GeDiPNet: Comprehensive Gene Data - OMIM, HGNC, Ensembl, UniProt, GO, Transcription Factors & miRNA

Home
Browse
- Genes
- Diseases
- Pathways
  - Reactome
  - KEGG
Analysis
Help
Links
FAQ
Contact us

PECAM1 (platelet and endothelial cell adhesion molecule 1)

Gene

5175

Platelet and endothelial cell adhesion molecule 1

PECAM1

CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM

17q23.3

The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin super

Show/Hide all(227)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1224533	hsa-miR-1227	CLIP-seq
MIRT1224534	hsa-miR-1271	CLIP-seq
MIRT1224535	hsa-miR-1285	CLIP-seq
MIRT1224536	hsa-miR-182	CLIP-seq
MIRT1224537	hsa-miR-1972	CLIP-seq
MIRT1224538	hsa-miR-2278	CLIP-seq
MIRT1224539	hsa-miR-24	CLIP-seq
MIRT1224540	hsa-miR-2467-3p	CLIP-seq
MIRT1224541	hsa-miR-3065-5p	CLIP-seq
MIRT1224542	hsa-miR-31	CLIP-seq
MIRT1224543	hsa-miR-3168	CLIP-seq
MIRT1224544	hsa-miR-3187-5p	CLIP-seq
MIRT1224545	hsa-miR-3192	CLIP-seq
MIRT1224546	hsa-miR-3195	CLIP-seq
MIRT1224547	hsa-miR-339-5p	CLIP-seq
MIRT1224548	hsa-miR-3622b-5p	CLIP-seq
MIRT1224549	hsa-miR-3688-5p	CLIP-seq
MIRT1224550	hsa-miR-3929	CLIP-seq
MIRT1224551	hsa-miR-3945	CLIP-seq
MIRT1224552	hsa-miR-4252	CLIP-seq
MIRT1224553	hsa-miR-4253	CLIP-seq
MIRT1224554	hsa-miR-4257	CLIP-seq
MIRT1224555	hsa-miR-4284	CLIP-seq
MIRT1224556	hsa-miR-4314	CLIP-seq
MIRT1224557	hsa-miR-4419b	CLIP-seq
MIRT1224558	hsa-miR-4421	CLIP-seq
MIRT1224559	hsa-miR-4433	CLIP-seq
MIRT1224560	hsa-miR-4459	CLIP-seq
MIRT1224561	hsa-miR-4468	CLIP-seq
MIRT1224562	hsa-miR-4475	CLIP-seq
MIRT1224563	hsa-miR-4477a	CLIP-seq
MIRT1224564	hsa-miR-4478	CLIP-seq
MIRT1224565	hsa-miR-4499	CLIP-seq
MIRT1224566	hsa-miR-4505	CLIP-seq
MIRT1224567	hsa-miR-4521	CLIP-seq
MIRT1224568	hsa-miR-4642	CLIP-seq
MIRT1224569	hsa-miR-4646-5p	CLIP-seq
MIRT1224570	hsa-miR-4650-5p	CLIP-seq
MIRT1224571	hsa-miR-4693-3p	CLIP-seq
MIRT1224572	hsa-miR-4695-5p	CLIP-seq
MIRT1224573	hsa-miR-4722-5p	CLIP-seq
MIRT1224574	hsa-miR-4786-5p	CLIP-seq
MIRT1224575	hsa-miR-4793-3p	CLIP-seq
MIRT1224576	hsa-miR-508-5p	CLIP-seq
MIRT1224577	hsa-miR-548u	CLIP-seq
MIRT1224578	hsa-miR-612	CLIP-seq
MIRT1224579	hsa-miR-645	CLIP-seq
MIRT1224580	hsa-miR-658	CLIP-seq
MIRT1224581	hsa-miR-661	CLIP-seq
MIRT1224582	hsa-miR-665	CLIP-seq
MIRT1224583	hsa-miR-766	CLIP-seq
MIRT1224584	hsa-miR-767-5p	CLIP-seq
MIRT1224585	hsa-miR-96	CLIP-seq
MIRT2065497	hsa-miR-122	CLIP-seq
MIRT2065498	hsa-miR-1225-3p	CLIP-seq
MIRT2065499	hsa-miR-1229	CLIP-seq
MIRT2065500	hsa-miR-1233	CLIP-seq
MIRT2065501	hsa-miR-1246	CLIP-seq
MIRT2065502	hsa-miR-1273f	CLIP-seq
MIRT1224535	hsa-miR-1285	CLIP-seq
MIRT1224540	hsa-miR-2467-3p	CLIP-seq
MIRT2065503	hsa-miR-3134	CLIP-seq
MIRT2065504	hsa-miR-3135b	CLIP-seq
MIRT2065505	hsa-miR-3155	CLIP-seq
MIRT2065506	hsa-miR-3155b	CLIP-seq
MIRT1224544	hsa-miR-3187-5p	CLIP-seq
MIRT1224546	hsa-miR-3195	CLIP-seq
