MED15 (mediator complex subunit 15)

Gene

• Entrez ID: 51586
• Gene name: Mediator complex subunit 15
• Gene symbol: MED15
• Synonyms: ARC105, CAG7A, CTG7A, PCQAP, TIG-1, TIG1, TNRC7
• Chromosome: 22
• Chromosome location: 22q11.21
• Summary: The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT047371	hsa-miR-34a-5p	CLASH	23622248
MIRT045202	hsa-miR-186-5p	CLASH	23622248
MIRT042961	hsa-miR-324-3p	CLASH	23622248
MIRT042132	hsa-miR-484	CLASH	23622248
MIRT037735	hsa-miR-744-5p	CLASH	23622248
MIRT1141025	hsa-miR-1207-5p	CLIP-seq
MIRT1141026	hsa-miR-1271	CLIP-seq
MIRT1141027	hsa-miR-128	CLIP-seq
MIRT1141028	hsa-miR-182	CLIP-seq
MIRT1141029	hsa-miR-205	CLIP-seq
MIRT1141030	hsa-miR-27a	CLIP-seq
MIRT1141031	hsa-miR-27b	CLIP-seq
MIRT1141032	hsa-miR-298	CLIP-seq
MIRT1141033	hsa-miR-3144-5p	CLIP-seq
MIRT1141034	hsa-miR-3191	CLIP-seq
MIRT1141035	hsa-miR-3660	CLIP-seq
MIRT1141036	hsa-miR-3686	CLIP-seq
MIRT1141037	hsa-miR-3714	CLIP-seq
MIRT1141038	hsa-miR-4277	CLIP-seq
MIRT1141039	hsa-miR-4459	CLIP-seq
MIRT1141040	hsa-miR-4462	CLIP-seq
MIRT1141041	hsa-miR-4512	CLIP-seq
MIRT1141042	hsa-miR-4526	CLIP-seq
MIRT1141043	hsa-miR-4652-5p	CLIP-seq
MIRT1141044	hsa-miR-4695-5p	CLIP-seq
MIRT1141045	hsa-miR-4733-5p	CLIP-seq
MIRT1141046	hsa-miR-4736	CLIP-seq
MIRT1141047	hsa-miR-4763-3p	CLIP-seq
MIRT1141048	hsa-miR-4793-5p	CLIP-seq
MIRT1141049	hsa-miR-491-5p	CLIP-seq
MIRT1141050	hsa-miR-513a-5p	CLIP-seq
MIRT1141051	hsa-miR-552	CLIP-seq
MIRT1141052	hsa-miR-96	CLIP-seq
MIRT1141053	hsa-miR-1185	CLIP-seq
MIRT1141054	hsa-miR-1343	CLIP-seq
MIRT1141055	hsa-miR-149	CLIP-seq
MIRT1141056	hsa-miR-1972	CLIP-seq
MIRT1141057	hsa-miR-224	CLIP-seq
MIRT1141058	hsa-miR-2278	CLIP-seq
MIRT1141059	hsa-miR-3064-5p	CLIP-seq
MIRT1141060	hsa-miR-3126-3p	CLIP-seq
MIRT1141061	hsa-miR-3189-3p	CLIP-seq
MIRT1141062	hsa-miR-3192	CLIP-seq
MIRT1141063	hsa-miR-328	CLIP-seq
MIRT1141064	hsa-miR-3605-5p	CLIP-seq
MIRT1141065	hsa-miR-3657	CLIP-seq
MIRT1141035	hsa-miR-3660	CLIP-seq
MIRT1141066	hsa-miR-3679-5p	CLIP-seq
MIRT1141067	hsa-miR-3689a-3p	CLIP-seq
MIRT1141068	hsa-miR-3689c	CLIP-seq
MIRT1141069	hsa-miR-4293	CLIP-seq
MIRT1141039	hsa-miR-4459	CLIP-seq
MIRT1141041	hsa-miR-4512	CLIP-seq
MIRT1141070	hsa-miR-4520a-3p	CLIP-seq
MIRT1141042	hsa-miR-4526	CLIP-seq
MIRT1141071	hsa-miR-4669	CLIP-seq
MIRT1141044	hsa-miR-4695-5p	CLIP-seq
MIRT1141072	hsa-miR-4717-3p	CLIP-seq
MIRT1141073	hsa-miR-4717-5p	CLIP-seq
MIRT1141074	hsa-miR-4728-5p	CLIP-seq
MIRT1141075	hsa-miR-4794	CLIP-seq
MIRT1141076	hsa-miR-4802-3p	CLIP-seq
MIRT1141077	hsa-miR-4802-5p	CLIP-seq
MIRT1141078	hsa-miR-544b	CLIP-seq
MIRT1141035	hsa-miR-3660	CLIP-seq
MIRT1141039	hsa-miR-4459	CLIP-seq
MIRT1141042	hsa-miR-4526	CLIP-seq
MIRT1141044	hsa-miR-4695-5p	CLIP-seq
MIRT2040003	hsa-miR-342-5p	CLIP-seq
MIRT2040004	hsa-miR-4664-5p	CLIP-seq
MIRT1141037	hsa-miR-3714	CLIP-seq
MIRT2568935	hsa-miR-1207-3p	CLIP-seq
MIRT2568936	hsa-miR-1250	CLIP-seq
MIRT2568937	hsa-miR-138	CLIP-seq
MIRT2568938	hsa-miR-15a	CLIP-seq
MIRT2568939	hsa-miR-15b	CLIP-seq
MIRT2568940	hsa-miR-16	CLIP-seq
MIRT2568941	hsa-miR-1908	CLIP-seq
MIRT2568942	hsa-miR-195	CLIP-seq
MIRT2568943	hsa-miR-214	CLIP-seq
MIRT2568944	hsa-miR-3065-3p	CLIP-seq
MIRT2568945	hsa-miR-3189-5p	CLIP-seq
MIRT2568946	hsa-miR-3194-5p	CLIP-seq
MIRT2568947	hsa-miR-3616-3p	CLIP-seq
MIRT2568948	hsa-miR-3619-5p	CLIP-seq
MIRT2568949	hsa-miR-3907	CLIP-seq
MIRT2568950	hsa-miR-424	CLIP-seq
MIRT2568951	hsa-miR-4290	CLIP-seq
MIRT2568952	hsa-miR-4291	CLIP-seq
MIRT2568953	hsa-miR-4292	CLIP-seq
MIRT2568954	hsa-miR-4308	CLIP-seq
MIRT2568955	hsa-miR-4446-3p	CLIP-seq
MIRT2568956	hsa-miR-4456	CLIP-seq
MIRT2568957	hsa-miR-4469	CLIP-seq
MIRT2568958	hsa-miR-4530	CLIP-seq
MIRT2568959	hsa-miR-4640-5p	CLIP-seq
MIRT2568960	hsa-miR-4649-3p	CLIP-seq
