SERPINE2 (serpin family E member 2)

Gene

• Entrez ID: 5270
• Gene name: Serpin family E member 2
• Gene symbol: SERPINE2
• Synonyms: GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI
• Chromosome: 2
• Chromosome location: 2q36.1
• Summary: This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for ch

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001419	hsa-miR-16-5p	pSILAC	18668040
MIRT028560	hsa-miR-30a-5p	Proteomics	18668040
MIRT001419	hsa-miR-16-5p	Proteomics;Other	18668040
MIRT044124	hsa-miR-30e-3p	CLASH	23622248
MIRT1338896	hsa-miR-3163	CLIP-seq
MIRT1338897	hsa-miR-410	CLIP-seq
MIRT1338898	hsa-miR-4528	CLIP-seq
MIRT1338899	hsa-miR-586	CLIP-seq
MIRT1553544	hsa-miR-1244	CLIP-seq
MIRT1553545	hsa-miR-1275	CLIP-seq
MIRT1553546	hsa-miR-1299	CLIP-seq
MIRT1553547	hsa-miR-132	CLIP-seq
MIRT1553548	hsa-miR-186	CLIP-seq
MIRT1553549	hsa-miR-194	CLIP-seq
MIRT1553550	hsa-miR-199a-3p	CLIP-seq
MIRT1553551	hsa-miR-199b-3p	CLIP-seq
MIRT1553552	hsa-miR-2052	CLIP-seq
MIRT1553553	hsa-miR-2053	CLIP-seq
MIRT1553554	hsa-miR-212	CLIP-seq
MIRT1553555	hsa-miR-296-3p	CLIP-seq
MIRT1553556	hsa-miR-3065-5p	CLIP-seq
MIRT1553557	hsa-miR-3120-3p	CLIP-seq
MIRT1553558	hsa-miR-3129-5p	CLIP-seq
MIRT1553559	hsa-miR-3133	CLIP-seq
MIRT1553560	hsa-miR-3182	CLIP-seq
MIRT1553561	hsa-miR-3545-3p	CLIP-seq
MIRT1553562	hsa-miR-3591-5p	CLIP-seq
MIRT1553563	hsa-miR-3606	CLIP-seq
MIRT1553564	hsa-miR-3654	CLIP-seq
MIRT1553565	hsa-miR-3920	CLIP-seq
MIRT1553566	hsa-miR-3973	CLIP-seq
MIRT1553567	hsa-miR-3975	CLIP-seq
MIRT1338897	hsa-miR-410	CLIP-seq
MIRT1553568	hsa-miR-4269	CLIP-seq
MIRT1553569	hsa-miR-4326	CLIP-seq
MIRT1553570	hsa-miR-4433	CLIP-seq
MIRT1553571	hsa-miR-4443	CLIP-seq
MIRT1553572	hsa-miR-4511	CLIP-seq
MIRT1553573	hsa-miR-451b	CLIP-seq
MIRT1553574	hsa-miR-4525	CLIP-seq
MIRT1338898	hsa-miR-4528	CLIP-seq
MIRT1553575	hsa-miR-4539	CLIP-seq
MIRT1553576	hsa-miR-4638-3p	CLIP-seq
MIRT1553577	hsa-miR-4652-3p	CLIP-seq
MIRT1553578	hsa-miR-4659a-3p	CLIP-seq
MIRT1553579	hsa-miR-4659b-3p	CLIP-seq
MIRT1553580	hsa-miR-4665-5p	CLIP-seq
MIRT1553581	hsa-miR-4668-5p	CLIP-seq
MIRT1553582	hsa-miR-4696	CLIP-seq
MIRT1553583	hsa-miR-4716-3p	CLIP-seq
MIRT1553584	hsa-miR-4723-5p	CLIP-seq
MIRT1553585	hsa-miR-4766-5p	CLIP-seq
MIRT1553586	hsa-miR-5096	CLIP-seq
MIRT1553587	hsa-miR-513a-3p	CLIP-seq
MIRT1553588	hsa-miR-542-3p	CLIP-seq
MIRT1553589	hsa-miR-545	CLIP-seq
MIRT1553590	hsa-miR-548an	CLIP-seq
MIRT1553591	hsa-miR-548b-3p	CLIP-seq
MIRT1553592	hsa-miR-548p	CLIP-seq
MIRT1553593	hsa-miR-583	CLIP-seq
MIRT1338899	hsa-miR-586	CLIP-seq
