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PLA2G5 (phospholipase A2 group V)

Gene

5322

Phospholipase A2 group V

PLA2G5

FRFB, GV-PLA2, PLA2-10, hVPLA(2)

1p36.13

This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholip

Show/Hide all(6)

SNP ID	Visualize variation	Clinical significance	Consequence
rs200954922	C>T	Affects	Coding sequence variant, stop gained
rs387906795	G>A,T	Affects	Coding sequence variant, missense variant
rs387906796	G>A	Affects	Coding sequence variant, missense variant
rs746408116	G>A	Affects	Stop gained, coding sequence variant
rs766454085	A>-	Affects	3 prime UTR variant, frameshift variant, coding sequence variant
rs1569848362	->G	Pathogenic	Frameshift variant, coding sequence variant

Show/Hide all(101)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021933	hsa-miR-128-3p	Microarray	17612493
MIRT441766	hsa-miR-3125	PAR-CLIP	22100165
MIRT441767	hsa-miR-3916	PAR-CLIP	22100165
MIRT441765	hsa-miR-6859-5p	PAR-CLIP	22100165
MIRT441764	hsa-miR-6847-5p	PAR-CLIP	22100165
MIRT441763	hsa-miR-922	PAR-CLIP	22100165
MIRT441762	hsa-miR-2467-3p	PAR-CLIP	22100165
MIRT441761	hsa-miR-192-3p	PAR-CLIP	22100165
MIRT441766	hsa-miR-3125	PAR-CLIP	22100165
MIRT441767	hsa-miR-3916	PAR-CLIP	22100165
MIRT441765	hsa-miR-6859-5p	PAR-CLIP	22100165
MIRT441764	hsa-miR-6847-5p	PAR-CLIP	22100165
MIRT441763	hsa-miR-922	PAR-CLIP	22100165
MIRT441762	hsa-miR-2467-3p	PAR-CLIP	22100165
MIRT441761	hsa-miR-192-3p	PAR-CLIP	22100165
MIRT441766	hsa-miR-3125	PAR-CLIP	22100165
MIRT441767	hsa-miR-3916	PAR-CLIP	22100165
MIRT441765	hsa-miR-6859-5p	PAR-CLIP	22100165
MIRT441764	hsa-miR-6847-5p	PAR-CLIP	22100165
MIRT441763	hsa-miR-922	PAR-CLIP	22100165
MIRT441762	hsa-miR-2467-3p	PAR-CLIP	22100165
MIRT441761	hsa-miR-192-3p	PAR-CLIP	22100165
MIRT441766	hsa-miR-3125	PAR-CLIP	22100165
MIRT441767	hsa-miR-3916	PAR-CLIP	22100165
MIRT441765	hsa-miR-6859-5p	PAR-CLIP	22100165
MIRT441764	hsa-miR-6847-5p	PAR-CLIP	22100165
MIRT441763	hsa-miR-922	PAR-CLIP	22100165
MIRT441762	hsa-miR-2467-3p	PAR-CLIP	22100165
MIRT441761	hsa-miR-192-3p	PAR-CLIP	22100165
MIRT1238804	hsa-miR-1179	CLIP-seq
MIRT1238805	hsa-miR-1253	CLIP-seq
MIRT1238806	hsa-miR-1264	CLIP-seq
MIRT1238807	hsa-miR-1266	CLIP-seq
MIRT1238808	hsa-miR-1293	CLIP-seq
MIRT1238809	hsa-miR-136	CLIP-seq
