GeDiPNet: Comprehensive Gene Data - OMIM, HGNC, Ensembl, UniProt, GO, Transcription Factors & miRNA

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PKM (pyruvate kinase M1/2)

Gene

5315

Pyruvate kinase M1/2

PKM

CTHBP, HEL-S-30, OIP3, PK3, PKM2, TCB, THBP1, p58

15q23

This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyro

Show/Hide all(149)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001816	hsa-miR-133a-3p	Immunohistochemistry	18464261
MIRT001815	hsa-miR-133b	Immunohistochemistry	18464261
MIRT005520	hsa-miR-326	Luciferase reporter assay, qRT-PCR, Western blot	20667897
MIRT005520	hsa-miR-326	Luciferase reporter assay, qRT-PCR, Western blot	20667897
MIRT005520	hsa-miR-326	Luciferase reporter assay, qRT-PCR, Western blot	20667897
MIRT005520	hsa-miR-326	Luciferase reporter assay, qRT-PCR, Western blot	20667897
MIRT001815	hsa-miR-133b	Other	18464261
MIRT001816	hsa-miR-133a-3p	Other	18464261
MIRT023396	hsa-miR-122-5p	Microarray	17612493
MIRT028653	hsa-miR-30a-5p	Proteomics	18668040
MIRT050390	hsa-miR-23a-3p	CLASH	23622248
MIRT049024	hsa-miR-92a-3p	CLASH	23622248
MIRT049024	hsa-miR-92a-3p	CLASH	23622248
MIRT047865	hsa-miR-30c-5p	CLASH	23622248
MIRT046929	hsa-miR-221-3p	CLASH	23622248
MIRT046680	hsa-miR-222-3p	CLASH	23622248
MIRT046680	hsa-miR-222-3p	CLASH	23622248
MIRT046067	hsa-miR-125b-5p	CLASH	23622248
MIRT046067	hsa-miR-125b-5p	CLASH	23622248
MIRT044585	hsa-miR-320a	CLASH	23622248
MIRT043843	hsa-miR-330-3p	CLASH	23622248
MIRT043754	hsa-miR-328-3p	CLASH	23622248
MIRT005520	hsa-miR-326	CLASH	23622248
MIRT042876	hsa-miR-324-3p	CLASH	23622248
MIRT042646	hsa-miR-423-3p	CLASH	23622248
MIRT041665	hsa-miR-484	CLASH	23622248
MIRT041665	hsa-miR-484	CLASH	23622248
MIRT041665	hsa-miR-484	CLASH	23622248
MIRT040961	hsa-miR-18a-3p	CLASH	23622248
MIRT039183	hsa-miR-769-5p	CLASH	23622248
MIRT039032	hsa-miR-766-3p	CLASH	23622248
MIRT038436	hsa-miR-296-3p	CLASH	23622248
MIRT038155	hsa-miR-423-5p	CLASH	23622248
MIRT036965	hsa-miR-877-3p	CLASH	23622248
MIRT036697	hsa-miR-935	CLASH	23622248
MIRT036045	hsa-miR-1301-3p	CLASH	23622248
MIRT036045	hsa-miR-1301-3p	CLASH	23622248
MIRT052783	hsa-miR-1260b	CLASH	23622248
MIRT052808	hsa-miR-3187-3p	CLASH	23622248
MIRT023396	hsa-miR-122-5p	Luciferase reporter assay, qRT-PCR, Western blot	24466275
MIRT023396	hsa-miR-122-5p	PAR-CLIP	23592263
MIRT470969	hsa-miR-4694-3p	PAR-CLIP	23592263
MIRT470968	hsa-miR-1296-3p	PAR-CLIP	23592263
MIRT470967	hsa-miR-4650-5p	PAR-CLIP	23592263
MIRT470966	hsa-miR-199a-3p	PAR-CLIP	23592263