MIRT2065507	hsa-miR-3607-5p	CLIP-seq
MIRT2065508	hsa-miR-3614-5p	CLIP-seq
MIRT2065509	hsa-miR-3652	CLIP-seq
MIRT2065510	hsa-miR-3664-5p	CLIP-seq
MIRT1224554	hsa-miR-4257	CLIP-seq
MIRT2065511	hsa-miR-4320	CLIP-seq
MIRT2065512	hsa-miR-4430	CLIP-seq
MIRT2065513	hsa-miR-451b	CLIP-seq
MIRT2065514	hsa-miR-455-3p	CLIP-seq
MIRT2065515	hsa-miR-4634	CLIP-seq
MIRT2065516	hsa-miR-4639-3p	CLIP-seq
MIRT2065517	hsa-miR-4724-5p	CLIP-seq
MIRT2065518	hsa-miR-4766-3p	CLIP-seq
MIRT2065519	hsa-miR-4768-3p	CLIP-seq
MIRT1224574	hsa-miR-4786-5p	CLIP-seq
MIRT1224575	hsa-miR-4793-3p	CLIP-seq
MIRT2065520	hsa-miR-484	CLIP-seq
MIRT2065521	hsa-miR-5095	CLIP-seq
MIRT2065522	hsa-miR-510	CLIP-seq
MIRT2065523	hsa-miR-578	CLIP-seq
MIRT1224578	hsa-miR-612	CLIP-seq
MIRT1224581	hsa-miR-661	CLIP-seq
MIRT2065524	hsa-miR-668	CLIP-seq
MIRT2065497	hsa-miR-122	CLIP-seq
MIRT2065499	hsa-miR-1229	CLIP-seq
MIRT2065501	hsa-miR-1246	CLIP-seq
MIRT1224535	hsa-miR-1285	CLIP-seq
MIRT2293266	hsa-miR-146b-3p	CLIP-seq
MIRT1224539	hsa-miR-24	CLIP-seq
MIRT2293267	hsa-miR-302a	CLIP-seq
MIRT2293268	hsa-miR-302b	CLIP-seq
MIRT2293269	hsa-miR-302c	CLIP-seq
MIRT2293270	hsa-miR-302d	CLIP-seq
MIRT2293271	hsa-miR-302e	CLIP-seq
MIRT1224542	hsa-miR-31	CLIP-seq
MIRT2293272	hsa-miR-3126-3p	CLIP-seq
MIRT2065503	hsa-miR-3134	CLIP-seq
MIRT2065504	hsa-miR-3135b	CLIP-seq
MIRT2293273	hsa-miR-3140-5p	CLIP-seq
MIRT2065505	hsa-miR-3155	CLIP-seq
MIRT2065506	hsa-miR-3155b	CLIP-seq
MIRT2293274	hsa-miR-3173-5p	CLIP-seq
MIRT2293275	hsa-miR-3180	CLIP-seq
MIRT2293276	hsa-miR-3180-3p	CLIP-seq
MIRT1224544	hsa-miR-3187-5p	CLIP-seq
MIRT1224546	hsa-miR-3195	CLIP-seq
MIRT2293277	hsa-miR-3196	CLIP-seq
MIRT1224547	hsa-miR-339-5p	CLIP-seq
MIRT2293278	hsa-miR-3616-5p	CLIP-seq
MIRT2293279	hsa-miR-3622a-3p	CLIP-seq
MIRT2293280	hsa-miR-3622b-3p	CLIP-seq
MIRT2293281	hsa-miR-3647-5p	CLIP-seq
MIRT2065509	hsa-miR-3652	CLIP-seq
MIRT2065510	hsa-miR-3664-5p	CLIP-seq
MIRT2293282	hsa-miR-372	CLIP-seq
MIRT2293283	hsa-miR-373	CLIP-seq
MIRT2293284	hsa-miR-3926	CLIP-seq
MIRT2293285	hsa-miR-3940-3p	CLIP-seq
MIRT1224552	hsa-miR-4252	CLIP-seq
MIRT1224555	hsa-miR-4284	CLIP-seq
MIRT2293286	hsa-miR-4293	CLIP-seq
MIRT2065511	hsa-miR-4320	CLIP-seq
MIRT1224558	hsa-miR-4421	CLIP-seq
MIRT2065512	hsa-miR-4430	CLIP-seq
MIRT2293287	hsa-miR-4488	CLIP-seq
MIRT2065514	hsa-miR-455-3p	CLIP-seq
MIRT2065515	hsa-miR-4634	CLIP-seq
MIRT2065516	hsa-miR-4639-3p	CLIP-seq
MIRT2293288	hsa-miR-4697-5p	CLIP-seq
MIRT2293289	hsa-miR-4731-5p	CLIP-seq
MIRT2293290	hsa-miR-4749-3p	CLIP-seq
MIRT2293291	hsa-miR-4763-5p	CLIP-seq
MIRT1224574	hsa-miR-4786-5p	CLIP-seq
MIRT1224575	hsa-miR-4793-3p	CLIP-seq
MIRT2293292	hsa-miR-4795-5p	CLIP-seq
MIRT2065520	hsa-miR-484	CLIP-seq
MIRT1224576	hsa-miR-508-5p	CLIP-seq
MIRT2065522	hsa-miR-510	CLIP-seq
MIRT2293293	hsa-miR-512-3p	CLIP-seq
MIRT2293294	hsa-miR-520a-3p	CLIP-seq
MIRT2293295	hsa-miR-520b	CLIP-seq