MIRT1553594	hsa-miR-590-3p	CLIP-seq
MIRT1553595	hsa-miR-625	CLIP-seq
MIRT1553596	hsa-miR-671-5p	CLIP-seq
MIRT1553597	hsa-miR-875-3p	CLIP-seq
MIRT1553598	hsa-miR-921	CLIP-seq
MIRT1553599	hsa-miR-924	CLIP-seq
MIRT1553600	hsa-miR-936	CLIP-seq
MIRT2433032	hsa-miR-1200	CLIP-seq
MIRT1553544	hsa-miR-1244	CLIP-seq
MIRT1553545	hsa-miR-1275	CLIP-seq
MIRT2433033	hsa-miR-1286	CLIP-seq
MIRT2433034	hsa-miR-1298	CLIP-seq
MIRT1553546	hsa-miR-1299	CLIP-seq
MIRT1553547	hsa-miR-132	CLIP-seq
MIRT1553548	hsa-miR-186	CLIP-seq
MIRT1553549	hsa-miR-194	CLIP-seq
MIRT1553550	hsa-miR-199a-3p	CLIP-seq
MIRT1553551	hsa-miR-199b-3p	CLIP-seq
MIRT1553552	hsa-miR-2052	CLIP-seq
MIRT1553553	hsa-miR-2053	CLIP-seq
MIRT1553554	hsa-miR-212	CLIP-seq
MIRT1553555	hsa-miR-296-3p	CLIP-seq
MIRT1553556	hsa-miR-3065-5p	CLIP-seq
MIRT1553557	hsa-miR-3120-3p	CLIP-seq
MIRT1553558	hsa-miR-3129-5p	CLIP-seq
MIRT1553559	hsa-miR-3133	CLIP-seq
MIRT2433035	hsa-miR-3140-5p	CLIP-seq
MIRT1338896	hsa-miR-3163	CLIP-seq
MIRT1553560	hsa-miR-3182	CLIP-seq
MIRT1553561	hsa-miR-3545-3p	CLIP-seq
MIRT1553565	hsa-miR-3920	CLIP-seq
MIRT1338897	hsa-miR-410	CLIP-seq
MIRT2433036	hsa-miR-421	CLIP-seq
MIRT2433037	hsa-miR-4294	CLIP-seq
MIRT1553569	hsa-miR-4326	CLIP-seq
MIRT1553571	hsa-miR-4443	CLIP-seq
MIRT1553572	hsa-miR-4511	CLIP-seq
MIRT1553573	hsa-miR-451b	CLIP-seq
MIRT1553574	hsa-miR-4525	CLIP-seq
MIRT1338898	hsa-miR-4528	CLIP-seq
MIRT1553575	hsa-miR-4539	CLIP-seq
MIRT1553578	hsa-miR-4659a-3p	CLIP-seq
MIRT1553579	hsa-miR-4659b-3p	CLIP-seq
MIRT1553580	hsa-miR-4665-5p	CLIP-seq
MIRT1553581	hsa-miR-4668-5p	CLIP-seq
MIRT1553582	hsa-miR-4696	CLIP-seq
MIRT2433038	hsa-miR-4709-5p	CLIP-seq
MIRT1553583	hsa-miR-4716-3p	CLIP-seq
MIRT2433039	hsa-miR-4722-5p	CLIP-seq
MIRT1553584	hsa-miR-4723-5p	CLIP-seq
MIRT1553585	hsa-miR-4766-5p	CLIP-seq
MIRT2433040	hsa-miR-4775	CLIP-seq
MIRT1553587	hsa-miR-513a-3p	CLIP-seq
MIRT1553590	hsa-miR-548an	CLIP-seq
MIRT1553591	hsa-miR-548b-3p	CLIP-seq
MIRT1338899	hsa-miR-586	CLIP-seq
MIRT1553594	hsa-miR-590-3p	CLIP-seq
MIRT1553595	hsa-miR-625	CLIP-seq
MIRT2433041	hsa-miR-664	CLIP-seq
MIRT1553596	hsa-miR-671-5p	CLIP-seq
MIRT1553597	hsa-miR-875-3p	CLIP-seq
MIRT2433042	hsa-miR-888	CLIP-seq
MIRT1553599	hsa-miR-924	CLIP-seq
MIRT1553600	hsa-miR-936	CLIP-seq
MIRT1553544	hsa-miR-1244	CLIP-seq
MIRT2433034	hsa-miR-1298	CLIP-seq
MIRT1553546	hsa-miR-1299	CLIP-seq
MIRT1553547	hsa-miR-132	CLIP-seq
MIRT2440156	hsa-miR-1470	CLIP-seq
MIRT1553548	hsa-miR-186	CLIP-seq
MIRT1553549	hsa-miR-194	CLIP-seq
MIRT1553550	hsa-miR-199a-3p	CLIP-seq
