PLAT (plasminogen activator, tissue type)

Gene

• Entrez ID: 5327
• Gene name: Plasminogen activator, tissue type
• Gene symbol: PLAT
• Synonyms: T-PA, TPA
• Chromosome: 8
• Chromosome location: 8p11.21
• Summary: This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and l

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs114878147	G>A	Conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005838	hsa-miR-204-5p	Microarray	21282569
MIRT005953	hsa-miR-21-5p	Luciferase reporter assay, Microarray, qRT-PCR	21131358
MIRT017829	hsa-miR-335-5p	Microarray	18185580
MIRT735970	hsa-miR-142-5p	Microarray, qRT-PCR	31552107
MIRT1239429	hsa-miR-1178	CLIP-seq
MIRT1239430	hsa-miR-1237	CLIP-seq
MIRT1239431	hsa-miR-1324	CLIP-seq
MIRT1239432	hsa-miR-186	CLIP-seq
MIRT1239433	hsa-miR-2113	CLIP-seq
MIRT1239434	hsa-miR-3133	CLIP-seq
MIRT1239435	hsa-miR-3182	CLIP-seq
MIRT1239436	hsa-miR-3185	CLIP-seq
MIRT1239437	hsa-miR-320a	CLIP-seq
MIRT1239438	hsa-miR-320b	CLIP-seq
MIRT1239439	hsa-miR-320c	CLIP-seq
MIRT1239440	hsa-miR-320d	CLIP-seq
MIRT1239441	hsa-miR-329	CLIP-seq
MIRT1239442	hsa-miR-340	CLIP-seq
MIRT1239443	hsa-miR-3622b-5p	CLIP-seq
MIRT1239444	hsa-miR-362-3p	CLIP-seq
MIRT1239445	hsa-miR-3941	CLIP-seq
MIRT1239446	hsa-miR-4251	CLIP-seq
MIRT1239447	hsa-miR-4270	CLIP-seq
MIRT1239448	hsa-miR-4303	CLIP-seq
MIRT1239449	hsa-miR-4329	CLIP-seq
MIRT1239450	hsa-miR-4429	CLIP-seq
MIRT1239451	hsa-miR-4441	CLIP-seq
MIRT1239452	hsa-miR-466	CLIP-seq
MIRT1239453	hsa-miR-4672	CLIP-seq
MIRT1239454	hsa-miR-4695-3p	CLIP-seq
MIRT1239455	hsa-miR-4701-5p	CLIP-seq
MIRT1239456	hsa-miR-4711-3p	CLIP-seq
MIRT1239457	hsa-miR-4724-3p	CLIP-seq
MIRT1239458	hsa-miR-542-3p	CLIP-seq
MIRT1239459	hsa-miR-570	CLIP-seq
MIRT1239460	hsa-miR-579	CLIP-seq
MIRT1239461	hsa-miR-588	CLIP-seq
MIRT1239462	hsa-miR-603	CLIP-seq
MIRT1239463	hsa-miR-767-3p	CLIP-seq
MIRT1239442	hsa-miR-340	CLIP-seq
MIRT2432149	hsa-miR-4509	CLIP-seq
MIRT2432150	hsa-miR-4666-3p	CLIP-seq
MIRT2432151	hsa-miR-4744	CLIP-seq
MIRT2432152	hsa-miR-4768-5p	CLIP-seq
MIRT2432153	hsa-miR-561	CLIP-seq
MIRT1239429	hsa-miR-1178	CLIP-seq
MIRT2594990	hsa-miR-1224-5p	CLIP-seq
MIRT1239430	hsa-miR-1237	CLIP-seq
MIRT2594991	hsa-miR-1291	CLIP-seq
MIRT2594992	hsa-miR-1304	CLIP-seq
MIRT2594993	hsa-miR-1587	CLIP-seq
MIRT2594994	hsa-miR-1913	CLIP-seq
MIRT2594995	hsa-miR-193a-5p	CLIP-seq
MIRT2594996	hsa-miR-2110	CLIP-seq
MIRT1239433	hsa-miR-2113	CLIP-seq
MIRT2594997	hsa-miR-3137	CLIP-seq
MIRT2594998	hsa-miR-3140-3p	CLIP-seq
MIRT2594999	hsa-miR-3140-5p	CLIP-seq
MIRT2595000	hsa-miR-3147	CLIP-seq
MIRT2595001	hsa-miR-3153	CLIP-seq
