RASD1 (ras related dexamethasone induced 1)

Gene

• Entrez ID: 51655
• Gene name: Ras related dexamethasone induced 1
• Gene symbol: RASD1
• Synonyms: AGS1, DEXRAS1, MGC:26290
• Chromosome: 17
• Chromosome location: 17p11.2
• Summary: This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004439	hsa-miR-375	Luciferase reporter assay, Microarray, qRT-PCR	20978187
MIRT018256	hsa-miR-335-5p	Microarray	18185580
MIRT492476	hsa-miR-139-3p	PAR-CLIP	20371350
MIRT492475	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT492474	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT492473	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT492471	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT492472	hsa-miR-3175	PAR-CLIP	20371350
MIRT492470	hsa-miR-3180	PAR-CLIP	20371350
MIRT492469	hsa-miR-3180-3p	PAR-CLIP	20371350
MIRT492468	hsa-miR-3196	PAR-CLIP	20371350
MIRT492467	hsa-miR-6816-5p	PAR-CLIP	20371350
MIRT492466	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT492465	hsa-miR-4488	PAR-CLIP	20371350
MIRT492464	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT492476	hsa-miR-139-3p	PAR-CLIP	20371350
MIRT492475	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT492474	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT492473	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT492471	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT492472	hsa-miR-3175	PAR-CLIP	20371350
MIRT492470	hsa-miR-3180	PAR-CLIP	20371350
MIRT492469	hsa-miR-3180-3p	PAR-CLIP	20371350
MIRT492468	hsa-miR-3196	PAR-CLIP	20371350
MIRT492467	hsa-miR-6816-5p	PAR-CLIP	20371350
MIRT492466	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT492465	hsa-miR-4488	PAR-CLIP	20371350
MIRT492464	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT492476	hsa-miR-139-3p	PAR-CLIP	23592263
MIRT492475	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT492474	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT492473	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT492471	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT492472	hsa-miR-3175	PAR-CLIP	23592263
MIRT492470	hsa-miR-3180	PAR-CLIP	23592263
MIRT492469	hsa-miR-3180-3p	PAR-CLIP	23592263
MIRT492468	hsa-miR-3196	PAR-CLIP	23592263
MIRT492467	hsa-miR-6816-5p	PAR-CLIP	23592263
MIRT492466	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT492465	hsa-miR-4488	PAR-CLIP	23592263
MIRT492464	hsa-miR-4697-5p	PAR-CLIP	23592263
MIRT492466	hsa-miR-1237-5p	PAR-CLIP	26701625
MIRT492476	hsa-miR-139-3p	PAR-CLIP	26701625
MIRT492476	hsa-miR-139-3p	PAR-CLIP	26701625
MIRT492476	hsa-miR-139-3p	PAR-CLIP	26701625
MIRT492476	hsa-miR-139-3p	PAR-CLIP	26701625
MIRT492476	hsa-miR-139-3p	PAR-CLIP	26701625
MIRT492475	hsa-miR-149-3p	PAR-CLIP	26701625
MIRT492475	hsa-miR-149-3p	PAR-CLIP	26701625
MIRT492475	hsa-miR-149-3p	PAR-CLIP	26701625
MIRT492475	hsa-miR-149-3p	PAR-CLIP	26701625
MIRT492475	hsa-miR-149-3p	PAR-CLIP	26701625
MIRT492472	hsa-miR-3175	PAR-CLIP	26701625
MIRT492472	hsa-miR-3175	PAR-CLIP	26701625
MIRT492472	hsa-miR-3175	PAR-CLIP	26701625
