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PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)

Gene

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

PIK3CG

IMD97, PI3CG, PI3K, PI3Kgamma, PIK3, p110gamma, p120-PI3K

7

7q22.3

Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta)

Show/Hide all(228)

miRTarBase ID	miRNA	Experiments	Reference
MIRT006815	hsa-miR-29b-3p	Microarray, qRT-PCR, Western blot	22297492
MIRT006831	hsa-miR-126-3p	Immunocytochemistry, Luciferase reporter assay, qRT-PCR, Western blot	22900072
MIRT019349	hsa-miR-148b-3p	Microarray	17612493
MIRT029342	hsa-miR-26b-5p	Microarray	19088304
MIRT006831	hsa-miR-126-3p	Microarray, qRT-PCR, Western blot, SILAC (Stable Isotope Labeling of Amino acids in Culture)	23142521
MIRT437359	hsa-miR-27a-3p	Luciferase reporter assay, qRT-PCR	24086481
MIRT437359	hsa-miR-27a-3p	Luciferase reporter assay, qRT-PCR	24086481
MIRT438408	hsa-miR-10a-5p	Luciferase reporter assay, qRT-PCR, Western blot	24522205
MIRT438408	hsa-miR-10a-5p	Luciferase reporter assay, qRT-PCR, Western blot	24522205
MIRT438277	hsa-miR-7-5p	Luciferase reporter assay, Western blot	24603851
MIRT438408	hsa-miR-10a-5p	Luciferase reporter assay, qRT-PCR, Western blot	24522205
MIRT438408	hsa-miR-10a-5p	Luciferase reporter assay, qRT-PCR, Western blot	24522205
MIRT438277	hsa-miR-7-5p	Luciferase reporter assay, Western blot	24603851
MIRT516718	hsa-miR-8485	HITS-CLIP	21572407
MIRT516717	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT516716	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT516715	hsa-miR-603	HITS-CLIP	21572407
MIRT516714	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT542013	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT516713	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT516707	hsa-miR-3941	HITS-CLIP	21572407
MIRT516706	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT516705	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT516704	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT693454	hsa-miR-548a-3p	HITS-CLIP	23313552
MIRT693453	hsa-miR-548ar-3p	HITS-CLIP	23313552
MIRT693452	hsa-miR-548az-3p	HITS-CLIP	23313552
MIRT693451	hsa-miR-548e-3p	HITS-CLIP	23313552
MIRT693450	hsa-miR-548f-3p	HITS-CLIP	23313552
MIRT693449	hsa-miR-5582-3p	HITS-CLIP	23313552
MIRT693448	hsa-miR-548g-3p	HITS-CLIP	23313552
MIRT516718	hsa-miR-8485	HITS-CLIP	23313552
MIRT516714	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT542013	hsa-miR-5580-3p	HITS-CLIP	23313552
MIRT693447	hsa-miR-3163	HITS-CLIP	23313552
MIRT542012	hsa-miR-410-3p	HITS-CLIP	23313552
MIRT516713	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT693446	hsa-miR-511-3p	HITS-CLIP	23313552
MIRT516712	hsa-miR-4679	HITS-CLIP	23313552
