ATP6V0B (ATPase H+ transporting V0 subunit b)

Gene

• Entrez ID: 533
• Gene name: ATPase H+ transporting V0 subunit b
• Gene symbol: ATP6V0B
• Synonyms: ATP6F, HATPL, VMA16
• Chromosome: 1
• Chromosome location: 1p34.1
• Summary: This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this enzyme is necessary for such varied processes as protein sorting, zymoge

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT341458	hsa-miR-548aa	PAR-CLIP	23592263
MIRT341461	hsa-miR-548ap-3p	PAR-CLIP	23592263
MIRT341455	hsa-miR-548t-3p	PAR-CLIP	23592263
MIRT452083	hsa-miR-548n	PAR-CLIP	23592263
MIRT341462	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT341454	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT341456	hsa-miR-3609	PAR-CLIP	23592263
MIRT341459	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT452082	hsa-miR-5692a	PAR-CLIP	23592263
MIRT341453	hsa-miR-634	PAR-CLIP	23592263
MIRT341457	hsa-miR-3942-5p	PAR-CLIP	23592263
MIRT341460	hsa-miR-4703-5p	PAR-CLIP	23592263
MIRT452081	hsa-miR-3622a-5p	PAR-CLIP	23592263
MIRT341451	hsa-miR-95-5p	PAR-CLIP	23592263
MIRT452080	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT452079	hsa-miR-1915-3p	PAR-CLIP	23592263
MIRT452078	hsa-miR-6764-5p	PAR-CLIP	23592263
MIRT452077	hsa-miR-4726-3p	PAR-CLIP	23592263
MIRT452076	hsa-miR-1827	PAR-CLIP	23592263
MIRT452075	hsa-miR-3177-3p	PAR-CLIP	23592263
MIRT452074	hsa-miR-564	PAR-CLIP	23592263
MIRT452073	hsa-miR-4433a-5p	PAR-CLIP	23592263
MIRT452072	hsa-miR-4316	PAR-CLIP	23592263
MIRT452071	hsa-miR-4433b-5p	PAR-CLIP	23592263
MIRT341458	hsa-miR-548aa	PAR-CLIP	23592263
MIRT341461	hsa-miR-548ap-3p	PAR-CLIP	23592263
MIRT341455	hsa-miR-548t-3p	PAR-CLIP	23592263
MIRT452083	hsa-miR-548n	PAR-CLIP	23592263
MIRT341462	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT341454	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT341456	hsa-miR-3609	PAR-CLIP	23592263
MIRT341459	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT452082	hsa-miR-5692a	PAR-CLIP	23592263
MIRT341453	hsa-miR-634	PAR-CLIP	23592263
MIRT341457	hsa-miR-3942-5p	PAR-CLIP	23592263
MIRT341460	hsa-miR-4703-5p	PAR-CLIP	23592263
MIRT452081	hsa-miR-3622a-5p	PAR-CLIP	23592263
MIRT341451	hsa-miR-95-5p	PAR-CLIP	23592263
MIRT452080	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT452079	hsa-miR-1915-3p	PAR-CLIP	23592263
MIRT452078	hsa-miR-6764-5p	PAR-CLIP	23592263
MIRT452077	hsa-miR-4726-3p	PAR-CLIP	23592263
MIRT452076	hsa-miR-1827	PAR-CLIP	23592263
MIRT452075	hsa-miR-3177-3p	PAR-CLIP	23592263
MIRT452074	hsa-miR-564	PAR-CLIP	23592263
MIRT452073	hsa-miR-4433a-5p	PAR-CLIP	23592263
MIRT452072	hsa-miR-4316	PAR-CLIP	23592263
MIRT452071	hsa-miR-4433b-5p	PAR-CLIP	23592263
MIRT808610	hsa-miR-1224-5p	CLIP-seq
MIRT808611	hsa-miR-1234	CLIP-seq
MIRT808612	hsa-miR-1254	CLIP-seq
MIRT808613	hsa-miR-1269	CLIP-seq
MIRT808614	hsa-miR-1269b	CLIP-seq
MIRT808615	hsa-miR-1275	CLIP-seq
MIRT808616	hsa-miR-1288	CLIP-seq
MIRT808617	hsa-miR-15a	CLIP-seq
MIRT808618	hsa-miR-15b	CLIP-seq
MIRT808619	hsa-miR-16	CLIP-seq
MIRT808620	hsa-miR-1912	CLIP-seq
MIRT808621	hsa-miR-195	CLIP-seq
MIRT808622	hsa-miR-214	CLIP-seq
MIRT808623	hsa-miR-3116	CLIP-seq
MIRT808624	hsa-miR-3619-5p	CLIP-seq
MIRT808625	hsa-miR-3689d	CLIP-seq
