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PITPNA (phosphatidylinositol transfer protein alpha)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5306
Gene nameGene Name - the full gene name approved by the HGNC.
Phosphatidylinositol transfer protein alpha
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
PITPNA
SynonymsGene synonyms aliases
HEL-S-36, PI-TPalpha, PITPN, VIB1A
ChromosomeChromosome number
17
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17p13.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. The protein is implicated in phospholipase C signaling and in the production of phosphatidyl
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT049660 hsa-miR-92a-3p CLASH 23622248
MIRT043471 hsa-miR-331-3p CLASH 23622248
MIRT042415 hsa-miR-18b-5p CLASH 23622248
MIRT039821 hsa-miR-615-3p CLASH 23622248
MIRT039821 hsa-miR-615-3p CLASH 23622248
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32814053
GO:0005634 Component Nucleus ISS
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005737 Component Cytoplasm ISS
GO:0005829 Component Cytosol TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q00169
Protein name Phosphatidylinositol transfer protein alpha isoform (PI-TP-alpha) (PtdIns transfer protein alpha) (PtdInsTP alpha)
Protein function Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes (PubMed:10531358, PubMed:14962392, PubMed:15522822, PubMed:18636990, PubMed:22822086). Shows a preference for PI and PC containing shorter saturat
PDB 1UW5 , 8PQO
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02121 IP_trans
2 252
Phosphatidylinositol transfer protein
Family
Sequence
Sequence length 270
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Chronic obstructive pulmonary disease Chronic Obstructive Airway Disease rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928 26503814

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