PLEK (pleckstrin)

Gene

• Entrez ID: 5341
• Gene name: Pleckstrin
• Gene symbol: PLEK
• Synonyms: P47, PLEK1
• Chromosome: 2
• Chromosome location: 2p14

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT532353	hsa-miR-3923	PAR-CLIP	22012620
MIRT532352	hsa-miR-1250-3p	PAR-CLIP	22012620
MIRT532351	hsa-miR-153-5p	PAR-CLIP	22012620
MIRT532350	hsa-miR-5696	PAR-CLIP	22012620
MIRT532349	hsa-miR-579-3p	PAR-CLIP	22012620
MIRT532348	hsa-miR-664b-3p	PAR-CLIP	22012620
MIRT532347	hsa-miR-520a-5p	PAR-CLIP	22012620
MIRT532346	hsa-miR-525-5p	PAR-CLIP	22012620
MIRT532345	hsa-miR-183-3p	PAR-CLIP	22012620
MIRT532344	hsa-miR-4452	PAR-CLIP	22012620
MIRT532343	hsa-miR-3180-5p	PAR-CLIP	22012620
MIRT532342	hsa-miR-6875-3p	PAR-CLIP	22012620
MIRT532341	hsa-miR-4659a-3p	PAR-CLIP	22012620
MIRT532340	hsa-miR-4659b-3p	PAR-CLIP	22012620
MIRT532353	hsa-miR-3923	PAR-CLIP	22012620
MIRT532352	hsa-miR-1250-3p	PAR-CLIP	22012620
MIRT532351	hsa-miR-153-5p	PAR-CLIP	22012620
MIRT532350	hsa-miR-5696	PAR-CLIP	22012620
MIRT532349	hsa-miR-579-3p	PAR-CLIP	22012620
MIRT532348	hsa-miR-664b-3p	PAR-CLIP	22012620
MIRT532347	hsa-miR-520a-5p	PAR-CLIP	22012620
MIRT532346	hsa-miR-525-5p	PAR-CLIP	22012620
MIRT532345	hsa-miR-183-3p	PAR-CLIP	22012620
MIRT532344	hsa-miR-4452	PAR-CLIP	22012620
MIRT532343	hsa-miR-3180-5p	PAR-CLIP	22012620
MIRT532342	hsa-miR-6875-3p	PAR-CLIP	22012620
MIRT532341	hsa-miR-4659a-3p	PAR-CLIP	22012620
MIRT532340	hsa-miR-4659b-3p	PAR-CLIP	22012620
MIRT1240704	hsa-miR-1229	CLIP-seq
MIRT1240705	hsa-miR-1343	CLIP-seq
MIRT1240706	hsa-miR-148a	CLIP-seq
MIRT1240707	hsa-miR-148b	CLIP-seq
MIRT1240708	hsa-miR-152	CLIP-seq
MIRT1240709	hsa-miR-3074-5p	CLIP-seq
MIRT1240710	hsa-miR-3124-3p	CLIP-seq
MIRT1240711	hsa-miR-3613-5p	CLIP-seq
MIRT1240712	hsa-miR-3690	CLIP-seq
MIRT1240713	hsa-miR-4254	CLIP-seq
MIRT1240714	hsa-miR-4493	CLIP-seq
MIRT1240715	hsa-miR-4650-5p	CLIP-seq
MIRT1240716	hsa-miR-4699-5p	CLIP-seq
MIRT1240717	hsa-miR-4709-3p	CLIP-seq
MIRT1240718	hsa-miR-4753-5p	CLIP-seq
MIRT1240719	hsa-miR-4757-5p	CLIP-seq
MIRT1240720	hsa-miR-579	CLIP-seq
MIRT1240721	hsa-miR-582-5p	CLIP-seq
MIRT1240722	hsa-miR-600	CLIP-seq
MIRT1240720	hsa-miR-579	CLIP-seq
MIRT1240720	hsa-miR-579	CLIP-seq
MIRT2070770	hsa-miR-4506	CLIP-seq
MIRT2297937	hsa-miR-1323	CLIP-seq
MIRT2297938	hsa-miR-2467-5p	CLIP-seq
MIRT2297939	hsa-miR-3188	CLIP-seq
MIRT2297940	hsa-miR-3975	CLIP-seq
MIRT2297941	hsa-miR-4649-3p	CLIP-seq
MIRT2297942	hsa-miR-485-5p	CLIP-seq
MIRT2297943	hsa-miR-539	CLIP-seq
MIRT2297944	hsa-miR-548o	CLIP-seq
MIRT2297945	hsa-miR-558	CLIP-seq
MIRT1240720	hsa-miR-579	CLIP-seq
MIRT2456632	hsa-miR-4330	CLIP-seq
MIRT2456633	hsa-miR-4749-3p	CLIP-seq
MIRT2595395	hsa-miR-1226	CLIP-seq
MIRT2595396	hsa-miR-197	CLIP-seq
MIRT2595397	hsa-miR-2682	CLIP-seq
MIRT2456632	hsa-miR-4330	CLIP-seq
MIRT2595398	hsa-miR-449c	CLIP-seq
MIRT2595399	hsa-miR-4514	CLIP-seq
MIRT2595400	hsa-miR-4645-5p	CLIP-seq
MIRT1240715	hsa-miR-4650-5p	CLIP-seq
MIRT2595401	hsa-miR-4673	CLIP-seq
MIRT2595402	hsa-miR-4692	CLIP-seq
MIRT2595403	hsa-miR-4733-3p	CLIP-seq
MIRT2456633	hsa-miR-4749-3p	CLIP-seq
MIRT2595395	hsa-miR-1226	CLIP-seq
MIRT2688060	hsa-miR-146a	CLIP-seq
MIRT2688061	hsa-miR-146b-5p	CLIP-seq
MIRT2595396	hsa-miR-197	CLIP-seq
MIRT2595397	hsa-miR-2682	CLIP-seq
MIRT2688062	hsa-miR-4434	CLIP-seq
MIRT2595398	hsa-miR-449c	CLIP-seq
MIRT2595399	hsa-miR-4514	CLIP-seq
MIRT2688063	hsa-miR-4516	CLIP-seq
MIRT2688064	hsa-miR-4531	CLIP-seq
MIRT2595400	hsa-miR-4645-5p	CLIP-seq
MIRT1240715	hsa-miR-4650-5p	CLIP-seq
MIRT2595401	hsa-miR-4673	CLIP-seq
MIRT2595402	hsa-miR-4692	CLIP-seq
MIRT1240716	hsa-miR-4699-5p	CLIP-seq
MIRT2595403	hsa-miR-4733-3p	CLIP-seq
MIRT2688065	hsa-miR-642a	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002244	Process	Hematopoietic progenitor cell differentiation	IEP	2768345
GO:0002576	Process	Platelet degranulation	IEP	7559487
GO:0002576	Process	Platelet degranulation	TAS
GO:0005080	Function	Protein kinase C binding	IDA	8615792
GO:0005515	Function	Protein binding	IPI	8999861, 19722192
GO:0005576	Component	Extracellular region	TAS
GO:0005737	Component	Cytoplasm	IDA	8694752, 9060471
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0006904	Process	Vesicle docking involved in exocytosis	ISS
GO:0007229	Process	Integrin-mediated signaling pathway	IDA	10995449
GO:0010572	Process	Positive regulation of platelet activation	ISS
GO:0010920	Process	Negative regulation of inositol phosphate biosynthetic process	IDA	7559487, 7782310
GO:0010925	Process	Positive regulation of inositol-polyphosphate 5-phosphatase activity	IDA	8999861
GO:0016020	Component	Membrane	HDA	19946888
GO:0030030	Process	Cell projection organization	IDA	9060471
GO:0030836	Process	Positive regulation of actin filament depolymerization	IDA	10497244
GO:0030845	Process	Phospholipase C-inhibiting G protein-coupled receptor signaling pathway	IDA	7782310
GO:0030866	Process	Cortical actin cytoskeleton organization	IDA	10497244
GO:0031529	Process	Ruffle organization	IDA	10497244
GO:0031532	Process	Actin cytoskeleton reorganization	IBA	21873635
GO:0031532	Process	Actin cytoskeleton reorganization	IDA	10497244
GO:0032233	Process	Positive regulation of actin filament bundle assembly	IDA	10497244
GO:0032587	Component	Ruffle membrane	IDA	9060471
GO:0033625	Process	Positive regulation of integrin activation	ISS
GO:0042803	Function	Protein homodimerization activity	IDA	8694752
GO:0043325	Function	Phosphatidylinositol-3,4-bisphosphate binding	IDA	15698571
GO:0045744	Process	Negative regulation of G protein-coupled receptor signaling pathway	IDA	7782310
GO:0046488	Process	Phosphatidylinositol metabolic process	IDA	7559487
GO:0050849	Process	Negative regulation of calcium-mediated signaling	NAS	8999861
GO:0060305	Process	Regulation of cell diameter	IDA	10995449
GO:0070493	Process	Thrombin-activated receptor signaling pathway	IDA	7782310
GO:0070527	Process	Platelet aggregation	HMP	23382103
GO:0070527	Process	Platelet aggregation	ISS
GO:0070528	Process	Protein kinase C signaling	ISS
GO:0070560	Process	Protein secretion by platelet	ISS