MIRT808626	hsa-miR-3690	CLIP-seq
MIRT808627	hsa-miR-378	CLIP-seq
MIRT808628	hsa-miR-378b	CLIP-seq
MIRT808629	hsa-miR-378c	CLIP-seq
MIRT808630	hsa-miR-378d	CLIP-seq
MIRT808631	hsa-miR-378e	CLIP-seq
MIRT808632	hsa-miR-378f	CLIP-seq
MIRT808633	hsa-miR-378h	CLIP-seq
MIRT808634	hsa-miR-378i	CLIP-seq
MIRT808635	hsa-miR-3940-5p	CLIP-seq
MIRT808636	hsa-miR-422a	CLIP-seq
MIRT808637	hsa-miR-424	CLIP-seq
MIRT808638	hsa-miR-4291	CLIP-seq
MIRT808639	hsa-miR-4418	CLIP-seq
MIRT808640	hsa-miR-4426	CLIP-seq
MIRT808641	hsa-miR-4447	CLIP-seq
MIRT808642	hsa-miR-4472	CLIP-seq
MIRT808643	hsa-miR-4476	CLIP-seq
MIRT808644	hsa-miR-4507	CLIP-seq
MIRT808645	hsa-miR-4515	CLIP-seq
MIRT808646	hsa-miR-4525	CLIP-seq
MIRT808647	hsa-miR-4647	CLIP-seq
MIRT808648	hsa-miR-4662b	CLIP-seq
MIRT808649	hsa-miR-4665-5p	CLIP-seq
MIRT808650	hsa-miR-4704-5p	CLIP-seq
MIRT808651	hsa-miR-4719	CLIP-seq
MIRT808652	hsa-miR-4723-5p	CLIP-seq
MIRT808653	hsa-miR-4740-5p	CLIP-seq
MIRT808654	hsa-miR-4751	CLIP-seq
MIRT808655	hsa-miR-4797-5p	CLIP-seq
MIRT808656	hsa-miR-497	CLIP-seq
MIRT808657	hsa-miR-509-3-5p	CLIP-seq
MIRT808658	hsa-miR-509-5p	CLIP-seq
MIRT808659	hsa-miR-513b	CLIP-seq
MIRT808660	hsa-miR-515-3p	CLIP-seq
MIRT808661	hsa-miR-519e	CLIP-seq
MIRT808662	hsa-miR-552	CLIP-seq
MIRT808663	hsa-miR-596	CLIP-seq
MIRT808664	hsa-miR-625	CLIP-seq
MIRT808665	hsa-miR-761	CLIP-seq
MIRT808666	hsa-miR-764	CLIP-seq
MIRT808667	hsa-miR-922	CLIP-seq
MIRT808668	hsa-miR-1291	CLIP-seq
MIRT808669	hsa-miR-1321	CLIP-seq
MIRT808670	hsa-miR-145	CLIP-seq
MIRT808671	hsa-miR-1909	CLIP-seq
MIRT808672	hsa-miR-1915	CLIP-seq
MIRT808673	hsa-miR-3591-3p	CLIP-seq
MIRT808674	hsa-miR-4267	CLIP-seq
MIRT808675	hsa-miR-4270	CLIP-seq
MIRT808676	hsa-miR-4441	CLIP-seq
MIRT808677	hsa-miR-4475	CLIP-seq
MIRT808678	hsa-miR-451b	CLIP-seq
MIRT808679	hsa-miR-4728-5p	CLIP-seq
MIRT808680	hsa-miR-4739	CLIP-seq
MIRT808681	hsa-miR-4756-5p	CLIP-seq
MIRT808682	hsa-miR-4766-5p	CLIP-seq
MIRT808683	hsa-miR-488	CLIP-seq
MIRT808684	hsa-miR-766	CLIP-seq
MIRT808610	hsa-miR-1224-5p	CLIP-seq
MIRT808611	hsa-miR-1234	CLIP-seq
MIRT808612	hsa-miR-1254	CLIP-seq
MIRT808613	hsa-miR-1269	CLIP-seq
MIRT808614	hsa-miR-1269b	CLIP-seq
MIRT808616	hsa-miR-1288	CLIP-seq
MIRT808668	hsa-miR-1291	CLIP-seq
MIRT808669	hsa-miR-1321	CLIP-seq
MIRT808617	hsa-miR-15a	CLIP-seq
MIRT808618	hsa-miR-15b	CLIP-seq
MIRT808619	hsa-miR-16	CLIP-seq
MIRT808671	hsa-miR-1909	CLIP-seq
MIRT808621	hsa-miR-195	CLIP-seq
MIRT808622	hsa-miR-214	CLIP-seq
MIRT808623	hsa-miR-3116	CLIP-seq
MIRT808673	hsa-miR-3591-3p	CLIP-seq
MIRT808624	hsa-miR-3619-5p	CLIP-seq
MIRT808626	hsa-miR-3690	CLIP-seq
MIRT808627	hsa-miR-378	CLIP-seq
MIRT808628	hsa-miR-378b	CLIP-seq
MIRT808629	hsa-miR-378c	CLIP-seq
MIRT808630	hsa-miR-378d	CLIP-seq
MIRT808631	hsa-miR-378e	CLIP-seq
MIRT808632	hsa-miR-378f	CLIP-seq
MIRT808633	hsa-miR-378h	CLIP-seq
MIRT808634	hsa-miR-378i	CLIP-seq
MIRT808636	hsa-miR-422a	CLIP-seq
MIRT808637	hsa-miR-424	CLIP-seq
MIRT808675	hsa-miR-4270	CLIP-seq
MIRT808638	hsa-miR-4291	CLIP-seq
MIRT808639	hsa-miR-4418	CLIP-seq
MIRT808676	hsa-miR-4441	CLIP-seq
MIRT808645	hsa-miR-4515	CLIP-seq
MIRT808678	hsa-miR-451b	CLIP-seq
MIRT808679	hsa-miR-4728-5p	CLIP-seq
MIRT808680	hsa-miR-4739	CLIP-seq