MIRT2595002	hsa-miR-3160-5p	CLIP-seq
MIRT2595003	hsa-miR-3173-5p	CLIP-seq
MIRT2595004	hsa-miR-3189-5p	CLIP-seq
MIRT2595005	hsa-miR-3194-5p	CLIP-seq
MIRT1239437	hsa-miR-320a	CLIP-seq
MIRT1239438	hsa-miR-320b	CLIP-seq
MIRT1239439	hsa-miR-320c	CLIP-seq
MIRT1239440	hsa-miR-320d	CLIP-seq
MIRT2595006	hsa-miR-324-3p	CLIP-seq
MIRT1239441	hsa-miR-329	CLIP-seq
MIRT1239443	hsa-miR-3622b-5p	CLIP-seq
MIRT1239444	hsa-miR-362-3p	CLIP-seq
MIRT2595007	hsa-miR-3691-3p	CLIP-seq
MIRT2595008	hsa-miR-370	CLIP-seq
MIRT2595009	hsa-miR-378g	CLIP-seq
MIRT2595010	hsa-miR-3915	CLIP-seq
MIRT2595011	hsa-miR-3928	CLIP-seq
MIRT1239445	hsa-miR-3941	CLIP-seq
MIRT1239446	hsa-miR-4251	CLIP-seq
MIRT1239447	hsa-miR-4270	CLIP-seq
MIRT2595012	hsa-miR-4271	CLIP-seq
MIRT1239448	hsa-miR-4303	CLIP-seq
MIRT1239449	hsa-miR-4329	CLIP-seq
MIRT2595013	hsa-miR-4428	CLIP-seq
MIRT1239450	hsa-miR-4429	CLIP-seq
MIRT2595014	hsa-miR-4433	CLIP-seq
MIRT2595015	hsa-miR-4434	CLIP-seq
MIRT2595016	hsa-miR-4437	CLIP-seq
MIRT1239451	hsa-miR-4441	CLIP-seq
MIRT2595017	hsa-miR-4459	CLIP-seq
MIRT2595018	hsa-miR-4481	CLIP-seq
MIRT2432149	hsa-miR-4509	CLIP-seq
MIRT2595019	hsa-miR-4516	CLIP-seq
MIRT2595020	hsa-miR-4531	CLIP-seq
MIRT2595021	hsa-miR-4533	CLIP-seq
MIRT2595022	hsa-miR-4640-5p	CLIP-seq
MIRT1239452	hsa-miR-466	CLIP-seq
MIRT2432150	hsa-miR-4666-3p	CLIP-seq
MIRT1239453	hsa-miR-4672	CLIP-seq
MIRT2595023	hsa-miR-4674	CLIP-seq
MIRT2595024	hsa-miR-4689	CLIP-seq
MIRT2595025	hsa-miR-4698	CLIP-seq
MIRT1239455	hsa-miR-4701-5p	CLIP-seq
MIRT1239457	hsa-miR-4724-3p	CLIP-seq
MIRT2595026	hsa-miR-4725-3p	CLIP-seq
MIRT2595027	hsa-miR-4726-5p	CLIP-seq
MIRT2595028	hsa-miR-4731-3p	CLIP-seq
MIRT2595029	hsa-miR-4731-5p	CLIP-seq
MIRT2595030	hsa-miR-4732-5p	CLIP-seq
MIRT2432151	hsa-miR-4744	CLIP-seq
MIRT2595031	hsa-miR-4745-5p	CLIP-seq
MIRT2595032	hsa-miR-4747-5p	CLIP-seq
MIRT2595033	hsa-miR-4758-3p	CLIP-seq
MIRT2595034	hsa-miR-4763-5p	CLIP-seq
MIRT2595035	hsa-miR-4768-3p	CLIP-seq
MIRT2432152	hsa-miR-4768-5p	CLIP-seq
MIRT2595036	hsa-miR-4797-5p	CLIP-seq
MIRT2595037	hsa-miR-4801	CLIP-seq
MIRT2595038	hsa-miR-491-5p	CLIP-seq
MIRT2595039	hsa-miR-516b	CLIP-seq
MIRT2595040	hsa-miR-541	CLIP-seq
MIRT1239458	hsa-miR-542-3p	CLIP-seq
MIRT2432153	hsa-miR-561	CLIP-seq
MIRT1239459	hsa-miR-570	CLIP-seq
MIRT1239460	hsa-miR-579	CLIP-seq
MIRT1239461	hsa-miR-588	CLIP-seq
MIRT2595041	hsa-miR-596	CLIP-seq
MIRT1239462	hsa-miR-603	CLIP-seq
MIRT2595042	hsa-miR-654-5p	CLIP-seq
MIRT1239463	hsa-miR-767-3p	CLIP-seq
MIRT2594990	hsa-miR-1224-5p	CLIP-seq
MIRT1239430	hsa-miR-1237	CLIP-seq