MIRT1238810	hsa-miR-28-5p	CLIP-seq
MIRT1238811	hsa-miR-302a	CLIP-seq
MIRT1238812	hsa-miR-302b	CLIP-seq
MIRT1238813	hsa-miR-302c	CLIP-seq
MIRT1238814	hsa-miR-302d	CLIP-seq
MIRT1238815	hsa-miR-302e	CLIP-seq
MIRT1238816	hsa-miR-3074-3p	CLIP-seq
MIRT1238817	hsa-miR-3139	CLIP-seq
MIRT1238818	hsa-miR-3192	CLIP-seq
MIRT1238819	hsa-miR-326	CLIP-seq
MIRT1238820	hsa-miR-330-5p	CLIP-seq
MIRT1238821	hsa-miR-3664-3p	CLIP-seq
MIRT1238822	hsa-miR-3668	CLIP-seq
MIRT1238823	hsa-miR-3689a-3p	CLIP-seq
MIRT1238824	hsa-miR-3689c	CLIP-seq
MIRT1238825	hsa-miR-372	CLIP-seq
MIRT1238826	hsa-miR-373	CLIP-seq
MIRT1238827	hsa-miR-4251	CLIP-seq
MIRT1238828	hsa-miR-4310	CLIP-seq
MIRT1238829	hsa-miR-4314	CLIP-seq
MIRT1238830	hsa-miR-4483	CLIP-seq
MIRT1238831	hsa-miR-4518	CLIP-seq
MIRT1238832	hsa-miR-4527	CLIP-seq
MIRT1238833	hsa-miR-4646-5p	CLIP-seq
MIRT1238834	hsa-miR-4652-3p	CLIP-seq
MIRT1238835	hsa-miR-4728-5p	CLIP-seq
MIRT1238836	hsa-miR-515-5p	CLIP-seq
MIRT1238837	hsa-miR-516b	CLIP-seq
MIRT1238838	hsa-miR-519a	CLIP-seq
MIRT1238839	hsa-miR-519b-3p	CLIP-seq
MIRT1238840	hsa-miR-519c-3p	CLIP-seq
MIRT1238841	hsa-miR-520a-3p	CLIP-seq
MIRT1238842	hsa-miR-520b	CLIP-seq
MIRT1238843	hsa-miR-520c-3p	CLIP-seq
MIRT1238844	hsa-miR-520d-3p	CLIP-seq
MIRT1238845	hsa-miR-520e	CLIP-seq
MIRT1238846	hsa-miR-548c-3p	CLIP-seq
MIRT1238847	hsa-miR-708	CLIP-seq
MIRT1238848	hsa-miR-765	CLIP-seq
MIRT1238849	hsa-miR-873	CLIP-seq
MIRT2070261	hsa-miR-1254	CLIP-seq
MIRT2070262	hsa-miR-127-5p	CLIP-seq
MIRT2070263	hsa-miR-3116	CLIP-seq
MIRT2070264	hsa-miR-320e	CLIP-seq
MIRT2070265	hsa-miR-590-3p	CLIP-seq
MIRT2070266	hsa-miR-671-5p	CLIP-seq
MIRT1238805	hsa-miR-1253	CLIP-seq
MIRT2297528	hsa-miR-298	CLIP-seq
MIRT1238811	hsa-miR-302a	CLIP-seq
MIRT1238812	hsa-miR-302b	CLIP-seq
MIRT1238813	hsa-miR-302c	CLIP-seq
MIRT1238814	hsa-miR-302d	CLIP-seq
MIRT1238815	hsa-miR-302e	CLIP-seq
MIRT1238825	hsa-miR-372	CLIP-seq
MIRT1238826	hsa-miR-373	CLIP-seq
MIRT1238827	hsa-miR-4251	CLIP-seq
MIRT1238838	hsa-miR-519a	CLIP-seq
MIRT1238839	hsa-miR-519b-3p	CLIP-seq
MIRT1238840	hsa-miR-519c-3p	CLIP-seq
MIRT1238841	hsa-miR-520a-3p	CLIP-seq
MIRT1238842	hsa-miR-520b	CLIP-seq
MIRT1238843	hsa-miR-520c-3p	CLIP-seq
MIRT1238844	hsa-miR-520d-3p	CLIP-seq
MIRT1238845	hsa-miR-520e	CLIP-seq
MIRT2392592	hsa-miR-3183	CLIP-seq
MIRT2392593	hsa-miR-4723-3p	CLIP-seq