MIRT470965	hsa-miR-199b-3p	PAR-CLIP	23592263
MIRT470964	hsa-miR-3129-5p	PAR-CLIP	23592263
MIRT470963	hsa-miR-4254	PAR-CLIP	23592263
MIRT470962	hsa-miR-17-3p	PAR-CLIP	23592263
MIRT470961	hsa-miR-6804-5p	PAR-CLIP	23592263
MIRT470960	hsa-miR-3659	PAR-CLIP	23592263
MIRT470959	hsa-miR-1254	PAR-CLIP	23592263
MIRT470958	hsa-miR-3116	PAR-CLIP	23592263
MIRT470957	hsa-miR-4533	PAR-CLIP	23592263
MIRT470956	hsa-miR-3202	PAR-CLIP	23592263
MIRT470955	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT470954	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT470953	hsa-miR-3689d	PAR-CLIP	23592263
MIRT470952	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT470951	hsa-miR-504-3p	PAR-CLIP	23592263
MIRT470950	hsa-miR-6822-3p	PAR-CLIP	23592263
MIRT470949	hsa-miR-4668-5p	PAR-CLIP	23592263
MIRT470948	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT470947	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT470946	hsa-miR-5698	PAR-CLIP	23592263
MIRT470945	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT470944	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT470943	hsa-miR-4525	PAR-CLIP	23592263
MIRT470942	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT470941	hsa-miR-363-5p	PAR-CLIP	23592263
MIRT470940	hsa-miR-6745	PAR-CLIP	23592263
MIRT470939	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT470938	hsa-miR-7847-3p	PAR-CLIP	23592263
MIRT470937	hsa-miR-4447	PAR-CLIP	23592263
MIRT470936	hsa-miR-4472	PAR-CLIP	23592263
MIRT470935	hsa-miR-4727-3p	PAR-CLIP	23592263
MIRT470934	hsa-miR-6515-5p	PAR-CLIP	23592263
MIRT470933	hsa-miR-1275	PAR-CLIP	23592263
MIRT470932	hsa-miR-4665-5p	PAR-CLIP	23592263
MIRT470931	hsa-miR-6730-5p	PAR-CLIP	23592263
MIRT439960	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439960	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT001815	hsa-miR-133b	Western blot	27073574
MIRT001815	hsa-miR-133b	Western blot	27073574
MIRT001815	hsa-miR-133b	qRT-PCR, Western blot	28641694
MIRT470955	hsa-miR-1249-5p	PAR-CLIP	26701625
MIRT470955	hsa-miR-1249-5p	PAR-CLIP	26701625
MIRT470933	hsa-miR-1275	PAR-CLIP	26701625
MIRT470956	hsa-miR-3202	PAR-CLIP	26701625
MIRT005520	hsa-miR-326	PAR-CLIP	26701625
MIRT737182	hsa-miR-330-5p	PAR-CLIP	26701625
MIRT470943	hsa-miR-4525	PAR-CLIP	26701625
MIRT470932	hsa-miR-4665-5p	PAR-CLIP	26701625
MIRT470947	hsa-miR-4723-5p	PAR-CLIP	26701625
MIRT470942	hsa-miR-5010-5p	PAR-CLIP	26701625
MIRT470946	hsa-miR-5698	PAR-CLIP	26701625
MIRT470948	hsa-miR-625-5p	PAR-CLIP	26701625
MIRT470934	hsa-miR-6515-5p	PAR-CLIP	26701625