MIRT2594991	hsa-miR-1291	CLIP-seq
MIRT2594992	hsa-miR-1304	CLIP-seq
MIRT2594993	hsa-miR-1587	CLIP-seq
MIRT2594994	hsa-miR-1913	CLIP-seq
MIRT2594995	hsa-miR-193a-5p	CLIP-seq
MIRT2594996	hsa-miR-2110	CLIP-seq
MIRT1239433	hsa-miR-2113	CLIP-seq
MIRT2594997	hsa-miR-3137	CLIP-seq
MIRT2594998	hsa-miR-3140-3p	CLIP-seq
MIRT2594999	hsa-miR-3140-5p	CLIP-seq
MIRT2595000	hsa-miR-3147	CLIP-seq
MIRT2595001	hsa-miR-3153	CLIP-seq
MIRT2595002	hsa-miR-3160-5p	CLIP-seq
MIRT2595003	hsa-miR-3173-5p	CLIP-seq
MIRT2595004	hsa-miR-3189-5p	CLIP-seq
MIRT2595005	hsa-miR-3194-5p	CLIP-seq
MIRT2595006	hsa-miR-324-3p	CLIP-seq
MIRT1239441	hsa-miR-329	CLIP-seq
MIRT1239444	hsa-miR-362-3p	CLIP-seq
MIRT2595007	hsa-miR-3691-3p	CLIP-seq
MIRT2595008	hsa-miR-370	CLIP-seq
MIRT2595009	hsa-miR-378g	CLIP-seq
MIRT2595010	hsa-miR-3915	CLIP-seq
MIRT2595011	hsa-miR-3928	CLIP-seq
MIRT1239445	hsa-miR-3941	CLIP-seq
MIRT1239446	hsa-miR-4251	CLIP-seq
MIRT1239447	hsa-miR-4270	CLIP-seq
MIRT2595012	hsa-miR-4271	CLIP-seq
MIRT1239448	hsa-miR-4303	CLIP-seq
MIRT1239449	hsa-miR-4329	CLIP-seq
MIRT2595013	hsa-miR-4428	CLIP-seq
MIRT2595014	hsa-miR-4433	CLIP-seq
MIRT2595015	hsa-miR-4434	CLIP-seq
MIRT2595016	hsa-miR-4437	CLIP-seq
MIRT1239451	hsa-miR-4441	CLIP-seq
MIRT2595017	hsa-miR-4459	CLIP-seq
MIRT2595018	hsa-miR-4481	CLIP-seq
MIRT2595019	hsa-miR-4516	CLIP-seq
MIRT2595020	hsa-miR-4531	CLIP-seq
MIRT2595021	hsa-miR-4533	CLIP-seq
MIRT2595022	hsa-miR-4640-5p	CLIP-seq
MIRT1239452	hsa-miR-466	CLIP-seq
MIRT1239453	hsa-miR-4672	CLIP-seq
MIRT2595023	hsa-miR-4674	CLIP-seq
MIRT2595024	hsa-miR-4689	CLIP-seq
MIRT2595025	hsa-miR-4698	CLIP-seq
MIRT1239457	hsa-miR-4724-3p	CLIP-seq
MIRT2595026	hsa-miR-4725-3p	CLIP-seq
MIRT2595027	hsa-miR-4726-5p	CLIP-seq
MIRT2595028	hsa-miR-4731-3p	CLIP-seq
MIRT2595029	hsa-miR-4731-5p	CLIP-seq
MIRT2595031	hsa-miR-4745-5p	CLIP-seq
MIRT2595032	hsa-miR-4747-5p	CLIP-seq
MIRT2595033	hsa-miR-4758-3p	CLIP-seq
MIRT2595034	hsa-miR-4763-5p	CLIP-seq
MIRT2595035	hsa-miR-4768-3p	CLIP-seq
MIRT2595036	hsa-miR-4797-5p	CLIP-seq
MIRT2595037	hsa-miR-4801	CLIP-seq
MIRT2595038	hsa-miR-491-5p	CLIP-seq
MIRT2595039	hsa-miR-516b	CLIP-seq
MIRT2595040	hsa-miR-541	CLIP-seq
MIRT1239459	hsa-miR-570	CLIP-seq
MIRT1239460	hsa-miR-579	CLIP-seq
MIRT2595041	hsa-miR-596	CLIP-seq
MIRT1239462	hsa-miR-603	CLIP-seq
MIRT2595042	hsa-miR-654-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ATF2	Activation	8647095
CREB1	Repression	8647095
CREM	Unknown	9851700
JUN	Activation	1963081
JUN	Unknown	9851700
JUND	Unknown	9851700
NF1	Repression	15044208
SP1	Unknown	21437359;9851700
SP3	Unknown	21437359

