ERGIC3 (ERGIC and golgi 3)

Gene

• Entrez ID: 51614
• Gene name: ERGIC and golgi 3
• Gene symbol: ERGIC3
• Synonyms: C20orf47, C2orf47, CGI-54, Erv46, NY-BR-84, PRO0989, SDBCAG84, dJ477O4.2
• Chromosome: 20
• Chromosome location: 20q11.22

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT007115	hsa-miR-490-3p	GFP reporter assay	23212913
MIRT007115	hsa-miR-490-3p	GFP reporter assay	23212913
MIRT032333	hsa-let-7b-5p	Proteomics	18668040
MIRT968941	hsa-miR-1275	CLIP-seq
MIRT968942	hsa-miR-140-3p	CLIP-seq
MIRT968943	hsa-miR-151-5p	CLIP-seq
MIRT968944	hsa-miR-151b	CLIP-seq
MIRT968945	hsa-miR-1972	CLIP-seq
MIRT968946	hsa-miR-2467-3p	CLIP-seq
MIRT968947	hsa-miR-3689d	CLIP-seq
MIRT968948	hsa-miR-4270	CLIP-seq
MIRT968949	hsa-miR-4441	CLIP-seq
MIRT968950	hsa-miR-4505	CLIP-seq
MIRT968951	hsa-miR-4525	CLIP-seq
MIRT968952	hsa-miR-4656	CLIP-seq
MIRT968953	hsa-miR-4665-5p	CLIP-seq
MIRT968954	hsa-miR-4723-5p	CLIP-seq
MIRT968955	hsa-miR-4731-5p	CLIP-seq
MIRT968956	hsa-miR-485-5p	CLIP-seq
MIRT968957	hsa-miR-625	CLIP-seq
MIRT968958	hsa-miR-637	CLIP-seq
MIRT968941	hsa-miR-1275	CLIP-seq
MIRT968942	hsa-miR-140-3p	CLIP-seq
MIRT968943	hsa-miR-151-5p	CLIP-seq
MIRT968944	hsa-miR-151b	CLIP-seq
MIRT968945	hsa-miR-1972	CLIP-seq
MIRT968946	hsa-miR-2467-3p	CLIP-seq
MIRT968959	hsa-miR-3125	CLIP-seq
MIRT968960	hsa-miR-3150b-3p	CLIP-seq
MIRT968947	hsa-miR-3689d	CLIP-seq
MIRT968961	hsa-miR-3916	CLIP-seq
MIRT968948	hsa-miR-4270	CLIP-seq
MIRT968962	hsa-miR-4283	CLIP-seq
MIRT968949	hsa-miR-4441	CLIP-seq
MIRT968963	hsa-miR-4489	CLIP-seq
MIRT968964	hsa-miR-4492	CLIP-seq
MIRT968965	hsa-miR-4498	CLIP-seq
MIRT968950	hsa-miR-4505	CLIP-seq
MIRT968951	hsa-miR-4525	CLIP-seq
MIRT968952	hsa-miR-4656	CLIP-seq
MIRT968953	hsa-miR-4665-5p	CLIP-seq
MIRT968966	hsa-miR-4705	CLIP-seq
MIRT968967	hsa-miR-4714-3p	CLIP-seq
MIRT968954	hsa-miR-4723-5p	CLIP-seq
MIRT968955	hsa-miR-4731-5p	CLIP-seq
MIRT968968	hsa-miR-4784	CLIP-seq
MIRT968956	hsa-miR-485-5p	CLIP-seq
MIRT968969	hsa-miR-583	CLIP-seq
MIRT968957	hsa-miR-625	CLIP-seq
MIRT968958	hsa-miR-637	CLIP-seq
MIRT968970	hsa-miR-762	CLIP-seq
MIRT968948	hsa-miR-4270	CLIP-seq
MIRT968949	hsa-miR-4441	CLIP-seq
MIRT968969	hsa-miR-583	CLIP-seq
MIRT968962	hsa-miR-4283	CLIP-seq
MIRT968963	hsa-miR-4489	CLIP-seq
MIRT968964	hsa-miR-4492	CLIP-seq
MIRT968965	hsa-miR-4498	CLIP-seq
MIRT968950	hsa-miR-4505	CLIP-seq
MIRT968967	hsa-miR-4714-3p	CLIP-seq
MIRT968955	hsa-miR-4731-5p	CLIP-seq
MIRT968970	hsa-miR-762	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005783	Component	Endoplasmic reticulum	IBA	21873635
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IBA	21873635
GO:0006890	Process	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA	21873635
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA	21873635
GO:0030134	Component	COPII-coated ER to Golgi transport vesicle	IBA	21873635
GO:0030173	Component	Integral component of Golgi membrane	IBA	21873635
GO:0030176	Component	Integral component of endoplasmic reticulum membrane	IBA	21873635
GO:0033116	Component	Endoplasmic reticulum-Golgi intermediate compartment membrane	IEA

