PGGT1B (protein geranylgeranyltransferase type I subunit beta)

Gene

• Entrez ID: 5229
• Gene name: Protein geranylgeranyltransferase type I subunit beta
• Gene symbol: PGGT1B
• Synonyms: BGGI, GGTI
• Chromosome: 5
• Chromosome location: 5q22.3
• Summary: Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which `A` is an aliphatic amino acid and `X` is leucine (summarized by Zhang et al., 1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022675	hsa-miR-124-3p	Microarray	18668037
MIRT053412	hsa-miR-591	Microarray	23807165
MIRT438832	hsa-miR-582-5p	qRT-PCR	23295946
MIRT438821	hsa-miR-582-3p	qRT-PCR	23295946
MIRT438832	hsa-miR-582-5p	qRT-PCR	23295946
MIRT438821	hsa-miR-582-3p	qRT-PCR	23295946
MIRT566468	hsa-miR-1276	PAR-CLIP	20371350
MIRT566467	hsa-miR-4802-3p	PAR-CLIP	20371350
MIRT566466	hsa-miR-942-3p	PAR-CLIP	20371350
MIRT566465	hsa-miR-3614-5p	PAR-CLIP	20371350
MIRT566464	hsa-let-7a-3p	PAR-CLIP	20371350
MIRT566463	hsa-let-7b-3p	PAR-CLIP	20371350
MIRT566462	hsa-let-7f-1-3p	PAR-CLIP	20371350
MIRT566461	hsa-miR-98-3p	PAR-CLIP	20371350
MIRT566460	hsa-miR-4789-5p	PAR-CLIP	20371350
MIRT566459	hsa-let-7f-2-3p	PAR-CLIP	20371350
MIRT566458	hsa-miR-1185-1-3p	PAR-CLIP	20371350
MIRT566457	hsa-miR-1185-2-3p	PAR-CLIP	20371350
MIRT566456	hsa-miR-487a-5p	PAR-CLIP	20371350
MIRT566455	hsa-miR-487b-5p	PAR-CLIP	20371350
MIRT450764	hsa-miR-30a-5p	PAR-CLIP	22100165
MIRT450763	hsa-miR-30b-5p	PAR-CLIP	22100165
MIRT450762	hsa-miR-30c-5p	PAR-CLIP	22100165
MIRT450761	hsa-miR-30e-5p	PAR-CLIP	22100165
MIRT450760	hsa-miR-30d-5p	PAR-CLIP	22100165
MIRT450759	hsa-miR-4282	PAR-CLIP	22100165
MIRT450758	hsa-miR-4795-5p	PAR-CLIP	22100165
MIRT450757	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT450756	hsa-miR-573	PAR-CLIP	22100165
MIRT566468	hsa-miR-1276	PAR-CLIP	20371350
MIRT566467	hsa-miR-4802-3p	PAR-CLIP	20371350
MIRT566466	hsa-miR-942-3p	PAR-CLIP	20371350
MIRT566465	hsa-miR-3614-5p	PAR-CLIP	20371350
MIRT566464	hsa-let-7a-3p	PAR-CLIP	20371350
MIRT566463	hsa-let-7b-3p	PAR-CLIP	20371350
MIRT566462	hsa-let-7f-1-3p	PAR-CLIP	20371350
MIRT566461	hsa-miR-98-3p	PAR-CLIP	20371350
MIRT566460	hsa-miR-4789-5p	PAR-CLIP	20371350
MIRT566459	hsa-let-7f-2-3p	PAR-CLIP	20371350
MIRT566458	hsa-miR-1185-1-3p	PAR-CLIP	20371350
MIRT566457	hsa-miR-1185-2-3p	PAR-CLIP	20371350
MIRT566456	hsa-miR-487a-5p	PAR-CLIP	20371350