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004252	Function	Serine-type endopeptidase activity	IBA	21873635
GO:0004252	Function	Serine-type endopeptidase activity	IDA	1695900, 8508955
GO:0004252	Function	Serine-type endopeptidase activity	TAS
GO:0005102	Function	Signaling receptor binding	IPI	8186264
GO:0005515	Function	Protein binding	IPI	2503541, 10340997, 12694198, 24196407
GO:0005515	Function	Protein binding	TAS	8186264
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	1632457
GO:0006464	Process	Cellular protein modification process	TAS	3087818
GO:0006508	Process	Proteolysis	IBA	21873635
GO:0007596	Process	Blood coagulation	TAS	3839198
GO:0009986	Component	Cell surface	IDA	1632457
GO:0014909	Process	Smooth muscle cell migration	IBA	21873635
GO:0031639	Process	Plasminogen activation	IBA	21873635
GO:0031639	Process	Plasminogen activation	IDA	12694198, 17849409, 24196407
GO:0042730	Process	Fibrinolysis	TAS
GO:0045861	Process	Negative regulation of proteolysis	IDA	1695900
GO:0048008	Process	Platelet-derived growth factor receptor signaling pathway	IBA	21873635
GO:0051219	Function	Phosphoprotein binding	IPI	8186264
GO:0062023	Component	Collagen-containing extracellular matrix	IDA	1632457
GO:0070062	Component	Extracellular exosome	HDA	20458337