Show/Hide all(34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IBA	21873635
GO:0005543	Function	Phospholipid binding	IBA	21873635
GO:0005576	Component	Extracellular region	TAS
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006644	Process	Phospholipid metabolic process	IBA	21873635
GO:0006654	Process	Phosphatidic acid biosynthetic process	TAS
GO:0010518	Process	Positive regulation of phospholipase activity	IDA	22837859
GO:0010744	Process	Positive regulation of macrophage derived foam cell differentiation	ISS
GO:0019370	Process	Leukotriene biosynthetic process	IDA	20432503
GO:0032009	Component	Early phagosome	ISS
GO:0032010	Component	Phagolysosome	ISS
GO:0034374	Process	Low-density lipoprotein particle remodeling	ISS
GO:0034638	Process	Phosphatidylcholine catabolic process	IDA	23533611
GO:0035965	Process	Cardiolipin acyl-chain remodeling	IDA	23533611
GO:0036148	Process	Phosphatidylglycerol acyl-chain remodeling	TAS
GO:0036149	Process	Phosphatidylinositol acyl-chain remodeling	TAS
GO:0036150	Process	Phosphatidylserine acyl-chain remodeling	TAS
GO:0036151	Process	Phosphatidylcholine acyl-chain remodeling	TAS
GO:0036152	Process	Phosphatidylethanolamine acyl-chain remodeling	TAS
GO:0047498	Function	Calcium-dependent phospholipase A2 activity	IBA	21873635
GO:0047499	Function	Calcium-independent phospholipase A2 activity	IDA	23533611
GO:0050482	Process	Arachidonic acid secretion	IBA	21873635
GO:0050766	Process	Positive regulation of phagocytosis	ISS
GO:0055037	Component	Recycling endosome	IEA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IDA	22837859
GO:0090265	Process	Positive regulation of immune complex clearance by monocytes and macrophages	IDA	20432503
GO:0090385	Process	Phagosome-lysosome fusion	ISS
GO:0102567	Function	Phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)	IEA
GO:0102568	Function	Phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)	IEA
GO:1903028	Process	Positive regulation of opsonization	ISS
GO:1905036	Process	Positive regulation of antifungal innate immune response	ISS
GO:1905164	Process	Positive regulation of phagosome maturation	ISS

MIM	HGNC	e!Ensembl
601192	9038	ENSG00000127472

Protein

UniProt ID

P39877

Protein name

Phospholipase A2 group V (EC 3.1.1.4) (PLA2-10) (Phosphatidylcholine 2-acylhydrolase 5)

Protein function

Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:8300559). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), preferent

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00068	Phospholip_A2_1	22 → 130	Phospholipase A2	Domain

Sequence

MKGLLPLAWFLACSVPAVQGGLLDLKSMIEKVTGKNALTNYGFYGCYCGWGGRGTPKDGT
DWCCWAHDHCYGRLEEKGCNIRTQSYKYRFAWGVVTCEPGPFCHVNLCACDRKLVYCLKR
NLRSYNPQYQYFPNILCS

Sequence length

138

Interactions

View interactions

	KEGG		Reactome
	Glycerophospholipid metabolism Ether lipid metabolism Arachidonic acid metabolism Linoleic acid metabolism alpha-Linolenic acid metabolism Metabolic pathways Ras signaling pathway Vascular smooth muscle contraction Pancreatic secretion Fat digestion and absorption		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA

Associated diseases

Show/Hide Causal Diseases (2)

Causal
Disease name	Disease term	dbSNP ID	References
Benign flecked retina	Familial benign flecked retina	rs746408116, rs766454085
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	27903959

Show/Hide Unknown Diseases (2)

Unknown
Disease name	Disease term	dbSNP ID	References
Disorder of eye	Disorder of eye
Fleck retina	Fleck Retina, Familial Benign		22137173

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