MIRT566455	hsa-miR-487b-5p	PAR-CLIP	20371350
MIRT450764	hsa-miR-30a-5p	PAR-CLIP	22100165
MIRT450763	hsa-miR-30b-5p	PAR-CLIP	22100165
MIRT450762	hsa-miR-30c-5p	PAR-CLIP	22100165
MIRT450761	hsa-miR-30e-5p	PAR-CLIP	22100165
MIRT450760	hsa-miR-30d-5p	PAR-CLIP	22100165
MIRT450759	hsa-miR-4282	PAR-CLIP	22100165
MIRT450758	hsa-miR-4795-5p	PAR-CLIP	22100165
MIRT450757	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT450756	hsa-miR-573	PAR-CLIP	22100165
MIRT1227385	hsa-miR-105	CLIP-seq
MIRT1227386	hsa-miR-1271	CLIP-seq
MIRT1227387	hsa-miR-139-5p	CLIP-seq
MIRT1227388	hsa-miR-214	CLIP-seq
MIRT1227389	hsa-miR-3124-3p	CLIP-seq
MIRT1227390	hsa-miR-3129-3p	CLIP-seq
MIRT1227391	hsa-miR-3146	CLIP-seq
MIRT1227392	hsa-miR-3152-5p	CLIP-seq
MIRT1227393	hsa-miR-3163	CLIP-seq
MIRT1227394	hsa-miR-329	CLIP-seq
MIRT1227395	hsa-miR-3609	CLIP-seq
MIRT1227396	hsa-miR-3613-3p	CLIP-seq
MIRT1227397	hsa-miR-3619-5p	CLIP-seq
MIRT1227398	hsa-miR-3622a-3p	CLIP-seq
MIRT1227399	hsa-miR-3622b-3p	CLIP-seq
MIRT1227400	hsa-miR-362-3p	CLIP-seq
MIRT1227401	hsa-miR-3646	CLIP-seq
MIRT1227402	hsa-miR-3662	CLIP-seq
MIRT1227403	hsa-miR-3671	CLIP-seq
MIRT1227404	hsa-miR-384	CLIP-seq
MIRT1227405	hsa-miR-3941	CLIP-seq
MIRT1227406	hsa-miR-3973	CLIP-seq
MIRT1227407	hsa-miR-4255	CLIP-seq
MIRT1227408	hsa-miR-4291	CLIP-seq
MIRT1227409	hsa-miR-4488	CLIP-seq
MIRT1227410	hsa-miR-4659a-3p	CLIP-seq
MIRT1227411	hsa-miR-4659b-3p	CLIP-seq
MIRT1227412	hsa-miR-4668-3p	CLIP-seq
MIRT1227413	hsa-miR-4697-5p	CLIP-seq
MIRT1227414	hsa-miR-4699-5p	CLIP-seq
MIRT1227415	hsa-miR-4717-5p	CLIP-seq
MIRT1227416	hsa-miR-4722-5p	CLIP-seq
MIRT1227417	hsa-miR-4733-5p	CLIP-seq
MIRT1227418	hsa-miR-4768-3p	CLIP-seq
MIRT1227419	hsa-miR-4774-3p	CLIP-seq
MIRT1227420	hsa-miR-4775	CLIP-seq
MIRT1227421	hsa-miR-4789-3p	CLIP-seq
MIRT1227422	hsa-miR-520g	CLIP-seq
MIRT1227423	hsa-miR-520h	CLIP-seq
MIRT1227424	hsa-miR-548ac	CLIP-seq
MIRT1227425	hsa-miR-548ae	CLIP-seq
MIRT1227426	hsa-miR-548ah	CLIP-seq
MIRT1227427	hsa-miR-548aj	CLIP-seq
MIRT1227428	hsa-miR-548am	CLIP-seq
MIRT1227429	hsa-miR-548c-3p	CLIP-seq
MIRT1227430	hsa-miR-548d-3p	CLIP-seq
MIRT1227431	hsa-miR-548l	CLIP-seq
MIRT1227432	hsa-miR-548p	CLIP-seq
MIRT1227433	hsa-miR-548v	CLIP-seq
MIRT1227434	hsa-miR-548x	CLIP-seq
MIRT1227435	hsa-miR-548z	CLIP-seq
MIRT1227436	hsa-miR-570	CLIP-seq