MIRT2293296	hsa-miR-520c-3p	CLIP-seq
MIRT2293297	hsa-miR-520d-3p	CLIP-seq
MIRT2293298	hsa-miR-520e	CLIP-seq
MIRT2293299	hsa-miR-548s	CLIP-seq
MIRT2293300	hsa-miR-573	CLIP-seq
MIRT2293301	hsa-miR-596	CLIP-seq
MIRT1224578	hsa-miR-612	CLIP-seq
MIRT1224581	hsa-miR-661	CLIP-seq
MIRT2293302	hsa-miR-663b	CLIP-seq
MIRT2065524	hsa-miR-668	CLIP-seq
MIRT1224583	hsa-miR-766	CLIP-seq
MIRT2293303	hsa-miR-874	CLIP-seq
MIRT2065504	hsa-miR-3135b	CLIP-seq
MIRT2392368	hsa-miR-3158-3p	CLIP-seq
MIRT2392369	hsa-miR-3612	CLIP-seq
MIRT2065509	hsa-miR-3652	CLIP-seq
MIRT2065512	hsa-miR-4430	CLIP-seq
MIRT2392370	hsa-miR-4443	CLIP-seq
MIRT2392371	hsa-miR-4446-3p	CLIP-seq
MIRT2392372	hsa-miR-4492	CLIP-seq
MIRT2392373	hsa-miR-4498	CLIP-seq
MIRT2392374	hsa-miR-4717-5p	CLIP-seq
MIRT2392375	hsa-miR-650	CLIP-seq
MIRT2392376	hsa-miR-762	CLIP-seq
MIRT2456227	hsa-miR-3675-3p	CLIP-seq
MIRT2456228	hsa-miR-3925-3p	CLIP-seq
MIRT2456229	hsa-miR-4662a-5p	CLIP-seq
MIRT2456230	hsa-miR-4676-5p	CLIP-seq
MIRT2456231	hsa-miR-4684-5p	CLIP-seq
MIRT2456232	hsa-miR-4755-3p	CLIP-seq
MIRT2456233	hsa-miR-548c-3p	CLIP-seq
MIRT2456234	hsa-miR-549	CLIP-seq
MIRT2456235	hsa-miR-575	CLIP-seq
MIRT1224583	hsa-miR-766	CLIP-seq
MIRT2456227	hsa-miR-3675-3p	CLIP-seq
MIRT2456229	hsa-miR-4662a-5p	CLIP-seq
MIRT2456230	hsa-miR-4676-5p	CLIP-seq
MIRT2456231	hsa-miR-4684-5p	CLIP-seq
MIRT2456232	hsa-miR-4755-3p	CLIP-seq
MIRT2456233	hsa-miR-548c-3p	CLIP-seq
MIRT2456235	hsa-miR-575	CLIP-seq
MIRT2591312	hsa-miR-1273e	CLIP-seq
MIRT2591313	hsa-miR-146a	CLIP-seq
MIRT2591314	hsa-miR-146b-5p	CLIP-seq
MIRT2456227	hsa-miR-3675-3p	CLIP-seq
MIRT2456228	hsa-miR-3925-3p	CLIP-seq
MIRT2293284	hsa-miR-3926	CLIP-seq
MIRT1224560	hsa-miR-4459	CLIP-seq
MIRT2456229	hsa-miR-4662a-5p	CLIP-seq
MIRT2456230	hsa-miR-4676-5p	CLIP-seq
MIRT2456231	hsa-miR-4684-5p	CLIP-seq
MIRT1224572	hsa-miR-4695-5p	CLIP-seq
MIRT2456232	hsa-miR-4755-3p	CLIP-seq
MIRT2065519	hsa-miR-4768-3p	CLIP-seq
MIRT2456233	hsa-miR-548c-3p	CLIP-seq
MIRT2293299	hsa-miR-548s	CLIP-seq
MIRT2456234	hsa-miR-549	CLIP-seq
MIRT2456235	hsa-miR-575	CLIP-seq
MIRT1224580	hsa-miR-658	CLIP-seq
MIRT1224582	hsa-miR-665	CLIP-seq
MIRT1224583	hsa-miR-766	CLIP-seq
MIRT2591312	hsa-miR-1273e	CLIP-seq
MIRT2591313	hsa-miR-146a	CLIP-seq
MIRT2591314	hsa-miR-146b-5p	CLIP-seq
MIRT2456227	hsa-miR-3675-3p	CLIP-seq
MIRT2293284	hsa-miR-3926	CLIP-seq
MIRT1224560	hsa-miR-4459	CLIP-seq
MIRT2456229	hsa-miR-4662a-5p	CLIP-seq
MIRT2456230	hsa-miR-4676-5p	CLIP-seq
MIRT2456231	hsa-miR-4684-5p	CLIP-seq
MIRT1224572	hsa-miR-4695-5p	CLIP-seq
MIRT2456232	hsa-miR-4755-3p	CLIP-seq
MIRT2065519	hsa-miR-4768-3p	CLIP-seq
MIRT2456233	hsa-miR-548c-3p	CLIP-seq
MIRT2293299	hsa-miR-548s	CLIP-seq
MIRT2456235	hsa-miR-575	CLIP-seq
MIRT1224580	hsa-miR-658	CLIP-seq
MIRT1224582	hsa-miR-665	CLIP-seq
MIRT1224583	hsa-miR-766	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
GATA2	Unknown	9028949

