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PGA5 (pepsinogen A5)
Gene
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5222
Gene nameGene Name - the full gene name approved by the HGNC.
Pepsinogen A5
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
PGA5
SynonymsGene synonyms aliases
Pg5
ChromosomeChromosome number
11
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q12.2
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the act
Transcription factors
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Transcription factor Regulation Reference
SOX2 Activation 17136346
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0004190 Function Aspartic-type endopeptidase activity IEA
GO:0006508 Process Proteolysis IEA
GO:0007586 Process Digestion IEA
GO:0044267 Process Cellular protein metabolic process TAS
GO:0070062 Component Extracellular exosome HDA 23533145
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P0DJD9
Protein name Pepsin A-5 (EC 3.4.23.1) (Pepsinogen-5)
Protein function Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07966 A1_Propeptide
17 → 45
A1 Propeptide
Motif
PF00026 Asp
75 → 387
Eukaryotic aspartyl protease
 Family
Sequence
Sequence length 388
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
 
KEGG
  
Reactome
  Protein digestion and absorption   Surfactant metabolism
Associated diseases
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Unknown
Disease name Disease term dbSNP ID References
Eosinophilia Esophagitis 12928072

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