MIRT492472	hsa-miR-3175	PAR-CLIP	26701625
MIRT492472	hsa-miR-3175	PAR-CLIP	26701625
MIRT492469	hsa-miR-3180-3p	PAR-CLIP	26701625
MIRT492469	hsa-miR-3180-3p	PAR-CLIP	26701625
MIRT492469	hsa-miR-3180-3p	PAR-CLIP	26701625
MIRT492469	hsa-miR-3180-3p	PAR-CLIP	26701625
MIRT492469	hsa-miR-3180-3p	PAR-CLIP	26701625
MIRT492470	hsa-miR-3180	PAR-CLIP	26701625
MIRT492470	hsa-miR-3180	PAR-CLIP	26701625
MIRT492470	hsa-miR-3180	PAR-CLIP	26701625
MIRT492470	hsa-miR-3180	PAR-CLIP	26701625
MIRT492470	hsa-miR-3180	PAR-CLIP	26701625
MIRT492468	hsa-miR-3196	PAR-CLIP	26701625
MIRT492468	hsa-miR-3196	PAR-CLIP	26701625
MIRT492468	hsa-miR-3196	PAR-CLIP	26701625
MIRT492468	hsa-miR-3196	PAR-CLIP	26701625
MIRT492468	hsa-miR-3196	PAR-CLIP	26701625
MIRT492465	hsa-miR-4488	PAR-CLIP	26701625
MIRT492464	hsa-miR-4697-5p	PAR-CLIP	26701625
MIRT492474	hsa-miR-4728-5p	PAR-CLIP	26701625
MIRT492474	hsa-miR-4728-5p	PAR-CLIP	26701625
MIRT492474	hsa-miR-4728-5p	PAR-CLIP	26701625
MIRT492474	hsa-miR-4728-5p	PAR-CLIP	26701625
MIRT492474	hsa-miR-4728-5p	PAR-CLIP	26701625
MIRT492473	hsa-miR-6785-5p	PAR-CLIP	26701625
MIRT492473	hsa-miR-6785-5p	PAR-CLIP	26701625
MIRT492473	hsa-miR-6785-5p	PAR-CLIP	26701625
MIRT492473	hsa-miR-6785-5p	PAR-CLIP	26701625
MIRT492473	hsa-miR-6785-5p	PAR-CLIP	26701625
MIRT492467	hsa-miR-6816-5p	PAR-CLIP	26701625
MIRT492467	hsa-miR-6816-5p	PAR-CLIP	26701625
MIRT492467	hsa-miR-6816-5p	PAR-CLIP	26701625
MIRT492467	hsa-miR-6816-5p	PAR-CLIP	26701625
MIRT492467	hsa-miR-6816-5p	PAR-CLIP	26701625
MIRT492471	hsa-miR-6883-5p	PAR-CLIP	26701625
MIRT492471	hsa-miR-6883-5p	PAR-CLIP	26701625
MIRT492471	hsa-miR-6883-5p	PAR-CLIP	26701625
MIRT492471	hsa-miR-6883-5p	PAR-CLIP	26701625
MIRT492471	hsa-miR-6883-5p	PAR-CLIP	26701625
MIRT492476	hsa-miR-139-3p	PAR-CLIP	20371350
MIRT492475	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT492474	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT492473	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT492471	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT492472	hsa-miR-3175	PAR-CLIP	20371350
MIRT492470	hsa-miR-3180	PAR-CLIP	20371350
MIRT492469	hsa-miR-3180-3p	PAR-CLIP	20371350
MIRT492468	hsa-miR-3196	PAR-CLIP	20371350
MIRT492467	hsa-miR-6816-5p	PAR-CLIP	20371350
MIRT492466	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT492465	hsa-miR-4488	PAR-CLIP	20371350
MIRT492464	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT492476	hsa-miR-139-3p	PAR-CLIP	20371350
MIRT492475	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT492474	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT492473	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT492471	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT492472	hsa-miR-3175	PAR-CLIP	20371350
MIRT492470	hsa-miR-3180	PAR-CLIP	20371350
MIRT492469	hsa-miR-3180-3p	PAR-CLIP	20371350
MIRT492468	hsa-miR-3196	PAR-CLIP	20371350
MIRT492467	hsa-miR-6816-5p	PAR-CLIP	20371350
MIRT492466	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT492465	hsa-miR-4488	PAR-CLIP	20371350
MIRT492464	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT492476	hsa-miR-139-3p	PAR-CLIP	23592263