Other IDs

• MIM: 173370
• HGNC: 9051
• e!Ensembl: ENSG00000104368

Protein

• UniProt ID: P00750
• Protein name: Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) (Alteplase) (Reteplase) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B]
• Protein function: Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migrat
• PDB: 1A5H, 1BDA, 1PK2, 1PML, 1RTF, 1TPG, 1TPK, 1TPM, 1TPN, 5BRR, 5ZLZ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00039	fn1	41 → 78	Fibronectin type I domain	Domain
  PF00008	EGF	86 → 117	EGF-like domain	Domain
  PF00051	Kringle	127 → 208	Kringle domain	Domain
  PF00051	Kringle	215 → 296	Kringle domain	Domain
  PF00089	Trypsin	311 → 556	Trypsin	Domain

• Sequence:

  MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV
  LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
  IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR
  NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN
  SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
  LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
  ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
  QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
  LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
  DVPGVYTKVTNYLDWIRDNMRP

• Sequence length: 562

Pathways

KEGG:

Apelin signaling pathway
Complement and coagulation cascades
Transcriptional misregulation in cancer
Prostate cancer
Fluid shear stress and atherosclerosis

Reactome:

Signaling by PDGF
Dissolution of Fibrin Clot

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Cerebral infarction	Cerebral Infarction	rs2230500	9183334, 1899364, 1579960, 15502123, 18544249, 16148626
Dermatitis	Dermatitis, Allergic Contact	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	17374397
Hypertension	Hypertensive disease	rs13306026, rs13333226	22352330
Myocardial infarction	Myocardial Infarction, Myocardial Failure	rs12316150, rs41303970, rs909253, rs7291467, rs2234693	9183334, 12848087, 1430592, 10645301, 1899364, 20122609, 15215796, 2494454, 1898952, 7902905, 10914357, 8554022, 2521976, 8598594, 3121335, 7775709, 11382373, 11489769, 2105625, 12227717, 2505604, 1900011, 18195371, 7488445, 8328192, 3089627, 15301905, 10505926, 2104561, 19341228, 10171637, 1492007, 12074692, 22352330
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	21898905
Thrombophilia	Thrombophilia, Thrombophilia, Familial, Due To Decreased Release Of Tissue Plasminogen Activator	rs118203912, rs118203911, rs121918141, rs121918142, rs121918143, rs121918144, rs121918145, rs121918146, rs121918147, rs121918148, rs121918149, rs121918151, rs121918152, rs121918153, rs121918154, rs1558715857, rs121918155, rs121918157, rs121918158, rs2104934553, rs121918159, rs121918160, rs121918477, rs121918473, rs121918474, rs267606981, rs2107137679, rs121918475, rs387906674, rs387907201, rs369504169, rs142742242, rs373983977, rs368074804, rs574132670, rs757583846, rs863224838, rs121918476, rs1333329860, rs1553424043, rs1553808038, rs5017717, rs374476971, rs1553809314, rs1553423955, rs767112991, rs1558718572, rs571278160, rs766261022, rs1321566264, rs1559926604, rs1241365457, rs759677822, rs1448630830, rs1305782685, rs1571577365, rs1247269491, rs777486993, rs201907715, rs769277939, rs199469503, rs1575904540, rs199469494, rs199469471, rs1189377845, rs1576182848, rs1688218776, rs1456533664, rs1709033502, rs1708668246, rs1708665916

