRTLP
  CQAYVNQGENLETDQWPQKLIMQLIPQQLLTTLGPLFRNSQLAQFHFTNRDCDSLKGLCR
  IMGNGFAGCMLFPHISPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVSAIRQVITTRKQAV
  GPGGVNSGPVQIVNNKFLAWSGVMEWQEPRPEPNSRSKRWLPSHVYVNQGEILRTEQWPR
  KLYMQLIPQQLLTTLVPLFRNSRLVQFHFTKDLETLKSLCRIMDNGFAGCVHFSYKASCE
  IRVLMLLYSSEKKIFIGLIPHDQGNFVNGIRRVIANQQQVLQRNLEQEQQQRGMGG

• Sequence length: 416

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	21364753

Unknown
Disease name	Disease term	dbSNP ID	References
Stomach neoplasms	Malignant neoplasm of stomach, Stomach Neoplasms		21364753