MIRT492475	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT492474	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT492473	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT492471	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT492472	hsa-miR-3175	PAR-CLIP	23592263
MIRT492470	hsa-miR-3180	PAR-CLIP	23592263
MIRT492469	hsa-miR-3180-3p	PAR-CLIP	23592263
MIRT492468	hsa-miR-3196	PAR-CLIP	23592263
MIRT492467	hsa-miR-6816-5p	PAR-CLIP	23592263
MIRT492466	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT492465	hsa-miR-4488	PAR-CLIP	23592263
MIRT492464	hsa-miR-4697-5p	PAR-CLIP	23592263
MIRT1292104	hsa-miR-106a	CLIP-seq
MIRT1292105	hsa-miR-106b	CLIP-seq
MIRT1292106	hsa-miR-130a	CLIP-seq
MIRT1292107	hsa-miR-130b	CLIP-seq
MIRT1292108	hsa-miR-17	CLIP-seq
MIRT1292109	hsa-miR-1908	CLIP-seq
MIRT1292110	hsa-miR-2052	CLIP-seq
MIRT1292111	hsa-miR-20a	CLIP-seq
MIRT1292112	hsa-miR-20b	CLIP-seq
MIRT1292113	hsa-miR-2113	CLIP-seq
MIRT1292114	hsa-miR-224	CLIP-seq
MIRT1292115	hsa-miR-2467-3p	CLIP-seq
MIRT1292116	hsa-miR-2467-5p	CLIP-seq
MIRT1292117	hsa-miR-301a	CLIP-seq
MIRT1292118	hsa-miR-301b	CLIP-seq
MIRT1292119	hsa-miR-30a	CLIP-seq
MIRT1292120	hsa-miR-30b	CLIP-seq
MIRT1292121	hsa-miR-30c	CLIP-seq
MIRT1292122	hsa-miR-30d	CLIP-seq
MIRT1292123	hsa-miR-30e	CLIP-seq
MIRT1292124	hsa-miR-3121-5p	CLIP-seq
MIRT1292125	hsa-miR-3122	CLIP-seq
MIRT1292126	hsa-miR-3609	CLIP-seq
MIRT1292127	hsa-miR-3614-5p	CLIP-seq
MIRT1292128	hsa-miR-3616-3p	CLIP-seq
MIRT1292129	hsa-miR-3666	CLIP-seq
MIRT1292130	hsa-miR-3689a-3p	CLIP-seq
MIRT1292131	hsa-miR-3689c	CLIP-seq
MIRT1292132	hsa-miR-3913-5p	CLIP-seq
MIRT1292133	hsa-miR-3960	CLIP-seq
MIRT1292134	hsa-miR-4283	CLIP-seq
MIRT1292135	hsa-miR-4295	CLIP-seq
MIRT1292136	hsa-miR-4326	CLIP-seq
MIRT1292137	hsa-miR-4436b-3p	CLIP-seq
MIRT1292138	hsa-miR-4495	CLIP-seq
MIRT1292139	hsa-miR-4508	CLIP-seq
MIRT1292140	hsa-miR-454	CLIP-seq
MIRT1292141	hsa-miR-4717-3p	CLIP-seq
MIRT1292142	hsa-miR-4796-3p	CLIP-seq
MIRT1292143	hsa-miR-514	CLIP-seq
MIRT1292144	hsa-miR-514b-3p	CLIP-seq
MIRT1292145	hsa-miR-519a	CLIP-seq
MIRT1292146	hsa-miR-519b-3p	CLIP-seq
MIRT1292147	hsa-miR-519c-3p	CLIP-seq
MIRT1292148	hsa-miR-519d	CLIP-seq
MIRT1292149	hsa-miR-548ah	CLIP-seq
MIRT1292150	hsa-miR-599	CLIP-seq
MIRT1292151	hsa-miR-663	CLIP-seq
MIRT1292152	hsa-miR-744	CLIP-seq
MIRT1292153	hsa-miR-93	CLIP-seq
MIRT1292104	hsa-miR-106a	CLIP-seq
MIRT1292105	hsa-miR-106b	CLIP-seq
MIRT1292106	hsa-miR-130a	CLIP-seq
MIRT1292107	hsa-miR-130b	CLIP-seq
MIRT1292108	hsa-miR-17	CLIP-seq
MIRT1292110	hsa-miR-2052	CLIP-seq
MIRT1292111	hsa-miR-20a	CLIP-seq
MIRT1292112	hsa-miR-20b	CLIP-seq
MIRT1292113	hsa-miR-2113	CLIP-seq
MIRT1292114	hsa-miR-224	CLIP-seq
MIRT1292117	hsa-miR-301a	CLIP-seq
MIRT1292118	hsa-miR-301b	CLIP-seq
MIRT1292119	hsa-miR-30a	CLIP-seq
MIRT1292120	hsa-miR-30b	CLIP-seq
MIRT1292121	hsa-miR-30c	CLIP-seq
MIRT1292122	hsa-miR-30d	CLIP-seq
MIRT1292123	hsa-miR-30e	CLIP-seq
MIRT1292124	hsa-miR-3121-5p	CLIP-seq
MIRT1292126	hsa-miR-3609	CLIP-seq