MIRT470934	hsa-miR-6515-5p	PAR-CLIP	26701625
MIRT470954	hsa-miR-6797-5p	PAR-CLIP	26701625
MIRT470954	hsa-miR-6797-5p	PAR-CLIP	26701625
MIRT470961	hsa-miR-6804-5p	PAR-CLIP	26701625
MIRT470961	hsa-miR-6804-5p	PAR-CLIP	26701625
MIRT470945	hsa-miR-6870-5p	PAR-CLIP	26701625
MIRT470944	hsa-miR-7111-5p	PAR-CLIP	26701625
MIRT470938	hsa-miR-7847-3p	PAR-CLIP	26701625
MIRT470938	hsa-miR-7847-3p	PAR-CLIP	26701625
MIRT737182	hsa-miR-330-5p	Luciferase reporter assay, Western blotting, qRT-PCR	31956955
MIRT023396	hsa-miR-122-5p	PAR-CLIP	23592263
MIRT470969	hsa-miR-4694-3p	PAR-CLIP	23592263
MIRT470968	hsa-miR-1296-3p	PAR-CLIP	23592263
MIRT470967	hsa-miR-4650-5p	PAR-CLIP	23592263
MIRT470966	hsa-miR-199a-3p	PAR-CLIP	23592263
MIRT470965	hsa-miR-199b-3p	PAR-CLIP	23592263
MIRT470964	hsa-miR-3129-5p	PAR-CLIP	23592263
MIRT470963	hsa-miR-4254	PAR-CLIP	23592263
MIRT470962	hsa-miR-17-3p	PAR-CLIP	23592263
MIRT470961	hsa-miR-6804-5p	PAR-CLIP	23592263
MIRT470960	hsa-miR-3659	PAR-CLIP	23592263
MIRT470959	hsa-miR-1254	PAR-CLIP	23592263
MIRT470958	hsa-miR-3116	PAR-CLIP	23592263
MIRT470957	hsa-miR-4533	PAR-CLIP	23592263
MIRT470956	hsa-miR-3202	PAR-CLIP	23592263
MIRT470955	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT470954	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT470953	hsa-miR-3689d	PAR-CLIP	23592263
MIRT470952	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT470951	hsa-miR-504-3p	PAR-CLIP	23592263
MIRT470950	hsa-miR-6822-3p	PAR-CLIP	23592263
MIRT470949	hsa-miR-4668-5p	PAR-CLIP	23592263
MIRT470948	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT470947	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT470946	hsa-miR-5698	PAR-CLIP	23592263
MIRT470945	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT470944	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT470943	hsa-miR-4525	PAR-CLIP	23592263
MIRT470942	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT470941	hsa-miR-363-5p	PAR-CLIP	23592263
MIRT470940	hsa-miR-6745	PAR-CLIP	23592263
MIRT470939	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT470938	hsa-miR-7847-3p	PAR-CLIP	23592263
MIRT470937	hsa-miR-4447	PAR-CLIP	23592263
MIRT470936	hsa-miR-4472	PAR-CLIP	23592263
MIRT470935	hsa-miR-4727-3p	PAR-CLIP	23592263
MIRT470934	hsa-miR-6515-5p	PAR-CLIP	23592263
MIRT470933	hsa-miR-1275	PAR-CLIP	23592263
MIRT470932	hsa-miR-4665-5p	PAR-CLIP	23592263
MIRT470931	hsa-miR-6730-5p	PAR-CLIP	23592263
MIRT755902	hsa-miR-489-3p	Luciferase reporter assay, Western blotting, qRT-PCR	34868902

