DTL (denticleless E3 ubiquitin protein ligase adapter)

Gene

• Entrez ID: 51514
• Gene name: Denticleless E3 ubiquitin protein ligase adapter
• Gene symbol: DTL
• Synonyms: CDT2, DCAF2, L2DTL, RAMP
• Chromosome: 1
• Chromosome location: 1q32.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004848	hsa-miR-192-5p	Luciferase reporter assay, qRT-PCR	19074876
MIRT006563	hsa-miR-30a-5p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	22287560
MIRT006563	hsa-miR-30a-5p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	22287560
MIRT006563	hsa-miR-30a-5p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	22287560
MIRT006563	hsa-miR-30a-5p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	22287560
MIRT024273	hsa-miR-215-5p	Microarray	19074876
MIRT004848	hsa-miR-192-5p	Reporter assay;Microarray;Other	19074876
MIRT030300	hsa-miR-26b-5p	Microarray	19088304
MIRT030601	hsa-miR-24-3p	Microarray	19748357
MIRT049694	hsa-miR-92a-3p	CLASH	23622248
MIRT755968	hsa-miR-96-5p	Luciferase reporter assay, Western blotting, qRT-PCR	38133379
MIRT946588	hsa-miR-1179	CLIP-seq
MIRT946589	hsa-miR-1207-5p	CLIP-seq
MIRT946590	hsa-miR-1266	CLIP-seq
MIRT946591	hsa-miR-1284	CLIP-seq
MIRT946592	hsa-miR-137	CLIP-seq
MIRT946593	hsa-miR-141	CLIP-seq
MIRT946594	hsa-miR-193a-3p	CLIP-seq
MIRT946595	hsa-miR-193b	CLIP-seq
MIRT946596	hsa-miR-200a	CLIP-seq
MIRT946597	hsa-miR-217	CLIP-seq
MIRT946598	hsa-miR-23a	CLIP-seq
MIRT946599	hsa-miR-23b	CLIP-seq
MIRT946600	hsa-miR-23c	CLIP-seq
MIRT946601	hsa-miR-24	CLIP-seq
MIRT946602	hsa-miR-2682	CLIP-seq
MIRT946603	hsa-miR-3124-3p	CLIP-seq
MIRT946604	hsa-miR-3127-5p	CLIP-seq
MIRT946605	hsa-miR-3140-3p	CLIP-seq
MIRT946606	hsa-miR-3200-5p	CLIP-seq
MIRT946607	hsa-miR-323-3p	CLIP-seq
MIRT946608	hsa-miR-331-5p	CLIP-seq
MIRT946609	hsa-miR-34c-3p	CLIP-seq
MIRT946610	hsa-miR-3545-3p	CLIP-seq
MIRT946611	hsa-miR-3658	CLIP-seq
MIRT946612	hsa-miR-3660	CLIP-seq
MIRT946613	hsa-miR-3685	CLIP-seq
MIRT946614	hsa-miR-3691-3p	CLIP-seq
MIRT946615	hsa-miR-376c	CLIP-seq
MIRT946616	hsa-miR-380	CLIP-seq
MIRT946617	hsa-miR-384	CLIP-seq
MIRT946618	hsa-miR-3918	CLIP-seq
MIRT946619	hsa-miR-3936	CLIP-seq
MIRT946620	hsa-miR-3941	CLIP-seq
MIRT946621	hsa-miR-3973	CLIP-seq
MIRT946622	hsa-miR-411	CLIP-seq
MIRT946623	hsa-miR-4284	CLIP-seq
MIRT946624	hsa-miR-4303	CLIP-seq
MIRT946625	hsa-miR-4307	CLIP-seq
MIRT946626	hsa-miR-4310	CLIP-seq
MIRT946627	hsa-miR-4420	CLIP-seq
MIRT946628	hsa-miR-4423-3p	CLIP-seq
MIRT946629	hsa-miR-4477a	CLIP-seq
MIRT946630	hsa-miR-448	CLIP-seq
MIRT946631	hsa-miR-4495	CLIP-seq
MIRT946632	hsa-miR-449c	CLIP-seq
MIRT946633	hsa-miR-4502	CLIP-seq
MIRT946634	hsa-miR-450b-5p	CLIP-seq
MIRT946635	hsa-miR-4514	CLIP-seq
MIRT946636	hsa-miR-4518	CLIP-seq
MIRT946637	hsa-miR-4526	CLIP-seq
MIRT946638	hsa-miR-4539	CLIP-seq
MIRT946639	hsa-miR-4639-3p	CLIP-seq
MIRT946640	hsa-miR-4643	CLIP-seq
MIRT946641	hsa-miR-4652-3p	CLIP-seq
MIRT946642	hsa-miR-466	CLIP-seq
MIRT946643	hsa-miR-4661-5p	CLIP-seq
MIRT946644	hsa-miR-4662a-3p	CLIP-seq
MIRT946645	hsa-miR-4668-3p	CLIP-seq
MIRT946646	hsa-miR-4672	CLIP-seq
MIRT946647	hsa-miR-4692	CLIP-seq
MIRT946648	hsa-miR-4724-5p	CLIP-seq
MIRT946649	hsa-miR-4728-5p	CLIP-seq
MIRT946650	hsa-miR-4729	CLIP-seq
MIRT946651	hsa-miR-4742-3p	CLIP-seq
MIRT946652	hsa-miR-4763-3p	CLIP-seq
MIRT946653	hsa-miR-4778-5p	CLIP-seq
MIRT946654	hsa-miR-4789-3p	CLIP-seq
MIRT946655	hsa-miR-4789-5p	CLIP-seq
MIRT946656	hsa-miR-4793-5p	CLIP-seq
MIRT946657	hsa-miR-4795-3p	CLIP-seq
MIRT946658	hsa-miR-4796-5p	CLIP-seq
MIRT946659	hsa-miR-4802-3p	CLIP-seq
MIRT946660	hsa-miR-507	CLIP-seq
MIRT946661	hsa-miR-520d-5p	CLIP-seq
MIRT946662	hsa-miR-520g	CLIP-seq