MIRT1227437	hsa-miR-580	CLIP-seq
MIRT1227438	hsa-miR-595	CLIP-seq
MIRT1227439	hsa-miR-603	CLIP-seq
MIRT1227440	hsa-miR-607	CLIP-seq
MIRT1227441	hsa-miR-610	CLIP-seq
MIRT1227442	hsa-miR-637	CLIP-seq
MIRT1227443	hsa-miR-761	CLIP-seq
MIRT1227444	hsa-miR-922	CLIP-seq
MIRT1227445	hsa-miR-96	CLIP-seq
MIRT1227386	hsa-miR-1271	CLIP-seq
MIRT1227390	hsa-miR-3129-3p	CLIP-seq
MIRT2066611	hsa-miR-3647-3p	CLIP-seq
MIRT2066612	hsa-miR-548a-3p	CLIP-seq
MIRT2066613	hsa-miR-548an	CLIP-seq
MIRT2066614	hsa-miR-548e	CLIP-seq
MIRT2066615	hsa-miR-548f	CLIP-seq
MIRT1227437	hsa-miR-580	CLIP-seq
MIRT1227445	hsa-miR-96	CLIP-seq
MIRT1227386	hsa-miR-1271	CLIP-seq
MIRT2294142	hsa-miR-1323	CLIP-seq
MIRT2294143	hsa-miR-140-3p	CLIP-seq
MIRT2294144	hsa-miR-191	CLIP-seq
MIRT2294145	hsa-miR-197	CLIP-seq
MIRT1227388	hsa-miR-214	CLIP-seq
MIRT2294146	hsa-miR-3120-3p	CLIP-seq
MIRT2294147	hsa-miR-3201	CLIP-seq
MIRT2294148	hsa-miR-3591-5p	CLIP-seq
MIRT2294149	hsa-miR-3606	CLIP-seq
MIRT1227397	hsa-miR-3619-5p	CLIP-seq
MIRT2294150	hsa-miR-3908	CLIP-seq
MIRT1227408	hsa-miR-4291	CLIP-seq
MIRT2294151	hsa-miR-4420	CLIP-seq
MIRT2294152	hsa-miR-4446-5p	CLIP-seq
MIRT2294153	hsa-miR-4709-3p	CLIP-seq
MIRT2294154	hsa-miR-4755-5p	CLIP-seq
MIRT2294155	hsa-miR-4774-5p	CLIP-seq
MIRT2294156	hsa-miR-4791	CLIP-seq
MIRT2294157	hsa-miR-548o	CLIP-seq
MIRT2294158	hsa-miR-642a	CLIP-seq
MIRT2294159	hsa-miR-668	CLIP-seq
MIRT1227443	hsa-miR-761	CLIP-seq
MIRT2294160	hsa-miR-921	CLIP-seq
MIRT1227444	hsa-miR-922	CLIP-seq
MIRT1227445	hsa-miR-96	CLIP-seq
MIRT1227385	hsa-miR-105	CLIP-seq
MIRT2592110	hsa-miR-1237	CLIP-seq
MIRT2592111	hsa-miR-1248	CLIP-seq
MIRT2592112	hsa-miR-1305	CLIP-seq
MIRT2294144	hsa-miR-191	CLIP-seq
MIRT2592113	hsa-miR-203	CLIP-seq
MIRT2592114	hsa-miR-2278	CLIP-seq
MIRT2592115	hsa-miR-2355-5p	CLIP-seq
MIRT2592116	hsa-miR-28-3p	CLIP-seq
MIRT1227389	hsa-miR-3124-3p	CLIP-seq
MIRT2592117	hsa-miR-3149	CLIP-seq
MIRT2592118	hsa-miR-3161	CLIP-seq
MIRT2592119	hsa-miR-3168	CLIP-seq
MIRT2294147	hsa-miR-3201	CLIP-seq
MIRT2294148	hsa-miR-3591-5p	CLIP-seq
MIRT2294149	hsa-miR-3606	CLIP-seq
MIRT1227401	hsa-miR-3646	CLIP-seq
MIRT1227402	hsa-miR-3662	CLIP-seq
MIRT1227403	hsa-miR-3671	CLIP-seq
MIRT2592120	hsa-miR-3679-3p	CLIP-seq
MIRT2592121	hsa-miR-374a	CLIP-seq
MIRT2592122	hsa-miR-374b	CLIP-seq
MIRT2592123	hsa-miR-376a	CLIP-seq
