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SERPINA4 (serpin family A member 4)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5267
Gene nameGene Name - the full gene name approved by the HGNC.
Serpin family A member 4
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
SERPINA4
SynonymsGene synonyms aliases
KAL, KLST, KST, PI-4, PI4, kallistatin
ChromosomeChromosome number
14
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q32.13
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT609249 hsa-miR-141-5p HITS-CLIP 23824327
MIRT609246 hsa-miR-5088-3p HITS-CLIP 23824327
MIRT609245 hsa-miR-1237-3p HITS-CLIP 23824327
MIRT609244 hsa-miR-4287 HITS-CLIP 23824327
MIRT609243 hsa-miR-4685-3p HITS-CLIP 23824327
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002576 Process Platelet degranulation TAS
GO:0004867 Function Serine-type endopeptidase inhibitor activity IBA 21873635
GO:0005576 Component Extracellular region HDA 27068509
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space HDA 20551380
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P29622
Protein name Kallistatin (Kallikrein inhibitor) (Peptidase inhibitor 4) (PI-4) (Serpin A4)
Protein function Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of
PDB 6F02
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00079 Serpin
53 424
Serpin (serine protease inhibitor)
Domain
Sequence
Sequence length 427
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    Platelet degranulation
Associated diseases
Unknown
Disease name Disease term dbSNP ID References
Liver carcinoma Liver carcinoma 19709125
Malignant mesothelioma Malignant mesothelioma 23056237

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