Show/Hide all(37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001934	Process	Positive regulation of protein phosphorylation	IMP	15985432, 26706435
GO:0002576	Process	Platelet degranulation	TAS
GO:0004888	Function	Transmembrane signaling receptor activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	9162084, 9312087, 9774457, 10704309, 10801826, 15985432, 17580308, 18672896, 25241761, 26607202, 28514442, 32814053
GO:0005615	Component	Extracellular space	IDA	9290466
GO:0005886	Component	Plasma membrane	IDA	17464107
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005911	Component	Cell-cell junction	IDA	15572031
GO:0006909	Process	Phagocytosis	IDA	12110892
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IMP	27958302
GO:0007159	Process	Leukocyte cell-cell adhesion	IMP	17580308
GO:0007165	Process	Signal transduction	TAS	7994021
GO:0007166	Process	Cell surface receptor signaling pathway	IBA	21873635
GO:0008037	Process	Cell recognition	TAS	1690453
GO:0030198	Process	Extracellular matrix organization	TAS
GO:0030335	Process	Positive regulation of cell migration	IDA	15572031
GO:0030667	Component	Secretory granule membrane	TAS
GO:0031092	Component	Platelet alpha granule membrane	TAS
GO:0032991	Component	Protein-containing complex	IDA	26607202
GO:0035633	Process	Maintenance of blood-brain barrier	NAS	30280653
GO:0035696	Process	Monocyte extravasation	IMP	11078691
GO:0042803	Function	Protein homodimerization activity	IDA	26702061, 27958302
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0045121	Component	Membrane raft	IEA
GO:0050731	Process	Positive regulation of peptidyl-tyrosine phosphorylation	IMP	26706435
GO:0050900	Process	Leukocyte migration	TAS
GO:0050904	Process	Diapedesis	IDA	19342684
GO:0061028	Process	Establishment of endothelial barrier	IMP	7589563
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0070830	Process	Bicellular tight junction assembly	IMP	26607202
GO:0072011	Process	Glomerular endothelium development	IEP	17464107
GO:0072672	Process	Neutrophil extravasation	IMP	17580308, 22266279
GO:0098609	Process	Cell-cell adhesion	IDA	15572031
GO:0098742	Process	Cell-cell adhesion via plasma-membrane adhesion molecules	IBA	21873635
GO:0098742	Process	Cell-cell adhesion via plasma-membrane adhesion molecules	IMP	17580308
GO:0150107	Process	Positive regulation of protein localization to cell-cell junction	IDA	26706435