MIRT946663	hsa-miR-520h	CLIP-seq
MIRT946664	hsa-miR-524-5p	CLIP-seq
MIRT946665	hsa-miR-548ag	CLIP-seq
MIRT946666	hsa-miR-548ai	CLIP-seq
MIRT946667	hsa-miR-548k	CLIP-seq
MIRT946668	hsa-miR-548l	CLIP-seq
MIRT946669	hsa-miR-548n	CLIP-seq
MIRT946670	hsa-miR-548t	CLIP-seq
MIRT946671	hsa-miR-557	CLIP-seq
MIRT946672	hsa-miR-577	CLIP-seq
MIRT946673	hsa-miR-584	CLIP-seq
MIRT946674	hsa-miR-587	CLIP-seq
MIRT946675	hsa-miR-622	CLIP-seq
MIRT946676	hsa-miR-653	CLIP-seq
MIRT946677	hsa-miR-660	CLIP-seq
MIRT946678	hsa-miR-892b	CLIP-seq
MIRT946679	hsa-miR-935	CLIP-seq
MIRT946680	hsa-miR-940	CLIP-seq
MIRT946622	hsa-miR-411	CLIP-seq
MIRT946657	hsa-miR-4795-3p	CLIP-seq
MIRT946676	hsa-miR-653	CLIP-seq
MIRT1980379	hsa-miR-936	CLIP-seq
MIRT946680	hsa-miR-940	CLIP-seq
MIRT946591	hsa-miR-1284	CLIP-seq
MIRT2215399	hsa-miR-1912	CLIP-seq
MIRT946594	hsa-miR-193a-3p	CLIP-seq
MIRT946595	hsa-miR-193b	CLIP-seq
MIRT946603	hsa-miR-3124-3p	CLIP-seq
MIRT2215400	hsa-miR-3130-5p	CLIP-seq
MIRT2215401	hsa-miR-3144-3p	CLIP-seq
MIRT946607	hsa-miR-323-3p	CLIP-seq
MIRT946608	hsa-miR-331-5p	CLIP-seq
MIRT2215402	hsa-miR-3646	CLIP-seq
MIRT946614	hsa-miR-3691-3p	CLIP-seq
MIRT946616	hsa-miR-380	CLIP-seq
MIRT946622	hsa-miR-411	CLIP-seq
MIRT946629	hsa-miR-4477a	CLIP-seq
MIRT946630	hsa-miR-448	CLIP-seq
MIRT2215403	hsa-miR-4482	CLIP-seq
MIRT946631	hsa-miR-4495	CLIP-seq
MIRT946639	hsa-miR-4639-3p	CLIP-seq
MIRT946655	hsa-miR-4789-5p	CLIP-seq
MIRT946658	hsa-miR-4796-5p	CLIP-seq
MIRT946661	hsa-miR-520d-5p	CLIP-seq
MIRT946664	hsa-miR-524-5p	CLIP-seq
MIRT946668	hsa-miR-548l	CLIP-seq
MIRT946673	hsa-miR-584	CLIP-seq
MIRT946674	hsa-miR-587	CLIP-seq
MIRT946675	hsa-miR-622	CLIP-seq
MIRT946678	hsa-miR-892b	CLIP-seq
MIRT1980379	hsa-miR-936	CLIP-seq
MIRT2448564	hsa-miR-335	CLIP-seq
MIRT2448565	hsa-miR-4764-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	IDA	18794347
GO:0000209	Process	Protein polyubiquitination	TAS	17085480
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	18794347, 20129063
GO:0005515	Function	Protein binding	IPI	16949367, 17041588, 18794347, 23213251, 26431207, 27906959, 32814053
GO:0005634	Component	Nucleus	IDA	17106265, 26431207
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0005730	Component	Nucleolus	IDA
GO:0005813	Component	Centrosome	IDA	17106265
GO:0005829	Component	Cytosol	IDA
GO:0006260	Process	DNA replication	IEA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IDA	18794347
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IMP	26431207
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	TAS	17085480
GO:0006513	Process	Protein monoubiquitination	IDA	20129063
GO:0006974	Process	Cellular response to DNA damage stimulus	IDA	20129063
GO:0006974	Process	Cellular response to DNA damage stimulus	IMP	16949367
GO:0009411	Process	Response to UV	IDA	18794347
GO:0010971	Process	Positive regulation of G2/M transition of mitotic cell cycle	IMP	16949367
GO:0019985	Process	Translesion synthesis	IDA	20129063
GO:0031464	Component	Cul4A-RING E3 ubiquitin ligase complex	IDA	17085480, 18794347, 20129063, 21628527
GO:0031465	Component	Cul4B-RING E3 ubiquitin ligase complex	IDA	18794347
GO:0031965	Component	Nuclear membrane	IEA
GO:0042769	Process	DNA damage response, detection of DNA damage	TAS
GO:0043687	Process	Post-translational protein modification	TAS
GO:0045732	Process	Positive regulation of protein catabolic process	IMP	16949367
GO:0048511	Process	Rhythmic process	IEA
GO:0051726	Process	Regulation of cell cycle	IMP	17085480
GO:0072425	Process	Signal transduction involved in G2 DNA damage checkpoint	IMP	17085480
GO:0080008	Component	Cul4-RING E3 ubiquitin ligase complex	IMP	16949367