MIRT2568961	hsa-miR-4656	CLIP-seq
MIRT2568962	hsa-miR-4687-5p	CLIP-seq
MIRT2568963	hsa-miR-4706	CLIP-seq
MIRT2568964	hsa-miR-4721	CLIP-seq
MIRT2568965	hsa-miR-4726-5p	CLIP-seq
MIRT2568966	hsa-miR-4749-5p	CLIP-seq
MIRT2568967	hsa-miR-4758-3p	CLIP-seq
MIRT2568968	hsa-miR-497	CLIP-seq
MIRT2568969	hsa-miR-663	CLIP-seq
MIRT2568970	hsa-miR-761	CLIP-seq
MIRT2568971	hsa-miR-922	CLIP-seq
MIRT2568972	hsa-miR-939	CLIP-seq
MIRT2568935	hsa-miR-1207-3p	CLIP-seq
MIRT2568936	hsa-miR-1250	CLIP-seq
MIRT2568937	hsa-miR-138	CLIP-seq
MIRT2568938	hsa-miR-15a	CLIP-seq
MIRT2568939	hsa-miR-15b	CLIP-seq
MIRT2568940	hsa-miR-16	CLIP-seq
MIRT2568941	hsa-miR-1908	CLIP-seq
MIRT2568942	hsa-miR-195	CLIP-seq
MIRT2568943	hsa-miR-214	CLIP-seq
MIRT2568944	hsa-miR-3065-3p	CLIP-seq
MIRT2568945	hsa-miR-3189-5p	CLIP-seq
MIRT2568946	hsa-miR-3194-5p	CLIP-seq
MIRT2568947	hsa-miR-3616-3p	CLIP-seq
MIRT2568948	hsa-miR-3619-5p	CLIP-seq
MIRT2568949	hsa-miR-3907	CLIP-seq
MIRT2568950	hsa-miR-424	CLIP-seq
MIRT2568952	hsa-miR-4291	CLIP-seq
MIRT2568953	hsa-miR-4292	CLIP-seq
MIRT2568954	hsa-miR-4308	CLIP-seq
MIRT2568955	hsa-miR-4446-3p	CLIP-seq
MIRT2568956	hsa-miR-4456	CLIP-seq
MIRT2568958	hsa-miR-4530	CLIP-seq
MIRT2568959	hsa-miR-4640-5p	CLIP-seq
MIRT2568960	hsa-miR-4649-3p	CLIP-seq
MIRT2568961	hsa-miR-4656	CLIP-seq
MIRT2568963	hsa-miR-4706	CLIP-seq
MIRT2568964	hsa-miR-4721	CLIP-seq
MIRT2568965	hsa-miR-4726-5p	CLIP-seq
MIRT2568966	hsa-miR-4749-5p	CLIP-seq
MIRT2568967	hsa-miR-4758-3p	CLIP-seq
MIRT2568968	hsa-miR-497	CLIP-seq
MIRT2568969	hsa-miR-663	CLIP-seq
MIRT2568970	hsa-miR-761	CLIP-seq
MIRT2568971	hsa-miR-922	CLIP-seq
MIRT2568972	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003712	Function	Transcription coregulator activity	IEA
GO:0005515	Function	Protein binding	IPI	16799563, 16904669, 17500595, 18385733, 18568018, 24882805
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0006367	Process	Transcription initiation from RNA polymerase II promoter	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016592	Component	Mediator complex	IEA

Other IDs

• MIM: 607372
• HGNC: 14248
• e!Ensembl: ENSG00000099917

Protein

• UniProt ID: Q96RN5
• Protein name: Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a) (Mediator complex subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associat
• Protein function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RN
• PDB: 2GUT, 7EMF, 7ENA, 7ENC, 7ENJ, 7LBM, 8GXQ, 8GXS, 8J9A, 8T9D, 8TQW, 8TRH
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09606	Med15	17 → 787	ARC105 or Med15 subunit of Mediator complex non-fungal	Family

• Sequence:

  MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVA
  RLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMG
  QPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQ
  QQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQR
  IAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQ
  PPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQ
  PQVQQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAIPSSSIPLGRQ
  PMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSF
  LPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLS
  KYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMA
  VPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVC
  TRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPP
  LELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSV
  HQACLSAA

• Sequence length: 788

Pathways

Reactome:

PPARA activates gene expression
Generic Transcription Pathway
Transcriptional regulation of white adipocyte differentiation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	12497610, 15318033

Unknown
Disease name	Disease term	dbSNP ID	References
Schizoaffective disorder	Schizoaffective Disorder		12497610