MIM	HGNC	e!Ensembl
173445	8823	ENSG00000261371

Protein

UniProt ID

P16284

Protein name

Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31)

Protein function

Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:17580308, PubMed:19342684). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECA

PDB

2KY5 , 5C14 , 5GNI

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13895	Ig_2	327 → 404	Immunoglobulin domain	Domain
PF17736	Ig_C17orf99	409 → 496	C17orf99 Ig domain	Domain

Sequence

MQPRWAQGATMWLGVLLTLLLCSSLEGQENSFTINSVDMKSLPDWTVQNGKNLTLQCFAD
VSTTSHVKPQHQMLFYKDDVLFYNISSMKSTESYFIPEVRIYDSGTYKCTVIVNNKEKTT
AEYQVLVEGVPSPRVTLDKKEAIQGGIVRVNCSVPEEKAPIHFTIEKLELNEKMVKLKRE
KNSRDQNFVILEFPVEEQDRVLSFRCQARIISGIHMQTSESTKSELVTVTESFSTPKFHI
SPTGMIMEGAQLHIKCTIQVTHLAQEFPEIIIQKDKAIVAHNRHGNKAVYSVMAMVEHSG
NYTCKVESSRISKVSSIVVNITELFSKPELESSFTHLDQGERLNLSCSIPGAPPANFTIQ
KEDTIVSQTQDFTKIASKSDSGTYICTAGIDKVVKKSNTVQIVVCEMLSQPRISYDAQFE
VIKGQTIEVRCESISGTLPISYQLLKTSKVLENSTKNSNDPAVFKDNPTEDVEYQCVADN
CHSHAKMLSEVLRVKVIAPVDEVQISILSSKVVESGEDIVLQCAVNEGSGPITYKFYREK
EGKPFYQMTSNATQAFWTKQKASKEQEGEYYCTAFNRANHASSVPRSKILTVRVILAPWK
KGLIAVVIIGVIIALLIIAAKCYFLRKAKAKQMPVEMSRPAVPLLNSNNEKMSDPNMEAN
SHYGHNDDVRNHAMKPINDNKEPLNSDVQYTEVQVSSAESHKDLGKKDTETVYSEVRKAV
PDAVESRYSRTEGSLDGT

Sequence length

738

Interactions

View interactions

	KEGG		Reactome
	Efferocytosis Cell adhesion molecules Leukocyte transendothelial migration Malaria Fluid shear stress and atherosclerosis		Platelet degranulation Cell surface interactions at the vascular wall PECAM1 interactions Integrin cell surface interactions Platelet sensitization by LDL Neutrophil degranulation

Associated diseases

Show/Hide Causal Diseases (3)

Causal
Disease name	Disease term	dbSNP ID	References
Autism	Autistic Disorder	rs121964908, rs121912597, rs2710102, rs7794745, rs142990298, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542, rs1751123722, rs1750373491, rs1751075634	17509538
Autoimmune diseases	Autoimmune Diseases	rs41285370, rs869025224	10848805
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537	28530674, 29212778

Show/Hide Unknown Diseases (2)

Unknown
Disease name	Disease term	dbSNP ID	References
Coronary arteriosclerosis	Coronary Arteriosclerosis		28530674
Coronary heart disease	Coronary heart disease	rs9289231, rs281864746	21378988

| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412