MIRT808653	hsa-miR-4740-5p	CLIP-seq
MIRT808654	hsa-miR-4751	CLIP-seq
MIRT808681	hsa-miR-4756-5p	CLIP-seq
MIRT808682	hsa-miR-4766-5p	CLIP-seq
MIRT808655	hsa-miR-4797-5p	CLIP-seq
MIRT808683	hsa-miR-488	CLIP-seq
MIRT808656	hsa-miR-497	CLIP-seq
MIRT808657	hsa-miR-509-3-5p	CLIP-seq
MIRT808658	hsa-miR-509-5p	CLIP-seq
MIRT808660	hsa-miR-515-3p	CLIP-seq
MIRT808661	hsa-miR-519e	CLIP-seq
MIRT808662	hsa-miR-552	CLIP-seq
MIRT808663	hsa-miR-596	CLIP-seq
MIRT808665	hsa-miR-761	CLIP-seq
MIRT808666	hsa-miR-764	CLIP-seq
MIRT808667	hsa-miR-922	CLIP-seq
MIRT2481627	hsa-miR-933	CLIP-seq
MIRT808610	hsa-miR-1224-5p	CLIP-seq
MIRT808611	hsa-miR-1234	CLIP-seq
MIRT808612	hsa-miR-1254	CLIP-seq
MIRT808613	hsa-miR-1269	CLIP-seq
MIRT808614	hsa-miR-1269b	CLIP-seq
MIRT808616	hsa-miR-1288	CLIP-seq
MIRT808668	hsa-miR-1291	CLIP-seq
MIRT808669	hsa-miR-1321	CLIP-seq
MIRT808617	hsa-miR-15a	CLIP-seq
MIRT808618	hsa-miR-15b	CLIP-seq
MIRT808619	hsa-miR-16	CLIP-seq
MIRT808671	hsa-miR-1909	CLIP-seq
MIRT808621	hsa-miR-195	CLIP-seq
MIRT808622	hsa-miR-214	CLIP-seq
MIRT808623	hsa-miR-3116	CLIP-seq
MIRT808673	hsa-miR-3591-3p	CLIP-seq
MIRT808624	hsa-miR-3619-5p	CLIP-seq
MIRT808626	hsa-miR-3690	CLIP-seq
MIRT808627	hsa-miR-378	CLIP-seq
MIRT808628	hsa-miR-378b	CLIP-seq
MIRT808629	hsa-miR-378c	CLIP-seq
MIRT808630	hsa-miR-378d	CLIP-seq
MIRT808631	hsa-miR-378e	CLIP-seq
MIRT808632	hsa-miR-378f	CLIP-seq
MIRT808633	hsa-miR-378h	CLIP-seq
MIRT808634	hsa-miR-378i	CLIP-seq
MIRT808636	hsa-miR-422a	CLIP-seq
MIRT808637	hsa-miR-424	CLIP-seq
MIRT808675	hsa-miR-4270	CLIP-seq
MIRT808638	hsa-miR-4291	CLIP-seq
MIRT808639	hsa-miR-4418	CLIP-seq
MIRT808676	hsa-miR-4441	CLIP-seq
MIRT808645	hsa-miR-4515	CLIP-seq
MIRT808678	hsa-miR-451b	CLIP-seq
MIRT808679	hsa-miR-4728-5p	CLIP-seq
MIRT808680	hsa-miR-4739	CLIP-seq
MIRT808653	hsa-miR-4740-5p	CLIP-seq
MIRT808654	hsa-miR-4751	CLIP-seq
MIRT808681	hsa-miR-4756-5p	CLIP-seq
MIRT808682	hsa-miR-4766-5p	CLIP-seq
MIRT808655	hsa-miR-4797-5p	CLIP-seq
MIRT808683	hsa-miR-488	CLIP-seq
MIRT808656	hsa-miR-497	CLIP-seq
MIRT808657	hsa-miR-509-3-5p	CLIP-seq
MIRT808658	hsa-miR-509-5p	CLIP-seq
MIRT808660	hsa-miR-515-3p	CLIP-seq
MIRT808661	hsa-miR-519e	CLIP-seq
MIRT808662	hsa-miR-552	CLIP-seq
MIRT808663	hsa-miR-596	CLIP-seq
MIRT808665	hsa-miR-761	CLIP-seq
MIRT808666	hsa-miR-764	CLIP-seq
MIRT808667	hsa-miR-922	CLIP-seq
MIRT2481627	hsa-miR-933	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005215	Function	Transporter activity	TAS	9653649
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005774	Component	Vacuolar membrane	IEA
GO:0008286	Process	Insulin receptor signaling pathway	TAS
GO:0010008	Component	Endosome membrane	TAS
GO:0016021	Component	Integral component of membrane	IBA	21873635
GO:0016241	Process	Regulation of macroautophagy	NAS	22982048
GO:0030670	Component	Phagocytic vesicle membrane	TAS
GO:0033179	Component	Proton-transporting V-type ATPase, V0 domain	IEA
GO:0033572	Process	Transferrin transport	TAS
GO:0034220	Process	Ion transmembrane transport	TAS
GO:0046961	Function	Proton-transporting ATPase activity, rotational mechanism	IBA	21873635
GO:0090383	Process	Phagosome acidification	TAS
GO:1902600	Process	Proton transmembrane transport	IEA