MIRT516711	hsa-miR-3689a-5p	HITS-CLIP	23313552
MIRT516710	hsa-miR-3689b-5p	HITS-CLIP	23313552
MIRT516709	hsa-miR-3689e	HITS-CLIP	23313552
MIRT516708	hsa-miR-3689f	HITS-CLIP	23313552
MIRT516705	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT516704	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT516718	hsa-miR-8485	PAR-CLIP	21572407
MIRT516717	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT516716	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT516715	hsa-miR-603	PAR-CLIP	21572407
MIRT516714	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT542013	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT542012	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT516713	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT516707	hsa-miR-3941	PAR-CLIP	21572407
MIRT516706	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT516705	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT516704	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT516718	hsa-miR-8485	PAR-CLIP	23446348
MIRT516717	hsa-miR-329-3p	PAR-CLIP	23446348
MIRT516716	hsa-miR-362-3p	PAR-CLIP	23446348
MIRT516715	hsa-miR-603	PAR-CLIP	23446348
MIRT516714	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT516713	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT516712	hsa-miR-4679	PAR-CLIP	23446348
MIRT516711	hsa-miR-3689a-5p	PAR-CLIP	23446348
MIRT516710	hsa-miR-3689b-5p	PAR-CLIP	23446348
MIRT516709	hsa-miR-3689e	PAR-CLIP	23446348
MIRT516708	hsa-miR-3689f	PAR-CLIP	23446348
MIRT516707	hsa-miR-3941	PAR-CLIP	23446348
MIRT516706	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT516705	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT516704	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT439973	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT439973	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT006831	hsa-miR-126-3p	Luciferase reporter assay	27729613
MIRT006831	hsa-miR-126-3p	qRT-PCR, Western blot	26659078
MIRT516718	hsa-miR-8485	HITS-CLIP	21572407
MIRT516717	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT516716	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT516715	hsa-miR-603	HITS-CLIP	21572407
MIRT516714	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT542013	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT516713	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT516707	hsa-miR-3941	HITS-CLIP	21572407
MIRT516706	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT516705	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT516704	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT693454	hsa-miR-548a-3p	HITS-CLIP	23313552
MIRT693453	hsa-miR-548ar-3p	HITS-CLIP	23313552
MIRT693452	hsa-miR-548az-3p	HITS-CLIP	23313552
MIRT693451	hsa-miR-548e-3p	HITS-CLIP	23313552