Other IDs

• MIM: 616971
• HGNC: 15927
• e!Ensembl: ENSG00000125991

Protein

• UniProt ID: Q9Y282
• Protein name: Endoplasmic reticulum-Golgi intermediate compartment protein 3 (Serologically defined breast cancer antigen NY-BR-84)
• Protein function: Possible role in transport between endoplasmic reticulum and Golgi. Positively regulates trafficking of the secretory proteins SERPINA1/alpha1-antitrypsin and HP/haptoglobin (PubMed:31142615).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13850	ERGIC_N	7 → 97	Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)	Domain
  PF07970	COPIIcoated_ERV	145 → 363	Endoplasmic reticulum vesicle transporter	Family

• Sequence:

  MEALGKLKQFDAYPKTLEDFRVKTCGGATVTIVSGLLMLLLFLSELQYYLTTEVHPELYV
  DKSRGDKLKINIDVLFPHMPCAYLSIDAMDVAGEQQLDVEHNLFKQRLDKDGIPVSSEAE
  RHELGKVEVTVFDPDSLDPDRCESCYGAEAEDIKCCNTCEDVREAYRRRGWAFKNPDTIE
  QCRREGFSQKMQEQKNEGCQVYGFLEVNKVAGNFHFAPGKSFQQSHVHVHDLQSFGLDNI
  NMTHYIQHLSFGEDYPGIVNPLDHTNVTAPQASMMFQYFVKVVPTVYMKVDGEVLRTNQF
  SVTRHEKVANGLLGDQGLPGVFVLYELSPMMVKLTEKHRSFTHFLTGVCAIIGGMFTVAG
  LIDSLIYHSARAIQKKIDLGKTT