Unknown
Disease name	Disease term	dbSNP ID	References
Aphasia	Aphasia, Aphasia, Acquired, Aphasia, Global, Aphasia, Progressive, Aphasia, Mixed		12690208
Arterial occlusive disease	Arterial Occlusive Diseases		15557913
Atheromatous embolus	Cholesterol Embolism		7939511
Atherosclerosis	Atherosclerosis	rs699947, rs59439148	12677255
Cerebral infraction	Infarction, Middle Cerebral Artery		20547619, 17690543, 18453163, 12297567
Brain infarction	Subcortical Infarction, Brain Infarction		1899364, 16148626, 15502123, 18544249, 9183334, 1579960, 16190367
Cardiac tamponade	Cardiac Tamponade		9633741
Cerebral embolism and thrombosis	Cerebral Embolism and Thrombosis		7482654, 8427107
Cerebral ischemia	Brain Ischemia		9400355, 16126134, 21037505, 7477192, 9479658, 15087567, 9566367, 10572812, 17086147, 20123226, 11108748, 11940547, 12511774, 15017018, 20488584, 14986460, 17903870, 9633741, 16809570, 20536612, 9259745, 20212195, 12221155, 17525387
Cerebral thrombosis	Cerebral Thrombosis, Middle Cerebral Artery Thrombosis, Brain Thrombosis		8678742, 20547619, 18453163, 17690543, 12297567
Cerebral thrombus	Brain Thrombus, Cerebral Thrombus		8678742
Cerebral vasospasm	Cerebral Vasospasm		19057314
Chylopericardium	Chylopericardium		9633741
Congestive heart failure	Congestive heart failure	rs2301610, rs3833910, rs12301951, rs201674674, rs186741807, rs150140412, rs786205727, rs757840030, rs552050895, rs759465783, rs201978086, rs572757800, rs1572143354, rs749160569	22352330
Conus medullaris syndrome	Conus Medullaris Syndrome		12227717
Coronary thrombosis	Coronary Thrombosis		1452937, 15301905, 8172379
Dysphasia	Dysphasia		12690208
Embolism and thrombosis	Embolism and Thrombosis, Brain Embolism and Thrombosis		9684808, 7482654, 8427107
Heart failure	Heart failure, Left-Sided Heart Failure, Heart Failure, Right-Sided	rs121918074, rs142027794, rs148791216, rs72648927, rs71578935, rs142416150, rs199830512, rs755445214, rs150102469, rs779568205, rs907992794, rs1202130741	22352330
Intracranial embolism and thrombosis	Intracranial Embolism and Thrombosis		8427107, 7482654
Intracranial thrombosis	Intracranial Thrombosis		8678742
Intracranial vasospasm	Vasospasm, Intracranial		19057314
Lethal hydranencephaly-diaphragmatic hernia syndrome	Lethal hydranencephaly-diaphragmatic hernia syndrome
Lupus erythematosus	Lupus Erythematosus, Systemic		28714469
Non rare thrombophilia	NON RARE IN EUROPE: Non rare thrombophilia
Pericardial effusion	Pericardial effusion		9633741
Pulmonary thromboembolism	Pulmonary Thromboembolisms		9199818, 2123154, 1899825, 19415734, 3122266, 9266785, 8082347, 3105914, 8451030
Respiratory failure	Respiratory Failure		25331496
Spinal cord compression	Compression of spinal cord		12227717
Stroke	Cerebrovascular accident, Acute Cerebrovascular Accidents		18753472, 20212195, 16126134, 11108748, 18346647, 18560214, 20536612, 9707184, 10572812, 20705933, 17903947, 9633741, 17086147, 15017018, 9479658, 16908730, 2124386, 18369171, 12511774, 8427107, 11940547, 8598594, 20488584, 17525387, 12221155, 14986460, 17612434, 15016487, 10346413, 18753474, 17903870, 9479657, 16809570, 10171637, 11239184, 20123226, 9259745, 12384244, 11061250, 7477192, 11739841, 9933289, 19286598, 25245553, 12230423, 9056608, 9400355, 1598096, 16184341, 9566367, 10436095, 9472885, 14581697, 15087567, 11113218, 14657446, 2514002, 9836764, 9933289, 7477192, 17903947, 9472885, 17903870, 9259745, 9056608, 12221155, 19286598, 20536612, 9479658, 2124386, 9479657, 10171637, 20212195, 15087567, 12384244, 18560214, 2514002, 16809570, 8427107, 14657446, 20488584, 20705933, 11239184, 11739841, 11113218, 17525387, 14986460, 12511774, 10346413, 18369171, 9836764, 12230423, 11940547, 9566367, 25245553, 20123226, 11108748, 11061250, 18346647, 15016487, 17612434, 9633741, 8598594, 15017018, 16908730, 18753474, 16126134, 18753472, 16184341, 9707184, 10572812, 1598096, 14581697, 10436095, 17086147, 9400355
Thrombosis	Deep Vein Thrombosis		15557913, 11144008, 19415734