MIRT1292127	hsa-miR-3614-5p	CLIP-seq
MIRT1292129	hsa-miR-3666	CLIP-seq
MIRT1292154	hsa-miR-3944-5p	CLIP-seq
MIRT1292135	hsa-miR-4295	CLIP-seq
MIRT1292136	hsa-miR-4326	CLIP-seq
MIRT1292138	hsa-miR-4495	CLIP-seq
MIRT1292140	hsa-miR-454	CLIP-seq
MIRT1292141	hsa-miR-4717-3p	CLIP-seq
MIRT1292142	hsa-miR-4796-3p	CLIP-seq
MIRT1292143	hsa-miR-514	CLIP-seq
MIRT1292144	hsa-miR-514b-3p	CLIP-seq
MIRT1292145	hsa-miR-519a	CLIP-seq
MIRT1292146	hsa-miR-519b-3p	CLIP-seq
MIRT1292147	hsa-miR-519c-3p	CLIP-seq
MIRT1292148	hsa-miR-519d	CLIP-seq
MIRT1292149	hsa-miR-548ah	CLIP-seq
MIRT1292150	hsa-miR-599	CLIP-seq
MIRT1292153	hsa-miR-93	CLIP-seq
MIRT1292113	hsa-miR-2113	CLIP-seq
MIRT1292150	hsa-miR-599	CLIP-seq
MIRT1292110	hsa-miR-2052	CLIP-seq
MIRT1292113	hsa-miR-2113	CLIP-seq
MIRT1292124	hsa-miR-3121-5p	CLIP-seq
MIRT1292154	hsa-miR-3944-5p	CLIP-seq
MIRT1292136	hsa-miR-4326	CLIP-seq
MIRT1292150	hsa-miR-599	CLIP-seq
MIRT1292104	hsa-miR-106a	CLIP-seq
MIRT1292105	hsa-miR-106b	CLIP-seq
MIRT1292106	hsa-miR-130a	CLIP-seq
MIRT1292107	hsa-miR-130b	CLIP-seq
MIRT1292108	hsa-miR-17	CLIP-seq
MIRT1292110	hsa-miR-2052	CLIP-seq
MIRT1292111	hsa-miR-20a	CLIP-seq
MIRT1292112	hsa-miR-20b	CLIP-seq
MIRT1292117	hsa-miR-301a	CLIP-seq
MIRT1292118	hsa-miR-301b	CLIP-seq
MIRT2439844	hsa-miR-3120-3p	CLIP-seq
MIRT1292126	hsa-miR-3609	CLIP-seq
MIRT2439845	hsa-miR-365	CLIP-seq
MIRT1292129	hsa-miR-3666	CLIP-seq
MIRT1292135	hsa-miR-4295	CLIP-seq
MIRT1292140	hsa-miR-454	CLIP-seq
MIRT2439846	hsa-miR-4725-5p	CLIP-seq
MIRT1292142	hsa-miR-4796-3p	CLIP-seq
MIRT2439847	hsa-miR-504	CLIP-seq
MIRT1292145	hsa-miR-519a	CLIP-seq
MIRT1292146	hsa-miR-519b-3p	CLIP-seq
MIRT1292147	hsa-miR-519c-3p	CLIP-seq
MIRT1292148	hsa-miR-519d	CLIP-seq
MIRT1292149	hsa-miR-548ah	CLIP-seq
MIRT1292153	hsa-miR-93	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003924	Function	GTPase activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 32814053
GO:0005525	Function	GTP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0007165	Process	Signal transduction	TAS	10471929, 10673050
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	10840027
GO:0007263	Process	Nitric oxide mediated signal transduction	IEA
GO:0016529	Component	Sarcoplasmic reticulum	IEA
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA

Other IDs

• MIM: 605550
• HGNC: 15828
• e!Ensembl: ENSG00000108551

Protein

• UniProt ID: Q9Y272
• Protein name: Dexamethasone-induced Ras-related protein 1 (Activator of G-protein signaling 1)
• Protein function: Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00071	Ras	26 → 196	Ras family	Domain

• Sequence:

  MKLAAMIKKMCPSDSELSIPAKNCYRMVILGSSKVGKTAIVSRFLTGRFEDAYTPTIEDF
  HRKFYSIRGEVYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRDSFEEVQRLRQQ
  ILDTKSCLKNKTKENVDVPLVICGNKGDRDFYREVDQREIEQLVGDDPQRCAYFEISAKK
  NSSLDQMFRALFAMAKLPSEMSPDLHRKVSVQYCDVLHKKALRNKKLLRAGSGGGGGDPG
  DAFGIVAPFARRPSVHSDLMYIREKASAGSQAKDKERCVIS

• Sequence length: 281

Pathways

KEGG:

Circadian entrainment
Cushing syndrome

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		17013881