MIRT2592124	hsa-miR-376b	CLIP-seq
MIRT1227404	hsa-miR-384	CLIP-seq
MIRT1227406	hsa-miR-3973	CLIP-seq
MIRT2592125	hsa-miR-421	CLIP-seq
MIRT2294151	hsa-miR-4420	CLIP-seq
MIRT2592126	hsa-miR-4424	CLIP-seq
MIRT2592127	hsa-miR-4427	CLIP-seq
MIRT2592128	hsa-miR-4445	CLIP-seq
MIRT1227409	hsa-miR-4488	CLIP-seq
MIRT2592129	hsa-miR-4637	CLIP-seq
MIRT2592130	hsa-miR-4652-3p	CLIP-seq
MIRT1227410	hsa-miR-4659a-3p	CLIP-seq
MIRT1227411	hsa-miR-4659b-3p	CLIP-seq
MIRT2592131	hsa-miR-4680-3p	CLIP-seq
MIRT1227413	hsa-miR-4697-5p	CLIP-seq
MIRT2294153	hsa-miR-4709-3p	CLIP-seq
MIRT2592132	hsa-miR-4729	CLIP-seq
MIRT1227420	hsa-miR-4775	CLIP-seq
MIRT2592133	hsa-miR-4777-5p	CLIP-seq
MIRT2592134	hsa-miR-4790-3p	CLIP-seq
MIRT2294156	hsa-miR-4791	CLIP-seq
MIRT2592135	hsa-miR-4795-3p	CLIP-seq
MIRT2592136	hsa-miR-518d-5p	CLIP-seq
MIRT2592137	hsa-miR-519b-5p	CLIP-seq
MIRT2592138	hsa-miR-519c-5p	CLIP-seq
MIRT2592139	hsa-miR-520c-5p	CLIP-seq
MIRT2592140	hsa-miR-526a	CLIP-seq
MIRT1227424	hsa-miR-548ac	CLIP-seq
MIRT1227425	hsa-miR-548ae	CLIP-seq
MIRT1227427	hsa-miR-548aj	CLIP-seq
MIRT1227428	hsa-miR-548am	CLIP-seq
MIRT1227429	hsa-miR-548c-3p	CLIP-seq
MIRT1227430	hsa-miR-548d-3p	CLIP-seq
MIRT1227431	hsa-miR-548l	CLIP-seq
MIRT2592141	hsa-miR-548n	CLIP-seq
MIRT1227434	hsa-miR-548x	CLIP-seq
MIRT1227435	hsa-miR-548z	CLIP-seq
MIRT1227436	hsa-miR-570	CLIP-seq
MIRT2592142	hsa-miR-577	CLIP-seq
MIRT1227439	hsa-miR-603	CLIP-seq
MIRT1227440	hsa-miR-607	CLIP-seq
MIRT1227442	hsa-miR-637	CLIP-seq
MIRT2592143	hsa-miR-643	CLIP-seq
MIRT2592144	hsa-miR-646	CLIP-seq
MIRT2294159	hsa-miR-668	CLIP-seq
MIRT2294160	hsa-miR-921	CLIP-seq
MIRT1227385	hsa-miR-105	CLIP-seq
MIRT2592110	hsa-miR-1237	CLIP-seq
MIRT2592111	hsa-miR-1248	CLIP-seq
MIRT2592112	hsa-miR-1305	CLIP-seq
MIRT2294144	hsa-miR-191	CLIP-seq
MIRT2592113	hsa-miR-203	CLIP-seq
MIRT1227388	hsa-miR-214	CLIP-seq
MIRT2687735	hsa-miR-219-5p	CLIP-seq
MIRT2592115	hsa-miR-2355-5p	CLIP-seq
MIRT2687736	hsa-miR-24	CLIP-seq
MIRT2592116	hsa-miR-28-3p	CLIP-seq
MIRT1227389	hsa-miR-3124-3p	CLIP-seq
MIRT2592117	hsa-miR-3149	CLIP-seq
MIRT2592118	hsa-miR-3161	CLIP-seq
MIRT2592119	hsa-miR-3168	CLIP-seq
MIRT2294147	hsa-miR-3201	CLIP-seq
MIRT2294148	hsa-miR-3591-5p	CLIP-seq
MIRT2294149	hsa-miR-3606	CLIP-seq
MIRT1227395	hsa-miR-3609	CLIP-seq
MIRT1227397	hsa-miR-3619-5p	CLIP-seq