MIRT1553551	hsa-miR-199b-3p	CLIP-seq
MIRT1553553	hsa-miR-2053	CLIP-seq
MIRT1553554	hsa-miR-212	CLIP-seq
MIRT1553555	hsa-miR-296-3p	CLIP-seq
MIRT1553557	hsa-miR-3120-3p	CLIP-seq
MIRT1553558	hsa-miR-3129-5p	CLIP-seq
MIRT1553559	hsa-miR-3133	CLIP-seq
MIRT1338896	hsa-miR-3163	CLIP-seq
MIRT1553560	hsa-miR-3182	CLIP-seq
MIRT2440157	hsa-miR-323b-3p	CLIP-seq
MIRT1553562	hsa-miR-3591-5p	CLIP-seq
MIRT1553563	hsa-miR-3606	CLIP-seq
MIRT2440158	hsa-miR-370	CLIP-seq
MIRT1553565	hsa-miR-3920	CLIP-seq
MIRT1338897	hsa-miR-410	CLIP-seq
MIRT2433036	hsa-miR-421	CLIP-seq
MIRT2440159	hsa-miR-4255	CLIP-seq
MIRT1553569	hsa-miR-4326	CLIP-seq
MIRT1553570	hsa-miR-4433	CLIP-seq
MIRT2440160	hsa-miR-4446-5p	CLIP-seq
MIRT1553572	hsa-miR-4511	CLIP-seq
MIRT1553573	hsa-miR-451b	CLIP-seq
MIRT1338898	hsa-miR-4528	CLIP-seq
MIRT1553578	hsa-miR-4659a-3p	CLIP-seq
MIRT1553579	hsa-miR-4659b-3p	CLIP-seq
MIRT2440161	hsa-miR-4667-3p	CLIP-seq
MIRT1553582	hsa-miR-4696	CLIP-seq
MIRT2433038	hsa-miR-4709-5p	CLIP-seq
MIRT2440162	hsa-miR-4755-5p	CLIP-seq
MIRT1553585	hsa-miR-4766-5p	CLIP-seq
MIRT2440163	hsa-miR-4773	CLIP-seq
MIRT2440164	hsa-miR-4793-5p	CLIP-seq
MIRT2440165	hsa-miR-4797-3p	CLIP-seq
MIRT1553587	hsa-miR-513a-3p	CLIP-seq
MIRT1553591	hsa-miR-548b-3p	CLIP-seq
MIRT1338899	hsa-miR-586	CLIP-seq
MIRT1553594	hsa-miR-590-3p	CLIP-seq
MIRT2440166	hsa-miR-642a	CLIP-seq
MIRT2433041	hsa-miR-664	CLIP-seq
MIRT1553596	hsa-miR-671-5p	CLIP-seq
MIRT1553597	hsa-miR-875-3p	CLIP-seq
MIRT2440167	hsa-miR-875-5p	CLIP-seq
MIRT1553598	hsa-miR-921	CLIP-seq
MIRT1553600	hsa-miR-936	CLIP-seq
MIRT1553557	hsa-miR-3120-3p	CLIP-seq
MIRT1553560	hsa-miR-3182	CLIP-seq
MIRT1553565	hsa-miR-3920	CLIP-seq
MIRT1553570	hsa-miR-4433	CLIP-seq
MIRT1553573	hsa-miR-451b	CLIP-seq
MIRT1553578	hsa-miR-4659a-3p	CLIP-seq
MIRT1553579	hsa-miR-4659b-3p	CLIP-seq
MIRT1553582	hsa-miR-4696	CLIP-seq
MIRT1553585	hsa-miR-4766-5p	CLIP-seq
MIRT1553587	hsa-miR-513a-3p	CLIP-seq
MIRT2433032	hsa-miR-1200	CLIP-seq
MIRT1553544	hsa-miR-1244	CLIP-seq
MIRT2433034	hsa-miR-1298	CLIP-seq
MIRT1553546	hsa-miR-1299	CLIP-seq
MIRT1553547	hsa-miR-132	CLIP-seq
MIRT1553548	hsa-miR-186	CLIP-seq
MIRT1553549	hsa-miR-194	CLIP-seq
MIRT1553550	hsa-miR-199a-3p	CLIP-seq
MIRT1553551	hsa-miR-199b-3p	CLIP-seq
MIRT1553552	hsa-miR-2052	CLIP-seq
MIRT1553553	hsa-miR-2053	CLIP-seq
MIRT1553554	hsa-miR-212	CLIP-seq
MIRT1553555	hsa-miR-296-3p	CLIP-seq
MIRT1553556	hsa-miR-3065-5p	CLIP-seq
MIRT1553557	hsa-miR-3120-3p	CLIP-seq
MIRT1553558	hsa-miR-3129-5p	CLIP-seq
MIRT1553559	hsa-miR-3133	CLIP-seq
MIRT2433035	hsa-miR-3140-5p	CLIP-seq