MIRT693450	hsa-miR-548f-3p	HITS-CLIP	23313552
MIRT693449	hsa-miR-5582-3p	HITS-CLIP	23313552
MIRT693448	hsa-miR-548g-3p	HITS-CLIP	23313552
MIRT516718	hsa-miR-8485	HITS-CLIP	23313552
MIRT516714	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT542013	hsa-miR-5580-3p	HITS-CLIP	23313552
MIRT693447	hsa-miR-3163	HITS-CLIP	23313552
MIRT542012	hsa-miR-410-3p	HITS-CLIP	23313552
MIRT516713	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT693446	hsa-miR-511-3p	HITS-CLIP	23313552
MIRT516712	hsa-miR-4679	HITS-CLIP	23313552
MIRT516711	hsa-miR-3689a-5p	HITS-CLIP	23313552
MIRT516710	hsa-miR-3689b-5p	HITS-CLIP	23313552
MIRT516709	hsa-miR-3689e	HITS-CLIP	23313552
MIRT516708	hsa-miR-3689f	HITS-CLIP	23313552
MIRT516705	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT516704	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT516718	hsa-miR-8485	PAR-CLIP	21572407
MIRT516717	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT516716	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT516715	hsa-miR-603	PAR-CLIP	21572407
MIRT516714	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT542013	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT542012	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT516713	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT516707	hsa-miR-3941	PAR-CLIP	21572407
MIRT516706	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT516705	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT516704	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT516718	hsa-miR-8485	PAR-CLIP	23446348
MIRT516717	hsa-miR-329-3p	PAR-CLIP	23446348
MIRT516716	hsa-miR-362-3p	PAR-CLIP	23446348
MIRT516715	hsa-miR-603	PAR-CLIP	23446348
MIRT516714	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT516713	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT516712	hsa-miR-4679	PAR-CLIP	23446348
MIRT516711	hsa-miR-3689a-5p	PAR-CLIP	23446348
MIRT516710	hsa-miR-3689b-5p	PAR-CLIP	23446348
MIRT516709	hsa-miR-3689e	PAR-CLIP	23446348
MIRT516708	hsa-miR-3689f	PAR-CLIP	23446348
MIRT516707	hsa-miR-3941	PAR-CLIP	23446348
MIRT516706	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT516705	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT516704	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT1234187	hsa-miR-1276	CLIP-seq
MIRT1234188	hsa-miR-1976	CLIP-seq
MIRT1234189	hsa-miR-24	CLIP-seq
MIRT1234190	hsa-miR-3199	CLIP-seq
MIRT1234191	hsa-miR-3653	CLIP-seq
MIRT1234192	hsa-miR-3658	CLIP-seq
MIRT1234193	hsa-miR-378g	CLIP-seq
MIRT1234194	hsa-miR-4269	CLIP-seq
MIRT1234195	hsa-miR-4437	CLIP-seq
MIRT1234196	hsa-miR-4438	CLIP-seq
MIRT1234197	hsa-miR-4496	CLIP-seq
MIRT1234198	hsa-miR-4514	CLIP-seq
MIRT1234199	hsa-miR-4674	CLIP-seq
MIRT1234200	hsa-miR-4692	CLIP-seq