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
ZBTB7A	Repression	25184678

Show/Hide all(49)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IEA
GO:0001666	Process	Response to hypoxia	IEA
GO:0001889	Process	Liver development	IEA
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003729	Function	MRNA binding	ISS
GO:0004743	Function	Pyruvate kinase activity	IBA	21873635
GO:0004743	Function	Pyruvate kinase activity	IDA	20005212
GO:0004743	Function	Pyruvate kinase activity	TAS	2040271, 2813362, 2854097
GO:0005515	Function	Protein binding	IPI	12620389, 17500595, 17620599, 18191611, 18298799, 18519040, 21044950, 21620138, 21725354, 22056988, 25241761, 27199445, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IDA	17308100, 18191611
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	18298799
GO:0005739	Component	Mitochondrion	HDA	20833797
GO:0005791	Component	Rough endoplasmic reticulum	ISS
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	NAS	2813362
GO:0005829	Component	Cytosol	TAS
GO:0005929	Component	Cilium	IEA
GO:0006096	Process	Glycolytic process	IBA	21873635
GO:0006754	Process	ATP biosynthetic process	IEA
GO:0007584	Process	Response to nutrient	IEA
GO:0009629	Process	Response to gravity	IEA
GO:0012501	Process	Programmed cell death	IDA	17308100
GO:0014870	Process	Response to muscle inactivity	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0023026	Function	MHC class II protein complex binding	HDA	20458337
GO:0030955	Function	Potassium ion binding	IEA
GO:0031100	Process	Animal organ regeneration	IEA
GO:0031982	Component	Vesicle	HDA	19190083
GO:0032869	Process	Cellular response to insulin stimulus	IBA	21873635
GO:0034774	Component	Secretory granule lumen	TAS
GO:0042802	Function	Identical protein binding	IEA
GO:0042866	Process	Pyruvate biosynthetic process	IEA
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0043403	Process	Skeletal muscle tissue regeneration	IEA
GO:0043531	Function	ADP binding	IEA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0061621	Process	Canonical glycolysis	TAS
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	23658023
GO:0070062	Component	Extracellular exosome	HDA	11487543, 12519789, 19056867, 19199708, 20458337, 21362503, 23533145
GO:0070324	Function	Thyroid hormone binding	IEA
GO:1902912	Component	Pyruvate kinase complex	IEA
GO:1903561	Component	Extracellular vesicle	HDA	24769233
GO:1903672	Process	Positive regulation of sprouting angiogenesis	IMP	27199445
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS
GO:2000767	Process	Positive regulation of cytoplasmic translation	ISS

MIM	HGNC	e!Ensembl
179050	9021	ENSG00000067225

Protein

UniProt ID

P14618

Protein name

Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein

Protein function

Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active te

PDB

1T5A , 1ZJH , 3BJF , 3BJT , 3G2G , 3GQY , 3GR4 , 3H6O , 3ME3 , 3SRD , 3SRF , 3SRH , 3U2Z , 4B2D , 4FXF , 4FXJ , 4G1N , 4JPG , 4QG6 , 4QG8 , 4QG9 , 4QGC , 4RPP , 4WJ8 , 4YJ5 , 5X0I , 5X1V , 5X1W , 6B6U , 6GG3 , 6GG4 , 6GG5 , 6GG6 , 6JFB , 6NU1 , 6NU5 , 6NUB , 6TTF , 6TTH , 6TTI , 6TTQ , 6V74 , 6V75 , 6V76 , 6WP3 , 6WP4 , 6WP5 , 6WP6 , 7L21 , 8G2E , 8HGF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00224	PK	42 → 395	Pyruvate kinase, barrel domain	Family
PF02887	PK_C	410 → 528	Pyruvate kinase, alpha/beta domain	Domain

Sequence

MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVET
LKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIR
TGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGL
ISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMV
FASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIE
IPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM
LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEAS
FKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQE
AWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP

Sequence length

531

Interactions

View interactions

	KEGG		Reactome
	Glycolysis / Gluconeogenesis Pyruvate metabolism Metabolic pathways Carbon metabolism Biosynthesis of amino acids Glucagon signaling pathway Type II diabetes mellitus Human papillomavirus infection Viral carcinogenesis Central carbon metabolism in cancer		Neutrophil degranulation Glycolysis

Associated diseases

Show/Hide Causal Diseases (2)

Causal
Disease name	Disease term	dbSNP ID	References
Carcinoma	Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	16316942
Osteoporosis	Osteoporosis, Age-Related, Osteoporosis, Osteoporosis, Senile, Post-Traumatic Osteoporosis	rs72658152, rs72667023, rs587776916, rs72656370, rs768615287	18924182

Show/Hide Unknown Diseases (2)

Unknown
Disease name	Disease term	dbSNP ID	References
Anaplastic carcinoma	Anaplastic carcinoma		16316942
Liver carcinoma	Liver carcinoma		19363144

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