Other IDs

• MIM: 603717
• HGNC: 861
• e!Ensembl: ENSG00000117410

Protein

• UniProt ID: Q99437
• Protein name: V-type proton ATPase 21 kDa proteolipid subunit c'' (V-ATPase 21 kDa proteolipid subunit c'') (Vacuolar proton pump 21 kDa proteolipid subunit c'') (hATPL)
• Protein function: Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33
• PDB: 6WLW, 6WM2, 6WM3, 6WM4, 7U4T, 7UNF
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00137	ATP-synt_C	52 → 111	ATP synthase subunit C	Family
  PF00137	ATP-synt_C	138 → 197	ATP synthase subunit C	Family

• Sequence:

  MTGLALLYSGVFVAFWACALAVGVCYTIFDLGFRFDVAWFLTETSPFMWSNLGIGLAISL
  SVVGAAWGIYITGSSIIGGGVKAPRIKTKNLVSIIFCEAVAIYGIIMAIVISNMAEPFSA
  TDPKAIGHRNYHAGYSMFGAGLTVGLSNLFCGVCVGIVGSGAALADAQNPSLFVKILIVE
  IFGSAIGLFGVIVAILQTSRVKMGD

• Sequence length: 205

Pathways

KEGG:

Oxidative phosphorylation
Metabolic pathways
Lysosome
Phagosome
Synaptic vesicle cycle
Vibrio cholerae infection
Epithelial cell signaling in Helicobacter pylori infection
Tuberculosis
Human papillomavirus infection
Rheumatoid arthritis

Reactome:

ROS and RNS production in phagocytes
Insulin receptor recycling
Transferrin endocytosis and recycling
Amino acids regulate mTORC1
Ion channel transport

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243