MIRT1234201	hsa-miR-4722-3p	CLIP-seq
MIRT1234202	hsa-miR-4742-5p	CLIP-seq
MIRT1234203	hsa-miR-4778-3p	CLIP-seq
MIRT1234204	hsa-miR-5095	CLIP-seq
MIRT1234205	hsa-miR-619	CLIP-seq
MIRT1234206	hsa-miR-885-5p	CLIP-seq
MIRT2068989	hsa-miR-1200	CLIP-seq
MIRT2068990	hsa-miR-1289	CLIP-seq
MIRT2068991	hsa-miR-1343	CLIP-seq
MIRT2068992	hsa-miR-1911	CLIP-seq
MIRT1234188	hsa-miR-1976	CLIP-seq
MIRT1234189	hsa-miR-24	CLIP-seq
MIRT2068993	hsa-miR-3198	CLIP-seq
MIRT1234190	hsa-miR-3199	CLIP-seq
MIRT1234193	hsa-miR-378g	CLIP-seq
MIRT1234194	hsa-miR-4269	CLIP-seq
MIRT2068994	hsa-miR-4294	CLIP-seq
MIRT2068995	hsa-miR-4309	CLIP-seq
MIRT2068996	hsa-miR-4324	CLIP-seq
MIRT1234195	hsa-miR-4437	CLIP-seq
MIRT1234196	hsa-miR-4438	CLIP-seq
MIRT1234198	hsa-miR-4514	CLIP-seq
MIRT2068997	hsa-miR-4534	CLIP-seq
MIRT1234199	hsa-miR-4674	CLIP-seq
MIRT1234200	hsa-miR-4692	CLIP-seq
MIRT1234201	hsa-miR-4722-3p	CLIP-seq
MIRT1234202	hsa-miR-4742-5p	CLIP-seq
MIRT1234204	hsa-miR-5095	CLIP-seq
MIRT2068998	hsa-miR-544b	CLIP-seq
MIRT2068989	hsa-miR-1200	CLIP-seq
MIRT2068992	hsa-miR-1911	CLIP-seq
MIRT1234188	hsa-miR-1976	CLIP-seq
MIRT1234189	hsa-miR-24	CLIP-seq
MIRT2296006	hsa-miR-2467-3p	CLIP-seq
MIRT2296007	hsa-miR-3125	CLIP-seq
MIRT2296008	hsa-miR-3692	CLIP-seq
MIRT1234193	hsa-miR-378g	CLIP-seq
MIRT2296009	hsa-miR-3916	CLIP-seq
MIRT2296010	hsa-miR-3925-3p	CLIP-seq
MIRT1234194	hsa-miR-4269	CLIP-seq
MIRT2296011	hsa-miR-4308	CLIP-seq
MIRT2068996	hsa-miR-4324	CLIP-seq
MIRT1234195	hsa-miR-4437	CLIP-seq
MIRT1234196	hsa-miR-4438	CLIP-seq
MIRT1234198	hsa-miR-4514	CLIP-seq
MIRT2296012	hsa-miR-4530	CLIP-seq
MIRT1234199	hsa-miR-4674	CLIP-seq
MIRT2296013	hsa-miR-4685-5p	CLIP-seq
MIRT1234200	hsa-miR-4692	CLIP-seq
MIRT1234201	hsa-miR-4722-3p	CLIP-seq
MIRT1234202	hsa-miR-4742-5p	CLIP-seq
MIRT1234203	hsa-miR-4778-3p	CLIP-seq
MIRT1234204	hsa-miR-5095	CLIP-seq
MIRT2296014	hsa-miR-515-5p	CLIP-seq
MIRT2068998	hsa-miR-544b	CLIP-seq
MIRT1234205	hsa-miR-619	CLIP-seq
MIRT2296015	hsa-miR-766	CLIP-seq
MIRT2296016	hsa-miR-922	CLIP-seq
MIRT2068989	hsa-miR-1200	CLIP-seq
MIRT2068992	hsa-miR-1911	CLIP-seq
MIRT1234188	hsa-miR-1976	CLIP-seq
MIRT1234194	hsa-miR-4269	CLIP-seq
MIRT2068996	hsa-miR-4324	CLIP-seq
MIRT1234198	hsa-miR-4514	CLIP-seq
MIRT1234200	hsa-miR-4692	CLIP-seq
MIRT1234201	hsa-miR-4722-3p	CLIP-seq
MIRT1234202	hsa-miR-4742-5p	CLIP-seq
MIRT2068998	hsa-miR-544b	CLIP-seq
MIRT2593958	hsa-miR-500a	CLIP-seq
MIRT2593959	hsa-miR-539	CLIP-seq
MIRT2593960	hsa-miR-548aa	CLIP-seq
MIRT2593961	hsa-miR-548ac	CLIP-seq
MIRT2593962	hsa-miR-548d-3p	CLIP-seq
MIRT2593963	hsa-miR-548z	CLIP-seq
MIRT2593959	hsa-miR-539	CLIP-seq
MIRT2593960	hsa-miR-548aa	CLIP-seq
MIRT2593961	hsa-miR-548ac	CLIP-seq
MIRT2593962	hsa-miR-548d-3p	CLIP-seq
MIRT2593963	hsa-miR-548z	CLIP-seq