Other IDs

• MIM: 610617
• HGNC: 30288
• e!Ensembl: ENSG00000143476

Protein

• UniProt ID: Q9NZJ0
• Protein name: Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein)
• Protein function: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyu
• PDB: 6QC0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00400	WD40	88 → 126	WD domain, G-beta repeat	Repeat
  PF00400	WD40	130 → 169	WD domain, G-beta repeat	Repeat
  PF00400	WD40	210 → 244	WD domain, G-beta repeat	Repeat
  PF00400	WD40	305 → 345	WD domain, G-beta repeat	Repeat
  PF00400	WD40	350 → 389	WD domain, G-beta repeat	Repeat

• Sequence:

  MLFNSVLRQPQLGVLRNGWSSQYPLQSLLTGYQCSGNDEHTSYGETGVPVPPFGCTFSSA
  PNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQ
  TAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYR
  QVNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGII
  KVWDLRKNYTAYRQEPIASKSFLYPGSSTRKLGYSSLILDSTGSTLFANCTDDNIYMFNM
  TGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHS
  QEVTSVCWCPSDFTKIATCSDDNTLKIWRLNRGLEEKPGGDKLSTVGWASQKKKESRPGL
  VTVTSSQSTPAKAPRAKCNPSNSSPSSAACAPSCAGDLPLPSNTPTFSIKTSPAKARSPI
  NRRGSVSSVSPKPPSSFKMSIRNWVTRTPSSSPPITPPASETKIMSPRKALIPVSQKSSQ
  AEACSESRNRVKRRLDSSCLESVKQKCVKSCNCVTELDGQVENLHLDLCCLAGNQEDLSK
  DSLGPTKSSKIEGAGTSISEPPSPISPYASESCGTLPLPLRPCGEGSEMVGKENSSPENK
  NWLLAMAAKRKAENPSPRSPSSQTPNSRRQSGKKLPSPVTITPSSMRKICTYFHRKSQED
  FCGPEHSTEL

• Sequence length: 730

Pathways

Reactome:

Recognition of DNA damage by PCNA-containing replication complex
Neddylation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Adenocarcinoma	Adenoid Cystic Carcinoma	rs121913530, rs886039394, rs121913474	16762588

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		28284560
Salivary gland neoplasm	Salivary Gland Neoplasms		16762588
Malignant neoplasm of salivary gland	Malignant neoplasm of salivary gland		16762588