MIRT1227401	hsa-miR-3646	CLIP-seq
MIRT1227402	hsa-miR-3662	CLIP-seq
MIRT1227403	hsa-miR-3671	CLIP-seq
MIRT2592120	hsa-miR-3679-3p	CLIP-seq
MIRT2592121	hsa-miR-374a	CLIP-seq
MIRT2592122	hsa-miR-374b	CLIP-seq
MIRT2592123	hsa-miR-376a	CLIP-seq
MIRT2592124	hsa-miR-376b	CLIP-seq
MIRT1227406	hsa-miR-3973	CLIP-seq
MIRT2592125	hsa-miR-421	CLIP-seq
MIRT2687737	hsa-miR-4284	CLIP-seq
MIRT1227408	hsa-miR-4291	CLIP-seq
MIRT2294151	hsa-miR-4420	CLIP-seq
MIRT2592126	hsa-miR-4424	CLIP-seq
MIRT2687738	hsa-miR-4432	CLIP-seq
MIRT2592128	hsa-miR-4445	CLIP-seq
MIRT1227409	hsa-miR-4488	CLIP-seq
MIRT2592129	hsa-miR-4637	CLIP-seq
MIRT2592130	hsa-miR-4652-3p	CLIP-seq
MIRT1227413	hsa-miR-4697-5p	CLIP-seq
MIRT2294153	hsa-miR-4709-3p	CLIP-seq
MIRT1227416	hsa-miR-4722-5p	CLIP-seq
MIRT2592132	hsa-miR-4729	CLIP-seq
MIRT1227417	hsa-miR-4733-5p	CLIP-seq
MIRT1227418	hsa-miR-4768-3p	CLIP-seq
MIRT1227420	hsa-miR-4775	CLIP-seq
MIRT2592133	hsa-miR-4777-5p	CLIP-seq
MIRT2687739	hsa-miR-4782-3p	CLIP-seq
MIRT2592134	hsa-miR-4790-3p	CLIP-seq
MIRT2294156	hsa-miR-4791	CLIP-seq
MIRT2592135	hsa-miR-4795-3p	CLIP-seq
MIRT2687740	hsa-miR-499-5p	CLIP-seq
MIRT2687741	hsa-miR-508-3p	CLIP-seq
MIRT2592136	hsa-miR-518d-5p	CLIP-seq
MIRT2592137	hsa-miR-519b-5p	CLIP-seq
MIRT2592138	hsa-miR-519c-5p	CLIP-seq
MIRT2592139	hsa-miR-520c-5p	CLIP-seq
MIRT1227422	hsa-miR-520g	CLIP-seq
MIRT1227423	hsa-miR-520h	CLIP-seq
MIRT2592140	hsa-miR-526a	CLIP-seq
MIRT1227424	hsa-miR-548ac	CLIP-seq
MIRT1227425	hsa-miR-548ae	CLIP-seq
MIRT1227426	hsa-miR-548ah	CLIP-seq
MIRT1227427	hsa-miR-548aj	CLIP-seq
MIRT1227428	hsa-miR-548am	CLIP-seq
MIRT1227429	hsa-miR-548c-3p	CLIP-seq
MIRT1227430	hsa-miR-548d-3p	CLIP-seq
MIRT1227431	hsa-miR-548l	CLIP-seq
MIRT2592141	hsa-miR-548n	CLIP-seq
MIRT1227434	hsa-miR-548x	CLIP-seq
MIRT1227435	hsa-miR-548z	CLIP-seq
MIRT1227436	hsa-miR-570	CLIP-seq
MIRT2592142	hsa-miR-577	CLIP-seq
MIRT1227439	hsa-miR-603	CLIP-seq
MIRT1227440	hsa-miR-607	CLIP-seq
MIRT1227442	hsa-miR-637	CLIP-seq
MIRT2592143	hsa-miR-643	CLIP-seq
MIRT2294159	hsa-miR-668	CLIP-seq
MIRT1227443	hsa-miR-761	CLIP-seq
MIRT2294160	hsa-miR-921	CLIP-seq
MIRT1227444	hsa-miR-922	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004661	Function	Protein geranylgeranyltransferase activity	IDA	16893176
GO:0004662	Function	CAAX-protein geranylgeranyltransferase activity	IBA	21873635