Show/Hide all(74)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IEA
GO:0001816	Process	Cytokine production	TAS	19075988
GO:0002250	Process	Adaptive immune response	TAS	17290298
GO:0002407	Process	Dendritic cell chemotaxis	TAS	18278175
GO:0002675	Process	Positive regulation of acute inflammatory response	IEA
GO:0002679	Process	Respiratory burst involved in defense response	TAS	19075988
GO:0003376	Process	Sphingosine-1-phosphate receptor signaling pathway	IMP	18558630
GO:0004672	Function	Protein kinase activity	TAS	19376709
GO:0005515	Function	Protein binding	IPI	12507995, 21393242, 23824069, 25556234, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	12507995
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA
GO:0005942	Component	Phosphatidylinositol 3-kinase complex	IBA	21873635
GO:0005943	Component	Phosphatidylinositol 3-kinase complex, class IA	IBA	21873635
GO:0005944	Component	Phosphatidylinositol 3-kinase complex, class IB	IBA	21873635
GO:0005944	Component	Phosphatidylinositol 3-kinase complex, class IB	IDA	12507995
GO:0006468	Process	Protein phosphorylation	IEA
GO:0006661	Process	Phosphatidylinositol biosynthetic process	TAS
GO:0006897	Process	Endocytosis	IEA
GO:0006954	Process	Inflammatory response	TAS	17290298
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	12507995
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IEA
GO:0010595	Process	Positive regulation of endothelial cell migration	IMP	18558630
GO:0010818	Process	T cell chemotaxis	TAS	18278175
GO:0010897	Process	Negative regulation of triglyceride catabolic process	IEA
GO:0014065	Process	Phosphatidylinositol 3-kinase signaling	IBA	21873635
GO:0014065	Process	Phosphatidylinositol 3-kinase signaling	IDA	12507995
GO:0014065	Process	Phosphatidylinositol 3-kinase signaling	IMP	18558630
GO:0014065	Process	Phosphatidylinositol 3-kinase signaling	TAS	17290298
GO:0014068	Process	Positive regulation of phosphatidylinositol 3-kinase signaling	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA	21873635
GO:0016020	Component	Membrane	IDA	12507995
GO:0016301	Function	Kinase activity	IDA	25327288
GO:0016303	Function	1-phosphatidylinositol-3-kinase activity	IBA	21873635
GO:0016303	Function	1-phosphatidylinositol-3-kinase activity	IDA	11277933, 16123124
GO:0016310	Process	Phosphorylation	IDA	25327288
GO:0016477	Process	Cell migration	IBA	21873635
GO:0030168	Process	Platelet activation	TAS
GO:0030593	Process	Neutrophil chemotaxis	TAS	17290298
GO:0032252	Process	Secretory granule localization	IEA
GO:0033628	Process	Regulation of cell adhesion mediated by integrin	TAS	18278175
GO:0035004	Function	Phosphatidylinositol 3-kinase activity	TAS	17290298
GO:0035005	Function	1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA	21873635
GO:0035005	Function	1-phosphatidylinositol-4-phosphate 3-kinase activity	IDA	16123124
GO:0035022	Process	Positive regulation of Rac protein signal transduction	IMP	18558630
GO:0035747	Process	Natural killer cell chemotaxis	TAS	18278175
GO:0036092	Process	Phosphatidylinositol-3-phosphate biosynthetic process	IBA	21873635
GO:0042098	Process	T cell proliferation	TAS	19075988
GO:0042110	Process	T cell activation	TAS	17290298
GO:0042802	Function	Identical protein binding	IPI	20562859, 23824069
GO:0043303	Process	Mast cell degranulation	TAS	17290298
GO:0043406	Process	Positive regulation of MAP kinase activity	IDA	12507995
GO:0045087	Process	Innate immune response	TAS	17290298
GO:0046854	Process	Phosphatidylinositol phosphorylation	IBA	21873635
GO:0046875	Function	Ephrin receptor binding	IPI	11416136
GO:0046934	Function	Phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IDA	15135396, 16123124
GO:0048015	Process	Phosphatidylinositol-mediated signaling	IBA	21873635
GO:0051897	Process	Positive regulation of protein kinase B signaling	IDA	12507995
GO:0052742	Function	Phosphatidylinositol kinase activity	IBA	21873635
GO:0052812	Function	Phosphatidylinositol-3,4-bisphosphate 5-kinase activity	IEA
GO:0055118	Process	Negative regulation of cardiac muscle contraction	TAS	19147653
GO:0070527	Process	Platelet aggregation	TAS	21035500
GO:0071320	Process	Cellular response to cAMP	IEA
GO:0072672	Process	Neutrophil extravasation	TAS	18278175
GO:0097284	Process	Hepatocyte apoptotic process	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA
GO:1903169	Process	Regulation of calcium ion transmembrane transport	IEA
GO:2000270	Process	Negative regulation of fibroblast apoptotic process	IEA