Other IDs

• MIM: 173570
• HGNC: 9070
• e!Ensembl: ENSG00000115956

Protein

• UniProt ID: P08567
• Protein name: Pleckstrin (Platelet 47 kDa protein) (p47)
• Protein function: Major protein kinase C substrate of platelets.
• PDB: 1PLS, 1W4M, 1X05, 1XX0, 1ZM0, 2CSO, 2I5C, 2I5F
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00169	PH	5 → 101	PH domain	Domain
  PF00610	DEP	139 → 219	Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)	Domain
  PF00169	PH	245 → 347	PH domain	Domain

• Sequence:

  MEPKRIREGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTSPCQ
  DFGKRMFVFKITTTKQQDHFFQAAFLEERDAWVRDIKKAIKCIEGGQKFARKSTRRSIRL
  PETIDLGALYLSMKDTEKGIKELNLEKDKKIFNHCFTGNCVIDWLVSNQSVRNRQEGLMI
  ASSLLNEGYLQPAGDMSKSAVDGTAENPFLDNPDAFYYFPDSGFFCEENSSDDDVILKEE
  FRGVIIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSV
  ESNSNGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQMASRTGK

• Sequence length: 350

Pathways

Reactome:

Platelet degranulation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	21150878
Autoimmune diseases	Autoimmune Diseases	rs41285370, rs869025224	21383967
Multiple sclerosis	Multiple Sclerosis	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039, rs483353038, rs61731956, rs568165874, rs767480544	22190364
Osteoporosis	Osteoporosis, Age-Related, Osteoporosis, Osteoporosis, Senile, Post-Traumatic Osteoporosis	rs72658152, rs72667023, rs587776916, rs72656370, rs768615287	18924182
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	12833524

Unknown
Disease name	Disease term	dbSNP ID	References
Celiac disease	Celiac Disease	rs2305764, rs35218876	20190752
Immune system diseases	Immune System Diseases		21383967