Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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5306 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Phosphatidylinositol transfer protein alpha |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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PITPNA |
SynonymsGene synonyms aliases
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HEL-S-36, PI-TPalpha, PITPN, VIB1A |
ChromosomeChromosome number
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17 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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17p13.3 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. The protein is implicated in phospholipase C signaling and in the production of phosphatidyl |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0005515 |
Function |
Protein binding |
IPI |
32814053 |
GO:0005634 |
Component |
Nucleus |
ISS |
|
GO:0005737 |
Component |
Cytoplasm |
IBA |
21873635 |
GO:0005737 |
Component |
Cytoplasm |
ISS |
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GO:0005829 |
Component |
Cytosol |
TAS |
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GO:0006629 |
Process |
Lipid metabolic process |
NAS |
8194769 |
GO:0007601 |
Process |
Visual perception |
TAS |
7914867 |
GO:0008525 |
Function |
Phosphatidylcholine transporter activity |
IBA |
21873635 |
GO:0008525 |
Function |
Phosphatidylcholine transporter activity |
IDA |
16274224, 22822086 |
GO:0008526 |
Function |
Phosphatidylinositol transfer activity |
IBA |
21873635 |
GO:0008526 |
Function |
Phosphatidylinositol transfer activity |
IDA |
10531358, 15522822, 16274224, 22822086 |
GO:0008526 |
Function |
Phosphatidylinositol transfer activity |
IMP |
14962392, 18636990 |
GO:0015914 |
Process |
Phospholipid transport |
IDA |
16274224, 22822086 |
GO:0031210 |
Function |
Phosphatidylcholine binding |
IBA |
21873635 |
GO:0031210 |
Function |
Phosphatidylcholine binding |
IDA |
15522822, 16274224, 22822086 |
GO:0031210 |
Function |
Phosphatidylcholine binding |
IMP |
14962392 |
GO:0035091 |
Function |
Phosphatidylinositol binding |
IBA |
21873635 |
GO:0035091 |
Function |
Phosphatidylinositol binding |
IDA |
15522822, 16274224, 22822086 |
GO:0035091 |
Function |
Phosphatidylinositol binding |
IMP |
14962392 |
GO:0035722 |
Process |
Interleukin-12-mediated signaling pathway |
TAS |
|
GO:0070062 |
Component |
Extracellular exosome |
HDA |
18570454 |
GO:0120009 |
Process |
Intermembrane lipid transfer |
IEA |
|
GO:0120019 |
Function |
Phosphatidylcholine transfer activity |
IDA |
15522822 |
GO:0120019 |
Function |
Phosphatidylcholine transfer activity |
IMP |
14962392 |
GO:1901611 |
Function |
Phosphatidylglycerol binding |
TAS |
22822086 |
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
Q00169 |
Protein name |
Phosphatidylinositol transfer protein alpha isoform (PI-TP-alpha) (PtdIns transfer protein alpha) (PtdInsTP alpha) |
Protein function |
Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes (PubMed:10531358, PubMed:14962392, PubMed:15522822, PubMed:18636990, PubMed:22822086). Shows a preference for PI and PC containing shorter saturat |
PDB |
1UW5
,
8PQO
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF02121 |
IP_trans |
2 → 252 |
Phosphatidylinositol transfer protein |
Family |
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Sequence |
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Sequence length |
270 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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