MIRT1338896	hsa-miR-3163	CLIP-seq
MIRT1553560	hsa-miR-3182	CLIP-seq
MIRT1553561	hsa-miR-3545-3p	CLIP-seq
MIRT1553562	hsa-miR-3591-5p	CLIP-seq
MIRT1553563	hsa-miR-3606	CLIP-seq
MIRT1553564	hsa-miR-3654	CLIP-seq
MIRT1553565	hsa-miR-3920	CLIP-seq
MIRT1553567	hsa-miR-3975	CLIP-seq
MIRT1338897	hsa-miR-410	CLIP-seq
MIRT2433036	hsa-miR-421	CLIP-seq
MIRT2440159	hsa-miR-4255	CLIP-seq
MIRT1553569	hsa-miR-4326	CLIP-seq
MIRT1553570	hsa-miR-4433	CLIP-seq
MIRT1553572	hsa-miR-4511	CLIP-seq
MIRT1553573	hsa-miR-451b	CLIP-seq
MIRT1338898	hsa-miR-4528	CLIP-seq
MIRT1553575	hsa-miR-4539	CLIP-seq
MIRT1553576	hsa-miR-4638-3p	CLIP-seq
MIRT1553578	hsa-miR-4659a-3p	CLIP-seq
MIRT1553579	hsa-miR-4659b-3p	CLIP-seq
MIRT1553582	hsa-miR-4696	CLIP-seq
MIRT2433038	hsa-miR-4709-5p	CLIP-seq
MIRT1553585	hsa-miR-4766-5p	CLIP-seq
MIRT2440165	hsa-miR-4797-3p	CLIP-seq
MIRT1553586	hsa-miR-5096	CLIP-seq
MIRT1553587	hsa-miR-513a-3p	CLIP-seq
MIRT1553589	hsa-miR-545	CLIP-seq
MIRT1553591	hsa-miR-548b-3p	CLIP-seq
MIRT1553593	hsa-miR-583	CLIP-seq
MIRT1338899	hsa-miR-586	CLIP-seq
MIRT1553594	hsa-miR-590-3p	CLIP-seq
MIRT2433041	hsa-miR-664	CLIP-seq
MIRT1553596	hsa-miR-671-5p	CLIP-seq
MIRT1553597	hsa-miR-875-3p	CLIP-seq
MIRT2433042	hsa-miR-888	CLIP-seq
MIRT1553598	hsa-miR-921	CLIP-seq
MIRT1553600	hsa-miR-936	CLIP-seq
MIRT2433032	hsa-miR-1200	CLIP-seq
MIRT1553544	hsa-miR-1244	CLIP-seq
MIRT1553545	hsa-miR-1275	CLIP-seq
MIRT2433034	hsa-miR-1298	CLIP-seq
MIRT1553546	hsa-miR-1299	CLIP-seq
MIRT1553547	hsa-miR-132	CLIP-seq
MIRT2440156	hsa-miR-1470	CLIP-seq
MIRT1553548	hsa-miR-186	CLIP-seq
MIRT1553549	hsa-miR-194	CLIP-seq
MIRT1553550	hsa-miR-199a-3p	CLIP-seq
MIRT1553551	hsa-miR-199b-3p	CLIP-seq
MIRT1553553	hsa-miR-2053	CLIP-seq
MIRT1553554	hsa-miR-212	CLIP-seq
MIRT1553555	hsa-miR-296-3p	CLIP-seq
MIRT1553556	hsa-miR-3065-5p	CLIP-seq
MIRT1553557	hsa-miR-3120-3p	CLIP-seq
MIRT1553558	hsa-miR-3129-5p	CLIP-seq
MIRT1553559	hsa-miR-3133	CLIP-seq
MIRT2433035	hsa-miR-3140-5p	CLIP-seq
MIRT1338896	hsa-miR-3163	CLIP-seq
MIRT1553560	hsa-miR-3182	CLIP-seq
MIRT2440157	hsa-miR-323b-3p	CLIP-seq
MIRT1553561	hsa-miR-3545-3p	CLIP-seq
MIRT1553562	hsa-miR-3591-5p	CLIP-seq
MIRT1553563	hsa-miR-3606	CLIP-seq
MIRT1553564	hsa-miR-3654	CLIP-seq
MIRT2440158	hsa-miR-370	CLIP-seq
MIRT1553565	hsa-miR-3920	CLIP-seq
MIRT1553567	hsa-miR-3975	CLIP-seq
MIRT1338897	hsa-miR-410	CLIP-seq
MIRT2433036	hsa-miR-421	CLIP-seq
MIRT2440159	hsa-miR-4255	CLIP-seq
MIRT1553569	hsa-miR-4326	CLIP-seq
MIRT1553570	hsa-miR-4433	CLIP-seq
MIRT1553571	hsa-miR-4443	CLIP-seq