GO:0004662	Function	CAAX-protein geranylgeranyltransferase activity	ISS
GO:0005515	Function	Protein binding	IPI	24981860, 32296183
GO:0005953	Component	CAAX-protein geranylgeranyltransferase complex	IBA	21873635
GO:0005953	Component	CAAX-protein geranylgeranyltransferase complex	IDA	16893176
GO:0008144	Function	Drug binding	IEA
GO:0008270	Function	Zinc ion binding	ISS
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0018215	Process	Protein phosphopantetheinylation	IEA
GO:0018342	Process	Protein prenylation	IBA	21873635
GO:0018344	Process	Protein geranylgeranylation	IBA	21873635
GO:0018344	Process	Protein geranylgeranylation	IDA	16893176
GO:0019840	Function	Isoprenoid binding	IEA
GO:0034097	Process	Response to cytokine	IEA
GO:0042277	Function	Peptide binding	IEA
GO:0045787	Process	Positive regulation of cell cycle	IEA
GO:0051771	Process	Negative regulation of nitric-oxide synthase biosynthetic process	IEA

Other IDs

• MIM: 602031
• HGNC: 8895
• e!Ensembl: ENSG00000164219

Protein

• UniProt ID: P53609
• Protein name: Geranylgeranyl transferase type-1 subunit beta (EC 2.5.1.59) (Geranylgeranyl transferase type I subunit beta) (GGTase-I-beta) (Type I protein geranyl-geranyltransferase subunit beta)
• Protein function: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, R
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00432	Prenyltrans	142 → 186	Prenyltransferase and squalene oxidase repeat	Repeat
  PF00432	Prenyltrans	191 → 234	Prenyltransferase and squalene oxidase repeat	Repeat
  PF00432	Prenyltrans	240 → 284	Prenyltransferase and squalene oxidase repeat	Repeat
  PF00432	Prenyltrans	289 → 333	Prenyltransferase and squalene oxidase repeat	Repeat

• Sequence:

  MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDM
  LDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSG
  HIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASC
  ICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVF
  SEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILS
  TQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQS
  WKTKDSKQCSENVHIST

• Sequence length: 377

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	22028818

Unknown
Disease name	Disease term	dbSNP ID	References
Lung neoplasms	Lung Neoplasms		22028818