MIM	HGNC	e!Ensembl
601232	8978	ENSG00000105851

Protein

UniProt ID

Protein name

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphatidylinositol 4,5-bisphosphate 3-kinase

Protein function

Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the memb

PDB

1E8Y , 1E8Z , 1HE8 , 2A4Z , 2A5U , 2CHW , 2CHX , 2CHZ , 2V4L , 3APC , 3APD , 3APF , 3CSF , 3CST , 3DBS , 3DPD , 3ENE , 3IBE , 3L08 , 3L13 , 3L16 , 3L17 , 3L54 , 3LJ3 , 3MJW , 3ML8 , 3ML9 , 3NZS , 3NZU , 3OAW , 3P2B , 3PRE , 3PRZ , 3PS6 , 3QAQ , 3QAR , 3QJZ , 3QK0 , 3R7Q , 3R7R , 3S2A , 3SD5 , 3T8M , 3TJP , 3TL5 , 3ZVV , 3ZW3 , 4ANU , 4ANV , 4ANW , 4ANX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00794	PI3K_rbd	203 → 312	PI3-kinase family, ras-binding domain	Domain
PF00792	PI3K_C2	377 → 519	Phosphoinositide 3-kinase C2	Domain
PF00613	PI3Ka	543 → 733	Phosphoinositide 3-kinase family, accessory domain (PIK domain)	Family
PF00454	PI3_PI4_kinase	827 → 1044	Phosphatidylinositol 3- and 4-kinase	Family

Sequence

MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLH
VAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLD
CLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGL
VTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDT
PGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNG
EEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRK
FRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKI
KDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEY
VLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEG
DRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQ
QEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYL
LQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAY
LRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLP
ESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQ
DMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTG
AFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNL
FHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLAL
RHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGW
TVQFNWFLHLVLGIKQGEKHSA

Sequence length

1102

Interactions

View interactions

	KEGG		Reactome
	Inositol phosphate metabolism Metabolic pathways cGMP-PKG signaling pathway Chemokine signaling pathway Phospholipase D signaling pathway PI3K-Akt signaling pathway Adrenergic signaling in cardiomyocytes Apelin signaling pathway Platelet activation Cholinergic synapse Oxytocin signaling pathway Salmonella infection Toxoplasmosis Kaposi sarcoma-associated herpesvirus infection		GPVI-mediated activation cascade Synthesis of PIPs at the plasma membrane G beta:gamma signalling through PI3Kgamma Erythropoietin activates Phosphoinositide-3-kinase (PI3K)

Associated diseases

Show/Hide Causal Diseases (4)

Causal
Disease name	Disease term	dbSNP ID	References
Autism	Autistic Disorder	rs121964908, rs121912597, rs2710102, rs7794745, rs142990298, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542, rs1751123722, rs1750373491, rs1751075634	14627686
Diffuse lymphoma	Diffuse Large B-Cell Lymphoma	rs121912651, rs121913289, rs121913293, rs878854402, rs869025340, rs1349928568, rs1569115687, rs121913291	21173233
Medulloblastoma	Medulloblastoma, Childhood Medulloblastoma, Adult Medulloblastoma, Desmoplastic Medulloblastoma, Melanotic medulloblastoma	rs1589970134, rs587776578, rs587776579, rs17847577, rs111033171, rs80359604, rs80358785, rs80358814, rs863224925, rs1555950011, rs1554231278, rs926177767, rs759412460, rs1564032829, rs761911009	21652733
Myocardial infarction	Myocardial Failure	rs12316150, rs41303970, rs909253, rs7291467, rs2234693	12963636

Show/Hide Unknown Diseases (4)

Unknown
Disease name	Disease term	dbSNP ID	References
Cirrhosis	Cirrhosis	rs119465999, rs144369314, rs8056684, rs112053857, rs75998507	12963636
Congestive heart failure	Congestive heart failure	rs2301610, rs3833910, rs12301951, rs201674674, rs186741807, rs150140412, rs786205727, rs757840030, rs552050895, rs759465783, rs201978086, rs572757800, rs1572143354, rs749160569	12963636
Heart failure	Heart failure, Left-Sided Heart Failure, Heart Failure, Right-Sided	rs121918074, rs142027794, rs148791216, rs72648927, rs71578935, rs142416150, rs199830512, rs755445214, rs150102469, rs779568205, rs907992794, rs1202130741	12963636
Medullomyoblastoma	Medullomyoblastoma		21652733

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