MIRT2440160	hsa-miR-4446-5p	CLIP-seq
MIRT1553573	hsa-miR-451b	CLIP-seq
MIRT1553574	hsa-miR-4525	CLIP-seq
MIRT1338898	hsa-miR-4528	CLIP-seq
MIRT1553575	hsa-miR-4539	CLIP-seq
MIRT1553576	hsa-miR-4638-3p	CLIP-seq
MIRT1553578	hsa-miR-4659a-3p	CLIP-seq
MIRT1553579	hsa-miR-4659b-3p	CLIP-seq
MIRT1553580	hsa-miR-4665-5p	CLIP-seq
MIRT2440161	hsa-miR-4667-3p	CLIP-seq
MIRT1553582	hsa-miR-4696	CLIP-seq
MIRT2433038	hsa-miR-4709-5p	CLIP-seq
MIRT1553583	hsa-miR-4716-3p	CLIP-seq
MIRT1553584	hsa-miR-4723-5p	CLIP-seq
MIRT2440162	hsa-miR-4755-5p	CLIP-seq
MIRT1553585	hsa-miR-4766-5p	CLIP-seq
MIRT2440164	hsa-miR-4793-5p	CLIP-seq
MIRT2440165	hsa-miR-4797-3p	CLIP-seq
MIRT1553586	hsa-miR-5096	CLIP-seq
MIRT1553587	hsa-miR-513a-3p	CLIP-seq
MIRT1553589	hsa-miR-545	CLIP-seq
MIRT1553593	hsa-miR-583	CLIP-seq
MIRT1338899	hsa-miR-586	CLIP-seq
MIRT1553594	hsa-miR-590-3p	CLIP-seq
MIRT1553595	hsa-miR-625	CLIP-seq
MIRT2440166	hsa-miR-642a	CLIP-seq
MIRT2433041	hsa-miR-664	CLIP-seq
MIRT1553596	hsa-miR-671-5p	CLIP-seq
MIRT1553597	hsa-miR-875-3p	CLIP-seq
MIRT2440167	hsa-miR-875-5p	CLIP-seq
MIRT2433042	hsa-miR-888	CLIP-seq
MIRT1553598	hsa-miR-921	CLIP-seq
MIRT1553600	hsa-miR-936	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IBA	21873635
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IDA	3997857, 19249338, 19855083
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IMP	19855083
GO:0005102	Function	Signaling receptor binding	IPI	17379830
GO:0005515	Function	Protein binding	IPI	3279057, 19911255, 25416956
GO:0005539	Function	Glycosaminoglycan binding	IDA	19855083
GO:0005576	Component	Extracellular region	IDA	3997857, 19855083
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005829	Component	Cytosol	IDA	19855083
GO:0007596	Process	Blood coagulation	TAS
GO:0008201	Function	Heparin binding	IDA	1939253, 3997857
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0010757	Process	Negative regulation of plasminogen activation	IMP	19855083
GO:0010766	Process	Negative regulation of sodium ion transport	IEA
GO:0010951	Process	Negative regulation of endopeptidase activity	IBA	21873635
GO:0010955	Process	Negative regulation of protein processing	IC	19855083
GO:0014067	Process	Negative regulation of phosphatidylinositol 3-kinase signaling	IEA
GO:0021683	Process	Cerebellar granular layer morphogenesis	IEA
GO:0030195	Process	Negative regulation of blood coagulation	IC	19855083
GO:0030195	Process	Negative regulation of blood coagulation	IDA	17379830
GO:0030308	Process	Negative regulation of cell growth	IEA
