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CDK14 (cyclin dependent kinase 14)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5218
Gene nameGene Name - the full gene name approved by the HGNC.
Cyclin dependent kinase 14
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
CDK14
SynonymsGene synonyms aliases
PFTAIRE1, PFTK1
ChromosomeChromosome number
7
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q21.13
SummarySummary of gene provided in NCBI Entrez Gene.
PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003763 hsa-miR-1-3p Microarray 15685193
MIRT003763 hsa-miR-1-3p Microarray 15685193
MIRT024450 hsa-miR-215-5p Microarray 19074876
MIRT026414 hsa-miR-192-5p Microarray 19074876
MIRT029296 hsa-miR-26b-5p Microarray 19088304
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000083 Process Regulation of transcription involved in G1/S transition of mitotic cell cycle IBA 21873635
GO:0000086 Process G2/M transition of mitotic cell cycle IDA 20059949
GO:0000308 Component Cytoplasmic cyclin-dependent protein kinase holoenzyme complex IDA 19524571, 20059949
GO:0004693 Function Cyclin-dependent protein serine/threonine kinase activity IBA 21873635
GO:0004693 Function Cyclin-dependent protein serine/threonine kinase activity IMP 19524571, 20059949
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID O94921
Protein name Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) (Serine/threonine-protein kinase PFTAIRE-1) (hPFTAIRE1)
Protein function Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylatio
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase
135 419
Protein kinase domain
Domain
Sequence
Sequence length 469
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
  Transcriptional misregulation in cancer  
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Common variable immunodeficiency Common Variable Immunodeficiency rs72553883, rs121908379, rs104894650, rs587776775, rs398122863, rs398122864, rs397514332, rs397514331, rs727502786, rs727502787, rs72553882, rs869320688, rs869320689, rs869320754, rs773694113, rs1553319504, rs201017642, rs1555550717, rs1558192723, rs1030733127, rs749636258, rs185689791, rs1559035937, rs1565214594, rs1560679469, rs1560711146, rs1569376229, rs1578790573, rs939459600, rs1572952530, rs1572950925, rs772481080, rs369363360, rs72553885, rs72553879, rs1265262160, rs1303637368, rs757598952, rs1016142312, rs1578771120, rs1578771197, rs1578793298, rs1578793312, rs1578809101, rs1578811073, rs1590715754, rs144718007, rs759649059, rs1723945421, rs2061279365 21497890
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601 27903959
Unknown
Disease name Disease term dbSNP ID References
Liver carcinoma Liver carcinoma 29246937, 22922871
Ovarian adenocarcinoma Ovarian Mucinous Adenocarcinoma

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