• Sequence length: 383

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs1801155, rs121908380, rs121908702, rs267606674, rs4939827, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800, rs63750198, rs63751109, rs863223312, rs63750710, rs63751615, rs63750206, rs63750781, rs63750899, rs63750691, rs63750217, rs121912965, rs63749939, rs63751194, rs63750693, rs63750540, rs63751221, rs193922370, rs80359596, rs397514632, rs483352909, rs200495564, rs397514684, rs397516436, rs398122386, rs79512956, rs74953290, rs587779001, rs63750677, rs63749837, rs267607816, rs63751715, rs267607819, rs267607815, rs267607822, rs63749906, rs587778883, rs63750472, rs63751012, rs63750715, rs63750580, rs267607706, rs267607709, rs267607710, rs587778894, rs63750749, rs63750483, rs63751015, rs63751153, rs63751094, rs63751118, rs63750316, rs63749981, rs587778906, rs267607821, rs587778908, rs63750020, rs587778909, rs63750713, rs267607825, rs63751592, rs281864936, rs587778913, rs587778914, rs63749795, rs63750855, rs63749916, rs63749923, rs63751472, rs63751689, rs267607832, rs267607837, rs267607836, rs587778923, rs63750028, rs587778928, rs587778929, rs587778930, rs63751277, rs587778933, rs267607842, rs267607843, rs63750192, rs587778934, rs63750193, rs587778937, rs587778938, rs267607845, rs63751244, rs63751393, rs63751460, rs267607849, rs267607853, rs267607856, rs267607850, rs63751657, rs267607854, rs267607852, rs587778942, rs63750309, rs63750587, rs63749863, rs63751486, rs63750016, rs63749868, rs63750375, rs63750035, rs63750604, rs63750386, rs63750150, rs63750486, rs63751428, rs267607866, rs63749986, rs63751594, rs63750152, rs63750850, rs267607867, rs267607868, rs63751632, rs267607871, rs63751892, rs587778956, rs63750469, rs587778958, rs63749792, rs267607875, rs63751255, rs281864938, rs63751202, rs63750726, rs63751310, rs63749900, rs587778964, rs267607879, rs267607878, rs587778966, rs267607883, rs267607887, rs63750061, rs63750663, rs587778968, rs587778971, rs63750809, rs63749867, rs63750864, rs587778972, rs63751275, rs267607718, rs267607722, rs63750769, rs267607717, rs587778973, rs267607716, rs267607720, rs63749995, rs63750859, rs587778975, rs63750114, rs587778976, rs63750603, rs267607889, rs267607723, rs63750561, rs63750499, rs63751642, rs63751022, rs587778981, rs63750971, rs267607898, rs267607906, rs267607903, rs587778989, rs587778992, rs267607894, rs267607901, rs267607892, rs63750437, rs587778997, rs587778998, rs63750005, rs63750641, rs63751421, rs11541859, rs63750266, rs111052004, rs267607726, rs267607727, rs63750453, rs267607734, rs267607735, rs63751665, rs267607736, rs267607732, rs63749816, rs63750539, rs267607739, rs587779006, rs587779008, rs267607745, rs267607742, rs63751595, rs267607743, rs587779010, rs587779012, rs63750057, rs63749818, rs63751124, rs587779014, rs587779015, rs63749820, rs63751302, rs267607750, rs267607751, rs267607749, rs63750891, rs63749959, rs63749804, rs267607765, rs267607760, rs587779021, rs267607759, rs63750515, rs587779023, rs63751021, rs63751480, rs267607772, rs267607773, rs587779024, rs63751653, rs587779027, rs267607767, rs587779029, rs63750706, rs63750385, rs267607774, rs267607778, rs267607780, rs587779034, rs63751711, rs267607784, rs587779035, rs63750823, rs63750822, rs267607787, rs63750303, rs63749839, rs63749827, rs267607789, rs267607790, rs267607791, rs267607786, rs267607771, rs267607795, rs267607794, rs267607788, rs267607799, rs267607801, rs587779045, rs63750034, rs587779047, rs63750216, rs63751707, rs63751598, rs267607803, rs267607777, rs63750144, rs267607805, rs63750547, rs63750489, rs63750993, rs587779054, rs63751259, rs63749926, rs63750796, rs587779058, rs63750745, rs63750582, rs180177084, rs587779866, rs200389141, rs587779950, rs587780104, rs587780183, rs587778536, rs587780683, rs587781554, rs267607712, rs587777627, rs587783057, rs730881734, rs41542214, rs730881273, rs786203456, rs786201990, rs786202767, rs748005072, rs786204317, rs786204318, rs797045117, rs63750549, rs863225383, rs863225384, rs863225373, rs863225376, rs863225377, rs863225378, rs863225379, rs863225380, rs863225381, rs63750059, rs267607823, rs864622457, rs869312767, rs869312753, rs876661059, rs876658915, rs876658923, rs876660860, rs876660822, rs876660458, rs876660214, rs876658657, rs876658247, rs876659226, rs876658821, rs876660589, rs876659068, rs876659681, rs876659608, rs878853794, rs878853778, rs878853780, rs878853785, rs886039423, rs886039424, rs1057517543, rs1057517541, rs756843954, rs1057517617, rs1057517558, rs1057519256, rs1060500689, rs764085979, rs1060500707, rs1060500699, rs1060500706, rs1060500703, rs1064795341, rs1064793607, rs1064794348, rs1064795441, rs1064794373, rs1064793172, rs1064794122, rs1064795515, rs1064794331, rs63750978, rs1114167435, rs1553641362, rs63751448, rs1553648029, rs1553648058, rs587778903, rs1553653237, rs1553664353, rs267607744, rs1553647995, rs1553648047, rs1553653084, rs1553663750, rs1553664436, rs1553488015, rs1553637293, rs63750310, rs63750443, rs63751596, rs1553646681, rs550890395, rs1064796057, rs1553642079, rs1553648023, rs587782087, rs746536721, rs1553653037, rs1248251121, rs1553646602, rs1434898623, rs1553665683, rs1553648068, rs1553645331, rs1553644123, rs1553658246, rs1553651299, rs1553648149, rs1553663159, rs1302248679, rs1553664119, rs1553658009, rs1553665977, rs1416171624, rs1553663834, rs1553664617, rs1553664702, rs1553647969, rs1553648040, rs1437454428, rs1553641273, rs63751101, rs1553646764, rs1553648225, rs1554082118, rs1553648201, rs1553149467, rs1553638868, rs1553665866, rs376736188, rs1553642707, rs1553645226, rs1553652883, rs63751435, rs1553653115, rs1553653195, rs63750300, rs1553662622, rs1553658104, rs1553648220, rs1559544064, rs63750584, rs267608083, rs1559551570, rs1559575107, rs1559553501, rs1565986506, rs1559524405, rs1559553492, rs1559554339, rs1559588540, rs1559558071, rs761329565, rs1559521039, rs1559574795, rs1567221417, rs1559578422, rs1481129490, rs1570714352, rs779783209, rs1575376830, rs1575469070, rs1575537843, rs1575620443, rs1575621506, rs587779022, rs1575414904, rs1575449093, rs1575469505, rs1575536254, rs1575537933, rs1575632112, rs1575639851, rs1575441094, rs1575449402, rs267607831, rs2081922847, rs2083403132, rs2085415927, rs2085469647, rs2043913790, rs147542208
Lung carcinoma	Non-Small Cell Lung Carcinoma	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193	27588471
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	27588471

Unknown
Disease name	Disease term	dbSNP ID	References
Lung neoplasms	Lung Neoplasms		27588471