GO:0030334	Process	Regulation of cell migration	NAS	2877744
GO:0031091	Component	Platelet alpha granule	IDA	19855083
GO:0031091	Component	Platelet alpha granule	IMP	19855083
GO:0031232	Component	Extrinsic component of external side of plasma membrane	IDA	19855083
GO:0031594	Component	Neuromuscular junction	ISS	2037625
GO:0032940	Process	Secretion by cell	IEA
GO:0033363	Process	Secretory granule organization	IEA
GO:0042177	Process	Negative regulation of protein catabolic process	IEA
GO:0042628	Process	Mating plug formation	IEA
GO:0045861	Process	Negative regulation of proteolysis	IDA	3997857, 17379830
GO:0045879	Process	Negative regulation of smoothened signaling pathway	IEA
GO:0048505	Process	Regulation of timing of cell differentiation	IEA
GO:0048711	Process	Positive regulation of astrocyte differentiation	IDA	1691280
GO:0050974	Process	Detection of mechanical stimulus involved in sensory perception	IEA
GO:0051966	Process	Regulation of synaptic transmission, glutamatergic	IEA
GO:0060291	Process	Long-term synaptic potentiation	IEA
GO:0060384	Process	Innervation	IEA
GO:0061108	Process	Seminal vesicle epithelium development	IEA
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	28327460
GO:0062023	Component	Collagen-containing extracellular matrix	IDA	3279057
GO:0090331	Process	Negative regulation of platelet aggregation	ISS	19855083
GO:1903561	Component	Extracellular vesicle	HDA	24769233

Other IDs

• MIM: 177010
• HGNC: 8951
• e!Ensembl: ENSG00000135919

Protein

• UniProt ID: P07093
• Protein name: Glia-derived nexin (GDN) (Peptidase inhibitor 7) (PI-7) (Protease nexin 1) (PN-1) (Protease nexin I) (Serpin E2)
• Protein function: Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.
• PDB: 4DY0, 4DY7
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00079	Serpin	31 → 398	Serpin (serine protease inhibitor)	Domain

• Sequence:

  MNWHLPLFLLASVTLPSICSHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIAS
  VLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNAS
  EIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTR
  LVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYN
  FIELPYHGESISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVA
  QTDLKEPLKVLGITDMFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTA
  ILIARSSPPWFIVDRPFLFFIRHNPTGAVLFMGQINKP

• Sequence length: 398

Pathways

KEGG:

Complement and coagulation cascades

Reactome:

Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
Dissolution of Fibrin Clot

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243